• Korean Architects
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• no.6 s.446
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• pp.54-57
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• 2006

경남 하동군은 경제자급구역 지정을 대비한 공공의료기관을 신축하여 소외계층에 대한 다양한 의료서비스 제공과 만성질환 등 신종질병 예방을 대처하고, 민간의료기관에서 기피하고 있는 노인치료, 치매사업, 재활프로그램 등 노인복지서비스 제공을 위한 공공의료기관 신축을 위해 설계경기를 실시한 바 당선작으로는 '태화건축사사무소(조태화) + 미가건축사사무소(이주용)'의 안을, 우수작으로는 '석림건축사사무소(이충호)'의 안을 각각 선정, 발표하였다.

• Radiation Oncology Journal
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• v.27 no.4
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• pp.173-180
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• 2009

Purpose: To investigate the role of radiotherapy for squamous cell carcinomas of the external auditory canal and middle ear. Materials and Methods: A series of 35 patients who were treated at a single institution from 1981 through 2007 were retrospectively analyzed. Thirteen patients were treated by radiotherapy alone; four by surgery only and 18 by a combination of surgery and radiotherapy. The total radiation dose ranged from 39~70 Gy (median, 66 Gy) in 13~35 fractions for radiotherapy alone and 44~70 Gy (median, 61.2 Gy) in 22~37 fractions for the combined therapy. Clinical end-points were the cause of specific survival (CSS) and local relapse-free survival (LRFS). The median follow-up time was 2.8 years (range, 0.2~14.6 years). Results: The 3-year CSS and LRFS rate was 80% and 63%, respectively. Based on a univariate analysis, performance status and residual disease after treatment had a significant impact on CSS; performance status and histologic grade for LRFS. Patients treated by radiotherapy alone had more residual disease following the course of treatment compared to patients treated with the combined therapy; 69% vs. 28%, respectively. Conclusion: Our results suggest that radiation alone was not an inferior treatment modality for CSS compared to the combined therapy for squamous cell carcinoma of the external auditory canal and middle ear. However, local failure after radiotherapy is the main issue that will require further improvement to gain optimal local control.

• Journal of the Korean Data and Information Science Society
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• v.22 no.2
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• pp.137-148
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• 2011

In this paper, we systematically investigate regional differences of the dead due to injuries in cities, towns and counties about transportation accidents, suicides and fall accidents, which have recently been an important issue of health problems in Korea, The data are from the Annual Report on the Cause of Death Statistics in Korea in 2008. They include the deaths over the age 19 from transportation accidents, suicides and fall accidents with the criterion of the International Statistical Classification of Diseases. Poisson HGLM is applied to estimate the mortality rate under the assumption that the number of deaths follow a Poisson distribution, by considering regions as random effects and by adjusting age, sex and standardized residence tax as fixed effects. Using the results of random effects prediction, the regional differences in cities, counties and towns are marked in disease mapping. The results showed that there were significant regional differences of mortality rates for transportation accidents and suicides, but no significant differences for fall accidents.

• Journal of Gastric Cancer
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• v.4 no.4
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• pp.257-262
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• 2004

Purpose: We reported our preliminary result in 2001. At that time, the follow-up period was too short to evaluate the survival benefit of adjuvant chemotherapy in gastric cancer without serosal invasion. Therefore, we followed those patients for 66 months to determine the long-term effects of adjuvant chemotherapy. Materials and Methods: We analyzed the recurrence pattern, the survival rate, and the disease-specific survival of 135 patients by reviewing their medical records and calling the patients or their relatives. All enrolled patients were included in the intention-to-treat analysis of efficacy. Results: The follow-up rate was $89.6\%$ (121/135), and the median follow-up duration was 66 months. Among the 135 patients, 4 relapsed in group 1 (5-FU+cisplatin), 7 in group 2 (mitomycin C+oral 5-FU), and 6 in group 3 (oral 5-FU only). The overall survival rate was $89\%$ in group 1, $84\%$ in group 2, and $82\%$ in group 3. There were no differences in the overall survival rates and the disease-specific survival rates among the three groups. Conclusion: Oral chemotherapeutic agents have an acceptable effect for adjuvant chemotherapy compared with intravenous agent. However, a large-scale, prospective, randomized study, including a control group, is needed for an exact evaluation.

• Landscaping Tree
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• s.114
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• pp.23-24
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• 2010

몇 년전 TV에서 강원도 고성군에서 꾸지뽕나무를 농경지에 집단으로 재배하여 그 잎에서 즙을 내여 칼국수를 만드는 것을 보았는데, 또 다른 매체에서는 이 나무를 골목으로 상황버섯을 종균을 접종시켜 재배하면 일반 골목 재배보다 항암 효과가 높은 버섯을 생산한다고 하고, 이 잎을 먹인 누에를 성인병 예방이나 치료약으로 사용하기 위해 최근들어 여기저기서 소득 작목으로 대량재배가 이루어지고 있다. 최근들어 꾸지뽕나무가 치료가 어려운 질병의 치료약으로 혹은 건강식품으로 찾는 이들이 많아졌다.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.12
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• pp.928-932
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• 2009

Most diseases are caused by complex processes of various factors. Although previous researches have tried to identify the causes of the disease, there are still lots of limitations to clarify the complex factors. Here, we present a disease classification model based on an evolutionary learning approach of combinatorial features using the data sets from the genetics and cohort studies. We implemented a system for finding the combinatorial risk factors and visualizing the results. Our results show that the proposed method not only improves classification accuracy but also identifies biologically meaningful sets of risk factors.

• Korean Journal of Poultry Science
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• v.20 no.2
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• pp.55-64
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• 1993

The experiment was conducted to compare the effects of supplements of copper, vitamin I and selenium on growth and immune responses of broiler chicks fed cornsoy diets. The basal diet contained 21% crude protein, 2,800 kcal ME, 10 mg Vitamin E, 10 mg copper and 0.1 mg selenium per kg diet. Additions of the basal diet were copper (150mg and 250 mg/kg) or combination of vitamin I(200 mg/kg) and selenium(2 mg/kg). Serum immunoglobulin G(IgG) concentrations and body weight gain were determined weekly from hatching to 7 weeks of age. Additions of copper(150mg, 250mg) to the basal diet were showed, at the four weeks of age, 4.8% and 4.5% higher in body weight gain than that of control group, respectively. The active immune system of copper and (Vit. E＋Se) treated groups developed one week earlier than control group(basal diet). Negative correlation between IgG concentration and body weight gain was showed at the period from hatching to three weeks of age and, thereafter, positive correlation were identified (p＜0.01). Mortality rates were observed lower in all treated groups than that of control. In conclusion, the lower the levels of serum IgG, at the first two weeks of age, the lower in disease Infection and the higher in body weight gain.

• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.282-290
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• 2018

Background: Anti-E or paired anti-E/-c antibodies can develop in patients with the Rh CDe phenotype. This study examined the differences in transfusion in patients with the CDe phenotype according to formation of anti-E or anti-E/-c antibodies. Methods: Retrospective reviews were carried out on the results of antibody identification tests performed in 2014. The Rh phenotype and antibody specificity were investigated. The transfusion and medical records of patients with the CDe phenotype were examined. Results: In total, 76 patients were included in the review. Of these 76 patients, 38 (50.0%) were of the CDe phenotype. Anti-E antibodies were the most frequent (60.5%), followed by anti-E/-c antibodies (23.7%). The total transfusion units and platelet transfusion units were significantly higher in patients with anti-E/-c antibodies (P=0.028 and P=0.01, respectively). The distribution of categorized diseases was similar in the patients with the anti-E and anti-E/-c antibodies. A frequency of transfusion episodes greater than or equal to four was higher in patients with hepatobiliary diseases (85.7%). Conclusion: In CDe phenotype patients, platelet transfusion was significantly higher in the anti-E/-c positive group than the anti-E positive group, indicating that platelets play a role in red blood cell alloimmunization. Because E is the most immunogenic antigen in Korea, it is important to define the disease group, in which patients with CDe phenotype require a transfusion of E and c-negative blood.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.7 no.1
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• pp.77-91
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• 1996

In order to elucidate the biological etiology and the effects of comorbidity on biological variables in tic disorders, plasma serotonin (5-hydroxlfryptamine, 5-HT) and 5-hydroxy- indoleacetic acid (5-HIAA) we.e measured in 87 tic disorders and 30 control subjects. The 87 tic disorder were composed of 45 Tourette's disorder(TS), 22 chronic motor tic disorders (CMT) and 20 transient tic disorders (TTD). Among these patients,43 patients were pure tic disorder (PT), 28 subject also had attention deficit hyperactivity disorder (T+ADHD) and 16 subjects had obsessive compulsive disorders (T+ OCD) as comorbid disorders. The results are summarized as follows : 1) Plasma 5-HT levels showed significant positive correlations with plasma 5-HIAA levels (Pennon r=0.77, p<0.05). 2) Plasma 5-HT and 5-HIAA levels showed no significant correlation with age in tic disorders. 3) Plasma 5-HIAA and 5-HT levels showed no significant correlations with age in control subjects. 4) There was significant difference in plasma 5-HT levels among TS, CMT, TTD and control groups (ANOVA F=34.48, df=3, 113, p<0.01), and post-hoc test using Scheffe method showed significant differences between control and TS, control and CMT, control and ITD groups. But, post-hoc test showed no significant differences between TS and CMT, TS and TTD, CMT and TTD groups. 5) There was significant difference in plasma 5-HIAA levels among TS, CMT, TTD and control groups (ANOVA F=26.48, df=3, 113, p<0.01), and post-hoc test using Scheffe method showed significant differences between control and TS, control and CMT, control and TTD groups. But, post-hoc test showed no significant differences between TS and CMT, TS and TTD, CMT and TID groups.f) There was significant difference in plasma 5-HT and 5-HIAA levels among PT, T+ADHD, T+OCD and contol groups (ANOVA 5-HT, F=37.59, df=3, 113, p<0.01, 5-HIAA, F=27.37, df=3, 113, p<0.01), and post-hoc test using Scheffe method showed signiscant differences between control and PT, control and T+ADHD and control and T+OCB. But, post-hoc test showed no significant differences between PT and T+ADHD, PT and T+ OCD and T+ADHD and T+ OCD. These results show that decreased 5-HT and 5-HIAA levels may play a role in the genesis of tic disorders, but these findings have no significant correlations with the severity of tic disorders. And the comorbid disorders of tics may have minimal effects on the biochemical abnormalities. Future studies must be focused on the effects of serotonin agonists and antagonists on tic disorders and molecular biological methodology may enhance to elucidate the mechanisms of these abnormal findings.

• The Journal of the Korea Contents Association
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• v.17 no.7
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• pp.579-591
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• 2017

The Illness Management and Recovery(IMR) Program was designed to improve self-management and recovery of people with mental illness. The purpose of this study was to identify the effects of the Korean version of the IMR program on recovery, knowledge against mental illness, hope among inpatients with severe mental illness. 92 participants diagnosed with schizophrenia, bipolar disorder and schizoaffective disorder were assigned to either an IMR group(n=51) or the control group(n=41) without randomization. Data collection had been conducted from June 2015 to December 2016. Mental Health Recovery Scale, Knowledge Scale, and Hope Scale was administered to participants before and after the intervention. Participants in the IMR program showed significant improvement in progress toward their recovery and knowledge about their mental illness compared with those receiving treatment as usual. However, changes in hope were not significant in both groups. This is the first evaluation of the effects of the Korean version of the IMR program. Our findings support potential benefits of implementing the Korean version of the IMR program.