• Journal of Sasang Constitutional Medicine
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• v.20 no.2
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• pp.135-144
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• 2008

1. Objectives The purpose of these 2 case studies is to evaluate the effects of Gihwangbeakho-tang which is based on the Sasang Constitutional Medicine for the Herpes zoster. 2. Methods We used Visual analogue sign(VAS) and pictures of the affected part for the assessment. 3. Results After two patients were treated with Gihwangbeakho-tang, the vesicles were cleared and the pain was decreased. 4. Conclusions These 2 case studies show an efficient result of using Gihwangbeakho-tang in the treatment of Herpes zoster.

• The Journal of Internal Korean Medicine
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• v.21 no.5
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• pp.863-867
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• 2000

Byun-jo(煩躁) is the word that including in irritability, restlessness, delirium, chest discomfort, insomnia in oriental medicine. Byun-jo is one of symptom in Soyangin(少陽人)(one of human type in Sasang constitutional medicine(四象醫學)) Interior-overheated-disease(裏熱證). In the book 'dongyi soose bowon(東醫壽世保元)', Soyangin Gihwangbeakho-tang(地黃白虎湯) is used at Soyangin Interior-overheated-disease. One post-stroke patient developed new syptom named Byun-jo for 2 months. the patient was classified as Soyangin by somatotype, the emotional patterns. the patient treated with Soyangin Gihwangbeakho-tang for 7days, and the symptom Byun-jo was disappeared. This result revealed that Soyangin Gihwangbeakho-tang was effect on reducing the symtom Byun-jo in Soyangin patient.

• Journal of Sasang Constitutional Medicine
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• v.14 no.3
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• pp.153-159
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• 2002

Parkinson's disease(PD) is characterized by chronic progress of mesencephalic dopaminergic neuronal death. Diagnostic criteria for PD require at least two of three motor sign: tremor, rigidity, or bradykinesia. Levodopa and the dopamine agonists are considerd first-line drug therapy. In the book ‘dongyi soose bowon(東醫壽世保元)’, Soyangin Gihwangbeakho-tang(地黃白虎湯) is used at Soyangin Interior-overheated-disease. This case is patient who is 69 years old lady, suffered by the tremor of jaw and a slight rigidity, bradykinesia etc. This patient was classified as Soyangin by features, somatotype and emotional patterns. She improved in the tremor of jaw and others with Gihwangbeakho-tang for 67days. The result revealed that Soyangin-Gihwangbeakho-tang was effected on the tremor of jaw and others with Parkinson's disease patient.

• Journal of Sasang Constitutional Medicine
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• v.20 no.2
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• pp.145-154
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• 2008

1. Objectives The purpose of this study is to evaluate the effect of Gihwangbaekho-tang which is based on the Sasang Constitutional Medicine for the cerebrovascular accident patient who has suffered from dysphasia and dysphagia. 2. Methods The subject is about 69-year-old cerebrovascular accident patient suffering from dysphasia and dysphagia who was diagnosed as Soyangin interior overheated disease based on his nature & emotion, physical chracteristics, symptoms, and we have prescribed Gihwangbaekho-tang. 3. Results and Conclusions Cerebrovascular accident parient is suffering from dysphagia, dysphasia, insomnia, constipation, quadroparesis treated with Gihwangbaekho-tang were improved. This study describes the improvement of dysphagia, dysphasia and other general sypmtoms using Gihwangbaekho-tang. Gihwangbaekho-tang takes effect Soyangin interior overheated disease.

• Journal of Sasang Constitutional Medicine
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• v.18 no.2
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• pp.139-147
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• 2006

1. Objectives Creutzfelt Jacob Disease is one of a group of neurodegenerative disorders causing spongiform encephalopathies due to a infection of prion or unconventional slow virus on central nerve system. The diagnosis of this disease is not easy and there is currently no cure. This article is to report our case about a female patient who was not diagnosed as CJD at the early period so that we treated her with Yangkyuksanhwa-tang(凉膈散火湯) and Jihwangbaekho-tang(地黃白虎湯). 2. Methods Magnetic resonance imaging(brain MRI), blood test and computer tomography were performed. The treatment for this patient was clinically based on Sasang Constitutional Medicine. 3. Results and Conclusions (1) Visual field defect, ataxia, myoclonus, sweating and dysuria were the main symptoms of the patient. (2) The pathological change in parenchyme was not revealed during the early periods by MR imaging. So the diagnosing CJD was not possible during the time in this case. (3) Jihwangbaekho-tang(地黃白虎湯) improved her myoclonus and sweating. Bur her mental disorder and the progress of the pathological change in the parenchyme was not able to be treated.

• Journal of Sasang Constitutional Medicine
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• v.19 no.2
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• pp.195-203
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• 2007

1. Objectives The purpose of this study is to evaluate the effects of Gihwangbaekho-tang which is based on the Sasang Constitutional Medicine for the patient who has suffered from hip joint pain. 2. Methods The subject is about 86-year-old patient suffering from hip joint pain who was diagnosed as Soyangin interior over heated disease based on his Nature & Emotion, physical characteristics, symptoms, and we have prescribed Gihwangbaekho-tang. We used Visual analogue scale(VAS) for the assessment of Hip joint pain. 3. Results and Conclusions The patient was treated with Gihwangbaekho-tang and hip joint pain, thirst, redness of the face, constipation and general condition were improved. This study describes tile improvement of Hip joint pain and the change of symptoms by using Gihwangbaekho-tang. In this study, we applied Gihwangbaekho-tang to 86-year-old patient for about forty days, and Gihwangbaekho-tang didn't cause any serious side effect on the patient.

• Journal of Sasang Constitutional Medicine
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• v.9 no.2
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• pp.203-225
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• 1997

Jihwangbakhotang(地黃白虎楊) is made by Li Je Ma, the creator of the Four Constitutional Medicine. Single and 13 weeks oral repeated dose toxicity studies were conducted in Sprague Dawley rats of both sexes to elucidate the potential acute and subchronic toxicity of JBT extract and reversibility of any effects. In the single dose study, JBT extract was administered orally to rats with the dose of 2 g/kg and 8 g/kg. In the long term administration of 13 weeks, the JBT extract of 125 mg/kg/day, 500 mg/kg/day, 2000 mg/kg/day was administered to rats. The change of blood weight, urine volume, electrolyte in urine, hematological change, the change of blood chemistry, autopsy finding, and histological observation were researched, the results were as follows; 1. The lethal dose of JBT extract seems to be over 10 g/kg, the single administration of JBT extract 8 g/kg showed no toxical signs except little increase of urine volume. 2. The change of body weight had the trend of decrease in the group of, but has no significance, and also the consumption of food and water had no changes. 3. The hematological changes induced by the 13 weeks administration of JBT extract showed the significance in the item of Hb, MCH, MCV, WBC in the group of 125 mg/kg/day. 4. In the test of blood chemistry, total cholesterol showed little decrease and A/G ratio showed little increase, but the change was not clear, and the standard error was large. So the result was obtained insignificantly and the toxicity of JBT extract was not observed. 5. In the male group after recovery period, the level of cholesterol and triglyceride decreased slightly, but the result was not significant. 6. In the urine test, the little change of electrolyte was appeared, but it seemed not to be the result induced by the toxicity of JBT extract. 7. In each group of male and female rats, the weight change of organ and the serum histological changes was observed, but the result did not showed the dose dependent toxicity. So the toxicity of JBT extract was not regarded. In the conclusion, the toxicity of JBT extract was not observed in the single dose treatment and long term repetitive administration of JBT extract.