• Communications for Statistical Applications and Methods
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• v.5 no.1
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• pp.99-105
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• 1998

본 논문에서는 매우 민감한 조사에서 모집단이 여러 개의 집락으로 구성되어 있을 때, 모집단으로부터 집락을 단순임의추출한 후 추출된 각 집락에서 다시 조사단위의 표본을 추출하는 2단계 집락추출법에 확률화응답모형을 적용하였다. 그리고, 일정한 비용 하에서 분산을 최소로 하는 1단계 집락의 수와 2단계 집락에서 추출된 조사단위의 수의 최적값을 구하여 최소분산의 형태를 도출하였다.

• The Korean Journal of Applied Statistics
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• v.13 no.2
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• pp.207-224
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• 2000

Generally cluster size is predetermined when we use the stratified two-stage cluster sampling But in case that the sizes of clusters vary greatly one may want to make the sizes to be about equal. In this paper we study the optimal cluster size in stratified twostage cluster sampling. Also we find the optimal primary sampling unit sizes and optimal secondary sampling unit sizes under the given cost restriction.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.4
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• pp.728-737
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• 2003

To evaluate microbial data and salivary measurements from clinically compatible, culture-based screening procedures employed with children younger than 36 months old. Plaque and stimulated saliva specimens were collected from 87 children. The pH of each saliva sample was measured before and after 0.94% lactic acid was added. Specimens were diluted and plated on selective media and non-selective media. Data collected were counts of mutans streptococci (MS) and lactobacilli (LB). In addition, total viable counts (TVC) of specimens, salivary pH and buffering capacity were also assessed. Each variable was compared to caries status of subjects. According to this study, the results were as followed: 1. Highly significant correlation with caries rates were found for counts of MS and LB. 2. The specific counts/ml saliva or plaque above which caries is predicted, or below which caries is not predicted were as follows: 1) Saliva MS; $10^5$ 2) Plaque MS; $2{\times}10^5$ 3) Saliva LB; $10^3$ 4) Plaque LB; $10^3$. 3. Salivary pH and buffering capacity versus caries status were not significant. 4. Microbial screening methods based on mutans streptococci had higher predictive values and odds ratios than methods for lactobacilli. 5. MS counts were clearly the best indicators of caries status in young children. This measurement can easily be obtained in a dental clinical setting both by conventional culture techniques, or commercial kits for MS recovery.

• Clinical and Experimental Pediatrics
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• v.45 no.2
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• pp.247-255
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• 2002

Purpose : This study was undertaken to obtain basic data about the megakaryocyte colony formation of fetal liver cells by using immunocytochemical staining and ex vivo culture with growth factors. Methods : The mononuclear cells were isolated from fetal liver and bone marrow with idiopathic thrombocytopenic purpura(ITP) and pancytopenia. These mononuclear cells were cultured in $MegaCult^{TM}-C$(Stem Cell Tech, Canada) media in the presence of growth factors and CFU-Megakaryocyte( CFU-Mk) colonies were counted on day 12. The expansion of CD34+ and CD41+ cell was analyzed by flow cytometry after 5 days incubation using flask culture. Results : The numbers of CFU-Mk colonies of mononuclear cells obtained from fetal liver in the 11th week gestational age were more than those in the 19th week specimens; growth factors could not enhance the colony expansion in all cases. Total numbers of CFU-Mk colony of fetal liver cells were higher than bone marrow from ITP or pancytopenia groups. The numbers of pure or large CFU-Mk colonies of fetal liver cells were also higher than bone marrow specimens. The rate of CD34+ cell expression of fetal liver was increased after flask culture and the enhancement effect of epression was seen only in cases which added thrombopoietin. The rate of CD41+ cell expression of fetal liver was increased after incubation, but the enhancement effect of growth factors was unclear. Conclusion : This study revealed good results about the megakaryocyte colony assay of fetal liver mononuclear cells using $MegaCult^{TM}-C$ media. This study suggests that the fetal liver could be a good source of megakaryocytic progenitor cells for clinical application in hematopoietic stem cell transplantation.

• Journal of the Korean Data and Information Science Society
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• v.27 no.2
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• pp.363-372
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• 2016

Two-stage sample designs are commonly used for household surveys in Korea using as clusters the enumeration districts (EDs). Since clustering decomposes the population variation into within- and between-cluster variations, the sample sizes allocated in stages can affect the overall precision. Alternative clusters are often considered due to diverse reasons such as the EDs' limitation in size, being out-of-date, and in-assessibility to their household lists. In addition, the EDs are currently under development by the Statistics Korea as an joint effort toward their transition from the traditional practice to the register census from 2015. We present an approach for evaluating the difference in the precision of the mean estimators of the sets of the cluster units in between a hierachical and nested form, where the design effect is used to reflect the effect of the clustering and the sample allocation. We also demonstrate our approach using the U.S. Census counts from the year 2000 for Anne Arundel County in Maryland. Our research shows that the within-cluster variance can be significantly different for survey variables and thus the choice of cluster units and the associated sample allocation scheme should reflect the corresponding variance decomposition due to clustering.

• The Korean Journal of Applied Statistics
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• v.26 no.2
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• pp.209-222
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• 2013

We apply stratified cluster sampling to a replicated systematic unrelated question model for a large scale survey in which the population is comprised of several strata developed by several clusters and with sensitive parameters. We first present a replicated systematic unrelated question model using an unrelated question model to procure sensitive information from the population of clusters and then develop a suggested model to an unrelated question by a stratified cluster replicated systematic sampling that can be used in large population of strata. We cover the proportional and optimum allocation for the suggested model. Finally, we compare and analyze the efficiency of the suggested model with the replicated systematic unrelated question model.

• Proceedings of the Korean Statistical Society Conference
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• 2005.05a
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• pp.245-250
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• 2005

보통 생태학 분야 등에 적용될 수 있는 적응집락추출계획(adaptive cluster sampling plan)을 수정하여, 표본의 크기 면에서 더 효율적인 Jumped 및 일반화 적응집락추출계획을 제안하였다. 이러한 계획 하에서 Hansen-Hurwitz(HH)와 Horvitz-Thompson (HT) 추정량으로 모수를 추정하였다. 제안한 새로운 계획들을 시뮬레이션을 통하여 기존의 계획과 비교하였다.

• The Korean Journal of Applied Statistics
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• v.11 no.1
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• pp.141-150
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• 1998

In this paper, we developed one-stage cluster randomized response model for obtaining quantitative data by using the Greenberg et al. model(1971) when the population was made up of sensitive quantitative clusters. We obtained the minimum variance by calculating the cluster's size and the optimum number of sample clusters under the some given constant cost. We compared the efficiency of our model with the Greenberg et al. model by simple random sampling.

• Radiation Oncology Journal
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• v.17 no.2
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• pp.158-165
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• 1999

Purpose : To investigate the percentage of colonies wi1h16or more cells distribution of human skin fibroblast according to in vitro aging, and to evaluate the relationship between percentage of colonies with 10 or more cells and in vivo donor age in human skin fibroblast culture. Material and Method : C1, C2, C3a, and C3b human skin fibroblast samples from three breast cancer patients were used as subjects. The C1, C2, and C3a donor were 44, 54, and 55 years old, respectively. C3a and C3b cells were isolated from the same person. Single cell suspension of skin fibroblasts was prepared with primary explant technique. One hundred cells are plated into 100m1 tissue culture flask and cultured for two weeks. The colony size was defined as colonies with 16 or more cells. The cultured cell was stained with crystal violet, and number of cells in each colony was determined with stereo microscope at $\times$10 magnification. Passage number of C1, C2, C3a and C3b skin fibroblast were 12th, 17th, and 14th, respectively. Results : Percentage of colonies with 16 or more cells of skin fibroblast samples decreased with increasing in vitro passage number. In contrast, cumulative population doublings of skin fibroblast sample increased with increasing in vitro passage number. Percentage of colonies with 16 or more cells also decreased with increasing population doublings in human skin fibroblast culture. There was strong correlation with percentage of colonies with 16 or more cells and population doublings En C3a skin fibroblast sampie. At the same point of population doublings, the percentage of colonies with 16 or more cells of the young C1 donor was higher level than the old C3a donor. Conclusion : The population doublings increased with increasing in vitro passage number but percentage of colonies with 16 or more cells decreased. The results of this study imply that percentage of colonies with 16 or more cell is useful as a indicator of in vitro human skin fibroblast aging and may estimate the in vivo donor age.

• The Korean Journal of Applied Statistics
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• v.17 no.2
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• pp.337-346
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• 2004

The Pearson chi-square goodness-of-fit test and the likelihood ratio tests are usually used for testing independence in two-way contingency tables under random sampling. But both of these tests may provide false results for the contingency table with clustered observations. In this case we consider the generalized linear mixed model which includes random effects of clustering in addition to the fixed effects of covariates. Both the heterogeneity between clusters and the dependency within a cluster can be explained via generalized linear mixed model. In this paper we introduce several types of generalized linear mixed model for testing independence in contingency tables with clustered observations. We also discuss the fitting of these models through a real dataset.