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http://dx.doi.org/10.7317/pk.2012.36.2.149

Lipoic Acid Conjugated Chitosan Copolymer for the Delivery of 5-Fluorouracil  

Lee, Sun-Young (Department of Applied Chemistry and Biological Engineering, Chungnam National University)
Kim, Young-Jin (Department of Applied Chemistry and Biological Engineering, Chungnam National University)
Publication Information
Polymer(Korea) / v.36, no.2, 2012 , pp. 149-154 More about this Journal
Abstract
The amphiphilic copolymer by the conjugation of biocompatible chitosan and antioxidant lipoic acid was studied as a drug delivery carrier. The amphiphilic copolymer was self-assembled to form nanoparticles in the aqueous solution. 5-Fluorouracil widely used as an anticancer drug was encapsulated inside the nanoparticles by a solid dispersion method. The degree of branching of lipoic acid on chitosan was controlled to obtain the optimal condition for the drug delivery carrier. The sizes of nanoparticles were about 250 nm by the dynamic light scattering. The encapsulation efficiency of nanoparticles were about 10%. The copolymer with 42% degree of branching showed the best performance as a drug delivery carrier.
Keywords
chitosan; lipoic acid; 5-fluorouracil; amphiphilic polymer; drug delivery system;
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1 I. C. Kwon, K. M. Kim, S. W. Kim, H. S. Jeong, and S. Y. Jeong, Polym. Sci. Tech., 15, 396 (2004).
2 J. H. Kim, Y. S. Kim, K. Park, S. Lee, H. Y. Nam, K. H. Min, H. G. Jo, J. H. Park, K. Choi, S. Y. Jeong, R. W. Park, I. S. Kim, K. Kim, and I. C. Kwon, J. Control. Release, 127, 41 (2008).   DOI   ScienceOn
3 T. C. Yih and M. Al-Fandi, J. Cell. Biochem., 97, 1184 (2006).   DOI   ScienceOn
4 L. Mu and S. S. Feng, J. Control. Release, 86, 33 (2003).   DOI   ScienceOn
5 H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori, J. Control. Release, 65, 271 (2000).   DOI   ScienceOn
6 G. Winzenburg, C. Schmidt, S. Fuchs, and T. Kissel, Adv. Drug Deliv. Rev., 56, 1453 (2004).   DOI   ScienceOn
7 Y. S. Wang, L. R. Liu, Q. Jiang, and Q. Q. Zhang, Eur. Polym. J., 43, 43 (2007).   DOI   ScienceOn
8 S. A. Agnihotri, N. N. Mallikarjuna, and T. M. Aminabhavi, J. Control. Release, 100, 5 (2004).   DOI   ScienceOn
9 Z. H. Liu, Y. P. Jiao, Y. F. Wang, C. R. Zhou, and Z. Y. Zhang, Adv. Drug Deliv. Rev., 60, 1650 (2008).   DOI   ScienceOn
10 W. Yue, P. J. Yao, Y. N. Wei, S. Q. Li, F. Lai, and X. M. Liu, Food Chem., 108, 1082 (2008).   DOI   ScienceOn
11 Y. Zhang, M. R. Huo, J. P. Zhou, D. Yu, and Y. P. Wu, Carbohydr. Polym., 77, 231 (2009).   DOI   ScienceOn
12 J. Bustamante, J. K. Lodge, L. Marcocci, H. J. Tritschler, L. Packer, and B. H. Rihn, Free Radical Biol. Med., 24, 1023 (1998).   DOI   ScienceOn
13 G. P. Biewenga, G. R. M. M. Haenen, and A. Bast, Gen. Pharmacol., 29, 315 (1997).   DOI   ScienceOn
14 E. Dozio, M. Ruscica, L. Passaparo, G. Dogliotti, L. Steffani, P. Marthyn, A. Pagani, G. Demartini, D. Esposti, F. Fraschini, and P. Magni, Eur. J. Pharmacol., 641, 29 (2010).   DOI   ScienceOn
15 E. J. Park and Y. J. Kim, Polymer(Korea), 32, 544 (2008).
16 S. K. Kwon, S. W. Kim, and Y. J. Kim, Polymer(Korea), 34, 501 (2010).
17 J. H. Park, G. Saravanakumar, K. Kim, and I. C. Kwon, Adv. Drug Deliv. Rev., 62, 28 (2010).   DOI   ScienceOn