• Journal of Animal Science and Technology
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• v.48 no.5
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• pp.651-662
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• 2006

Phthalate esters that are used as plasticizers and also found at low levels in foods such as dairy products are often mentioned as suspected endocrine disrupters. The purpose of the present study is to elucidate whether perinatal exposure to di-n-butyl phthalate(DBP), diisononyl phthalate (DINP) and di-2-ethylhexyl adipate (DEHA) affects several aspects of reproductive function in rats especially sexual differentiation of the brain. To this end, the dams were provided with pulverized soy-free diet containing 20, 200, 2,000 and 10,000 ppm of DBP, 40, 400, 4,000 and 20,000 ppm of DINP, or 480, 2,400 and 12,000 ppm of DEHA from gestational day (GD) 15 to postnatal day (PDN) 21, the day of weaning, and serum sex steroid hormone, gonadotropin levels and sexual behaviors after maturation were assessed. At Postnatal week (PNW) 20-21, serum levels of sex steroids and gonadotropins in both male and female rats, as well as estrous cyclicity in females, were not changed by perinatal exposure to DBP, DINP and DEHA, indicating that these chemicals did not affect sexual differentiation of the brain controlling the endocrine system of hypothalamo-pituitary-gonadal (HPG) axis. On the other hand, inhibitory influences on sexual behaviors, especially on ejaculation in males and lordosis in females, were observed by perinatal exposure to these chemicals. These results suggest that these chemicals may act directly on discrete regions of the hypothalamus regulating sexual behaviors, but not regulating gonadotropin secretion, thereby affect sexual differentiation of the brain with a resultant decrease in sex-specific behaviors in adulthood.

• Journal of Life Science
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• v.24 no.7
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• pp.798-803
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• 2014

Cathepsin D (CtsD), an aspartyl peptidase, is involved in apoptosis, resulting in the release of cytochrome C from mitochondria in cells. Here, we investigated microRNA regulation of CtsD expression in 3T3-L1 cells First, we observed the expression of CtsD in cells in response to doxorubicin (Dox). As expected, the level of CtsD mRNA was increased in 3T3-L1 cells exposed to Dox in a dose-dependent manner. Cellular viability of ectopically expressed CtsD cells was also decreased. Next, we used the miRanda program to search for particular microRNA targeting CtsD. MiR-145 was selected as a putative controller for CtsD because miR-145 had a high mirSVR score. In a reporter assay, the luciferase activity of cells containing the CtsD 3'-UTR region was decreased in cells transfected with miR-145 mimic compared to that of a control. The level of CtsD expression was down-regulated in preadipocytes ectopically expressing miR-145 and up-regulated by an miR-145 inhibitor. Cells also suppressed miR-145 expression when exposed to Dox. The miR-145 inhibitor reduced the cellular viability of 3T3-L1 cells. Taken together, these data suggest that miR-145 regulates CtsD-mediated cell death in adipocytes. These findings may have valuable implications concerning the molecular mechanism of CtsD-mediated cell death in obesity, suggesting that CtaD could be a useful therapeutic tool for the prevention and treatment of obesity by regulating fat cell numbers.

• Journal of the Korean Society for Railway
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• v.19 no.1
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• pp.77-86
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• 2016

Before urban railway vehicles reach their design life-span, operating agencies should determine when to buy new vehicles. Previous LCC (Life Cycle Cost) studies were limited because they independently focused on existing vehicles based on costs that directly impacted only the operating agency without considering effects such as social costs and the reduction of maintenance costs. Thus, it is difficult to systematically determine when to buy new vehicles. This study investigated the operating and maintenance related costs, especially from additional expenses and social costs due to unexpected vehicle failures and safety accidents, and did an economic analysis of scenarios with different discount rates. Considering that the public is very concerned about safety after the Sewol ferry accident, additional costs, which include social costs, should be included in the analysis. This study shows that the economic priority of scenarios may change depending on whether those costs are included and on the discount rate. The results of this study can help in the decision-making process for the planning and buying of new trains.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.72-75
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• 2018

Internet of Things (IOT) technology is rapidly becoming a reality in many parts of our lives through various products and services. Currently, the perception of Internet services for things is becoming common, and the B2C (Business to Consumer) market is explosively increasing as consumers are increasingly willing to purchase Internet devices. In particular, the economic effects of the Internet based smart home sector are known to be very large, and global manufacturers are launching various consumer oriented products based on smart home services.However, current smart home service products are closed systems because they provide independent devices for each manufacturer and provide only specific devices and services linked to them. There is a need for an environment that can provide intelligent smart home service through linkage between objects or services, and a controller that can provide smart control is needed. Therefore, this paper proposes a smart home remote control that can control the Internet devices and services of objects. The proposed smart home remote control provides an environment in which users can directly rescue services through the IFTTT automated service platform, which is an independent platform for each manufacturer.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1996.06b
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• pp.55-85
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• 1996

지르코니아 분말은 ZrO2 결정상이 온도변화에 따라 부피변화를 수반하는 상전이변태를 나타낸다. 단사정 ZrO2가 110$0^{\circ}C$에서는 정방정으로, 2$700^{\circ}C$ 내외에서는 입방정으로 결정구조가 가역적으로 변한다. 이 ZrO2에 금속산화물을 고용시키면 형석 (CaF2:Florite)형의 입방정 결정구조가 실온에서도 안정하게 존재하게 된다. 안정화제 산화물은 caO, MgO등 2가 산화물외에 3가 또는 4가의 금속산화물로서 Sc2O3, Y2O3, Sm2O3, Nd2O3, Gd2O3, Y2O3, CeO2 등이며 이들은 금속이온의 원자가가 변하기 쉬운 희토류 산화물이다. 안정화 지르코니아는 형석형 결정구조이며 결정화학적으로 보면 금속양이온이 산소이온에 대해서 정육면체형의 8배위를 하고 있다. 이때 이온반경비(양이온/음이온)에 따라 Zr+4자리와 O-2자리의 격자위치와 모양이 형성되므로 비틀어진 정육면체구조이건 이상적인 정육면체 형석구조를 이룬다. 이는 지르코니아의 결정상의 2상-3상인 부분안정화 지르코니아다결정체(PSZ : partially stabilized zirconia)이거나 단일상-2상인 정방정 지르코니아다결정체(TZP : tetragonal zirconia polycrystal)의 결정구조를 가지는데 기인한다. PSZ는 주로 MgO, CaO를 안정화제로 고용시켜 입방정 영역에서 소결하고 이를 다시 입방정과 정방정의 상 영역에서 열처리하여 입방정 입자내부에 정방정을 석출 형성시킨 것이며 TZP는 Y2O3 및 CeO2를 고용시켜 PSZ와 다르게 일반적인 상압소결한 정방정 결정상의 미립자이다. 산화지르코늄 분말은 지르콘사에서 열분해시킨 지르코늄소결.융해괴(caustic fusion clinker)를 산처리하여얻어진 지르코늄산용액(zirconyl acid solution : cloride, sulfide, nitride 등)으로부터 제조된다. 고순도 산화지르코늄은 용액 결정석출법에 의해 ZrOCl2.8H2O, 5ZrO2.3SO3.15H2O, ZrO(NO3)2.xH2O 등의 지르코늄 수화물만을 재결정화시킨 것으로부터 얻을 수 있으며 이 지르코늄염 수용액으로부터 입자미세구조를 효과적으로 제어하여 산화지르코늄 및 안정화 지르코니아 분말제조가 가능하다. 안정화 지르코니아 분말은 ZrO2와 안정화산화물의 고용을위하여 가열처리를 필요로 하며 일정온도에서 최적상태로 숙성하므로서 2가지 상(phase) 이상의 고용체를 가지게 된다. 안정화 지르코니아 분말은 고용처리온도를 낮추고 효과적으로 생성시키기 위해서는 지르코늄 및 안정화제염을 혼합하고 습식 직접합성하여 저온에서 고용체의 합해진상 영역을 생성시키는 것이다. 이는 지르코니아 원료분말의 미세구조를 제어하므로서 가능하며 이때 화학성분조성과 크기형태가 균일하게 분포된 입자분말을 얻을 수 있다.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.793-797
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• 2010

물리적 녹조저감 기술인 커튼형 수류차단막은 유입 하천과 저수지 천이부에서 높은 영양염류와 조류를 포함한 표층 수류의 차단 또는 우회를 통해 본류 수역의 녹조발생을 저감하는 대책이다. 본 연구에서는 2009년 5월 회남대교 약 2 km 상류에 시범 설치된 대청호의 수류차단막 효과를 분석하고자 선행연구에서 보정한 2차원 횡방향 평균 수리 및 수질 모델을 최근의 수문사상인 2009년 6~8월까지 적용하여 검보정하고 수치모의를 실시하였다. 저수지 수위와 실측수위를 비교한 결과, 7월 중순 유입량 증가에 따른 수위 상승을 잘 반영하였고, 결정계수값($R^2$)이 0.997로 나타나 모델은 저수지 물수지 계산에 있어서 높은 신뢰도를 보였다. 댐앞과 회남수역에서 수심별 수온예측 오차는 AME 0.258~$1.584^{\circ}C$, RMSE 0.393~$2.548^{\circ}C$의 범위로 실측값을 잘 반영하는 것으로 나타났다. 회남, 댐, 추동, 문의 수역의 표층에서 $PO_4$-P 및 Chl-a 농도에 대한 모의값과 실측값의 시계열 비교 결과, 모델은 저수지내 각 측정지점에서 실측값의 시계열 변화를 잘 모의하였고, 회남수역에서 7월 중순 홍수 유입에 따라 증가하였다. 특히, $PO_4$-P 농도가 0.06 mg/L까지 증가하는 것으로 나타났다. 이는 홍수기에 높은 영양염류를 포함한 탁수가 수류차단막 하단을 통과하여 수리학적 도수현상(Hydraulic jump)을 일으킨 것이 원인이라 판단된다. 수류차단막 설치에 따라 회남수역의 표층에서 Chl-a 농도의 저감 효과가 두드러졌으나, 댐, 추동 및 문의수역에서의 제어 효과는 미미하였다. 이와 같이 회남수역에서 효과가 큰 이유는 2009년 수문사상의 영향과 저수지 지형특성상 유입수의 영향을 직접받기 때문으로 판단된다. 또한, 회남수역에서 수류차단막 설치에 따른 T-N 및 T-P 평균 저감 효율(수류차단막이 설치되지 않은 경우에 대한 설치 후 농도 저감 비)은 각각 10.8% 및 19.1%이었으며, 평균 저감농도는 모의값을 기준으로 각각 1.637 mg/L에서 1.461 mg/L 및 0.047 mg/L에서 0.038 mg/L로 나타났다. DIN 및 $PO_4$-P 평균 저감 효율은 각각 6.4% 및 24.6%이었고, Chl-a 평균 저감 효율은 25.5%이었으며, 평균 저감농도는 모의값을 기준으로 0.025 mg/L에서 0.018 mg/L로 나타났다. 모의결과를 종합해 볼 때, 대청호에 시범 설치된 조류제어용 수류차단막은 2009년의 수문사상에서 회남수역의 녹조발생 저감에 기여한 것으로 판단된다. 또한 대청호에서 유사한 수문사상을 보인 2006년(62일간)에 비해 2009년(28일간)에 조류주의보 발령 일수가 대폭 줄었다는 사실도 차단막의 효과를 간접적으로 확인해 준다.

• Journal of the Korean Institute of Intelligent Systems
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• v.20 no.1
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• pp.54-59
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• 2010

This paper present to study the guidance system as localization technique using sensor fusion and line tracking technique using virtual line for AGV(autonomous guided vehicle). An existing AGV could drive on decided line only. And representative guidance systems of such guidance system are magnet-gyro guidance and wired guidance. However, those have had the high cost of installation and maintenance, and the difficulty of system change according to variation of working environment. To solve such problems, we make the localization system which is fused with a laser navigation and gyro, encoder. The system is robust against noise, and flexible according to working environment through sensor fusion. For line tracking of laser navigation without wire guidance, we set the virtual line in program, and design the driving controller based on difference of angle and distance between AGV's position and decided virtual line. To experiment, we use the AGV which is made by ourselves, and experiment the line tracking repeatedly on same experimental environment. In result, maximum distance error between decided virtual line and AGV's position was less than 49.93mm, and we verified that the proposed system is efficient for line tracking of actual AGV.

• Journal of Environmental Impact Assessment
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• v.28 no.6
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• pp.507-524
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• 2019

The purpose of this study was to validate the EFDC model for the weir pool of Gangjeong-Goryong Weir located in Nakdong River, and evaluate the effect of flow control and phosphate loading reduction on the water quality and algae biomass by group (Diatom, Green, Cyanobacteria). As a result of model validation using 2018 experimental data,the time series of water level and vertical distribution of water temperature, DO, organic matter, nitrogen, and phosphorus time series were properly simulated. Seasonal fluctuations of algae biomass by group were adequately reproduced, but the deviations between measured and simulated values were significant in some periods. As a result of scenario simulations to control the water level and flow rate, the thermal stratification was resolved as the water level was lowered and the flow rate increased. The flow velocity at which the water temperature stratification was resolved was about 0.1 m/s, which is consistent with the previous study results of Baekje Weir in Geum River. Simulations of the 2Q flow scenario showed that Chl-a decreased by 8.7% and the cell density of diatom and green algae declined. The cell density of cyanobacteria increased, however, because the high concentrations of cyanobacteria in the upstream boundary conditions directly affected downstream due to increased flow velocity. In the scenario simulation of reducing the influent phosphate load concentration (average 0.056 mg/L) to 50%, Chl-a decreased by 13.6%.The results suggest that the upstream algae concentration and phosphorus load reduction should be considered simultaneously with hydraulic control to prevent algal overgrowth of Gangjeong-Goryong Weir.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.4
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• pp.1824-1832
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• 2011

In this paper, a smart home service robot McBot II is newly developed in much more practical and intelligent system than McBot I which we had developed a few years ago. Thus far, vacuum-cleaners have lightened the burden of household chores but the operational labor that vacuum-cleaners entail has been very severe. Recently, a cleaning robot was commercialized to solve but it also was not successful because it still had the problem of mess-cleanup, which pertained to the clean-up of large trash and the arrangement of newspapers, clothes, etc. Hence, we develop a new home mess-cleanup robot McBot II to completely overcome this problem on real environments. The mechanical design and the basic control of McBot II, which performs mess-cleanup function etc. in house, is actually focused in this paper. McBot II is mechanically modeled in the same method that the human works in door by using the waist and the hands. The big-ranged vertical lift and the shoulder joints to be able to forward move are mechanically designed for the operating function as the human's waist when the robot works. The mobility of McBot II is designed in the holonomic mobile robot for the collision avoidance of obstacle and the high speed navigation on the small area in door. Finally, good performance of McBot II, which has been optimally desinged, is confirmed through the experimental results for the control of the robotic body, mobility, arms and hands in this paper.

• Journal of Korean Tunnelling and Underground Space Association
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• v.24 no.6
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• pp.745-756
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• 2022

The road tunnel is a semi-closed space that is blocked on all sides except the entrance and exit, and in the event of a fire, the smoke of the fire spreads longitudinally due to heat buoyancy caused by the fire and air currents that always exist in the tunnel. To solve this problem, smoke removal facilities are installed in road tunnels to secure a safe evacuation environment by controlling the direction of movement of smoke or directly smoking at fire points. In urban areas, the service level of urban roads decreases due to the increase in traffic due to the increase in population, and as a solution, the construction of underground roads in urban areas is increasing. When a fire occurs during hydrogen leakage through TPRD of a hydrogen fuel cell vehicle (FCEV), the fire intensity depends on the amount of leakage, and the maximum fire intensity depends on the orifice diameter of the TPRD. Considering the TPRD orifice diameter of 1.8 mm, this study analyzed the diffusion distance of fire smoke according to the wind speed of the roadway and the opening interval of the large exhaust port when the maximum fire intensity was 15 MW. As a result, it was analyzed that air flow in the tunnel could be controlled if the wind speed of the road in the tunnel was less than 1.25 m/s, and smoke could be controlled within 200 m from the fire if the damper interval was 50 m and 100 m.