• Journal of Periodontal and Implant Science
• /
• v.25 no.1
• /
• pp.99-110
• /
• 1995

치주치료의 궁극적 목표인 치주조직 재생에 대한 관심이 높아지는 가운데 치주조직 재생에 주된 역할을 하는 치주인대세포와 치근면 탈회에 의한 신부착 효과에 관한 많은 연구가 시도되고 있다. 그러나 광범위한 연구에도 불구하고 어떤 치근면 처리가 신부착 형성에 가장 효과적인지는 아직 논란의 대상으로 남아있다. 이에 저자는 결합조직 부착에 의한 재생에 필수적인 치은 및 치주인대 섬유아세포의 부착 및 증식을 tetracycline-HCL(TC)과 citric acid(CA)로 각각 처리된 상아질 표면에서 비교관찰하여 치주조직 재생에의 기여도를 추정하기 위해 본 연구를 시행하였다. 교정치료를 위하여 본원에 내원한 환자의 제일 소구치의 건강한 치은조직을 채취하고, 발치 후 효소처리에 의한 치주인대세포를 얻은 후 각각 세포배양하였다. 상아질 절편은 $3{\times}3{\times}0.2mm^3$로 준비하고 TC과 CA처리군으로 나눈 후 각각 치은 및 치주인대 섬유아세포를 부착시키고 초기부착은 8시간까지, 증식은 7일까지 고나찰하여 다음의 결과를 얻었다. 1. 각 군의 세포 부착은 시간이 지남에 따라 증가되었다. 2. 모든 군에서 7일째 빠른 증식상을 보였다. 3. 초기 부착시 치은과 치주인대 섬유아세포의 반응에는 유의한 차이가 없었다. 4. 반면에 치은과 치주인대 섬유아세포는 증식속도에서 차이를 나타내었으며 치은 섬유아세포가 좀 더 빠른 성장을 보였다. 5. 치근면 탈회에 따라 초기부착과 증식상에서 모두 유의성 있는 증가를 보였다. 6. CA는 초기부착에서, TC는 증식장에서 더욱 효과적으로 작용했다.

• Journal of dental hygiene science
• /
• v.14 no.3
• /
• pp.364-370
• /
• 2014

The purpose of this study was to examine association between oral health status and perceived general health symptom. We analyzed 14,231 subjects who participated in Korea National Health and Nutrition Examination Survey (2007~2009). All individuals were examined by a questionnaire about socioeconomic history, smoking and drinking habit, the frequency of daily tooth brushing, the presence of regular dental visit, and EuroQol-5D. Dental survey was conducted to find the decayed, missing, and filled teeth (DMFT) index and community periodontal index. Subjects with perceived problem with mobility had higher DMFT index (odds ratio, 1.18, p<0.001). Subjects with with perceived problem with pain/discomfort had higher DMFT index (odds ratio, 1.16, p<0.001). Self-rating general health symptom was not associated with periodontitis (p>0.05). Perceived general health was associated with DMFT index. It is recommendable that we can use the perceived general health to predict oral health status.

• Journal of Periodontal and Implant Science
• /
• v.34 no.3
• /
• pp.623-637
• /
• 2004

중증 만성 치주염과 1L-1B+3954 및 1L-1A+4845 유전자의 대립유전자 2 보유 유전자 다변성이 관련된다고 보고되었다. 그러나 이러한 1L-1 복합유전자 다변성과 만성 치주염 및 급진성 치주염과의 관련성에 대해서는 상반되게 보고되고 있는데 이는 인종적 배경과 질환특성의 차이에 기인한 것으로 보인다. 이 연구는 한국인에서 경도, 중등도와 중증의 만성 치주염 그리고 급진성 치주염 환자를 대상으로 하여 1L-1A+4845, 1L-1B+3954, 1L1B-511, 1L-1 RN intron 2 (VNTR) 유전자 다변성의 분포를 평가하고, 치주질환의 심도와 유형에 관련되는지 알아보고자 시행되었다. 전남대학교 병원 치주과에서 검진과 치료를 받은 100명의 치주질환자를 대상으로 하였고 질환군은 치주낭 깊이, 부착 소실, 골 소실을 기준으로 하여 경도, 중등도, 중증의 만성 치주염, 급진성 치주염군으로 분류하였다. 대조군으로는 전남대학교 병원 소아치과에 내원한 전신적으로 건강한 92명의 아동을 포함하였다. 각 대상 환자에서 채취된 협점막상피에서 genomic DNA를 얻어 1L-1A+4845, 1L-1B+3954, 1L-1B-511 genotype은 중합효소 연쇄반응을 시행한 후 제한 효소분해과정을 거쳐 전기영동 후 분리한 결과를 해석하였으며 1L-1 RN(VNTR) 유전형은 중합효소연쇄반응 후 분리한 결과를 해석하여 다음의 결과를 얻었다. 대립유전자 2 보유자 비율은 치주질환자에서 1L-1A+4845, 1L-1B+3954, 1L-1B-511, 1L-1 RN이 각각 61%, 13%, 76.6%, 34%였으며 대조군에서는 76.9%, 7.7%, 62.2%, 19.1%였다. 1L-1B+3954과 1L-1A+4845 대립유전자 2 보유자인 양성유전자형 비율은 경도, 중등도, 중증의 만성치주염, 급진성 치주염환자에서 각각 10%, 7.9%, 22.2%, 12% 였으며 치주질환자의 13%, 대조군의 7.7%에서 양성 복합유전자형(positive genotype)을 보였다. IL-1B-511 유전자 다변성은 치주질환자에서 대조군에 비하여 높았으며 급진성 치주염환자에서 대립유전자 2 보유자율이 유의하게 높았다(p<0.01). IL-1 RN intron 2 유전자 다변성은 중등도 및 중증 만성 치주염환자에서 대립유전자 2 보유자율이 유의하게 증가하였다. 이러한 결과는 IL-1 gene cluster의 유전형이 한국인에서도 치주염의 유형과 질환 심도에 관련될 수 있음을 시사하였다.

• Journal of Periodontal and Implant Science
• /
• v.35 no.3
• /
• pp.661-674
• /
• 2005

The purpose of this study was to quantify and compare the level of MMP-2, MMP-8 in the healthy, inflammed gingival tissue and inflammed gingival tissue associated with type 2 DM. We investigate whether expression of MMP-2, MMP-8 is increased by chronic periodontitis associated with type 2 DM. Gingival tissue samples were obtained during periodontal surgery or tooth extraction. Based on patient's systemic condition & clinical criteria of gingiva, each gingival samples were divided into three groups. Group l(n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from 8 systemically healthy patients. Group 2(n=8) is inflammed gingiva from patients with chronic periodontitis. Group 3(n=8) is inflammed gingiva from type 2 diabetic patients with chronic periodontitis. Tissue samples were prepared and analyzed by Western blotting. The quantification of MMP-2, MMP-8 was performed using a densitometer and statistically analyzed by ANOVA. MMP-2, MMP-8 was expressed in all samples including healthy gingiva and increased in group 3 compared to group 1 and 2, and showed that significant variation was observed between group 1 & 3 in MMP-8 results. In conclusion, this study demonstrated that human gingival tissue with chronic periodontitis associated to type 2 diabetes showed slightly elevated MMP-2, MMP-8 levels compared to healthy gingiva and non-diabetic inflamed gingiva.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.7 no.4
• /
• pp.917-924
• /
• 2012

This study was attempted in order to grasp the influence of smoking upon periodontal disease by analyzing relationship between the smoking realities and the periodontal disease risk in adults aged over 19 in our country. In the findings, the mean in CPI of the whole subjects was 1.92. Among 6989 whole subjects, the group whose CPI is 0-2 included 4707 people(67.3%). The group whose CPI is 3-4 included 2282 people(32.7%). As for the group whose CPI is more than 3 when confounder wasn't corrected, the risk on incidence of periodontal disease in the group with smoking in the past increased by 1.78 times(95% CI:1.56-2.02), compared to the group with no smoking. In the group with the current smoking, it increased by 1.75 times(95% CI:1.55-1.82). Even with correcting gender, age, educational level, and diabetes appearance, the risk on incidence of periodontal disease was higher by 1.28 times(95% CI:1.08-1.53) in the group with smoking in the past and by 1.82 times(95% CI:1.54-2.16) in the group with the current smoking than the group without smoking at all. Accordingly, smoking was indicated to be related to periodontal disease. Thus, the positive publicity needs to allow patients themselves to establish firm consciousness. In addition, dental hygienists need to perform systematic non-smoking educational guidance within doctor's office. Thus, it is thought to necessarily contribute to improving periodontal health.

• Journal of the Korea Convergence Society
• /
• v.12 no.1
• /
• pp.111-118
• /
• 2021

This study used raw data from the 2016-2018 National Health and Nutrition Survey to study the correlation between blood lipid and periodontal disease in Korean men and women, and selected the final 11,797 people as subjects of analysis. A stratified analysis of smoking and residential areas was conducted to see the link between blood lipid and periodontal disease in Korean men. In men, non-smokers had a significant correlation of 1.38(95% CI:1.09-1.76), and in men, the risk group had a odds ratio of 1.49(95% CI:1.16-1.91), and in smokers, the risk group had odds ratio of 1.76 (95% CI:1.39-2.23) shows that the warning group is significant in relation to the intersecting ratio 1.14(95% CI:1.16-1.70) and the risk group 1.60(95% CI:1.32-1.94) periodontal disease. In conclusion, men's blood lipids and periodontal diseases are associated with smoking or residential areas, and are especially intended to be used as basic data in developing health education programs related to systemic and periodontal diseases for men in urban areas. In developing education programs for men in urban areas in the future, we want to use them as basic data.

• Journal of the Korea Convergence Society
• /
• v.11 no.7
• /
• pp.273-280
• /
• 2020

Upon investigating the dental health of teeth and gum, and the cleanliness of the oral cavity of female college students in the early 20's, it was reported to be that the number of cariogenic bacteria was heavily related to the acidity of saliva or ammonia. Also, cariogenic bacteria and ammonia was found out to be related with proteins (p<0.01), and ammonia, the synthetic product of cariogenic bacteria was heavily related to blood and white blood cells (p<0.01). To conclude, the healthiness of teeth was related to the acidity of saliva and ammonia, the healthiness of gum was related to blood, proteins and white blood cells while the oral hygiene was most likely to be related to ammonia. This result matched to the seven oral disease cause analyses of the saliva analysis apparatus (Sill-Ha ST-4910), which implied further utilization of this data to clinical implications. However, this study is limited to young personnel who does not have any chronic or general diseases; therefore further study is required to generalize this study.

• Journal of dental hygiene science
• /
• v.8 no.4
• /
• pp.261-266
• /
• 2008

The purpose of this study was to examine the effects of the toothpick method, one of professional toothbrushing methods, on the prevention of periodontal diseases and the satisfaction level of patients with that. The subjects in this study were 33 patients who included 16 men and 17 women. After the toothpick method was applied to the selected patients from January 9 to February 28, 2008, the collected data were analyzed with SPSS (Statistical Package for the Social Science) 12.0 program. The findings of the study were as follows: First, the patients investigated showed a 0.71 reduction in PI than in the past. The index of bleeding upon probing stood at 5.12, which dropped from 8.09 in the beginning. Second, the patients gave a mean of 4.20 to the professional toothbrushing out of possible five points, which showed that they expressed satisfaction with that. Third, as for the relationship between general characteristics and satisfaction level, the women were more satisfied with that ($4.25{\pm}0.33$). By age group, those who were in their 60s and up found that more satisfactory ($4.31{\pm}0.30$). Fourth, as to changes in oral symptoms by gender, the largest number of the men and women considered their gums to become healthier after the professional toothbrushing was applied. The above-mentioned findings suggested that dental institutions should be equipped with well-educated oral health care personnels who are responsible for the periodontal health of patients, and the development of oral health promotion programs is urgently required as well.

• Journal of Digital Convergence
• /
• v.12 no.11
• /
• pp.461-468
• /
• 2014

This study was to figure out the influence of oral health behavior and periodontal status on their OHIP-14. Explained to 255 people who visited the scaling center of Dental Hygienics of a college in Gyeongbuk from March 7th to June 13th 2014 and it was agreed to perform. Result of dental plaque and calculus rate of those with no TBI were high; the less frequent do they teeth brushing the higher were their rate of dental plaque, bleeding and calculus, while their OHIP-14 was low. The rate of calculus of whom with no education on dental floss use and who do not use dental flosswas high. The more powerful for those with higher rate of dental plaque; while the lower was the rate of calculus the higher was OHIP-14. Therefore, the more do they brush their teeth and the lower are the rate of their calculus, the more positively has it been figured out to influence on the quality of their life of oral health. Consequently, public health program should be developed to educate them on the necessity of scaing on a regular basis and the cause calculus of occurrence, as well as a media through which they can easily participate in the program.

• Journal of the Korea Convergence Society
• /
• v.10 no.1
• /
• pp.239-244
• /
• 2019

The aim of this study was to evaluate the association between Lipid profiles and periodontal diseases in Korea adults. The date from the 2013, 2014 Korean National Health and Nutrition Survey were used, and 8,854 subjects over 30 years were included in the analysis. periodontal disease was assessed using the Community periodontal Index. Study participants with HDL between ${\leq}40mg/dL$(high) were 1.39 times(95% CI=1.16 to 1.66) as likely to have periodontal disease as those with normal levels and those with Triglyceride ${\geq}200mg/dL$(high) were 1.14 times(95% CI=1.02 to 1.27) as likely to have periodontal disease as those with normal levels. positive significant association was observed between serum lipid profiles and periodontal disease; however, further studies need to be conducted to understand the actual relationship between STC levels and periodontitis and to establish causality and directional association.