• Clinical and Experimental Pediatrics
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• v.51 no.5
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• pp.457-461
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• 2008

Kawasaki disease (KD) was first described by Dr. Tomisaku Kawasaki in his 1975 study, published in Pediatrics. Its pathogenesis is still not clearly understood. Early diagnosis and treatment are very important to preventing concomitant coronary artery complications. Most KD patients respond well to the standard treatment of aspirin and intravenous immunoglobulin; however, some of them are refractory to the standard treatment, and so adjuvant therapies with corticosteroids and anti-tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) antibody are necessary. In this article, the author reviews and summarizes the most recent literature on the treatment of refractory KD.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.sup1
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• pp.7-14
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• 2008

Special formulas are those in which one of the basic nutrients (usually the protein and/or carrbohydrate) has been changed to an alternative nutrient that an individual baby may better tolerate. The following are specialized formulas : Soy formulas, hypoallergenic formulas, Lactose free formulas, Premature baby formulas, Low phosphate formulas, Formulas for inborn errors of metabolism. Less is known about the long-term effects of feeding babies these special formulas and each formula has its unique properties and indications. The pediatrician must acquaint themselves with all commercially available infant formulas so as to provide the parent with reliable and unbiased information about them.

• Journal of radiological science and technology
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• v.27 no.1
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• pp.13-16
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• 2004

대장내시경검사는 역사적으로 돌아보면 원래 히포크라테스의 치루치료과정에서 직장경 사용으로부터 유래되며 그 후 Kelly의 25 cm 표준 S상 결장경의 발견으로 진전되었고 조명 및 각종 부속기구들이 많이 개선되면서 직장암의 발견에 기여해 왔다. 1911년에 독일 뮌헨의 Michael Hoffman이라는 광학 기술자가 프리즘을 여러 개를 연결하면 직선이 아닌 곡선에서도 빛을 그대로 전달할 수 있다는 사실을 발견하였고 이를 기초로 하여 1958년에 미국에서 Hirschowitz가 처음으로 섬유경(fiberscope)을 선보였고 그 이후 이용한 상부소화관에 대한 내시경 기술이 급속히 발전하기 시작하였고, 이를 기초로 1969년부터 ACMI, Olympus, Fujinon, Pentax 등 세계 유수의 내시경 회사들이 대장내시경을 제작하기 시작하였다. 1983년에 미국의 Welch-Allyn사가 CCD(Charge Coupled Device)라는 집광 장치를 만들어서 마치 내시경의 눈과 같은 작용을 해서 이것을 내시경 선단에 장치하고 전파를 이용하여 영상을 전달하여 이 상이 TV 모니터에 비치는 것을 보게 되는 전자내시경을 개발하여 현재는 상부내시경 뿐 아니라 대장내시경도 대부분이 전자 내시경으로 대체되어서 오늘에 이르고 있다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.sup1
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• pp.62-71
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• 2009

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of pediatric liver disease. Similar to NAFLD in adults, NAFLD in children is associated with obesity and insulin resistance and requires liver histology for diagnosis and staging. However, significant histological differences exist between adult and pediatric NAFLD. The rise in childhood obesity has been accompanied by an increase in pediatric NAFLD. Age, gender and race/ethnicity are significant determinants of risk, and sex hormones, insulin sensitivity and adipocytokines are implicated in the pathogenesis of pediatric NAFLD. There is no consensus for treatment of NAFLD, however, data suggest that diet, exercise and some pharmacological therapies may be of benefit. To evaluate and effectively treat pediatric NAFLD, the pathophysiology and natural history of the disease should be clarified and non-invasive methods for screening, diagnosis, and longitudinal assessment developed.

• The Journal of the Korean dental association
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• v.54 no.4
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• pp.258-273
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• 2016

In spite of appropriate treatment of peri-implantitis, the peri-implant bone loss was keep going, the clinician should remove the osseointegrated implant. the conventional methods are like a extraction of natural teeth, and use of trephine drills. In these days, many exclusive instruments are invented by implant companies. these instruments can make easy, least invasive, less traumatic removal of osseointegrated implants. In generally peri-implant bone loss progress steadily less sign and symptoms that the patient do not want to remove their implants. However, the failure of dental implant is big burden to clinicians and also patients. In the dental implant treatment, there is no 'failure' but only is 'replacement' or 'change'.

• The Journal of the Korean dental association
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• v.55 no.12
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• pp.862-869
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• 2017

Cleft lip and palate is the most common teratologic condition of oromaxillofacial units, probably associated with genetic and environmental causes. The goal of cleft surgery is to optimize facial esthetics and stomatognathic function while minimizing growth disturbances from surgical intervention. In this article, the author suggests the recent surgical strategies that minimize cleft nasal deformity and midfacial skeletal constriction. From the author's surgical experiences and literature reviews, only considerate surgeries would achieve functional improvement and facial esthetics in patients with cleft lip and palate.

• The Journal of the Korean dental association
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• v.55 no.12
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• pp.870-882
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• 2017

Maxillary growth is hindered by the restricting pressure from the scar tissue formed after lip closure and palate closure surgeries of the cleft. Therefore, the anteroposterior skeletal relationship of both jaws exacerbates as patient grows. Conventional facemask treatment is valuable for dentoalveolar compensatory treatment and for very mild maxillary hypoplasia. To achieve further maxillary protraction, bone-anchored facemask or bone-anchored maxillary protraction can be attempted. For moderate maxillary hypoplasia, surgical orthodontic treatment after growth completion can be an efficient treatment reducing uncontrollable problems. For moderate to severe maxillary hypoplasia, distraction osteogenesis (DO) can be used alone or with later surgical orthodontic treatment. To compensate the severe relapse after DO, overcorrection and bone plate placement after DO are recommended. In case of hypernasality, maxillary anterior segmental distraction osteogenesis can be chosen to prevent exacerbation of the hypernasality.

• Clinical and Experimental Pediatrics
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• v.49 no.7
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• pp.703-709
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• 2006

Since the advent of growth hormone(GH), children with a wide variety of growth disorders have received GH treatment. In GH deficiency(GHD), Turner syndrome, chronic renal failure, children born small for gestational age, Prader-Willi syndrome, and idiopathic short stature, the therapeutic effects and safety profile of GH are reviewed. GH therapy has been clearly shown to improve height velocity and final adult height in a variety of pediatric conditions in which growth is compromised irrespective of GHD. Early initiation and individualization of GH treatment has the potential to normalize childhood growth. The supra-physiological doses of GH have been shown to increase height velocity during childhood and final height in non-GHD conditions. Adverse events during GH therapy are uncommon and often not drug related. However continued surveillance into adult life is crucial, especially in children receiving supra-physiological doses or whose underlying condition increases their risk of adverse effects.

• Clinical and Experimental Pediatrics
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• v.49 no.7
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• pp.718-725
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• 2006

The pubertal activation of gonadotrophin releasing hormone(GnRH) requires coordinated changes in excitatory or inhibitory amino acids, growth factors, and a group of transcriptional regulators. The age of onset of puberty is progressing to younger age. Factors affecting early puberty include genetic traits, nutrition(body fat) and exposure to endocrine disrupting chemicals. In rapidly progressing central precocious puberty, gonadotrophin releasing hormone(GnRH) agonists(GnRHa) appear to increase final height if treated early stage. Further large scaled long-term follow-up study of the effects of GnRHa on final height is needed.

• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.176-180
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• 2011

Depressive disorders have strong genetic components. However, conventional linkage and association studies have not yielded definitive results. These might be due to the absence of objective diagnostic tests, the complex nature of human behavior or the incomplete penetrance of psychiatric traits. Imaging genetics explores the influences of genetic variation on the brain function or structure. This technique could provide a more sensitive assessment than traditional behavioral measures in psychiatric studies. Imaging genetics is a relatively new field of psychiatric researches, and may improve our understanding on neurobiology of psychiatric disorders. In this review, current understanding in neurobiology of depressive disorders, especially imaging genetic studies on serotonin transporter will be discussed.