• 대한두경부종양학회:학술대회논문집
• /
• 2006.11a
• /
• pp.201-201
• /
• 2006

• Journal of Korean Medicine Rehabilitation
• /
• v.18 no.3
• /
• pp.19-39
• /
• 2008

Objectives : It has been reported that CG was effective in decreasing injury to neural tissues. To investigate neural responses in the injured spinal cord, an extract of CG was examined to determine its effect on neural responses in the injured spinal cords of rats. Methods : After CG treatment was applied to the spinal cord of rats given a contusion injury, the re-growth responses of injured neural tissues and corticospinal tract axons was observed by measuring the number of GAP-43, Cdc2, and phospho-Erk1/2 proteins, CST axons, GFAP-stained astrocytes, and Glial scarring in the injured spinal cord. Results : Levels of GAP-43, Cdc2, and phospho-Erk1/2 proteins were found to have increased in the injured spinal cord region. The number of GFAP-stained astrocytes also increased within and around the injury cavity. Glial scarring, which was identified by CSPG immunofluorescence staining, was reduced by CG treatment. Anterograde tracing by Dil dye showed that the elongation of the CST axons in the dorso-medial white matter area was almost completely prevented at the injury site. Collateral sprouting was observed in the spinal cord rostrally close to the injury site, and CG treatment further increased axonal arborization in the corresponding region. In vivo migration of CST axons and astrocytes using an implanted polymer tube system showed more of an increase in enhanced migration of axons and astrocytes in CG-treated group compared to the injury control group. Conclusions : These results suggest that CG activated neural responses - including astrocyte migration - and promotes axonal regenerative activity in the injured spinal cord area.

• The Korean Journal of Physiology
• /
• v.4 no.2
• /
• pp.83-89
• /
• 1970

전기적 자극법은 심맥관계기능의 신경성조절을 이해하기위해 널리 이용되는 방법이며, 일반적으로 중추신경에는 고빈도, 말초신경에서는 저빈도 자극에 의해 최대반응이 유발된다고 알려지고 있으며, 이는 흥분파의 민도가 말초로 내려오며 감소되기 때물이라 해석되고 있다. 또한편 신경계의 어떤 단위위에서건 자극민도가 어느 한계를 넘으면 유발된 반응은 유지되지를 못하고 감쇠소실되는 것으로 이는 주로 시납스간 흥분파전달능 부전에 기인될 것이라고 믿어지고있다. 그러나 고위주추계와 말초를 연결하고 있는 척수에 있어서는 아직 최적전기적 자극조건도 분명히 알려져 있지 않을 뿐 아니라 이 부위에서도 고빈도자극시에 반응이 어느 정도 감쇠하는지에 대한 보고가 없기에 이를 추구코자 저자는 고양이의 상부경수를 면수와 연결부에서 완전 절단하기 전후 여러가지 자극조건으로 자극하여 몇 가지 결론을 얻었기에 보고하는 바이다. 1) 연수와 연결부에서 완전절단을 하기 전에는 경수$(C_1{\sim}C_2)$의 백질, 회백질의 여러부위에서 심맥관반응이 유발되었으나 절단후에는 백질중의 만두부위(좌 $2{\sim}3\;mm$, 배면으로 부터 $0.3{\sim}1.0\;mm$및 $2.5{\sim}3.5\;mm$)에만 반응이 유발되었으며, 이 두 부위는 심맥관계기능을 지배조절하는 원심성 섬유의 통로라고 사료되었다. 2) 최대반응은 자극조건(빈도 자극파지속시간 강도) 100/sec-1 mesc-3V 및 20/sec-3 msec-3V에서. 최장지속반응은 20/sec-3msec에서 유발되었으므로, 후자가 척수부에 있어 심맥관계반응을 유발키 위한 최적자극조건으로 생각된다. 3) 자극면도 20/sec 이하에서 반응유지가 잘된다는 결과는 생리적 조건하에서 척수를 통과하는 흥분파의 빈도가 20/sec를 넘지 않을 것이란 것을 시사한다. 4) 반응지속정도는 최초의 최대반응의 반으로 감쇠되기까지 소요되는시간 즉 50% 반응감쇠시간으로 표시하였으며, 척수에서는 대뇌피질 및 간뇌에서보다 심맥관계반응의 50%반응감쇠시간이 현저히 긴 것을 알 수 있었다.

• Journal of Yeungnam Medical Science
• /
• v.13 no.2
• /
• pp.234-242
• /
• 1996

Ten patients with a thoracolumbar spine fractures were treated with Kaneda internal fixation device through anterolateral approach during last 1 year. In all cases, spinal decompression, internal instrument fixation and hone fusion with rib were performed. No patient showed neurological deterioration after surgery and 6(60%) patients improved postoperatively with entering the next Frankel subgroup. Follwo-up patient evaluation showed the correction of the fracture deformity with good bony fusion, but 3 patient arc remained back pain. According to above results we concluded that anterolateral internal fixation combined with hone fusion using rib was good mechanical stability and decompression of protruding ventral bone fragments above conus medullaris level.

• Journal of the Korean Society of Radiology
• /
• v.82 no.6
• /
• pp.1628-1633
• /
• 2021

Spinal epidural arteriovenous fistulas (SEDAVFs) are rare spinal vascular malformations that are difficult to diagnose and treat. SEDAVFs can be asymptomatic; however, symptoms can arise from the compression of adjacent nerve roots by dilated vein and perimedullary venous reflux, caused by shunting into the epidural venous plexus. A 31-year-old male presented to our institution with a 2-year history of progressively worsening low-back pain, radiating thigh pain, and sensory changes in his lower extremities. MRI and CT angiography demonstrated dilated epidural vascular lesion compressing the nerve root. The SEDAVF was embolized with multiple coils, which alleviated the nerve root compression from the engorged venous varix and improved the patient's radiculopathy. Our experience from this case shows that endovascular coil embolization using the transarterial approach can be an effective treatment for SEDAVF and an alternative to surgical ligations.

• Applied Microscopy
• /
• v.40 no.1
• /
• pp.15-19
• /
• 2010

The present study was designed to demonstrate ionic zinc in the rat DRG by means of zinc selenium autometallography($ZnSe^{AMG}$). Ganglion cells varied in size from 15 to 100 ${\mu}m$. The smaller neurons were strongly stained with AMG, whereas the larger cells were weakly stained. Each large ganglion cell was surrounded by perineuronal satellite cells, showing apparent AMG staining. We demonstrated for the first time the existence of zinc-containing satellite cells in the rodent DRG. Using electron microscopy, fine AMG grains were observed scattered in the somata of the DRG neurons, especially small cells. However, much lower concentrations of the AMG grains occupied in the large cells, and these were mostly localized in lysosome-like organelles. These results indicate that zinc may be involved in sensory transmission in the DRG level.

• Applied Microscopy
• /
• v.29 no.1
• /
• pp.105-124
• /
• 1999

Histological and ultrastructural differentiations of the neuroepithelial cells in the mouse embryo during neurulation were observed. The neural plates and grooves consisted of pseudostratified columnar epithelium in the embryonic day (ED) 8 embryo were developed. In the ED 9 embryo, the neural tube was developed in all body length of embryo except both the cephalic and caudal ends. Secondary neurulation was shown at the tail bud of the ED 10 embryo. In the ED 8 embryo, the primitive streak was shown in the posterior end of the embryonic disc. The neuroepithelium, notochord and mesenchyme were well differentiated in the cephalic and cervical portions. In the ED 9 and 10 embryos, the roof plates of neural tubes were constituted of the closing of the surface ectodermal cells in the hindbrain and the neuroepithelial cells in the spinal cord. The floor plate of neural tube were consisted of the low pseudostratified columnar epithelium. The spinal motor nerve fibers were initially differentiated in the ED 10 embryo. According to the electron density of the cell and the differentiation of tell organelles, the neuroepithelial cells in the ED 9 and 10 embryos were classified into three types: dark, intermediate and light types. All types in the ED 9 embryo were observed but the dark cell in the ED 10 embryo was not done. The free ribosomes and polysomes in all neuroepithelial cells were developed. The RER and lipid droplets in the dark cell and the Golgi complex in the intermediate and light cells were observed. Many microfilaments in the cytoplasmic processes of intermediate cell and the microfilaments and microtubules in the light cell processes were observed to be well differentiated.

• Clinical and Experimental Pediatrics
• /
• v.51 no.12
• /
• pp.1350-1354
• /
• 2008

Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by diffuse proximal and distal weakness due to deletion of the survival motor neuron (SMN) gene localized on chromosome 5 (5q11.2-13.3). SMA has been considered as a pure lower motor neuron disorder, and a definitive diagnosis can be established by molecular genetic testing. Here, we describe two patients with severe hypotonia and frequent aspirations at early infancy. Nerve conduction studies showed more extensive sensory involvement in these patients diagnosed to have SMA by genetic study than in classical cases of SMA. To the best of our knowledge, this is the first report of SMA Type 1 with sensory nerve involvement in Korea.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1987.05a
• /
• pp.20.2-20
• /
• 1987

신경초종은 비교적 드문 질환으로서1908년Verocay가 이 종양의 특징적 조직소견인 Verocay body를 발견하고 이를 neurinoma라고 명명하였다. 이 종양은 양성종양으로서 뇌신경, 척수신경뿐 아니라 자율신경에서도 발생하여, 약 25%가 두경부에서 발생하고, 단일 부위로서는 청신경에서의 발생빈도가 가장 높으나 인후부 발생은 드물다. 저자들은 피열후두개추벽에 발생한 거대한 신경초종 1례를 치험하였기에 보고하는 바이다.

• Journal of Yeungnam Medical Science
• /
• v.15 no.1
• /
• pp.75-96
• /
• 1998

The local arrangement of sensory nerve cell bodies and nerve fibers in the brain stem, spinal ganglia and nodose ganglia were observed following injection of cholera toxin B subunit(CTB) and wheat germ agglutinin-horseradish peroxidase(WGA-HRP) into the rat intestine. The tracers were injected in the stomach(anterior and posterior portion), duodenum, jejunum, ileum, cecum, ascending colon or descending colon. After survival times of 48-96 hours, the rats were perfused and their brain, spinal and nodose ganglia were frozen sectioned ($40{\mu}m$). These sectiones were stained by CTB immunohistochemical and HRP histochemical staining methods and observed by dark and light microscopy. The results were as follows: 1. WGA-HRP labeled afferent terminal fields in the brain stem were seen in the stomach and cecum, and CTB labeled afferent terminal fields in the brain stem were seen in all parts of the intestine. 2. Afferent terminal fields innervating the intestine were heavily labeled bilaterally gelalinous part of nucleus of tractus solitarius(gelNTS), dorsomedial part of gelNTS, commissural part of NTS(comNTS), medial part of NTS(medNTS), wall of the fourth ventricle, ventral border of area postrema and comNTS in midline dorsal to the central canal. 3. WGA-HRP labeled sensory neurons were observed bilaterally within the spinal ganglia, and labeled sensory neurons innervating the stomach were observed in spinal ganglia $T_2-L_1$ and the most numerous in spinal ganglia $T_{8-9}$. 4. Labeled sensory neurons innervating the duodenum were observed in spinal ganglia $T_6-L_2$ and labeled cell number were fewer than the other parts of the intestines. 5. Labeled sensory neurons innervating the jejunum were observed in spinal ganglia $T_6-L_2$ and the most numerous area in the spinal ganglia were $T_{12}$ in left and $T_{13}$ in right. 6. Labeled sensory neurons innervating the ileum were observed in spinal ganglia $T_6-L_2$ and the most numerous area in the spinal ganglia were $T_{11}$ in left and $L_1$ in right. 7. Labeled sensory neurons innervating the cecum were observed in spinal ganglia $T_7-L_2$ and the most numerous area in the spinal ganglia were $T_{11}$ in left and $T_{11-12}$ in right. 8. Labeled sensory neurons innervating the ascending colon were observed in spinal ganglia $T_7-L_2$ in left, and $T_9-L_4$ in right. The most numerous area in the spinal ganglia were $T_9$ in left and $T_{11}$ in right. 9. Labeled sensory neurons innervating the descending colon were observed in spinal ganglia $T_9-L_2$ in left, and $T_6-L_2$ in right. The most numerous area in the spinal ganglia were $T_{13}$ in left and $L_1$ in right. 10. WGA-HRP labeled sensory neurons were observed bilaterally within the nodose ganglia, and the most numerous labeled sensory neurons innervating the abdominal organs were observed in the stomach. 11. The number of labeled sensory neurons within the nodose ganglia innervating small and large intestines were fewer than that of labeled sensory neurons innervating stomach These results indicated that area of sensory neurons innervated all parts of intestines were bilaterally gelatinous part of nucleus tractus solitarius(gelNTS), dorsomedial part of gelNTS, commissural part of NTS (comNTS), medial part of NTS, wall of the fourth ventricle, ventral border of area postrema and com NTS in midline dorsal to the central canal within brain stem, spinal ganglia $T_2-L_4$ and nodose ganglia. Labeled sensory neurons innervating the intestines except the stomach were observed in spinal ganglia $T_6-L_4$. The most labeled sensory neurons from the small intestine to large intestine came from middle thoracic spinal ganglia to upper lumbar spinal ganglia.