• YAKHAK HOEJI
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• v.30 no.1
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• pp.24-30
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• 1986

New antibiotics having moieties of penicillanic acid, cephalosporanic acid and ampicillin on both ends of the central alkylene were synthesized by reacting 6-aminopenicillanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and ampicillin with hexamethylene diisocyanate and sebacoyl chloride, respectively. Antibacterial activities of the compounds were also investigated. The compound derived from sabacic acid and ampicillin exhibited an enhanced antibacterial activities against gram-negative bacteria and was found to be a promising wide-spectrum antibiotic.

• Information and Communications Magazine
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• v.33 no.2
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• pp.80-85
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• 2016

군사용 목적으로 개발된 드론(drone)이 오픈소스로 시장을 형성하면서 급성장하여 우체국의 택배 시스템에 적용을 한다는 발표[10]를 보면 국가 신성장 동력으로 발전 가능성에 대하여 기대하고 있는 실정이다. 언론과 산업계에서 드론이 모든 것을 대체할 것이라고 인식되면서 기술의 한계점은 흐려지고 있다. 세계 시장에서는 중국의 DJI를 선두로 급속히 성장하고 있지만 규제 목소리 또한 만만치 않은 실정이다. 플랫폼 기업인 구글이나 페이스북 아마존 등에서는 드론을 적용[3]하기 시작하였지만 넘어야 할 산은 많은 것이 현실이다. 이러한 드론 기술의 수준과 해결 과제를 살펴보고 드론이란 무엇이며 국내외 동향을 살펴본다.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.221-237
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• 2023

This study was conducted as part of a phased study aimed at closely examining the mutual ecosystem between creators and viewers through paying attention to the personal media environment that is in the center of rapid changes in the media industry and particularly exploring the areas of activity of the single-person or minority media creators who lead the mobile media environment that could be accessed, viewed and produced anywhere. In particular, this study aimed to not only pay attention to the situation in which the potential to expand professional YouTuber areas encounters the changing desire and demand of content service users who continue to become more evolved as time passes, but also examine the influence of the reputation of professional YouTubers on users' loyalty and subscription intention, examine the moderating effect of sincerity on the relationship between YouTubers and users, and demonstrate such relationship formation process based on concrete data. In the conclusion section, implications that can be drawn from the study results and suggestions for further studies in the future were proposed.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.12 no.10
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• pp.773-784
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• 2002

This paper proposes an optimal design to improve the performance of the intake system by reducing the noise. We adapt the Taguchi method and column merging method for the above design. At the first stage of the design, the length and radius of each component of the current intake system are selected as control factors. Then the $L^{18}$ table of orthogonal array is used to get the effective main factors. At the second stage, the $L^{16}$ table of orthogonal array and the column merging method is combined to analyze subdivided significant factors. We know that the robust design with the column merging method provides better design for noise of intake system than the robust design itself.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.10 s.103
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• pp.1123-1130
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• 2005

We propose an optimal design to improve the capacity by reducing the noise of the intake system. The length and radius of each component of the current Intake system are selected as control factors. We accept the output from computer simulator with orthogonal arrays. Then, the Kriging estimates are computed. From this, we exploit the optimal design of the intake system by adapting simulated annealing. From the results of this optimal design, we conclude that Kriging method with the orthogonal arrays is the efficient method for Design and Analysis of Computer Experiments and we propose the useful results for the low noise intake system.

• Proceedings of the Korea Contents Association Conference
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• 2016.05a
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• pp.291-292
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• 2016

한국과학기술정보연구원(이하 KISTI)은 지난 6년 간 전사적으로 품질제고전략, 서비스만족전략, 이미지제고전략 등 3대 고객만족추진전략을 수립하여 체계적인 고객만족경영시스템을 구축하고 이를 강화하기 위한 노력을 기울여 왔다. KISTI는 고객을 대상으로 서비스하는 부분을 크게 5개 업무유형 11 세부 서비스로 구분하여 있다. 각 업무유형별로 산업계, 학계, 연구계, 관계 등 핵심 고객군을 세부적으로 설정하고, 각각의 업무 프로세스 및 서비스 청사진을 표준화하여 이행표준체계를 수립하였다. 국가 과학기술 연구망 업무를 수행하는 담당자별로 실명제를 통한 책임경영을 하고 핵심 고객의 니즈를 반영하기 위한 심층 FGI(Focus Group Interview) 및 DI(Depth Interview)를 진행하였다. 또한 정기적인 고객 Needs 및 VOC 문제점을 파악하기 위한 워크숍을 개최하여 활발한 개선활동을 진행하였다. 향후 연구로는 체계적인 정보서비스의 향상을 위해서는 일부 직원이 아닌 내부 직원 구성원이 모두 고객 지향적 마인드 형성을 해야 한다. 단순한 친절과 고객 편의 제공이 아닌, 전문성을 중심으로 서비스의 질적 수준을 향상 시켜야 한다는 "프로의식"이 내부 구성원들 사이에 확산되어야 진정한 고객중심의 경영이 이루어 질수 있다고 본다.

• Journal of the korean academy of Pediatric Dentistry
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• v.32 no.3
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• pp.416-426
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• 2005

Intravenous sedation have many advantages of rapid onset and recovery, ability of control sedation levels and duration through titration. Midazolam is most commonly used intravenous medication for sedation in pediatrics, endoscopy, oncologic procedures and so on. But in dentistry, midazolam intravenous sedation is usually for adult, and there are few reports for children. Todays, children who need sedation become more and older, intravenous sedation technique is going a matter of concern in pediatric dentistry. The purpose of this paper is to evaluate the efficacy of sedation and clinical success for different initial dosage of midazolam in intravenous sedation for pediatric dental patients. 16 healthy children (male 10, female 6), mean age $54.7{\pm}10.7$ months, who needed at least two separate treatment visits requiring local anesthesia were chosen for this study. Every children were taken 0.3mg/kg, maximum 5mg of midazolam by intramuscular route, and then 30~50% $N_2O-O_2$ for 10 minutes was given. On every visits, one of the following 2 different initial dosage was given by intravenous route : (1) Group I : 0.1mg/kg Midazolam (2) Group II : 0.2mg/kg Midazolam. Additional dosage was half of the first dose. Physiologic parameters (oxygen saturation, heart rate, respiratory rate, end-tidal carbon dioxide pressure) was recorded by ten procedure steps. Behavior was videotaped and rated using Ohio State University Behavioral Rating Scale and Automated Counting System by one investigator, blind to administered dosage. After the treatment, operator evaluated the clinical success. Physiologic parameters were stable and within normal range during treatment in both groups. The analyzed sedative effect, in behavioral evaluation, ratio of favorable Quiet was higher in group II, and clinical success rate of group II was better than group I. Induction time was rapid in group II, and recovery time was rapid in group I. And there was no statistically difference between two groups in every results.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.4
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• pp.568-574
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• 2009

Tongue-tie is a congenital anomaly characterized by an abnormally short lingual frenum, which may restrict tongue tip mobility, In the neonate and infant, tongue-tie was said to cause difficult breast-feeding, In the older infant, toddler and young child, poor speech has been frequently listed because movement of tongue tip is limit ed. Also as a abnormal tongue position, various orthodontic problems, later mechanical and social manifestations could be developed. Treatment options such as observation, speech therapy, frenotomy and frenectomy have been suggested. The optimal timing for the surgery has not been determined, but early intervention may be appropriate for the children with significant tongue-tie who has the significant potential to speech difficulties and later social and mechanical problems. Sedation is an effective method for incapable of cooperative and the handicapped children, necessary to early intervention. We report three cases, using oral sedation for the frenectomy in young children with severe tongue-tie. After treatments, we could find out sufficient tongue movement and improved speech ability.

• Journal of Hospice and Palliative Care
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• v.11 no.3
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• pp.140-146
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• 2008

Purpose: Sooner of later, end-of-life care decision-making will unfold and be settled during the professional lives of medical students. However, there is prevalent ambiguity and uncertainty between the palliative treatment and euthanasia. We conducted this survey to investigate attitudes of medical students towards end-of-life making decisions, and to find out which factors primarily influenced the attitudes. Methods: A study was conducted among medical students at one university, the Republic of Korea. A written questionnaire was sent to all the 1st, 2nd, and 3rd-year medical students. It presented 5 statements on end-of-life decision-making. Students were asked whether they agreed or disagreed with each statement. Results: The response rate was 74.4%, and 267 questionnaires were analyzed. Percentages of agreement with each statements on Voluntary active euthanasia (VAE), Physician assisted suicide (PAS), Withholding life-sustaining management, Withdrawing life-sustaining management, and Terminal sedation (TS) was 37.1%, 21.7%, 58.4%, 60.3%, and 41.6%, respectively. The grade of students, religious activity, and educational experience were determinant factors. Agreement on each statements was higher in the low religious activity group than in the high religious activity group. Agreement on TS was higher among 3rd year students during their clerkship than among 1st and 2nd year students. Age of students and the experience of dying-people care had no significant influence. Conclusion: In end-of-life decision-making, religious and educational factors influenced medical students' attitudes. Especially, the experience of education during clerkship had significant influence on the attitude. Proper teaching on end-of-life decisions should further be considered during medical students' clerkship.

• Journal of the korean academy of Pediatric Dentistry
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• v.28 no.3
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• pp.441-446
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• 2001

Flumazenil is a competitive antagonist of benzodiazepines. It is usually administered intravenously. However, if the intravenous route is not available then other routes of drug administration should be considered. This study was designed to evaluate the reversal effects of flumazenil after nasal administration. Twenty-five young, healthy adult volunteers participated in this clinical trial. The dosage of 0.08mg/kg midazolam was administered intravenously to induce deep sedation. Ten minutes after midazolam administration, 0.5mg of flumazenil was dropped nasally, over a period of one minute. Blood samples were taken to measure the concentration of midazolam and flumazenil at 0, 5, 10, and 20min after nasal administration of flumazenil, using High Performance Liquid Chromatography. The degree of sedation was evaluated with sedation score and bispectral index (BIS), Statistical analysis was performed by multivariate ANOVA and correlation analysis (P<0.05). Peak serum flumazenil concentration was reached in 10min. Sedation score decreased after midazolam administration and showed a significant increase after flumazenil administration. However, BIS decreased during the first 10min after midazolam administration and then no significant changes after flumazenil administration. There were two instances representing rapid and complete reversal of midazolam after intranasal administration of flumazenil. In conclusion, intranasal flumazenil administration may be effective in some patients when intravenous route is not available in condition of benzodiazepine overdose.