• Title/Summary/Keyword: 최소자극법

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Minimal Stimulation using rhFSH and GnRH Antagonist for IVF Treated Patients of Advanced Age (고령 불임여성의 체외수정술시 최소자극법의 효용성)

  • Kim, So-Ra;Kim, Chung-Hoon;Lee, Jin-Kyoung;Jeon, Gyun-Ho;Kim, Sung-Hoon;Chae, Hee-Dong;Kang, Byung-Moon
    • Clinical and Experimental Reproductive Medicine
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    • v.36 no.1
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    • pp.63-70
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    • 2009
  • Objective: This study was performed to investigate the effectiveness of minimal stimulation using rhFSH and GnRH antagonist compared with GnRH antagonist multidose protocol (MDP) in IVF treated patients with aged 40 and above. Methods: Seventy-five patients with aged 40 and above were equally randomized to minimal stimulation group (n=37) or GnRH antagonist MDP group (n=38). For minimal stimulation group, ultrasound monitoring was started on cycle day 7 or 8. Daily injections of 0.25 mg cetrorelix together with 150 IU rhFSH were started from the day at 13${\sim}$14 mm of a leading follicle diameter. For GnRH antagonist MDP group, daily injections of 225 IU rhFSH were initiated from cycle day 2 and GnRH antagonist was started at a dose of 0.25 mg/day on rhFSH stimulation day 6 or the day at 13${\sim}$14 mm of leading follicle diameter. In both groups, transvaginal ultrasound-guided oocyte retrieval was performed. According to cleavage and morphologic characteristics of embryos, embryos were transferred 3 to 5 days after oocyte retrieval. Results: There were no differences in patients' characteristics and cycle cancellation rate between the two groups. Total dose and duration of rhFSH used were significantly fewer and shorter in minimal stimulation group than those in GnRH antagonist MDP group. The numbers of oocytes retrieved, mature oocytes and transferred embryos were also lower in minimal stimulation group. However, there were no significant differences in the clinical pregnancy rate and miscarriage rate between the two groups. Conclusions: This study demonstrates that minimal stimulation protocol provides comparable pregnancy rates to GnRH antagonist MDP with fewer dose and days of rhFSH used, and thus can be a cost-effective alternative in women aged 40 and above.

An Assessment of Factory Odor Evaluation with Indirect Olfactory Method (간접관능법에 의한 사업장 발산악취 평가)

  • 김학민;정의석;김선규;김선태;박주철
    • Proceedings of the Korea Air Pollution Research Association Conference
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    • 2002.11a
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    • pp.183-184
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    • 2002
  • 악취현상 평가방법은 냄새유발물질의 농도를 정량적으로 분석하는 화학성분분석법과 복합취기물질에 의란 감각수준을 다수의 악취판정인이 평가하는 관능측정법으로 대별할 수 있다. 특히, 관능측정법의 경우 자극의 세기를 표현하는 직접관능법과 최소냄새감지한계회석배수를 구하는 간접관능법으로 구분할 수 있으며, 환경악취현상을 객관적으로 평가하기 위해서는 성분분석과 감각수준을 평가하는 두 방법에 의한 측정결과를 종합적으로 고려하는 것이 타당한 것으로 알려져 있다. (중략)

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Computerized Analysis of Thermoluminescence from ${\gamma}$-Ray Irradiated $\alpha$-$Al_2$$O_3$ (감마선 조사된 $\alpha$-$Al_2$$O_3$의 열자극에 관한 수치해석적인 분석)

  • 김태규;이병용;김성규;박영우;추성실
    • Progress in Medical Physics
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    • v.4 no.2
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    • pp.49-58
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    • 1993
  • The complex glow curves were split into isolated glow curves to be calculated the values of kinetic order, activation energy, escape frequency and density of initial trap from the independent glow curves using the mathematical method of thermally stimulated processes. The minimization of the intensity difference between measured and theoretical glow curve was done by the nonlinear least-square program. The results of the fitted curves were almost equal to the actual values of the parameters. Thermoluminescence from gamma ray irradiated ${\alpha}$-Al$_2$ $O_3$ over the range of 300K to 600K was split into six glow curves. The kinetic order, activation energy and escape frequency of first glow curve were obtained as 1, 1.12eV and 6.79X10$\^$12/sec$\^$-1/, respectively, which were similar to the results of other method. Also the parameters of the second and the third glow curve and so forth were calculated.

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A Design Method for Planar Minimum-Inductance Gradient Coils Considering Pole Piece Effect (Pole piece 효과를 고려한 MRI용 최소 인덕턴스 경사자계 코일 설계 기법)

  • 이수열;강현수;문찬홍;박현욱
    • Journal of Biomedical Engineering Research
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    • v.20 no.5
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    • pp.537-544
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    • 1999
  • 자기공명영상시스템의 경사자계코일을 영구자석의 자극에 부착할 경우 경사자계의 분포가 변하고 코일의 인덕턴스가 증가하는 현상이 생긴다. 본 논문에서는 이러한 자극효과를 고려하여 평면형 경사자계코일을 설계하는 방법을 제시하였다. 제사한 방법에는 자극 효과를 거울 전류로 모델링하였고, 모델링한 거울 전류를 고려하여 경사자계코일의 인덕턴스를 최소화하는 방법을 구했다. 또한 실제 상황과 가장 흡사한 자계 분포를 만들어주는 거울 전류의 크기를 구하기 위해 유한요소법을 적용하였다. 제시한 방법으로는 설계된 경사자계코일은 종래의 설계된 경사자계 코일에 비해 우수한 성능을 보였다.

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Multi-level Vector Error Diffusion Based on Primary Color Selection Considering Lightness (휘도를 고려한 기준색 선택 기반의 다단계 벡터 오차 확산법)

  • 박태용;조양호;이명영;하영호
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.41 no.5
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    • pp.77-85
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    • 2004
  • This paper proposes a multi-level vector error diffusion method using 64 primary colors to improve color impulse artifact in bright region. Vector error diffusion method causes color impulse artifact in bright region because we only use the Euclidean distance measure in quantization process. In order to reduce this artifact, the proposed method divides input color into chromatic color and achromatic color according to chroma value. In the case of chromatic color, input color is classified into bright region, middle bright region, and dark region according to lightness value. N candidate primary color is organized using lightness difference between input vector and 60 chromatic primary color vector in the case of bright region. Then, primary color with minimum vector norm between input vector and N candidate primary color in addition to 4 achromatic primary colors is selected as output color. As a result of experiments, the proposed method showed visually pleasing halftone output.

Assessment of Quick Sweat Absorbency and High Speed Drying Fabric Using a Psychophysical Method (정신물리학적 측정법을 이용한 흡한속건성평가)

  • 김주용;구지은
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2003.11a
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    • pp.1311-1318
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    • 2003
  • 최근 흡한 속건성은 사이언스 소재로 가장 보편적으로 이용되고 있는 소재 성능이다. 하지만 아직 제대로 된 측정 평가법이 존재하고 있지 않고, 몇몇 의류업체에서는 단순히 객관적 속성만을 측정하고 있다. 본 연구에서는 객관적 속성인지들의 연속적이 값들이 실제 인체에서는 얼마만큼의 변별력으로 인식되는지 정신물리학적 측정법으로 최소 자극치(PSE)를 구하여 등급을 나누어 보았다. 시료는 흡한속건성 직물로 가장 많이 이용되고 있는 Coolmax(R), Coolever(R), 친수성 이중직물의 3개 그룹으로 나누었고, 측정 인자로 객관적 속성인자는 cling force, drying time을, 이와 대응하는 주관적 속성인자는 clinginess, dampness를 측정하고 각각의 PSE값을 구하였다. 그룹에 따라 객관적 속성인자 값들이 이라고 느끼는 PSE 구간까지 도달하는 시간과 속력을 측정하여 그룹마다의 흡한속건 등급을 정하였다. 또한 설계된 소재의 성능을 간접적으로 알 수 있는 transmissibility라는 인자도 도입하여 수분 전달성도 객관적으로 살펴볼 수 있었다. Clinginess, Dampness, Transmissibility 각 인자들을 평가해본 결과 Coolmax(R) 가 가장 우수함을 알 수 있었다.

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Treatment of Transverse Patella Fracture with Minimally Invasive Load-Sharing Patellar Tendon Suture and Cannulated Screws (최소 침습 기법 슬개건 부하 분산 봉합술과 유관 나사못을 이용한 슬개골 횡골절의 치료)

  • Lee, Beom-Seok;Park, Byeong-Mun;Yang, Bong-Seok;Kim, Kyu-Wan
    • Journal of the Korean Orthopaedic Association
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    • v.56 no.6
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    • pp.540-545
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    • 2021
  • A transverse fracture is the most common type of displaced patella fracture requiring surgery. These fractures are commonly fixed with parallel Kirschner wires or screws that cross the fracture line, often with an additional tension band. Nevertheless, conventional fixation methods of patella fractures have prevalent complications caused by the protrusion of wires or pins. These complications necessitate additional surgery for hardware removal, increase medical cost, and can limit the function of the knee joint. This paper reports cases treated with a minimally invasive load-sharing percutaneous suture of the patella tendon. The procedure provides reliable fixation for transverse patella fractures, minimizes soft tissue injuries, preserves blood flow, and reduces postoperative pain. In addition, the procedure also reduces the irritation and pain caused by the internal fixture, thereby reducing the risk of restricted knee joint movement.

SNU 1.5MV Van de Graaff Accelerator (IV) -Fabrication and Aberration Analysis of Magnetic Quadrupole Lens- (SNU 1.5MV 반데그라프 가속기 (IV) -자기 4극 렌즈의 제작과 수차의 분석-)

  • Bak, H.I.;Choi, B.H.;Choi, H.D.
    • Nuclear Engineering and Technology
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    • v.18 no.1
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    • pp.1-8
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    • 1986
  • A magnetic quadrupole doublet was fabricated for use at the pre-target position of SNU 1.5MV Van de Graaff accelerator and then its optical characteristics were measured and analysed. The physical dimensions are: pole length 180mm, aperture radius 25mm, pole tip radius 28.75mm. Material for poles and return yokes is carbon steel KS-SM40C. Coils have 480 turns per one pole and air-cooling is adopted. Applying the d.c. current 2.99$\pm$0.03A to the lens, and using the Hall probe, magnetic field elements $B_{\theta}$ , $B_{\gamma}$, were measured at the selected Points along each coordinate direction r,$\theta$, z. From the area integration and orthogonal polynomial fitting for the measured data, the magnetic Field gradient G=566.3$\pm$2.1 gauss/cm at lens center, the effective length L=208.3$\pm$1.44mm along the lens axis have been obtained. The harmonic contents were determined up to 20-pole from the generalized least squares fitting. The results indicate that sextupole/quadrupole is below 1.4$\pm$0.9% and all the other multipoles are below 0.5% in the region within 18mm radius at the center of lens.

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Reduction of magnetic anomaly observations from helicopter surveys at varying elevations (고도가 변화하는 헬리콥터 탐사에서 얻어지는 자력이상의 변환)

  • Nakatsuka, Tadashi;Okuma, Shigeo
    • Geophysics and Geophysical Exploration
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    • v.9 no.1
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    • pp.121-128
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    • 2006
  • Magnetic survey flights by helicopters are usually parallel to the topographic surface, with a nominal clearance, but especially in high-resolution surveys the altitudes at which observations are made may be too variable to be regarded as a smooth surface. We have developed a reduction procedure for such data using the method of equivalent sources, where surrounding sources are included to control edge effects, and data from points distributed randomly in three dimensions are directly modelled. Although the problem is generally underdetermined, the method of conjugate gradients can be used to find a minimum-norm solution. There is freedom to select the harmonic function that relates the magnetic anomaly with the source. When the upward continuation function operator is selected, the equivalent source is the magnetic anomaly itself. If we select as source a distribution of magnetic dipoles in the direction of the ambient magnetic field, we can easily derive reduction-to-pole anomalies by rotating the direction of the magnetic dipoles to vertical.

국가적 수준의 치과의사 역량을 위한 치과마취과학의 교육역량과 치과의사국가고시 제고

  • Kim, Seung-Oh
    • Journal of The Korean Dental Society of Anesthesiology
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    • v.12 no.1
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    • pp.1-9
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    • 2012
  • 치과마취학의 교육목표는 치과치료 시 적절한 환자평가와 함께 동통 및 불안을 관리하기 위한 약품선택과 치과치료를 위한 흡입법과 정맥주사를 이용한 의식하진정법과 언제, 어떻게, 어디로 전신마취를 의뢰하는지를 알아야 할 사항과 특히 의학적 병력을 가진 환자와 특별한 관리가 필요한 소아 노인 장애인의 전반적 이해와 치료 전 전신적 환자평가를 할 수 있는 능력과 치과진료 중 일어날 수 있는 의료적 응급 상황과 치과응급상황을 식별하고 인공소생술을 포함한 치과 치료 과정에서 발생할 수 있는 의학적 응급상황들에 적절한 관리를 할 수 있어야 한다. 치의학교육의 최소한의 질 보장을 위한 국가적 수준의 치과의사 역량체계를 구축함으로써 치의학교육의 질 향상을 위한 치과대학(원)의 변화를 자극하고, 치과의료와 의료인력의 질적 증진 및 치과의료행위의 최소수준을 보장하는데 있다. 하지만 현행 국가고시에 있어 치과마취과학은 구강외과 과목에 포함되어 위 기술한 치과마취과학의 교육목표를 달성하는 데 어려움이 있다. 그러므로 국가수준의 치의학교육의 질에 대해 제고하고 학교의 교육과정 변화와 개선에 적용하고 국시원의 새로운 과목의 도입과 실기시험을 통하여 치과마취과학의 교육목표를 달성하는 데 목적이 있다.