• 약학회지
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• 제42권3호
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• pp.330-335
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• 1998

Gastrodia elata (GE) is a oriental medicinal herb which has been used traditionally for the treatment of various brain diseases including convulsion and epilepsy. In orde r to examine the mechanism of anticonvulsive effect, we treated the methanol extract of GE (500mg/kg, P.0) to the pentylenetetrazole (PTZ)-induced convulsive rats. Methanol extracts of GE significantly inhibited (35%) the convulsion state as well as the level of lipid peroxidation (25%) in the brain. The ether fraction of methanol extracts among the others effectively ibhibited in vitro lipid peroxidation dose dependently ($5.O{\times}10^{-6}{\sim}2.O{\times}1O^{-5}g/ml$). The scavenging effect on hydroxy radicals was found in all the fractions of ether, butanol, and dichloromethane. These results suggest that the anticonvulsive effect of GE is possibly due to the antioxidative effects of the active components in GE.

• 동의생리병리학회지
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• 제16권2호
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• pp.220-225
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• 2002

To determine the anti-stress effect of KCG(加味天麻鉤藤飮) extract on sprague-dawley rats. we conducted a research about the change of weight, activity, reactivity, c-fos protein, cytotoxicity against PC12 cell line and heal shock protein. 1) KCG extract siginificantly inhibited the decrease of body weight induced by stress, compared with the control group. 2) KCG extract had no siginificant effect in the activity and reactivity of rats between the control and the experimental groups. 3) KCG extract siginificantly restrained c-fos protein manifestation, compared with the control group. 4) KCG extract siginificantly restrained heat shock protein, compared with the control group. These results suggested that KCG might be usefully anti-stress effect.

• 생약학회지
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• 제14권3호
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• pp.107-112
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• 1983

Experimental studies were made to evaluate clinical efficacy and validate Oriental medicine description of 'Banhabaikchulchenma-Tang' which has been used for controlling of headache, heartburn and giddiness, etc. The results of these studies were as follows; 1) Suppressive actions were not shown on convulsion due to spine and diencephatic causes. 2) Analgesic action was recognized in mice and rats. 3) Sedative actions due to prolongation of hypnosis time, muscle relaxation and decreasing locomotive function were noted. 4) Relaxing action was noted in the ileum of mice, also antagonistic antispasmodic action was recognized on contraction of the ileum induced by acteylcholine and $BaCl_2$. In connection with results of these studies, efficacy based on the Oriental medical reference were consistant with actual experimental results. It is considered that 'Banhabaikchulchenma-Tang' has the therapeutic effect on the headache and giddiness, etc.

• 동의신경정신과학회지
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• 제24권1호
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• pp.27-44
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• 2013

Objectives : This study was designed to investigate the effects of Gastrodia elata Blume on the improvement of memory. Methods : This study was a 12 week, double blind, comparative clinical study. There were eligible who worked with a group of healthy seniors, all 60 years of age or older. 50 subjects were randomized either to Gastrodia elata Blume in powder form and steep in hot water or placebo. We measured the faculty of memory by using K-DRS, MMSE-K, Digit Span, Letter Fluency Test, Word List Memory Test, and the Trail Making Test, and after 12 weeks we measured the faculty of memory again using the same methods. Results : Gastrodia elata Blume steeps in the hot water group significantly increased. Initiation, perseveration level, and Memory level of K-DRS and MMSE-K score. There were no considerable differences between three groups in Digit Span and Trail Making Test score. Gastrodia elata Blume group showed significant advances in Letter Fluency Test and recognition of Word List Memory Test. Conclusions : The results suggest that Gastrodia elata Blume may have positive effects on memory improvement and function of the frontal lobe activation.

• Journal of Pharmaceutical Investigation
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• 제29권1호
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• pp.47-53
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• 1999

Gastrodia elata (GE) is an oriental medicinal herb which has been used traditionally for the treatment of various brain diseases including convulsion and epilepsy. The purpose of this study was to determine pharmacokinetic parameters of 4-hydroxy-3-methoxybenzaldehyde (HMBA) and p-hydroxybenzaldehyde (PHBA), constituents of GE, in rats. Male rats were cannulated in the femoral vein, femoral artery, bile duct and ureter. They received a single i.v. bolus dose of either HMBA or PHBA through the femoral vein. The concentration of HMBA or PHBA in plasma, bile and urine samples were analyzed by reversed-phase HPLC. HMBA and PHBA have very short half-lives, i.e. 4.03 and 2.26 minutes respectively. Most of HMBA and PHBA were thought to be eliminated through metabolism as the metabolized fraction approaches unity. Derivatives of HMBA or PHBA with longer biological half-lives should be designed to develop better anticonvulsants and more complete qualitative and quantitative understanding of the overall pharmacokinetic fate of these compounds awaits further investigation.

• 혜화의학회지
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• 제14권2호
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• pp.127-131
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• 2005

Headache is a term used to describe aching or pain that occurs in one or more areas of the head, face, mouth or neck. Headache can be chronic, recurrent or occasional. The pain can be mild or severe enough to disrupt daily activities. Headache involves the network of nerve fibers in the tissues, muscles and blood vessels located in the head and at the base of the skull. Headache also can result from syndromes involving the eyes, ears, neck, teeth or sinuses. In these cases, the underlying condition must be diagnosed and treated. Recently one patient was come with headache. The patient is a 35-year-old lady with complaints of very severe headache that strike as often as several times a week. She has the throbbing pain on the right side of her head with nausea, vomiting, fatigue, dizziness, coldness of hand and leg, or ringing in the ears sometimes etc. After treatment through Banhabaekchulcheonma-tang, most of the symptoms improved. Therefore, this application of oriental medicine is reported with a plea for further investigation.

• 한국응용곤충학회지
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• 제56권1호
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• pp.87-92
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• 2017

납작먹좀벌과(Platygasteridae)의 큰검정알벌속(Trissolcus)에 속하는 T. japonicus (Ashmead) (썩덩큰검정알벌, 신칭)이 과수원에서 과일에 심한 피해를 일으키는 해충인 썩덩나무노린재의 알에 기생하는 것으로 확인되었고, 생물적 방제인자로써 가능성이 기대된다. 또한 천마큰검정 알벌(T. itoi Ryu)이 북쪽비단노린재 알을, 검은다리큰검정알벌(T. nigripedius Nakagawa)이 알락수염노린재 알을 숙주로 각각 기생하는 것이 확인되었다. 동정을 위한 진단형질 및 영상자료와 한국에 분포하는 큰검정알벌속(Trissolcus)의 종들에 관한 숙주목록을 제공하였다.

• 대한한방내과학회지
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• 제19권2호
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• pp.107-124
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• 1998

The present experiment was desined to examine catecholamines, 5-hydroxytryptamine, amino acids, malondialdehyde(MDA) and free radical scavening activity, by administering Cheonmagudeungyeum extract of a variety of concentraction to senile brain The results were summarized as followings: 1. Cheonmagudeungyeum significantly increased noradrenaline in the hippocampus and hypothalamus of the brain tissue of senile rats, and even though Cheonmagudeungyeum increased noradrenaline also in other brain tissue, there was no significance. 2. Cheonmagudeungyeum had no effects on dopamine changes in all brain tissue of senile rats. 3. Cheonmagudeungyeum significantly increased 5-hydrotryptamine in cerebellum, but decreased in other brain tissue. 4. Cheonmagudeungyeum increased amino acid in the brain tissue of senile rats. 5. Cheonmagudeungyeum significantly decresed MDA and free radical in the brain tissue of senile rats. According to the above results, Cheonmagudeungyeum is assumed to improve brain function by reacting on biochemical of the senile brain, and that Cheonmagudeungyeum can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.

• 한국식품영양과학회지
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• 제28권5호
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• pp.1058-1063
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• 1999

The purpose of this study was to investigate the differences in proximate composition, free sugars, organic acids, fatty acids, amino acids, mineral components, hunter color values and calory values between freeze dried and steam dried Gastrodia elata Blume. Crude fat and crude fiber decreased during manu facture of steam dried Gastrodia elata Blume. The contents of sugars in steam dried Gastrodia elata Blume decreased during manufacture than that of freeze dried Gastrodia elata Blume. The contents of malic acid, oxalic acid, ketoglutaric acid, malonic acid and succinic acid in freeze dried were similar to those in steam dried Gastrodia elata Blume. Citric acid decreased in steam dried Gastrodia elata Blume. The contents of linoleic acid, palmitic acid and oleic acid in freeze dried were similar to those in steam dried Gastrodia elata Blume. The contents of free amino acids in steam dried Gastrodia elata Blume decreased during manufacture. The mineral component contents of the Gastrodia elata Blume were greater in the order of Mn

• 한방재활의학과학회지
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• 제19권3호
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• pp.1-13
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• 2009

Objectives : This study evaluates neuroprotective effect of Gastrodiae Rhizoma on apoptosis in the cerebral infarct. Methods : Cerebral infarct was induced by the middle cerebral artery occlusion (MCAO) for 2 hours with intraluminal thread method in Sprague-Dawley rats. Then ethanol extract of Gastrodiae Rhizoma was administered orally for 3 days. Infarct area and volume were evaluated with TTC staining. Neuronal apoptosis was identified with TUNEL labeling. Apoptosis modulatory effect was observed with immunohistochemical Bax, Bcl-2, iNOS, and MMP-9 expressions in penumbra. Results : 1. Ethanol extract of Gastrodiae Rhizoma reduced infarct size partly and volume significantly of in the MCAO rat brain. 2. Ethanol extract of Gastrodiae Rhizoma reduced TUNEL positive cell ratio in the penumbra of MCAO rat brain significantly. 3. Ethanol extract of Gastrodiae Rhizoma suppressed Bax, iNOS and MMP-9 expression in the penumbra of MCAO rat brain significantly. 4. Ethanol extract of Gastrodiae Rhizoma did not change Bcl-2 expression in the penumbra of MCAO rat brain. But expression ratio of Bcl-2 against Bax was increased in the Gastrodiae Rhizoma group. Conclusions : These results suggest that Gastrodiae Rhizoma plays an anti-apoptotic neuroprotective effect through suppression of Bax, iNOS, and MMP-9 expressions and relative up-regulation of Bcl-2 in the ischemic brain tissue.