• 제목/요약/키워드: 코호트연구

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Vitamin D and Depression (비타민 D와 우울증)

  • Cho, Su Kyung;Koo, Sle;Park, Kyong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.43 no.10
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    • pp.1467-1476
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    • 2014
  • Recent studies have shown that insufficient or deficient vitamin D status may be linked to increased risk of depressive conditions or depression. The aim of this study was to review all available evidence on vitamin D, depression, and any association between them. Cross-sectional, case-control, and cohort studies have reported contradictory results. Some have reported that low levels of vitamin D may be associated with higher risk of depression or depressive symptoms while others reported that vitamin D status may not be related to depression. Recent clinical trials examining the effects of vitamin D supplementation on depression have also showed discrepant results. However, meta-analysis study results are consistent regarding the beneficial effects of vitamin D. Several mechanisms that account for these beneficial effects of vitamin D on depression have been reported but remain largely speculative. Vitamin D deficiency is very common, and prevalence of depression is increasing in the Asian population, especially females. However, limited literature is available on this population. Considering research results of a potential inverse association between vitamin D level and prevalence of depression, it is important to advance our understanding of the role of vitamin D in depression and conduct well-designed prospective trials in the Asian population.

Dioxins and Health: Human Exposure Level and Epidemiologic Evidences of Health Effects (다이옥신과 건강: 인체 노출 수준 및 건강영향에 대한 역학적 연구)

  • Jang, Jae-Yeon;Kwon, Ho-Jang
    • Journal of Preventive Medicine and Public Health
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    • v.36 no.4
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    • pp.303-313
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    • 2003
  • General information is summarized, that is necessary to introduce a scientific assessment of the human health and exposure issue concerning dioxin and dioxin-like compound. Scientific literatures were reviewed to assess the background exposures to the dioxin-like compounds for normal residents. Epidemiologic studies were also reviewed to assess malignant and nonmalignant sweets of dioxins. In 1997, the International Agency for Research on Cancer classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a human carcinogen, primarily based on occupational cohort studies. The US Environmental Protection Agency made the same decision in it's Draft Dioxin Reassessment. Epidemiologic evidences point to a generalized excess of all cancers, without any pronounced excess at specific sites. Reported non-cancer effects included a range of conditions affecting most systems. Among them, chloracne, elevation in gamma glutamyl transferase(GGT), and alterations in reproductive hormones are related to TCDO, Other adverse outcomes, such as lipid concentrations, diabetes, circulatory and heart diseases, immunologic disorders, neurobehavioral effects, and developmental outcomes require further study before their respective relationships to TCDD can be more definitively assessed.

Occupational Injuries in Korea : A Comparison of Blue-Collar and White-Collar Worker's Rates and Underreporting (특집 - 제2회 산업보건학술제 수상 논문 - 한국의 산업재해 : 사무직과 생산직 근로자의 손상률 비교와 낮은 산재 보고율 -)

  • Won, Jong-Uk
    • 월간산업보건
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    • s.260
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    • pp.69-81
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    • 2009
  • $\bullet$ 목적 본 연구는 한국의 생산직 근로자와 사무직 근로자의 직업성 손상 및 질환의 차이를 비교하고 산재보고 축소(underreporting)의 규모를 추정하고자 수행되었다. $\bullet$ 방법 한국의 경인지역에서 구축된 근로자 건강진단 수진자 코호트와 1999-2001년 사이에 재직 중이었던 근로자의 건강보험 청구자료를 이용하였다. 근로자의 직무내용과 건강진단의 종류(특수건강진단 및 일반건강진단)로 사무직과 생산직 근로자로 구분하였으며, 이들 사이의 근골격계질환과 손상 및 중독에 해당하는 건강보험 이용률의 차이를 신고되지 않은 산재로 추정하였다. 이를 바탕으로 도수율, 산재발생률 및 재해율을 계산하였다. $\bullet$ 결과 생산직 근로자는 사무직 근로자보다 100 인년 당 3.47건 더 높은 건강보험이용률을 보였다. 이를 토대로 추정한 한국의 도수율은 12.57-18.1, 재해율은 2.74-3.29, 산재발생률은 3.62-5.44이었다. $\bullet$ 결론 한국 제조업의 산재발생률은 공식적인 통계보다 2-3배 더 높을 것으로 추정되지만, 연구의 제한점을 고려하여 이해할 필요가 있다.

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A Comparative Cohort Study on the Experiences of Job Loss and Job Seeking in Korea (생애주기에 따른 실직경험 및 구직활동에 관한 비교연구)

  • Yang, Sung-Eun
    • Korean Journal of Human Ecology
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    • v.21 no.1
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    • pp.41-58
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    • 2012
  • The purpose of this study was to compare the job loss and job seeking experiences between middle-aged men and their younger cohort. Participants included 11 middle-aged unemployed men and nine younger unemployed men. The study adopted a phenomenological approach. In-depth individual interviews were carried out and the theme analysis was used to analyze the interview data. The results showed that the two cohorts experienced the macroeconomic crises, the foreign exchange crisis in 1997 and the global financial crisis in 2008, differently. Their experiences affected their attribution of the unemployment and job seeking process. They expressed ambivalence toward their family while dealing with social isolation from extrafamilial support. Most of the participants criticized government employment support policies and services.

Image Analysis of Tongue for Deep Learning (이미지 딥러닝을 위한 설진 이미지 분석)

  • Seo, Jin-Beom;Lee, Jae-kyung;Cho, Young-Bok
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.10a
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    • pp.50-51
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    • 2021
  • In this paper, in order to design an image deep learning algorithm using a Lunar New Year image, a preliminary study on the shape and shadow of the image is conducted. In order to perform image deep learning, it is necessary to identify the characteristics of the Lunar New Year image, configure an appropriate label, and proceed with the preprocessing process. Image data is a cohort photo collected by Daejeon University, and based on this, we intend to establish a goal for conducting research from the data.

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Independent correlates of the toenail chromium level and the association between the chromium level and dyslipidemia (발톱 크롬 수준에 영향을 미치는 독립 요인과 크롬 수준과 이상지질혈증과의 연관성 분석)

  • Kang, Yeji;Lee, Yujin;Son, Jakyung;Park, Kyong
    • Journal of Nutrition and Health
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    • v.51 no.1
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    • pp.40-49
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    • 2018
  • Purpose: The number of patients with dyslipidemia have been increasing steadily over the past few decades in South Korea. The association between the chromium level and chronic disease has attracted considerable interest, but few studies have been conducted on the Korean population. The aim of this study was to identify the dietary and non-dietary correlates of the toenail chromium level, and evaluate the association between the toenail chromium level and dyslipidemia. Methods: The baseline data of an ongoing prospective cohort study in Yeungnam area in South Korea were analyzed. A total of 500 participants aged 35 years or older who completed questionnaires on their demographics, lifestyle characteristics, and medical information were included. The toenail chromium level was analyzed by neutron activation analysis. The dietary intake was assessed using a validated 146-item semi-quantitative food frequency questionnaire. The blood lipid profiles were obtained from medical examinations conducted by the Korean National Health Insurance Service or medical institutions. Results: Higher chromium levels were associated with the residential area (urban), higher education level, higher intakes of noodles and vegetables, and lower intake of fruits. Multiple logistic regression analysis showed that the toenail chromium levels were not associated significantly with the prevalence of dyslipidemia (odds ratio: 0.99, 95% confidence interval: 0.61 ~ 1.60). Conclusion: This study is the first study in Korea to determine the independent correlates of the toenail chromium levels and the association between chromium exposure and dyslipidemia. These findings provide useful scientific evidence for the development of chromium intake guidelines for the Korean population.

Association Between Lifestyle and Medical Expenses of Older Adults With Mental Illness: Using Korea Older Adults' Cohort Database (노인 코호트 DB를 이용한 정신과 질환 동반 노인의 생활 습관과 의료비 지출 크기의 연관성 분석 연구)

  • Jeong, Jiin;Bae, Suyeong;Yoo, Eun-Young;Hong, Ickpyo
    • Therapeutic Science for Rehabilitation
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    • v.12 no.1
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    • pp.51-63
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    • 2023
  • Objective : This study aimed to analyze the association between lifestyle and medical expenses of older adults with mental illness using claims data. Methods : We conducted secondary data analysis using the older adult cohort database provided by the Korea National Health Insurance Service. The lifestyle and medical expense variables were extracted from the cohort database. We used a generalized linear model to examine the association between lifestyle and medical expenses. Results : In total, 32,853 records were extracted. The results showed that smokers had medical expenses (estimate = -218,255, p = .037). As the number of days of walking increased, medical expenses significantly decreased (estimate = -58,843, p < .0001). Furthermore, as the number of days of drinking decreased, medical expenses increased (estimate = 692,289, p < .0001). Conclusion : This study analyzed the estimates of medical expenses according to lifestyle among older adults with mental illness. Smoking and exercise were negatively associated with medical expenses. These results suggest the importance of a healthy lifestyle for older adults with mental illness. In addition, this study can be used as clinical evidence for lifestyle management programs to improve physical and mental health.

Relationship between White Blood Cell Counts and the Metabolic Syndrome (백혈구 수와 대사증후군과의 관련성)

  • Seo, Hyun-Sook;Yun, Yong-Woon;Sohn, Seok-Joon
    • Journal of agricultural medicine and community health
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    • v.35 no.1
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    • pp.67-76
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    • 2010
  • Objectives: This study was attempted to identify the relationship between white blood cell counts and the metabolic syndrome. Methods: This study included 394 adults who visited the medical checkup center placed in Gwangju, January 1, 2008 to December 31, 2008. Index of blood test and physical checkup were performed on the study such as triglyceride, HDL-cholesterol, fasting sugar and white blood cell counts. Logistic regression analysis was used to evaluate the association between white blood cell counts, white blood cell differential count and metabolic syndrome with an adjustment age and smoking status. Results: The prevalence rate of metabolic syndrome was 25.3% among males and 13.3% among females, and was particularly high among males in their 40s. The increase in white blood cell counts lead to high prevalence of metabolic syndrome for both males and females. As white blood cell counts increased, the values of body mass index and cardiovascular risk factors were increased significantly. The odds ratio for elevated white blood cell counts increased significantly in the subjects with each components of the metabolic syndrome compared to the subjects without them. The lymphocyte counts in the white blood cell differential counts were higher in patients with metabolic syndrome than in those without. Conclusions: High level of white blood cell counts in normal range can be used as indicator in chronic inflammation. Increased white blood cell counts were significantly associated with metabolic syndrome.

Health life expectancy in Korea based on sample cohort database of National Health Insurance Services (국민건강보험 표본코호트DB를 이용한 한국인의 건강기대수명 연구)

  • Kwon, Tae Yeon;Lim, Ja Young;Park, Yousung
    • The Korean Journal of Applied Statistics
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    • v.30 no.3
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    • pp.475-486
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    • 2017
  • This paper estimates the health life expectancies for Korean people based on a sample cohort database collected through objective measurements by the National Health Insurance Service. Health life expectancy is estimated using the single-state approach of Sullivan (1971). The 9-order correction factor method of Greville (1945) and Brass-logit model of Brass (1971) are also adopted for unobserved or incompletely observed age-specific morbidity and mortality. Based on the mortality and morbidity estimated from sample cohort DB, men and women in Korea are expected to live a 'healthy life' for 61 and 60 years in 2013, respectively, whereas life expectancies of men and women are 80 and 87, respectively. We also estimate certain disease-free life expectancies for each of genders, income levels, and types of insurance from 2003 to 2013 in Korea. We found that there exists an inequality of healthy life expectancy in Korea for different genders, income levels, and types of insurance.

The Threshold of 0.5% Salt-water Taste and Risk of Stomach Cancer (0.5% 소금물에 대한 역치와 위암발생의 위험도)

  • Ohrr, Hee-Chul;Lee, Kang-Hee;Yi, Sang-Wook
    • Journal of agricultural medicine and community health
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    • v.25 no.2
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    • pp.293-302
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    • 2000
  • The relationship between sodium intake and stomach cancer risk has been studied much in Japan but a great portions still remain controversial. There has been few studies on relationship between sodium intake and stomach cancer in Korea. The goal of this nested case-control study is to investigate the association between sodium intake and stomach cancer risk in a rural county of Korea We estimated sodium intake indirectly by the threshold of salt-water taste of patients. This study was based on both of the data from 'Kangwha Cohort Study' which had been conducted from March 1985 and 'Kangwha Community Cancer Registry' which had been launched on July in 1982 by the College of Medicine, Department of Preventive Medicine. Yonsei University. A total of 145 patients who developed stomach cancer in Kangwha County were initially recruited as the case group. We tried to get two community-controls per stomach cancer case by matching age and gender. Finally we got information from 90 cases and 146 controls about the threshold of the salt taste and preference of salty food and so on. Some 79% of the information about ease group came from proxy respondents and 56% among controls. Risk ratios of developing stomach cancer adjusted for smoking, body mass index and self-stated health level were estimated. No statistically significant association between the threshold of salt taste and stomach cancer risk found in this study. We recommend some further studies utilizing urinary salt excretion, diet record method for better estimating of salt intake with a paticular emphasis on interaction effect between salty and spicy food in hospital-based case-control study designs.

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