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http://dx.doi.org/10.12925/jkocs.2021.38.2.368

Effects of Radiation Mutant Perilla frutescens var. crispa and Atractylodes macrocephala Koidzumi Complex Extract on the Mediators Related to Degenerative Arthritis  

Sim, Boo-Yong (Division of Integrated Biotechnology, Joongbu University)
Joo, In-Hwan (College of Oriental Medicine, Daejeon University)
Kim, Sung-Kyu (SFC bio Co., LTD)
Ji, Joong-Gu (Department of Herbal Health & Pharmacy, Joongbu University)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.2, 2021 , pp. 368-377 More about this Journal
Abstract
The present study aimed to evaluate the effects of radiation mutant Perilla frutescens var. crispa and Atractylodes macrocephala Koidzumi complex extract(Perilla frutescens var. crispa complex extract) on the mediators related to degenerative arthritis in a monosodium iodoacetate-induced rat model of degenerative arthritis. Perilla frutescens var. crispa complex extract was administered orally at doses of 25, 50 or 100 mg/kg/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 µl of 0.9% saline) into the intra-articular space of the rats' right knees. The rats subsequently received the same doses of oral Perilla frutescens var. crispa complex extract for another 4 weeks. It was evaluated that the treatment effects based on serum bio-markers, and morphological and histopathological analysis of the knee joints. Compared with those in negative control rats, the Perilla frutescens var. crispa complex extract treatments significantly reduced the serum levels of inflammation, bone metabolism markers (i.e., TNF-α, MMP-3, COX-2, PGE2, COMP, and Aggrecan). Otherwise, it was significantly increased the production of CTX-2 in cartilage absorption mediators. In addition, the Perilla frutescens var. crispa complex extract treatments effectively preserved the knee cartilage and synovial membrane. As a result, it indicates that the Perilla frutescens var. crispa complex extract improved degenerative arthritis symptoms. Thus, the Perilla frutescens var. crispa complex can be used in food material for the management of degenerative arthritis.
Keywords
bone metabolism; Atractylodes macrocephala Koidzumi; radiation mutant Perilla frutescens var. crispa; food material; degenerative arthritis;
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1 B. O. Cho, C. H. Jin, Y. D. Park, H. W. Ryu, M. W. Byun, K. I. Seo, I. Y. Jeong, "Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells", Bioscience, biotechnology, and biochemistry, Vol. 75, No. 7, pp. 1306-1311, (2011).   DOI
2 B. Y. Sim, J. H. Park, S. K. Kim, J. G. Ji, "Effects of anti-inflammatory on Perilla frutescens var. crispa Induced by mutants with γ-Ray". Journal of the Korean Applied Science and Technology, Vol. 36, No. 2, pp. 488-497, (2019).   DOI
3 Korea Economic Research Institute(KERI), Press release, (2021).
4 S. Glyn-Jones, A. J. R. Palmer, R. Agricola, A. J. Price, T. L. Vincent, H. Weinans, A. J. Carr, "Osteoarthritis", The Lancet, Vol. 386, No. 9991, pp. 376-387, (2015).   DOI
5 M. Hosoi, M. Ito, T. Yagura, R. P. Adams, G. Honda, "cDNA isolation and functional expression of myrcene synthase from Perilla frutescens", Biological and Pharmaceutical Bulletin, Vol. 27, No. 12, pp. 1979-1985. (2004).   DOI
6 C. H. Jin, H. J. Lee, Y. D. Park, D. S. Choi, D. S. Kim, S. Y. Kang, I. Y. Jeong, "Isoegomaketone inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages through the heme oxygenase-1 induction and inhibition of the interferon-β-STAT-1 pathway", Journal of agricultural and food chemistry, Vol. 58, No. 2, pp. 860-867, (2009).   DOI
7 B. J. Park, H. J. Choi, B. Y. Sim, M. Y. Yun, I. H. Yoo, D. H. Kim, "Effects of KV Pharmacopuncture on MIA-induced Osteoarthritis Rat", Journal of Physiology & Pathology in Korean Medicine, Vol. 31, No. 1, pp. 46-51, (2017).   DOI
8 S. H. Kim, Y. S. Lee, S. Y. Heo. Senior-friendly Food Market and Its Vitalization. pp. 184-185, Korea Rural Economic Institute, (2017).
9 S. K. Mok, H. K. You, H. S. Shin, "The effects of prostaglandin and dibutyryl cAMP on osteoblastic cell activity and osteoclast generation", Journal of Periodontal and Implant Science, Vol. 26, No. 2, pp. 448-468, (1996).
10 I. Pengas, S. Eldridge, A. Assiotis, M. McNicholas, J. E. Mendes, L. Laver, "MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy", Journal of experimental orthopaedics, Vol. 5, No. 1, p. 21, (2018).   DOI
11 G. Y. Min, J. M. Park, I. H. Joo, B. Y. Sim, H. J. Choi, H. Y. Kim, D. H. Kim, "Effects of Chondroitin on Blood Related Pathologic Factor and Weight Bearing in MIA Osteoarthritis Model", Journal of The Korean Society of Food Science and Nutrition, Vol. 48, No. 3, pp. 306-312, (2018).   DOI
12 National Health Insurance Service, Korean Statistical Information Service [Internet], Available From: http://kosis.kr/statHtml/statHtml.do?orgId=350&tblId=DT_35001_A074111&conn_path=I2. (accessed Dec., 18, 2019).
13 G. D. Anderson, K. L. Keys, P. A. De-Ciechi, J. L. Masferrer, "Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis", Inflammation Research, Vol. 58, No. 2, pp. 109-117, (2009).   DOI
14 N. E. Lane, "Pain management in osteoarthritis: the role of COX-2 inhibitors", Journal of Rheumatology, Vol. 24, No. 49, pp. 20-24, (1997).
15 B. Y. Sim, I. H. Joo, S. K. Kim, J. G. Ji, "Effects of Radiation Mutant Perilla frutescens var. crispa in Preventing and Alleviating Symptoms in a Monosodium Iodoacetate-Induced Osteoarthritis Rat Model", Journal of the Korean Applied Science and Technology, Vol. 37, No. 4, pp. 830-838, (2020).   DOI
16 M. Reijman, J. M. W. Hazes, S. M. A. Bierma-Zeinstra, B. W. Koes, S. Christgau, C. Christiansen, H. A. P. Pols, "A new marker for osteoarthritis: cross-sectional and longitudinal approach", Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, Vol. 50, No. 8, pp. 2471-2478, (2004).
17 M. H. Park, C. J. Kim, J. Y. Lee, C. Y. Keum, I. S. Kim, C. H. Jin, S. K. Kim, "Anti-Arthritic Effect of Radiation Mutant Perilla frutescens var. crispa and Atractylodes macrophala koidz", Journal of the Korean Applied Science and Technology, Vol. 37, No. 1, pp. 102-113, (2020).
18 Y. I. Lee, I. C. Shin, I. K. Lee, D. S. Kim, "Variation of Leaf Pigment Contents in Progenies of Perilla Mutants Induced by Gamma Ray", Plant Breeding & Biotechnology, Vol. 31, No. 2, pp. 110-113, (1999).
19 J. P. Pelletier, J. Martel-Pelletier, S. B. Abramson, "Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets", Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, Vol. 44. No. 6, pp. 1237-1247, (2001).   DOI
20 M. B. Goldring, M. Otero, D. A. Plumb, C. Dragomir, M. Favero, K. El Hachem, K. B. Marcu, "Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis", European cells & materials, Vol. 21, No. 1, pp. 202-220, (2011).   DOI