• Korean Journal of Plant Resources
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• v.17 no.3
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• pp.339-351
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• 2004

This study was conducted to evaluate the effect of phased horticultural therapy(HT) program on the experience of psychologic therapy and the development of job and social integration in the mentally handicapped persons. In this study, the mentally handicapped persons participated in HT program were chosen in disabled person's welfare institute of Jeonnam. HT program was performed twice a week with 1 hour activity for 4 months. As a results, the mentally handicapped persons participated in HT program showed high interest of horticulture and improvement of self-respect and the high satisfactory degree of HT program. Therefore, the mentally handicapped persons were showed the experience of both physical and mental therapy, improvement of self-esteem scale and sociality in HT program. Also, the application of HT program with continuously interest will be showed high improvement of physical, psychological and sentimental. In the course of this HT program progress, horticultural therapist and social welfare officer were showed the limitation of role. Therefore the leaders of group for successful HT program be required the comprehensive plan of more efficient HT program and induced technique of continuously up-phased improvements in HT program progress.

• Journal of Hospice and Palliative Care
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• v.19 no.1
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• pp.70-75
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• 2016

Advanced incurable cancer patients receive palliative chemotherapy to prolong their life and improve quality of life. However, physicians should assess the timing to discontinue the treatment, especially near the final months of life, as palliative chemotherapy may accompany considerable toxicity. Even though there are no clear guidelines regarding the withdrawal timing for anticancer treatment in palliative setting, it is important clarify the issue for quality of care for advanced cancer patients. Here, we present two patients who received palliative chemotherapy for advanced colon cancer and non-small cell lung cancer, respectively. In both cases, it was jointly determined to stop palliative chemotherapy, and best efforts are made to relieve troublesome symptoms. The cases and up-to-date literature review will highlight the importance of the timing of discontinuation of cancer treatments when changes are being made to the health care system and hospice and palliative medicine is taking root in Korea.

• The Journal of Korean Academy of Sensory Integration
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• v.6 no.1
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• pp.63-69
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• 2008

Introduction : This study presents a case report of a child with sensory integration dysfunction(mixed sensory modulation disorder and dyspraxia), and describes strategy of the sensory integration intervention to encourage child's inner drive and the change of adaptive response. Main Subject : The subject was a boy, age 5 years and 10 months, who participated in short-term intensive sensory integration therapy program which was provided in a 2008 sensory integration treatment course. Based on results of assessment to the child, This study identifies the treatment goals, contents of treatment and analyze adaptive response' change of four therapy sessions. Conclusion : This case report demonstrates improvement of the adaptive response by sensory integration intervention and impotent to encourage the child's inner drive. However, subjective date, which is sensory integration may produce an effect that is evident during treatment sessions and in home environment have suggested.

• Proceedings of the Acoustical Society of Korea Conference
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• 1998.08a
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• pp.201-208
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• 1998

구음마비환자의 특징적 문제로는 조음 명료성의 저하오 kdns율의 장애등이 논의되어왔다. 지금까지 조음 명료성을 진단하고 치료하기 위한 연구는 활발히 진행되어 왔으나 운율 장애를 측정, 치료하기 위한 연구는 극히 소수이며 특히, 우리나라의 경우는 전무한 상태이다. 이에 본 연구자는 정상군과 이완성 구음마비환자군의 운율적 차이를 음폭, 음도차, 지속시간, 강도의 측면에서 기술하여 진단과 치료를 위한 기초 자료를 제시하고자 한다. 실험 대상은 이완성 구음마비환자군 6명과 정상군 6명이다. 정상군은 환자군과 성별, 나이, 학력, 방언을 맞추어 선정한다. 본 연구는 억양 대비가 분명히 나타나는 의문형 어미와 서술형 어미를 선택한다. 예문은 억양 곡선을 잘 나타내기 위해 유성 자음과 모음으로 구성된 것으로 한다. 종결형 어미가 분석 목표이나 예문의 길이가 너무 짧은 경우 경도환자의 특징이 잘 나타나지 않을 수 있으므로, 주어+목적어+서술어로 구성된 3어절로 구성된 예문을 사용한다.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2005.04a
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• pp.87-88
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• 2005

사이버나이프를 이용한 두경부와 체부 등의 정위방사선수술에서는 목표점의 식별 및 위치 추적에 대하여 높은 정확성을 요구한다. 본 연구에서는 사이버나이프의 targeting의 정확성을 평가하고자 한다. 사이버나이프의 targeting의 정확성을 평가하기 위하여 두상 팬텀을 사용하였다. 환자 치료시와 동일한 CT 영상 프로토콜로 두상 팬텀의 영상을 얻어 치료계획을 세웠다. 팬텀에 radiochromic 필름을 삽입한 뒤 수립된 치료계획에 맞춰 팬텀에 방사선을 조사하였다. 방사선 조사시 위치 추적은 skull과 fiducial 추적의 두 가지 방법을 사용하였다. 방사선에 조사된 radiochromic 필름을 분석하여 정확성을 평가하였다. 본 연구를 통하여 실시간 영상유도 기술을 사용하는 사이버나이프는 약 1 mm의 targeting 에러를 보였다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.129-129
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• 1993

현재 암의 치료에 이용되고 있는 항암제들은 therapeutic index가 낮아서 면역 및 조혈기능 장애 등 해결 되어야 할 문제점 들을 안고 있다. 이에 본 여구자는 우수하고 안전한 항암제를 개발하여 암의 치료에 이바지하고자, 화학연구소에서 in vitro 세로독성을 확인한 화합물에 대하여 in vivo 항암력을 실험, 치료효과가 높은 유도체/유사체 개발에 필요한 정보를 제공함에 본 연구의 목표를 두고 있다. 1차년도 연구에서는 화학연구소측이 제공한 KS 0409를 실험 약물로, sarcoma 180 복수암에 대한 in vivo 항암력을 실험하였다. 약 4주령의 SPE(specific pathogen-free) ICR계 마우스 및 BALB/c 마우스를 실험동물로 하여 sarcoma 180 암세포 부유액(세포 농도, 1$\times$$10^{7}$ cells/ml)을 실험동물의 복강내에 0.1ml 씩 이식하고 암이식 24시간 후부터 매일 1회씩 9회 약물 주사를 시행하였다. 대조약물 cisplatin은 2% DMSO-생리식염수를 주사하였다. 생존일수 관찰은 60dlfRK지 하였으며 % T/C를 계산하여 항암력을 평가하였다. 단 60일 생존 동물은 평균수명 계산에서 제외하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2024.05a
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• pp.687-689
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• 2024

위암은 전 세계적인 주요 건강문제이며, 근치적 위절제술은 위암의 표준치료이다. 근치적 위절제술 후 치료목표는 합병증 발생을 낮춰 병전 상태로 빠르게 회복하는 데 있다. 따라서, 근치적 위절제술 후 합병증 발생 여부를 선별하여 예측할 수 있는 성능이 좋은 모델을 개발하는 것은 위암환자의 회복에 매우 중요하다. 랜덤포레스트 모델은 여러 개의 결정트리를 활용한 배깅 방식의 대표적인 알고리즘으로 의료 데이터를 기반으로 한 예측에 있어 뛰어난 성능을 보여 주었다. 그러나 실제 데이터는 불균형이 빈번하게 발생하여 모델의 예측 성능에 영향을 미치므로, 최적의 분류 임계값을 설정하여 다수 클래스에 대한 편향을 줄이는 것이 중요하다. 따라서, 본 연구는 최근 10년 간 일개 대학병원의 전자의무기록 데이터를 활용하여 근치적 위절제술 후 합병증 발생을 예측하는 랜덤포레스트 모델을 개발하고, 임계값 설정을 통해 불균형 데이터에 대한 모델의 성능을 평가하고자 한다.

• Childhood Kidney Diseases
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• v.18 no.2
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• pp.64-70
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• 2014

Purpose: The aims of this study were to assess the clinical and laboratory profiles of chronic kidney disease-mineral bone disorder (CKD-MBD) and to assess the effects of treatment of active vitamin D analogs on severe hyperparathyroidism (SHPT) in pediatric patients on chronic peritoneal dialysis. Methods: This is a retrospective study included 53 patients who had been undergoing dialysis for more than 1 year, between January 2003 and December 2012. Results: Even after treatment with phosphate binders and active vitamin D analogs, the $mean{\pm}standard$ deviation of the percentage of time during peritoneal dialysis that the patients' serum concentrations of phosphorus, corrected total calcium, and parathyroid hormone (PTH) fell within the Kidney Disease Outcomes Quality Initiative recommended ranges was $25.06{\pm}17.47%$, $53.30{\pm}23.03%$, and $11.52{\pm}9.51%$, respectively. Clinical symptoms or radiological signs of CKD-MBD were observed in 10 patients (18.9%). There were significant differences in percentage of time that the serum intact PTH concentration was outside of the recommended range between patients with and without symptoms or signs of CKD-MBD (below recommended range, $11.74{\pm}7.37%$ vs. $40.77{\pm}25.39%$, P <0.001; above the recommended range, $63.79{\pm}27.86%$ vs. $37.09{\pm}27.76%$, P =0.022). Of the 25 patients with SHPT, high-dose alfacalcidol treatment was required in 13 patients that controlled SHPT in 7 of these patients, without marked complications. Conclusion: Despite our efforts to manage CKD-MBD, patients' met the recommended ranges from relevant guidelines at a low frequency. The treatment of high-dose active vitamin D analogs was required in about half of the patients with SHPT and effective in about half of them.

• Korean Journal of Psychosomatic Medicine
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• v.8 no.2
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• pp.149-164
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• 2000

Somatization is regarded as a process rather than a diagnostic entity. It should be emphasized to identify psychopathology rather than to make a choice regarding diagnosis in assessing somatizing patients. Psychiatrists should be aware of the psychosocial cues underlying the patients' physical symptoms. Special skills and strategies are required by nonpsychiatric physicians to facilitate the patients' acceptance of psychiatric treatment. The goal of treatment for somatization is management but not cure. The approach should be flexible, depending on the patients' responses and need. The difficulty in diagnosing and treating somatization is likely to be related to abnormal illness behavior such as the patients' denial of their psychosocial problems and resistance to psychiatric approach. In conclusion, biopsychosocial approach is needed to treat these patients effectively. Psychiatrists should also teach other physicians the interview skill that they could identify these patients as early as possible and facilitate their acceptance of psychiatric treatment.

• Therapeutic Science for Rehabilitation
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• v.1 no.2
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• pp.14-22
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• 2012

Introduction : The purpose of scholarly paper is to review of motor learning concepts and to examine in integration of motor learning research finding in occupational therapy services for adults with hemiplegia. Body : The principles of motor learning is stage of learning, type of task, practice and feedback. Depending on stage of learning, therapist need to apply of the principles. In early stage of learning, therapists should be promote patient's awareness about therapeutic goals, task performance environment and how to perform. Whole practice, blocked practice and constant practice improve performance skill. In the latter stage of learning, therapists have to design a intervention protocol for patient to use the implicit feedback. Random practice and open task facilitates performance skills. Conclusion : When establishing the a intervention plan for adults with hemiplegia, therapists should systematically developed the principles of motor learning. Intervention program must be established by applying the principles of motor learning in accordance with the learner's level of task performance, and modified depending on the therapeutic progress.