• Journal of Korean Traditional Oncology
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• v.15 no.1
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• pp.119-128
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• 2010

항암치료는 현재 암환자의 주요한 치료임에도 불구하고 항암제내성과 같은 문제점을 가지고 있다. 약물내성은 다양한 기전에 의해 발생하는데 수송단백질의 과발현, 비독성화발현, 손상유전자의 복구, 세포사멸신호의 변화, STAT-3와 NF-${\kappa}B$의 발현 등이 포함된다. 암세포는 저산소환경에서 발생하며 일반세포에 비해 무산소해당에 상대적 의존도가 높고 이는 암세포의 성장과 전이를 촉진하는 인자가 된다. 항암제가 효과를 내기 위해서는 산소가 필요한데 저산소환경은 이를 방해하며 또한 유전자의 불안정화로 인해 약물내성이 유도된다. NF-${\kappa}B$는 주요 전사인자 중 하나로서 각종 염증과 암에서 지속적으로 활성화되며 암세포의 변화, 증식, 침윤, 전이에 관여한다. 환경적 스트레스 등과 대부분의 항암약제들이 NF-${\kappa}B$를 활성화시키며 임상적으로도 암환자의 생존과 연관된 중요한 예후인자이다. NF-${\kappa}B$의 발현은 항암제로 인한 암세포의 자멸을 회피하게 만들고 수송단백질을 활성화시켜 항암제내성을 유도한다. 강황, 적포도, 고추, 건칠 등 다양한 천연물에서 NF-${\kappa}B$를 억제시키는 효능이 발견되었으며 이는 항암제내성을 억제시키고 항암제의 효과를 증대시킨다. 저산소환경의 개선과 NF-${\kappa}B$의 억제는 상호연관성을 가지고 있으며 항암제내성의 개선뿐만 아니라 암치료제 개발의 새로운 연구목표가 될 수 있다.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1994.04a
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• pp.49-57
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• 1994

진정한 의미의 다운사이징을 구현하기 위해서는 필요한 분산데이타베이스의 구현은 현재 여러가지 기술적인 문제점들을 안고 있다. 따라서 동시성 제어(concurrency control)와 갱신 (update propagation), 복구(recovery), 질의어 처리(query processing), 카달로그 관리(catalog management)등과 같은 분산 환경에서의 데이타베이스에 관련된 기술적인 문제점들을 해결하기 위해서는 어떠한 최적의 방법들을 개발해야만 한다. 이러한 방법들의 개발은 관계형 데이타베이스의 데이타관리 분류체계를 통한 대안들의 선택과 운용에 의해 가능할 것이다. 분산 환경하에서 사용되어질 수 있는 관계형 데이타베이스의 데이타관리 분류체계를 availability, expression, currency의 관점에서 Basic table과 view로 구분하여 정립해 보았다. Basic table은 current update가 필수적이므로 availability와 expression의 관점에서 분류하였고, view는 physical file의 존재성 유무와 시간적 실행의 차이를 기준으로 분류하였다. 그리고 이러한 분류기준에 따른 특성들을 분산데이타베이스 구축에 이용하는 방법들에 대해 이야기 하였다. 다시 말해 non-current materialized view 뿐만 아니라 current materialized view를 동시에 지원하는 하나의 distributed view update architecture를 개발하는 것에 대해 하나의 방법으로 제시하였다. 즉 immediate update와 deferred update는 current view를 이용하고 periodical update는 non-current view를 이용하여 100%의 distributed data resources를 관리 할 수 있는 효율적인 distributed system를 개발하는 것을 제시하였다. 본 논문은 데이타베이스론의 입장에서 아직 정립되어 있지 않은 분산 환경하에서의 관계형 데이타베이스의 데이타관리의 분류체계를 나름대로 정립하였다는데 그 의의가 있다. 또한 이것의 응용은 현재 분산데이타베이스 구축에 있어 나타나는 기술적인 문제점들을 어느정도 보완할 수 있다는 점에서 그 중요성이 있다.

• The KIPS Transactions:PartD
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• v.11D no.5
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• pp.1041-1048
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• 2004

Database logs contain various information on database operations, but they are used to recover database systems from failures generally. This paper proposes a log analysis tool that provides useful information for database tuning. This tool provides users with information on work-load organization, database schemas, and resources usages of queries. This paper describes the tool in views of its architecture, functions, implementation, and verification. The tool is verified by running the TPC-W benchmark, and representative analysis results are also presented.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.4
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• pp.227-230
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• 2007

The multi-lamellar and liquid crystal structures have drawn great public attention in the functional cosmetic and skin-related medicinal areas recently. The structure of an emulsion containing aqueous phase as a binding water and fixed oil phase components forming an association compound of the multi-lamellar structure can reconstruct the intercellular lipid lamellar structure in the stratum corneum and restore barrier function of the skin. In this study, we investigated the beneficial effect of bio-mimic liquid crystal emulsions (BLCE) containing higher fatty alcohol, lecithin, and cholesterol on the skin barrier function, and evaluated its cytotoxicity.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2008.05a
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• pp.426-430
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• 2008

Though the air-conditioners in each train model have almost identical function, there is incompatibility between them because of their different electric capacity and parts, even spares manufactures are different in the manufactured year. It cause over cost in the maintenance and repair of the each air-conditioner. In this paper, all the air-conditioners in each train model have been classified by their capacity and features so that grasp the operation status and the repair process of the air-conditioners, and draft systematically cost-effective solutions. By finding a way to deal with the emergency repair and extending the air-conditioner life though improvement of checking up progress, increase of passenger revenue can be reached considerably.

• The KIPS Transactions:PartC
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• v.12C no.1 s.97
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• pp.83-96
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• 2005

The multichannel switch is an architecture widely used for ATM (Asynchronous Transfer Mode). It is known that the fault tolerant characteristic can be incorporated into the multichannel crossbar switching fabric. For example, if a link belonging to a multichannel group fails, the remaining links can assume responsibility for some of the traffic on the failed link. On the other hand, if a fault occurs in a switching element, it can lead to erroneous routing and sequencing in the multichannel switch. We investigate several fault localization algorithm in multichannel crossbar ATM switches with a view to early fault recovery. The optimal algorithm gives the best performance in terms of time to localization but it is computationally complex which makes it difficult to implement. We develop an on-line algorithm which is computationally more efficient than the optimal one. We evaluate its performance through simulation. The simulation results show that the Performance of the on-line algorithm is only slightly sub-optimal for both random and bursty traffic. There are cases where the proposed on-line algorithm cannot pinpoint down to a single fault. We enumerate those cases and investigate the causes. Finally, a fault recovery algorithm is described which utilizes the information provided by the fault localization algorithm The fault recovery algorithm providesadditionalrowsandcolumnstoallowcellstodetourthefaultyelement.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.12A
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• pp.2027-2035
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• 2001

In this paper, we present an audio stream delivery using the AMR (Adaptive Multi-Rate) coder that was adopted by ETSI and 3GPP as a standard vocoder for next generation IMT-2000 service in which includes combined sender (FEC) and receiver reconstruction technique in the Internet. By use of the media-specific FEC scheme, the possibility to recover lost packets can be much increased due to the addition of repair data to a main data stream, by which the contents of lost packets can be recovered. The AMR codec is based on the code-excited linear predictive (CELP) coding model. So we use a frame erasure concealment for CELP-based coders. The proposed scheme is evaluated with ITU-T G.729 (CS-ACELP) coder and AMR - 12.2 kbit/s through the SNR (Signal to Noise Ratio) and the MOS (Mean Opinion Score) test. The proposed scheme provides 1.1 higher in Mean Opinion Score value and 5.61 dB higher than AMR - 12.2 kbit/s in terms of SNR in 10% packet loss, and maintains the communicab1e quality speech at frame erasure rates lop to 20%.

• Journal of the Society of Disaster Information
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• v.11 no.1
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• pp.73-88
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• 2015

Due to the cases of recent global warming and unusual weather etc., large-scale natural disasters such as typhoons, floods, snow damage occur frequently across the continents such as Southeast Asia and North America, South America etc. and risks of earthquakes and tsunami are also increasing gradually in Korea which has been regarded as a safe zone and disaster types are also being diversified such as typhoons, floods, heat waves, heavy snow and damage scale is also enlarged. In addition, due to geographical characteristics or lack of infrastructure, disasters tended to occur intensively around a specific region or city in the past but disasters occur throughout the country in recent years so preparation for disaster prevention has emerged as an urgent challenge issue. Therefore, considering that the plan of obtaining the effective feedback function of disaster Information is very important in the proactive and software aspects for disaster reduction, this paper analyzed this three aspects of contents, procedural and contextual aspects and proposed the plan. First, in the content aspect, building disaster prevention information communication Infrastructure, building urban and regional disaster prevention system, obtaining concurrency and sharing of information and second, in the procedural aspect, active utilization of ICT(Information and Communication Technology) of the prevention stage, disaster prevention information collection and analysis reinforcement of the preparation stage, improvement of decision-making structure and field command system of the response stage, recovery system related information promotion of the recovery stage were proposed as alternatives and finally, in the contextual aspect, if disaster prevention information is effectively managed through maintenance of disaster prevention information related systems, obtaining domainality by disaster prevention work, improvement of the ability to judge the situation, obtaining comprehensive and feedback function etc, it is considered to significantly contribute to reducing natural disasters.

• Journal of Korean Society of Forest Science
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• v.86 no.1
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• pp.87-97
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• 1997

In this research, photo images of uncultivated marginal lands were simulated to visualize alternative land use patterns using image capture technology. Based on an original photos, 3 simulated images were created ; barren condition, aforested condition and shrub-covered condition. The simulated images were then used to evaluate respondents' visual preference(SBE value) and willingness to pay for the agricultural development tax as a hypothetical payment vehicle. The SBE values for barren condition are the lowest, as expected. When original condition is changed to forested or shrubbed, the SBE values are increased significantly. The logistic models for the willingness to pay for the various alternative land uses performed significantly, ${\rho}$ statistics for 6 models ranges from 0.3 to 0.4 and correct percentage for predicted probability are about 75%. Among independent variables, the amount of tax offered is the most influencing factor to predict the probability. Income also shows some relationship with no statistical significance. Other variables behave inconsistently in the model. When SBE and WTP are correlated, rather consistent trends can be observed. With the increase of SBE, WTP predicted by the model increases accordingly. It can be concluded that enhancement of scenic quality of the agricultural lands leads to increase of people's willingness to pay to support the rural environmental conservation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.9C
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• pp.840-848
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• 2007

A multiple description coding (MDC) scheme for 3-D Data is presented. First, a plane-based 3-D data is split into two descriptions, each of which has identical contribution in 3-D surface reconstruction. In order to maximize the visual quality of reconstructed 3-D data, then, plane parameters are modified according to channel error condition. Finally, these descriptions are compressed and transmitted over distinct channels. In decoder, if two descriptions are available, we reconstruct a high quality 3-D data. If only one description is transmitted, however, 3-D surface recovery scheme reduces artifacts on erroneous 3-D surface, yielding a smooth 3-D surface. Therefore, the proposed algorithm guarantees acceptable quality reconstruction of 3-D data even though one channel is totally lost.