• Title/Summary/Keyword: 캡슐화

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Preparation and Characterization of Double-Layered Coated Capsule Containing Low Molecular Marine Collagen and γ-Aminobutyric Acid Producing Lactobacillus brevis CFM20 (저분자 해양성 콜라겐과 γ-Aminobutyric Acid 생성 Lactobacillus brevis CFM20을 함유하는 이중코팅캡슐의 제조 및 특성)

  • Kim, Sun-Yeong;Oh, Do-Geon;Kim, Kwang-Yup
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.46 no.7
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    • pp.857-867
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    • 2017
  • This study was performed to encapsulate low molecular weight marine collagen and ${\gamma}$-aminobutyric acid (GABA)-producing lactic acid bacteria to inhibit degradation and improve survival rate during exposure to adverse conditions of the gastro-intestinal tract. Calcium-alginate method was used for the manufacture of a double-layered coated capsule. The inner core material was composed of collagen and lactic acid bacteria, and the coating materials were alginate and chitosan. The sizes and shapes of the double-coated capsule were affected mainly by centrifuge speed and pH. Manufactured capsules were observed with a scanning electron microscope and by confocal laser scanning microscopy to confirm the micromorphological changes of capsules and bacterial cells. As a result, double-layered coated capsules were not degraded at pH 1.2, whereas degradation occurred at pH 7.4. In addition, GABA and collagen were maintained in stable state at pH 1.2. Therefore, double-layered coated capsules developed in this study would not be degraded in the stomach and could be stably delivered to the small intestine to benefit intestinal and dermatic health.

Production of Glucosyl-xylitol Using Encapsulated Whole Cell CGTase (캡슐 고정화 전세포 CGTase를 이용한 Glucosyl-xylitol 생산)

  • 박중곤;박형우;이용현
    • KSBB Journal
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    • v.15 no.1
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    • pp.35-41
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    • 2000
  • We tried to prepare encapsulated whole cell cyclodextrin glucanotransferase(CGTase) in order to produce glycosyl-xylitol using xylitol as glucosyl acceptor. The organic nitrogen source was more effective for the production of CGTase from Bacillus macerans IFO 3490 than the inorganic one. Most of the CGTase which had been produced during cultivation was excreted to the growth medium. B. macerans cells inocculated in the capsule failed to grow to the high cell density. Adsorbents such as activated charcoal, Sephadex and Amberite resins could not adsorb efficiently the CGTase from the broth solution. We obtained successfully the encapsulated whole cell CGTase by immobilizing the concentrated broth solution in the calcium alginate capsules. The encapsulated whole cell CGTase carried out the transglycosylation reaction which converts xylitol into glucosyl-xylitol using dextrin as glucosyl donor.

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Application of PCM Technology to Concrete II : Effects of SSMA(Sulfonated Styrene-Maleic Anhydride) on the Properties of the 1-Dodecanol Micro-Capsule (PCM 기술의 콘크리트 적용 II : 계면중합법에 의한 1-도데카놀 마이크로 캡슐에 있어서 계면활성제로 사용된 SSMA의 표면활성도가 마이크로 캡슐의 특성에 미치는 영향)

  • Shin, Se-Soon;Jung, Jae-Yun;Lim, Myung-Kwan;Choi, Dong-Uk;Kim, Young-Ho
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.1 no.1
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    • pp.17-25
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    • 2013
  • Thermal storage technology used for indoor heating and cooling to maintain a constant temperature for a long period of time has an advantage of raising energy use efficiency. This, the phase changing material, which utilizes heat storage properties of the substances, capsulizes substances that melt at a constant temperature. This is applied to construction materials to block or save energy due to heat storage and heat protection during the process in which substances melt or freeze according to the indoor or outdoor temperature. The micro-encapsulation method is used to create thermal storage from phase changing material. This method can be broadly classified in 3 ways: chemical method, physical and chemical method and physical and mechanical method. In the physical and chemical method, a wet process using the micro-encapsulation process utilized. This process emulsifies the core material in a solvent then coats the monomer polymer on the wall of the emulsion to harden it. In this process, a surfactant is utilized to enhance the performance of the emulsion of the core material and the coating of the wall monomer. The performance of the micro-encapsulation, especially the coating thickness of the wall material and the uniformity of the coating, is largely dependent on the characteristics of the surfactant. This research compares the performance of the micro-capsules and heat storage for product according to molecular mass and concentration of the surfactant, SSMA (sulfonated styrene-maleic anhydride), when it comes to micro-encapsulation through interfacial polymerization, in which Dodecan-1 is transformed to melamin resin, a heat storage material using phase changing properties. In addition, the thickness of the micro-encapsulation wall material and residual melamine were reduced by adjusting the concentration of melamin resin microcapsules.

Citric Acid Production Using Encapsulated Aspergillus niger (Aspergillus niger 고정화 캡슐을 이용한 구연산 생산 특성)

  • 정수환;이태종박중곤장호남
    • KSBB Journal
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    • v.10 no.1
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    • pp.78-88
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    • 1995
  • The encapsulatpd A. niger grew up inside the capsule and mycelia penetrated through the pore of the capsule membrane. The mycelia on the capsule wall became loose when the carbon source and oxygen were deficient in the medium. On the contrary, the production rate increased and mycelia made a lump tightly when the carbon source and oxygen were sufficient. Namely, number of proper capsule of unit volume in the medium was existed. The phenomenon which was swelled of capsule membrane in cultivation could prevented by adding CaCl2 into the medium. According to the time adding CaCl2 into the medium, the production rate of citric acid was influenced. In case of adding CaCl2 into the medium at 7th day cultivation, the production yield of citric acid was increased about 40 percent higher than that of adding CaCl2 initially. The production yield of citric acid using encapsulated A. niger of flask culture was influenced with oxygen supply. The production yield of citric acid ($\Delta$p/$\Delta$s) of the flask culture was increased 3.88 time by using T-flask instead of parafilm sealed flask. Therefore, the productivity and consumption rate concerning production which was taken carbon source were increased when oxygen supply was sufficient. The production of citric acid using encapsulated A. niger was increased average 30 percent higher than that of bead in between 6th and 13th day cultivation.

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Effect of Liposome on the Stabilization of Ascorbic Acid (Ascorbic Acid 의 안정성에 대한 Liposome 의 효과)

  • Lee, Yu-Weon;Hwang, Yong-Il;Lee, Seung-Cheol
    • Korean Journal of Food Science and Technology
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    • v.31 no.2
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    • pp.280-284
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    • 1999
  • To overcome unstability of ascorbic acid, liposome was used to encapsulate it. Ascorbic acid was encapsulated with 46.8% efficiency inside soybean phosphatidyl choline liposomes by the dehydration-rehydration method. Stability of encapsulated ascorbic acid in liposome was enhanced compared to that in free aqueous solution. For example, most of ascorbic acid in acetate buffer (pH 5.0) was oxidized after 7 days, however, that in liposome was remained as reduced form with 22.8% after 40 days at same conditions. These results mean that encapsulation of ascorbic acid in liposome could provide protection tool for improvement in shelf life.

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Design Pattern to Improve the Applicability In a Reengineering Environment Represented with UML (재공학 환경에서 적용성 향상을 위한 디자인 패턴의 UML 표현)

  • 최성만;김송주;유철중;장옥배;이정열
    • Proceedings of the Korean Information Science Society Conference
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    • 2003.04c
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    • pp.148-150
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    • 2003
  • 본 논문은 재공학 환경에서 기존의 디자인 패턴을 적용성 향상을 위해 UML로 표현하였으며, 대상으로는 디자인 패턴 중에서 Strategy Pattern과 Visitor Pattern을 이용해 보았다. Strategy Pattern에서는{variation}과 {incomplete}를 이용하였다.{variation}은 메소드 구현시 패턴을 캡슐화하여 다양하게 변경될 수 있도록 하였다. 또한,{incomplete}는 주어진 관계를 만족하는 새로운 클래스가 패턴 인스턴스화 동안에 추가될 수 있도록 하였다. Visitor pattern에서의{extensible}은 클래스 인터페이스가 패턴을 캡슐화하고 있는 개념으로 다양하게 변경될 수 있도록 하였다. 즉, 클래스 인터페이스는 패턴 인스턴스화에 의존적이며 새로운 메소드와 속성을 클래스가 기능적으로 확장할 수 있는 기능을 갖는다.

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A Study on a Knowledge-Based Design System for Chip Encapsulation (반도체 칩의 캡슐화 성형을 위한 지식형 설계시스템에 관한 연구)

  • 허용정;한세진
    • Journal of the Korean Society for Precision Engineering
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    • v.15 no.2
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    • pp.99-106
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    • 1998
  • In this paper, we have constructed an expert system for semiconductor chip encapsulation which combines a knowledge-based system with CAE software. The knowledge-base module includes heuristic and pre analysis knowledge for evaluation and redesign. Evaluation of the initial design and generation of redesign recommendations can be developed from the rules as applied to a given chip package. The CAE programs can be used for simulating the filling and packing stage of encapsulation process. The expert system is a new tool which enables package design or process conditions with high yields and high productivity.

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Hierarchical Component for Educational Logic Circuit Simulator (교육용 논리회로 시뮬레이터를 위한 계층적 컴포넌트)

  • Yang, Seung-Ju;Kim, Eun-Ju;Lyu, Sung-Pil
    • Proceedings of the Korea Information Processing Society Conference
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    • 2009.04a
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    • pp.1009-1012
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    • 2009
  • 본 논문은 조립 개념을 탑재한 계층적 컴포넌트를 소개하며 이를 교육용 논리회로 시뮬레이터에 적용하여, 그 장점을 평가하고자 한다. 본 논문에서 제시하는 방법에 의한 컴포넌트의 설계과정은 계층 구조적이므로 설계 변경과 유지보수가 편리하고 컴포넌트의 재사용성을 상승시킨다. 이를 교육용 논리회로 시뮬레이터에 적용하면 다음과 같은 장점이 있다. 첫째, 불필요한 부분을 캡슐화하기 때문에 복잡성을 줄인다. 둘째, 그 캡슐화된 부분의 내부 회로도와 동작 상태를 확인할 수 있기 때문에 수준별 자율(자기 주도적) 학습에 효과적이다. 셋째, 병렬 개발이 가능해서 조별 협동 학습 수행이 가능하다.

Reduction of Wire Sweep during Chip Encapsulation by Runner Balancing and Ram Control (반도체 칩 캡슐화 공정에 있어서 와이어 스윕(wire sweep) 최소화에 관한 연구)

  • Han, S.;Huh, Y.J.
    • Journal of the Korean Society for Precision Engineering
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    • v.13 no.12
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    • pp.13-21
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    • 1996
  • In this paper, methods to reduce wire sweep during the chip-encapsulation process have been studide. Two methods have been tried for this purpose, namely runner balancing and ram velocity control. Runner balancing has been achieved automatically by using a computer program. Ram-velocity control has been achieved using empirical rules and results from a flow simulation of the encapsulation process. A mold which has 12 cavities for chip has been used as a case study. The simulation results show that the wire sweep obtained from the optimal process condition is about 1/5 of that from initial, unoptimized condition.

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