• 한우개량
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• v.6 no.5 s.23
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• pp.22-27
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• 2001

한우의 번식에 있어서 번식효율을 증진하기 위해서는 정확한 수정적기의 선택과 수정 후 가능하면 조기에 임신감정을 실시하여 공태기간을 최소로 단축시켜 번식우의 효율을 증진하고 송아지 생산비를 줄여야 할 것이다. 임신감정은 일반적으로 인공수정사나 수의사가 직장검사를 통해 태아를 확인하는 방법이 있으나, 이 방법은 수정 후 50-60일 이후부터 가능하며 숙련자에 따라 진단율이 다르며 암소에게 스트레스를 주고 태아나 난소에 손상을 주거나 심하면 태아의 조기폐사 등의 부작용이 있으며 진단율도 2-3만원 정도 소요된다. 최근 임신진단을 현장에서 간단히 조기에 진단할 수 있는 새로운 방법이 개발되어 있어 소개하기로 한다.

• Journal of Genetic Medicine
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• v.8 no.1
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• pp.1-16
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• 2011

Owing to the risk of fetal loss associated with prenatal diagnostic procedures (amniocentesis, chorionic villus sampling), noninvasive prenatal diagnosis (NIPD) is ultimate goal of prenatal diagnosis. The discovery of circulating cell-free fetal DNA (cffDNA) in maternal plasma in 1997 has opened up new probabilities for NIPD by Dr. Lo et al. The last decade has seen great development in NIPD. Fetal sex and fetal RhD status determination by cffDNA analysis is already in clinical use in certain countries. For routine use, this test is limited by the amount of cell-free maternal DNA in blood sample, the lack of universal fetal markers, and appropriate reference materials. To improve the accuracy of detection of fetal specific sequences in maternal plasma, internal positive controls to confirm to presence of fetal DNA should be analyzed. We have developed strategies for noninvasive determination of fetal gender, and fetal RhD genotyping using cffDNA in maternal plasma, using real-time quantitative polymerase chain reaction (RT-PCR) including RASSF1A epigenetic fetal DNA marker (gender-independent) as internal positive controls, which is to be first successful study of this kind in Korea. In our study, accurate detection of fetal gender through gestational age, and fetal RhD genotyping in RhD-negative pregnant women was achieved. In this assay, we show that the assay is sensitive, easy, fast, and reliable. These developments improve the reliability of the applications of circulating fetal DNA when used in clinical practice to manage sex-linked disorders (e.g., hemophilia, Duchenne muscular dystrophy), congenital adrenal hyperplasia (CAH), RhD incompatibility, and the other noninvasive pregnant diagnostic tests on the coming soon. The study was the first successful case in Korea using cffDNA in maternal plasma, which has created a new avenue for clinical applications of NIPD.

• Proceedings of the Korean Statistical Society Conference
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• 2002.11a
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• pp.299-304
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• 2002

본 연구에서는 자궁 내 태아의 발육지연이 주산기 사망률 및 이환율을 증가시키는 고위험 임신의 한 예로써, 태아 발육제한증과 관련한 비선형적인 자료를 통계적인 방법으로 접근하는데 초점을 두었다. 이에 정상태아와 발육제한증 태아를 판별하기 위한 분석을 실시함에 있어 신경망 이론 중 하나인 다층 퍼셉트론 모형으로 예측하고자 하였다.

• Clinical and Experimental Pediatrics
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• v.50 no.3
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• pp.268-271
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• 2007

Purpose : Premature narrowing of the foramen ovale is rare but serious clinical entity. Prenatal narrowing or obstruction of the foramen ovale shows symptoms such as right heart failure, fetal hydrops, triscupid regurgitation, left heart obstructive disease, and supraventricular tachycardia. This study aimed to assess the prenatal diagnosis and postnatal clinical course of restrictive foramen ovale in utero in otherwise normal heart. Methods : The subjects were five patients diagnosed with restrictive foramen ovale in utero from January 2001 to June 2005 at Chungnam National University Hospital. The diagnostic criteria was defined when the maximum diameter in a 4-chamber view is less than 2.5 mm and there is a continuous doppler velocity at the foramen ovale of more than 0.6m/s. Results : At the time of diagnosis of restrictive foramen ovale, gestation age was 34~37 wks, and chief complaints were fetal arrhythmia(2 cases), pericardial effusion, Ebstein anomaly and subaortic stenosis. Two cases which were diagnosed fetal hydrops and supraventricular tachycardia delivered by emergent cesarian section. Five cases were found to have right heart dilatation on echocardiogram after birth, but right heart dilatation became normalized at day 7 after birth and the clinical courses were not eventful. Conclusion : Identifying an obstructed foramen ovale in the fetus warrants the further search for additional cardiac and extracardiac anomalies, which may alter the prognosis. Delivery should be induced if possible in cases of foramen ovale obstruction with signs of cardiac decompensation.

• 가정의 벗
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• v.37 no.2 s.426
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• pp.12-13
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• 2004

출생아 100명중 1명에게 나타난다고 하는 선천성 심장병, 태아 심장 초음파 검사로 심장병이 있는 태아가 태어나지도 못하는 등 많은 문제를 가지고 있습니다. 그러나 치료 기술이 발전하여 조기 진단과 적절한 치료를 받게 되면 정상 수명까지 살 수 있습니다.

• 가정의 벗
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• v.34 no.2 s.390
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• pp.26-26
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• 2001

• Journal of the korean veterinary medical association
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• v.17 no.5
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• pp.49-53
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• 1981

• Journal of the korean veterinary medical association
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• v.5 no.2
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• pp.50-51
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• 1961

• Journal of Genetic Medicine
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• v.8 no.2
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• pp.100-104
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• 2011

Genetic testing has been generalized for the diagnosis of diseases and is an important method of research with advances in the life sciences. In particular, we should give better attention to the genetic test for a fetus. Because the fetus has no autonomy, ethical and social issues can arise. Therefore, appropriate genetic counseling is needed for parents to be informed with the characteristics, natural progress, and possible treatment of a genetic disease, prior to the prenatal genetic test. Physicians should also inform parents how a particular genetic risk factor relates with the likelihood of a disease, in order to assist the parents in making the best decision. Furthermore, the current law for prenatal genetic testing should be approached rationally.

• The Journal of the Korea Contents Association
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• v.17 no.4
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• pp.500-509
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• 2017

The purpose of this study was to evaluate the level of biomedical ethics awareness, empathy among college students. The participants were 469 university students in South Korea. The average score for biomedical ethics awareness was $2.89{\pm}.21$ ; The average the scores of empathy was $2.41{\pm}.35$. Biomedical ethics awareness showed a positive correlation with empathy(r=.203, p<.001). Emotional empathy showed a significant effect on biomedical ethics awareness. And the empathic concern of emotional empathy showed a significant effect on right to life fetus, artificial abortion, artificial insemination, prenatal diagnosis of fetus, right to life of newborn, euthanasia, brain death of biomedical ethics awareness. The results of this study suggest that biomedical ethics education to the emotional empathy should need for general university students.