• Journal of Applied Biological Chemistry
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• 제53권1호
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• pp.44-50
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• 2010

본 연구에서는 고지방식이로 비만을 유도한 암컷 백서에게 태음조위탕과 도담탕을 8주 동안 경구 투여하였을 때 에너지와 포도당 대사에 미치는 영향을 조사하였다. 태음조위탕은 체중과 복부지방에 지방 축적을 나타내는 mesenteric fat과 retroperitoneal fat 양을 감소시키는 경향은 있었지만 통계적으로 유의한 차이를 나타내지는 않았다. 태음조위탕은 대조군에 비해 식이섭취량을 감소시키는 경향을 나타내었다. 반면에 도담탕은 대조군에 비해 체중과 복부지방을 통계적으로 유의하게 감소시켰으며 이것은 식이 섭취량의 감소에 기인하였다. 에너지 소모량은 고지방식이군과 저지방식이군에 차이가 없었고 태음조위탕과 도담탕도 에너지 소모량에 영향을 미치지 않았다. 그러나 에너지원으로 지방을 사용하는 것은 도담탕이 대조군에 비해 높았다. 고지방식이에서는 체내 인슐린 저항성을 나타내는 $HOMA_{IR}$의 값이 높았고, 도담탕은 이것을 통계적으로 유의적으로 낮추었다. 또한, 간에 저장된 글리코겐양도 도담탕을 섭취한 백서에서 가장 많았고, 반면에 간에 저장된 중성 지방 함량은 가장 낮았다. 결론적으로 고지방을 장기간 투여한 암컷 백서에서 체내 에너지와 포도당 대사에 장애가 나타났으며, 태음조위탕과 도담탕이 모두 이러한 장애를 해소하는 경향이 있었으나 도담탕이 효과적으로 에너지와 포도당 대사를 정상화시켰다. 그러므로 비만인 사람에게서 효과적으로 에너지와 포도당 대사를 정상화시킬 수 있는 지에 대한 인체 실험을 하는 것이 필요할 것으로 사료된다.

• 대한한약
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• 통권4호
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• pp.316-319
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• 2000

• 사상체질의학회지
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• 제11권2호
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• pp.267-281
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• 1999

1. 연구목적 본 실험은 태음조위탕이 대뇌신경세포의 산화적 손상에 대한 효능을 밝히기 위한 것이다. 2. 연구방법 신생생쥐에서 순수 분리한 대뇌신경세포(大腦神經細胞)를 배양(培養)하여 glucose oxidase (GO)에 노출시킨 후 이의 독성효과(毒性效果)를 측정(測定)하였으며, 또한 GO에 의하여 유도(誘導)된 독성(毒性)에 대한 태음조위탕(太陰調胃湯)의 효과(效果)를 조사(調査)하였다. 3. 결과 및 결론 산소자유기(酸素自由基)인 GO는 MTTassay에 의한 세포생존율(細胞生存率)의 유의한 감소(減少)를 보였다. 산소자유기(酸素自由基)인 GO는 NR assay에 의한 세포생존율(細胞生存率)의 유의한 감소(減少)를 보였다. GO의 산화적(酸化的) 손상(損傷)에 의한 신경독성(神經毒性)에 대하여 태음조위탕(太陰調胃湯) 투여로 총단백질양의 유의한 증가(增加)를 보였다. GO의 산화적(酸化的) 손상(損傷)에 의한 신경독성(神經毒性)에 대하여 태음조위탕(太陰調胃湯) 투여로 lipid peroxidation의 유의한 감소(減少)를 보였다. 이상(以上)의 실험결과(實驗結果)는 태음조위탕(太陰調胃湯)이 대뇌신경세포(大腦神經細胞)의 산화적손상(酸化的損傷)에 대하여 유의성(有意性) 있는 방어적(防禦的) 작용(作用)을 나타낸 것으로, 이와 관련된 노화억제(老化抑制)나 뇌허혈(腦虛血), 다발성경화증(多發性硬化症), 치매 등 뇌기능손상(腦機能損傷)이나 저하(低下)로 유발되는 질환(疾患)에 대한 임상응용(臨床應用)에 대해서도 지속적(持續的)인 연구(硏究)가 필요(必要)하다고 사료(思料)된다.

• 대한한의학회지
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• 제25권2호
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• pp.87-97
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• 2004

Objectives : To identify the effect of Taeyeumjowee-tang on the treatment of obesity Methods : After having been fed a high-fat diet for 6 weeks, obese white rats were classified into three groups. Control group 1 was fed a high-fat diet for 2 more weeks. Control group 2 was fed a normal diet for 2 weeks. The Sample group was fed Taeyeumjowee-tang extract with a normal diet for 2 weeks. The result of the comparison among the three groups was as follows. Results : The Sample group decreased significantly as compared with the Control 1 and 2 groups in changes of the body weight, fat cell size, fat accumulation, insulin, triglyceride, total cholesterol, total lipid, free fatty acid and UCP1. Conclusions : Taeyeumjowee-tang has significant effect on the treatment of obesity resulting from a high-fat diet. Especially, it was a sure remedy for Control group 2 that was fed normal1y after having a high-fat diet.

• 동의생리병리학회지
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• 제22권6호
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• pp.1600-1605
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• 2008

The objectives of this study were to survey the adverse reactions by Taeeumjowi-tang and to compare the tendency of symptoms by Sasang constitutional type. The clinical data for this study were based on the medical records of 78 cases collected from an oriental clinic. The major results of this survey are following: The 5.8% of Taeeum-in who took Taeeumjowi-tang showed side effects. And the 52.4% of Soeum-in and 41.6% of Soyang-in also showed side effects against Taeeumjowi-tang. They complained of excitation, irritability, restlessness, hypersensitivity, tinnitus, insomnia, upper abdominal discomfort, poor appetite, thirst, perspiration, dizziness, chest pain, tremor and evacuation troubles in common. And these adverse symptoms were similar to that by Ma-hwang. Therefore if we make a suitable medication guide for Ma-hwang based on Sasang constitutional type, it will be able to maximize the efficacy and minimize the adverse effect.

• 사상체질의학회지
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• 제22권2호
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• pp.135-142
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• 2010

1. Objectives: The purpose of this case is to report that a Tae-eumin patient diagnosed as drug-induced liver injury (DILI) caused by Galgeunhaegi-tang (Gegenjieji-tang) treated with Taeumjowe-tang reduced ephedra to 2g (Taiyintiaowei-tang) and then liver function test Results: improved. 2. Methods: We diagnosed him as Tae-eumin Exterior cold disease induced from the esophagus affected by cold. We made him stop taking Galgeunhaegi-tang (Gegenjieji-tang) and take Taeumjowe-tang reduced ephedra to 2g. (Taiyintiaowei-tang) 3. Results: After our treatment, the symptom and the liver function test Results: improved. 4. Conclusions: The wrong diagnosis of constitution and pathological syndromes can be caused drug-induced liver injury. Taeumjowe-tang reduced ephedra to 2g (Taiyintiaowei-tang) may have an effect on treatment of drug-induced liver injury of Tae- eumin.

• 사상체질의학회지
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• 제24권4호
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• pp.51-61
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• 2012

Objectives : The purpose of this study was to investigate the anti-atherosclerotic effects of 4 herbal formulas for Sasang constitutional medicine (Yeoldahanso-tang: YDHST, Yanggyeoksanhwa-tang: YGSHT, Cheongsimyeonja-tang: CSYJT and Taeeumjowi-tang: TEJWT). Methods : The antioxidant activities of herbal formulas were studied by measuring free radical scavenging activities on ABTS and DPPH. The inhibitory effects on LDL oxidation was evaluated by the formation of TBARS, REM and fragmentation of apolipoprotein B-100 (ApoB). Effects of herbal formulas on macrophage lipid accumulation were determined in native LDL and LPS co-incubated macrophages using Oil Red O staining. Results : The scavenging activities on ABTS and DPPH of herbal formulas were increased in dose-dependent manner (YDHST>YGSHT>CSYJT>TEJWT). Herbal formulas reduced the oxidation properties of LDL induced by $CuSO_4$. YDHST, YGSHT and CSYJT showed strong suppressive effect on LDL oxidation than TEJWT. In addition, YDHST, YGSHT and CSYJT significantly inhibited foam cell formation in LDL/LPS stimulated RAW 264.7 cells. Conclusions : These results demonstrate that YDHST, YGSHT and CSYJT have potentials on anti-atherosclerosis by antioxidative effect and suppressive effect on LDL oxidation.

• 사상체질의학회지
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• 제29권3호
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• pp.248-261
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• 2017

Objectives The purpose of this study is to analyze the decision making process of prescribing Yeoldahanso-tang and Taeeumjowi-tang Choweseuncheng-tang using decision tree. Methods We used collected the prospective clinical data of TE type from September 2012 to July 2015. In this study, we used gender, BMI, blood pressure, pulse and clinical symptoms (digestion, sweat, defecation, urination, sleep, physical status, emotion, heat-coldness, water consumption, facial color) as variables. Decision trees were analyzed using open source R version 3.3.2. Results & Conclusions We found that the decision trees differed among institutions. However, in all institutions, it was found that stool type (ordinary symptom), urine frequency (ordinary and present symptom) and anxiety (ordinary symptom) were important in the decision of prescription. Besides, clinical informations such as sex, Body Mass Index and blood pressure affected the prescription decision.

• 한방비만학회지
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• 제10권1호
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• pp.29-40
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• 2010

Objective The aim of this study was to evaluate the influence of Gamitaeeumjowi-tang(GTT) prescribed by doctors of korean(KMD) medicine on liver function. Methods For this single-center, prospective, observational study, we enrolled patients who wished to take GTT prescribed by KMD for losing weight. sixty(60) patients took GTT for 33.8 days and completed questionnaires. Liver function tests(LFTs) were performed bofore(first test) and after each GTT treatment(finish test). For LFT, T-bil, ALP, AST, ALT were measured. Result There were no significant changes in LFT data between the first and finish tests. At first test, levels of test seven(7) patients were more than twice of normal range of upper limit, levels of eight(8) patients were more than normal range of upper limit, less than twice of normal range of upper limit. At last test, levels of nine(9) patients were more than normal range of upper limit, less than twice of normal range of upper limit. Conclusion The current study showed that ingestion of GTT prescribed by KMD did not increase the frequency of abnormal LFTs, at least in the short term.

• 사상체질의학회지
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• 제24권1호
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• pp.66-74
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• 2012

1. Objectives : The purpose of this case study is to report that the general symptoms in 83 years-old female pateint with diaphragmatic hernia improved through oral administration of Taeeumjowi-tang(太陰調胃湯) 2. Methods : We considered the patient as Taeeumin, and administered Taeeumjowi-tang(太陰調胃湯) to improve chief complaints, such as general weakness, anorexia, sense of distension, dyspnea. The change of symptoms were evaluated by VAS(visual analogue score). 3. Results : The patient received hospital treatment for 4 weeks, and the chief complaints such as general weakness, anorexia, sense of distension, dyspnea improved in general 4. Conclusions : The patient with the above symptoms (general weakness, anorexia, sense of distension, dyspnea) was confirmed as diaphragmatic hernia by chest CT scan. But the patient decided not to have surgical operation. Observating the progress, we treated the patient through oral administration of Taeeumjowi-tang(太陰調胃湯), acupuncture and moxibustion treatment. And the general symptoms improved.