• Title/Summary/Keyword: 최적 치환율

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Lipoic Acid Conjugated Chitosan Copolymer for the Delivery of 5-Fluorouracil (5-Fluorouracil 전달을 위한 리포산이 결합된 키토산 공중합체)

  • Lee, Sun-Young;Kim, Young-Jin
    • Polymer(Korea)
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    • v.36 no.2
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    • pp.149-154
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    • 2012
  • The amphiphilic copolymer by the conjugation of biocompatible chitosan and antioxidant lipoic acid was studied as a drug delivery carrier. The amphiphilic copolymer was self-assembled to form nanoparticles in the aqueous solution. 5-Fluorouracil widely used as an anticancer drug was encapsulated inside the nanoparticles by a solid dispersion method. The degree of branching of lipoic acid on chitosan was controlled to obtain the optimal condition for the drug delivery carrier. The sizes of nanoparticles were about 250 nm by the dynamic light scattering. The encapsulation efficiency of nanoparticles were about 10%. The copolymer with 42% degree of branching showed the best performance as a drug delivery carrier.

Fundamental Properties of Mortar with Magnet-Separated Converter-Slag Powder as SCM (자력 선별 전로슬래그 미분말을 결합재로 활용한 모르타르의 기초특성)

  • Beom-Soo Kim;Sun-Mi Choi;Jin-Man Kim
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.11 no.3
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    • pp.161-168
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    • 2023
  • Converter slag is a by-product generated by refining the pig iron produced into molten steel in the blast furnace, occupying about 15 % of the weight of steel production. It has a high free-CaO content that can generate expansion cracks when used for concrete aggregate. This is the main reason to make it difficult to recycle. To solve this problem, government guideline requires that converter slag has to be aged in an open yard for 90 days. However, aging can not be perfectly performed because it entails time and cost. In this study, we tried to investigate the applicability of converter slag as a cementitious material rather than an aggregate by mixing converter slag with mortar formulations. According to the EDS results of the converter slag in the experiment, we found that screening in the aggregate phase was more effective than that in the powder phase. When the particles separated by a magnet in the aggregate state were pulverized and used for concrete up to a 15 % replacement ratio, various engineering characteristics, such as flow, length change, and compressive strength, showed engineering characteristics similar to those of the control mix.

Development of Ready-mixed Shotcrete I : Basic Study (레디믹스트 숏크리트 개발 I : 기초 연구)

  • Kim, Dong-Min;Ma, Sang-Joon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.31 no.5C
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    • pp.171-185
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    • 2011
  • Ready-mixed shotcrete that mixed with high quality aggregate and can improve construction quality is produced in a dry mortar plant and transported to construction sites. Because of using aggregate that produced in a special plant, Ready-mixed shotcrete has many advantages : good grain-size distribution, minimum stone powder, high quality and standardization material, etc. In this basic study different from the existing study that limited to additive and accelerator, the improvement of aggregate quality was tried to upgrade the shotcrete performance. The investigation about the construction conditions of shotcrete was performed and the result of an opinion poll was analyzed for a good grasp of the problems in domestic shotcrete quality. Pilot Plant Test was also performed to minimize the material segregation in plant manufacturing process. In additions, the field test was performed to find the optimum contents of synthetic fiber, appearing the same flexible toughness with that of steel fiber, and to find the optimum replacement ratio of blast furnace slag.

Method of Decreasing Cracking Index by Different Mix Conditions for Separated Placement and its Field Application (콘크리트 배합요인별 상·하부 분리타설에 의한 수화열 균열지수 저감방안 및 현장적용)

  • Kim, Min-Ho;Han, Cheon-Goo
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.4 no.3
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    • pp.292-298
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    • 2016
  • In this research, considering the practical situation of separated placing method for mass concrete structure, an efficient method of controlling the heat of hydration is suggested by comparing between the simulated values and actual measurements conducted with the optimum mix design obtained from the various mix conditions with different types and amount of supplementary cementitious materials(SCMs). As the result of the research, firstly, the optimum mix designs for top and bottom layers were determined by Midas gen as OPC to FA of 85 to 15, and OPC to FA to BS of 50 to 20 to 30, respectively. The concrete mixtures prepared with the mix designs determined from the simulation satisfied the target performance range in slump, air content and compressive strength. Additionally, from temperature measurement for the actual mass concrete placed during spring, the maximum temperature difference between surface and core was about $10^{\circ}C$ with 59 and $49^{\circ}C$ for top and bottom layers, respectively, and 1.4 of cracking index was obtained. Therefore, considering the practical conditions of mass concrete construction, it is considered that the different heat of hydration method using different mix designs with SCMs can be an efficient method for controlling thermal cracking and settling cracking of mass concrete.

Analysis of Propylen Chlorohydrin in Hydroxypropyl Distarch Phosphate by Accelerated Solvent Extractor (ASE) (가속화용매추출기를 이용한 히드록시프로필인산이전분의 프로필렌클로로히드린 분석방법에 관한 연구)

  • Lee, Myung-Ja;Sin, Yeong-Min;Jeong, Eui-Han;Choi, Tae-Jin;Chung, Sook-Hyun;An, Won-Gun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.31 no.4
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    • pp.604-608
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    • 2002
  • Accelerated solvent extraction (ASE) was used for a rapid and simple extraction of propylenchlorohydrin (PCH) residue in hydroxylpropyl modified starch. The effects of temperature, pressure and extraction solvent on the extraction efficiency were investigated to find the optimal condition of ASE. The optimal conditions for PCH extraction in hydroxylpropyl modified starch were static time of 50 min, purge time of 300 sec, heating time of 5min, temperature of 12$0^{\circ}C$, pressure of 2500 psi, flush (%) with 100 volumes, and ethylacetate as an extraction solvent. The recovery (96.1%) of this method was higher than that (76.4%) of Code of Food Additive. Therefore, the ASE was a good method in both aspects of efficiency and effectiveness.

A Study on Resistance of Chloride Ion Penetration in Ground Granulated Blast-Furnace Slag Concrete (고로슬래그 미분말 콘크리트의 염화물 침투 저항성에 관한 연구)

  • Song, Ha-Won;Kwon, Seung-Jun;Lee, Suk-Won;Byun, Keun-Joo
    • Journal of the Korea Concrete Institute
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    • v.15 no.3
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    • pp.400-408
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    • 2003
  • Chloride ion inside concrete destroys the so-called passive film surrounding reinforcing bars inside concrete so that the so-called salt attack accelerates corrosion which is the most critical factor for durability as well as structural safety of reinforced concrete structures. Recently, as a solution of the salt attack, the ground granulated blast-furnace slag(GGBFS) have been used as binder or blended cement more extensively. In this paper, characteristics of chloride ion diffusion for the GGBFS concrete, which is known to possess better resistance to damage due to the chloride ion penetration than ordinary portland cement(OPC) concrete possesses, are analyzed and a chloride ion diffusion model for the GGBFS concrete is proposed by modifying an existing diffusion model for the OPC concrete. The proposed model is verified by comparing diffusion analysis results using the model accelerated chloride penetration test results for concrete specimens as well as field test results for an RC bridge pier. Then, an optimal resistance condition to chloride penetration for the GGBFS concrete is obtained according to degrees of fineness and replacement ratios of the GGBFS concrete. The result shows that the GGBFS concrete has better resistance to chloride ion penetration than OPC concrete has and the resistance is more affected by the replacement ratio than the degree of fineness of the GGBFS.

A Study on the Optimum Mix Proportion for Early Strength of Concrete in the Upper Layers of High Rise Building (Part I - 40MPa) (초고층 빌딩용 상층부 콘크리트의 조기강도 확보를 위한 최적배합 도출에 관한 연구 (Part I - 40MPa를 중심으로))

  • Jeon, In-Ki;Park, Yong-Kyu;Lee, Joo-Hun;Choi, Myung-Hwa;Yoon, Gi-Won
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.11a
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    • pp.321-324
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    • 2008
  • Recently increasing interest in high-rise building around the world for more than 100 floor, the trend is the increasing use of high-strength and high-flowable concrete so as of productivity improvements and cost savings to improve the performance of the early strength development. This study is to reach the optimal combination by reviewing the performance of high-rise building which is required. The results show that $30.0{\sim}32.5%$ of W/B, $155㎏/m^3$ of unit water and FA10+SP10 is best properties for early strength of concrete.

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A Development of concrete Pavement Material with Low Shrinkage and Reflection, High Strength and Performance (저수축 저반사 고강도 고내구성 콘크리트 포장재료 개발)

  • Kim, Hyo-Sung;Nam, Jeong-Hee;Eum, Ju-Yong;Cho, Yoon-Ho
    • International Journal of Highway Engineering
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    • v.11 no.1
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    • pp.13-24
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    • 2009
  • This study developed a high strength and performance concrete pavement material with low shrinkage and reflection of sunlight. Based on the literature review, a new mix-design of applying flash ash to improve the strength and performance of the concrete as well as to reduce the dry shrinkage is suggested. In addition, adding black pigment to reduce the reflection and technique of applying OAG (Optimized Aggregate Gradation) is also included. The result of the laboratory experiment indicates that the brightness and the reflection, which depends on the ratio of black pigment addition, did not deviate from the normal range. When OAG is considered for the mix-design, the strength and performance of the concrete improved greatly. In addition, the mix-design using fly ash reduced the dry shrinkage of concrete and improved the resistance to the permeation of chloride ion. Furthermore, the mix-design, which uses fly ash (25% replacement) and black pigment (3% addition) with the application of OAG, is found to be the most effective mix to reduce the shrinkage and reflection as well as improving the strength and performance of the concrete. The result of an economic analysis indicates that the initial construction cost of this proposed mix is more expensive than that of normal concrete pavement material. However, it can be more economic in the long run because the normal concrete pavement material is likely to cost more due to higher probability of maintenance and repair and higher social cost due to traffic accident, etc.

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임진강대 석류석의 성장과 다변형작용의 시간적-공간적 관계

  • 김윤섭;조문섭;안진호
    • Proceedings of the Mineralogical Society of Korea Conference
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    • 2003.05a
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    • pp.51-51
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    • 2003
  • 임진강대의 변성이질암은 전형적인 바로비안형 변성분대를 보이며, 남쪽으로 갈수록 변성도가 증가하여 석류석$\longrightarrow$십자석$\longrightarrow$남정석 대를 정의한다. 우리는 반상변정의 성장과 여러번에 걸친 광역변형작용의 연관성을 밝히기 위해 광물의 반응관계와 성장순서 그리고 미구조(microstructure)를 -특히 석류석에 대해서- 연구하였다. 임진강대는 크게 세 번에 걸쳐 변형작용을 받은 것으로 해석된다: (1) 지각 두께의 증가에 수반된 압축변형작용 (D$_{n-1}$), (2) 주 엽리(Sn)를 만든 변형작용(Dn), 그리고 (3) 연성전단작용에 수반된 신장변형작용(D$_{n+1}$ ). 석류석대의 석류석 반상변정에서는 약간 휘어진 포유물 궤적(inclusion trail)이 주 엽리면에 대해 연속적이며, 이는 Dn과 동시기에 반상변정이 생성되었음을 지시한다. 이러한 석류석은 녹니석과 백운모로 구성된 주 엽리를 치환하면서 자라기 때문에, 녹니석+백운모+석영=석류석+흑운모+$H_2O$의 반응에 의해 만들어진 것으로 해석된다. 석류석 자형변정(idioblast)이 주 엽리를 자르면서 성장하기도 하는데, 이는 Dn 이후에도 석류석이 후구조(post-tectonic) 광물로 성장했음을 지시한다. 또한, 이러한 석류석은 흑운모를 치환하기 때문에, 동구조(syn-tectonic) 석류석의 생성반응에서와는 달리 흑운모가 반응물임을 알 수 있다. 한편, 십자석대의 석류석은 포유물 궤적에 의해 정의되는 S$_{n-1}$면이 주 엽리면과 사각을 이루며 단속적이기 때문에, D$_{n-1}$과 Dn 사이에 자란 것으로 해석된다. 이와는 대조적으로 십자석은 주 엽리를 치환하면서 자라고 있어서 Dn과 동시기 혹은 Dn 이후에 자랐을 것으로 해석된다..의 환경문제를 발생하지 않으며, 공정액에 첨가제를 투입하지 않으므로 순환형 친환경공정으로 각광받을 수 있다. 본 연구에서는 고온, 고농도의 NaOH 수용액의 처리에 적합한 막소재와 발생될 수 있는 제반 문제점 등을 파악하였고, 장기간의 실험을 거쳐 최적 투과 압력(Trans membrane pressue), 세정 조건 및 주기, 막재질에 있어서 보강하여야 할 Point, 최적 운전 조건들을 토출해 내었고, 향후 실제 Plant에 적용할 계획이다.는 양적으로 다른 두 가지의 유사한 마그마가 수반된 것으로 추정된다. 것으로 추정된다.를 사용하지 않음으로써 효과적이고 만족할 만한 심근보호 효과를 보였다.를 보였다.4주까지에서는 비교적 폐포는 정상적 구조를 유지하면서 부분적으로 소폐동맥 중막의 비후와 간질에 호산구 침윤의 소견이 특징적으로 관찰되었다. 결론: 분리 폐 관류는 정맥주입 방법에 비해 고농도의 cisplatin 투여로 인한 다른 장기에서의 농도 증가 없이 폐 조직에 약 50배 정도의 고농도 cisplatin을 투여할 수 있었으며, 또한 분리 폐 관류 시 cisplatin에 의한 직접적 폐 독성은 발견되지 않았다이 낮았으나 통계학적 의의는 없었다[10.0%(4/40) : 8.2%(20/244), p>0.05]. 결론: 비디오흉강경술에서 재발을 낮추기 위해 수술시 폐야 전체를 관찰하여 존재하는 폐기포를 놓치지 않는 것이 중요하며, 폐기포를 확인하지 못한 경우와 이차성 자연기흉에 대해서는 흉막유착술에 더 세심한 주의가 필요하다는 것을 확인하였다. 비디오흉강경수술은 통증이 적고, 입원기간이 짧고, 사회로의 복귀가 빠르며, 고위험군에 적용할 수 있고, 무엇보다도 미용상의 이점이 크다는 면에서 자연기흉에 대해 유용한 치료방법임에는 틀림이 없으나 개흉술에 비해 재발율이 높고 비용이 비싸다는 문제가 제기되고 있는 만큼 더 세심한 주의와 장기 추적관찰이 필요하리라 사료된다.전 도부타민 심초음파는 관상동맥우회로술 후

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Analysis of Turbo Coding and Decoding Algorithm for DVB-RCS Next Generation (DVB-RCS Next Generation을 위한 터보 부복호화 방식 분석)

  • Kim, Min-Hyuk;Park, Tae-Doo;Lim, Byeong-Su;Lee, In-Ki;Oh, Deock-Gil;Jung, Ji-Won
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.36 no.9C
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    • pp.537-545
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    • 2011
  • This paper analyzed performance of three dimensional turbo code and turbo ${\Phi}$ codes proposed in the next generation DVB-RCS systems. In the view of turbo ${\Phi}$ codes, we proposed the optimal permutation and puncturing patterns for triple binary input data. We also proposed optimal post-encoder types and interleaving algorithm for three dimensional turbo codes. Based on optimal parameters, we simulated both turbo codes, and we confirmed that the performance of turbo ${\Phi}$ codes are better than that of three dimensional turbo codes. However, the complexity of turbo ${\Phi}$ is more complex than that of three dimensional turbo codes by 18%.