• Journal of Applied Biological Chemistry
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• v.65 no.4
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• pp.387-396
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• 2022

Skeletal muscle accounts for about 40-50% of body weight and is an important tissue that performs various functions, such as maintaining posture, supporting soft tissues, maintaining body temperature, and respiration. Cancer, which occurs widely around the world, causes cancer cachexia accompanied by muscular atrophy, which reduces the effectiveness of anticancer drugs and greatly reduces the quality of life and survival rate of cancer patients. Therefore, research to improve cancer cachexia is ongoing. However, there are few studies on the link between cancer and muscle atrophy. Cancer cells exhibit distinct microenvironment and metabolism from tumor cells, including tumor-associated macrophages (TAM), tumor-associated neutrophils (TAN), and insulin resistance due to the Warburg effect. Therefore, we summarize the microenvironment and metabolic characteristics of cancer cells, and the molecular mechanisms of muscle atrophy that can be affected by cytokine and insulin resistance. In addition, this suggests the possibility of improving cancer cachexia of substances affecting TAM, TAN, and Warburg effect. We also summarize the mechanisms identified so far through single agents and the signaling pathways mediated by them that may ameliorate cancer cachexia.

• Journal of the Korean Geotechnical Society
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• v.19 no.2
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• pp.237-246
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• 2003

The driven pile has environmental problems such as vibration and noise. Especially, if the site consists of gravel, cobble and weather rock, the driven pile can not be applied. Therefore, the application of the drilled shafts is increasing in Korea. However, the bearing capacity values by the suggested theoretical formulas are generally considered too conservative. In this paper, static load tests for the rock socketed drilled shaft at Gwangandaero and Suyeong3hogyo are performed and in order to estimate the side friction of the shaft, strain gauges are applied. The bearing capacities from the field test data and the bearing capacity values by the theoretical formula are compared. Even the static load tests didn't reach to the ultimate bearing capacity condition, and all the measured bearing capacity values were higher than those by the theoretical formulas. The field data also showed that the major bearing capacities were not due to end bearings but side friction resistances. Based on the above results, several suggestions are proposed for the drilled shaft design.

• 한국노년학
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• v.40 no.1
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• pp.111-130
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• 2020

This qualitative study aims to understand family members' caregiving experience for middle-aged and elderly breast cancer survivors at early stages. A total of four families of breast cancer survivors were given focus group interviews(FGI), and an additional family was interviewed individually. The thematic analyses of the FGI and individual in-depth interview discussions revealed the following four themes: first, day-to-day feelings like walking on thin ice (entangled emotions with each treatment stage, regret of watching a survivor's pain, fear of recurrence and death, concerns of changes in family relationships, and various feelings experienced as a daughter), second, caregiving has become a mainstay in my life (unfamiliar and unskilled care, losing my life), third, beginning to recover and different experiences between a survivor and a family caregiver (not understanding a survivor's pain from the abyss, forgetting that the survivor is still a cancer patient and that treating him or her casually), and fourth, moving forward (hope that things will be better, taking care of myself to prevent exhaustion). Based on the results of this study, we proposed social welfare services and policy measures to reflect the psychosocial needs of family caregivers of breast cancer survivors and support family caregivers during the care process.

• Proceedings of the Mineralogical Society of Korea Conference
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• 2001.06a
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• pp.133-133
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• 2001

우리는 괴산 덕평리 지역의 소위 구룡산층과 대전 추부 지역의 창리층 흑색 점판암에 대한 납 동위원소 연대측정 결과를 보고한다. 덕평리 지역의 흑색 점판암은 270 Ma 내외의 Pb-Pb 연대를 보이고 U-Pb 연대는 정의되지 않는다. 그 Pb-Pb 연대는 같은 시료의 22개 uraninite 입자에 대한 CHIME 연대와 오차범위 내에서 일치한다. 이로 보아 uraninite는 형성 또는 변성작용에 의한 동위원소적 재평형 작용 이후 폐쇄계를 잘 유지하였지만 흑색 점판암이 지질학적으로 최근에 지표에 노출된 이후에는 전암 규모에서 개방계로 거동하였음을 알 수 있다. 박편 미조직 관찰에 의하면 흑색 점판암의 1차광물인 uraninite 외에 풍화기원 2차광물인 uranocircite, francevillite가 관찰된다. 덕평리 지역 흑색 점판암의 최고 변성온도 조건은 50$0^{\circ}C$ 내외이므로 (Kim et al., 2000) uraninite CHIME 연대의 폐쇄온도가 50$0^{\circ}C$ 이상이거나 uraninite의 형성시기와 변성시기 사이에 시간차가 거의 없었다고 판단된다. 덕평리 지역의 U 광화작용 시기는 이번 자료에 의해 고생대 말로 정의될 수 있으나 그 연대가 흑색 점판암의 모물질인 해저 흑색 유기질 퇴적물의 초기 속성작용과 관련 있는지 후기의 변성작용과 관련 있는지에 대해서는 광물학적인 연구가 더 진행되어야 한다. 옥천대 변성퇴적암의 일부가 고생대 말에 퇴적되었을 가능성은 황강리층 역의 xenotime 및 monazite에 대한 CHIME 연대측정 결과 (약 367 Ma; Adachi et al., 1996)에 의해서 지지된다. 추부 지역 흑색 점판암의 Pb-Pb 연대는 170 Ma 내외로서 인접한 쥬라기 화강암의 관입시기를 지시하는 것으로 생각된다. 이는 화강암체로부터의 거리로 볼 때 덕평리 지역과 추부 지역의 시료 채취 위치가 유사하지만 지하 천부에 관입한 백악기 속리산 화강암 (91$\pm$6 Ma, Cheong and Chang, 1997)에 의해서는 덕평리 지역 흑색 점판암의 납 동위원소계가 영향받지 않았다는 점과 대조적이다.

• Asian Oncology Nursing
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• v.11 no.1
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• pp.41-48
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• 2011

Purpose: The study was to identify relationships between the family support, perceived health status and self esteem in Korean women with breast cancer. Methods: Data were collected by questionnaires from 214 women with breast cancer in inpatient and outpatient settings at three different university hospitals and one cancer hospital in B city, Korea. The instruments included Family Support Scale, Perceived Health Status Scale, and Self Esteem Scale. The collected data were analyzed using frequency, percentage, t-test, ANOVA, Scheffe's test, and Pearson's correlation coefficients by SPSS WIN 15.0 program. Results: There were significant differences in the family support by age, education, and cost burden. There were significant differences in the perceived health status by education, occupation, economic status, pain, fatigue, and cancer insurance. There were significant differences in the self esteem by age, occupation, economic status, type of religion, pain, fatigue, and cancer insurance. Self-esteem was significantly correlated with family support and perceived health status. Conclusion: These results suggested that promoting perceived health status and enhancing family support would increase self-esteem effectively among Korean women with breast cancer.

• Asian Oncology Nursing
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• v.8 no.1
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• pp.32-39
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• 2008

Purpose: This study was to identify the relationship between perceived family support and quality of life in hospitalized patient with terminal cancer. Method: Study subjects were 104 patients with terminal cancer who were hospitalized and treated at K university hospital, in Busan. Perceived family support and quality of life were measured using the Kang's Revised Family Support Scale and Youn's Quality of Life scale for terminal patients. Results: 1) The mean score of perceived family support was $4.23{\pm}0.61$. The mean score of quality of life was $5.83{\pm}1.37$. 2) The perceived family support was significantly different with primary care giver, food type, medical period after diagnosis. 3) The levels of quality of life was significantly different by number of children, effect of religion on the one' life, perceived state of disease and pain. 4) There was moderate positive correlation between perceived family support and quality of life. Conclusions: Increase in perceived family support was associated with increase in quality of life in hospitalized patients with terminal cancer. It is necessary that the development of nursing education program for family which help to support the patient with terminal cancer for increasing the quality of life of patient with terminal cancer.

• Asian Oncology Nursing
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• v.5 no.1
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• pp.31-39
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• 2005

Purpose: This study was to identify the levels of functional status, depression, family support and their relationship among those variables in head and neck cancer patients. Method: The subjects were 100 patients with head and neck cancer patients who visited at outpatients clinic in one university hospital in Taegu. The instrument used for this study were Functional Status in Head & Neck Cancer - Self Report Scale developed by Baker(1995), Self-Rating Depression Scale by Zung(1965) and Family support assessment tool by Kang hyun-suk(1984). The data were analysed percentage, mean, t-test, ANOVA and pearson's corelation using SAS program. Result: There was significantly negative correlation between functional status and depression(r=-.71) and between depression and family support(r=-.56). The relationship of functional status and family support was significant as r= .33. Conclusion: It was found that functional status, depression and family support of head and neck cancer patient were closely related each other. Therefore it is necessary to design nursing intervention to enhance family support or decrease depression for improving quality of life in head and neck cancer patient.

• Korean Journal of Adult Nursing
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• v.25 no.3
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• pp.298-311
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• 2013

Purpose: The purpose of this study was to compare reported physical symptoms, hope and family support of cancer patients between general hospitals and long-term care hospitals. Methods: Subjects were 175 patients diagnosed with cancers from two general hospitals and six long-term care hospitals located in G city. Subjects completed a questionnaire with questions about general characteristics and questions about the disease, physical symptoms, hope and family support. Data was collected from February to April and the data were analyzed using an independent t-test and one-way ANOVA. Results: The subjects in long-term care hospitals showed higher percentage in pain, nausea, fatigue, sleep disorder, and change in appearance. There was a significant difference in family support between two groups. A significant positive correlation was found between hope and family support in subjects in general and long-term care hospitals. Conclusion: Significant differences were found in some physical symptoms and family support between cancer patients in general hospitals and long-term care hospitals. Thus, nurses in long-term care hospitals need provide care suitable for the characteristics of cancer patients in long-term care hospitals.

• Korean Journal of Adult Nursing
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• v.17 no.5
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• pp.822-830
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• 2005

Purpose: The study was to identify the relationship between the spiritual well-being, family support and depression in cancer patients. Method: Data were collected by questionnaires from 116 inpatients with cancer at one university hospital in J area using Spiritual Well-being Scale, Family Support Scale, and BDI. The collected data were analyzed by SPSS WIN 12.0 program. Result: 1) The mean scores of well-being, family support, and depression were 107.28, 41.14, and 16.79 respectively. 2) There were significant differences in the spiritual well-being by age, education, religion, and social group. There were significant differences in the family support by age, education, and number of admission. There were significant differences in the depression by occupation and social group. 3) Depression was significantly correlated with spiritual well-being, and family support. 4) The most signifiant predictor which influenced depression in cancer patients was spiritual well-being, followed by occupation, age, family support. Conclusion: These results suggested that providing spiritual nursing intervention and enhancing family support will effectively decrease depression in cancer patients.

• Child Health Nursing Research
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• v.23 no.2
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• pp.238-248
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• 2017

Purpose: The main purpose of this study was to explore the adaptation experience of adolescent cancer survivors during and after cancer treatment, and their perceived social support networks. Methods: This study was a qualitative descriptive study using the in-depth interview. Eight adolescent cancer survivors who were diagnosed with cancer between 11 to 18 years old participated in the study. Results: The adaptation experiences of adolescent cancer survivors over time were identified within five categories for during their treatment such as "being catapulted from one's life," "standing at the center of discomfort," "falling behind the line," "accepting the change," "being developed", and another five categories for after the treatment including "being shackled," "encountering the forgotten reality," "overcoming and emerging from the reality," "growing into adulthood," "entering into a new orbit." Participants reported the various members of their social support network and their roles during and after the treatment as well. Conclusion: While adolescent cancer survivors adjusted to their changing situations after the cancer diagnosis, their internalized adaptation, as well as perceived social support from their diverse surrounding network, played significant roles. These findings will become a valuable asset for developing age-appropriate nursing interventions to promote psychosocial adjustment of adolescents with cancer.