• Korean Journal of Clinical Laboratory Science
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• v.53 no.2
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• pp.158-164
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• 2021

Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis. We previously reported that TG-induced cell death of macrophages is mediated via pannexin-1 activation, which increases the extracellular ATP and subsequent increase in potassium efflux, thereby activating the caspase-2/caspase-1/apoptotic caspases, including the caspase-8 pathway. Contrarily, some studies have reported that caspase-8 is an upstream molecule of caspase-1 and caspase-2 in several cellular processes. Therefore, this study was undertaken to investigate whether caspase-8 influences its upstream molecules in TG-stimulated macrophage cell death. We first confirmed that caspase-8 induces caspase-3 activation and poly ADP-ribose polymerase (PARP) cleavage in TG-treated macrophages. Next, we determined that the inhibition of caspase-8 results in reduced caspase-1 and -2 activity, which are upstream molecules of caspase-8 in TG-induced cell death of macrophages. We also found that ATP treatment restores the caspase-8 inhibitor-induced caspase-2 activity, thereby implying that caspase-8 affects the upstream molecules responsible for increasing the extracellular ATP levels in TG-induced macrophage cell death. Taken together, these findings indicate that caspase-8 potentiates the TG-induced macrophage cell death by activating its upstream molecules.

• Journal of Nutrition and Health
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• v.56 no.5
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• pp.469-482
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• 2023

Purpose: Obesity has emerged as a critical global public health concern as it is associated with and increases susceptibility to various diseases. This condition is characterized by the excessive enlargement of adipose tissue, primarily stemming from an inequity between energy intake and expenditure. The purpose of this study was to investigate the potential of sweet pumpkin powder in mitigating obesity and metabolic disorders in leptin-deficient obese (ob/ob) mice and to compare the effects of raw sweet pumpkin powder (HNSP01) and heat-treated sweet pumpkin powder (HNSP02). Methods: Leptin-deficient obese mice were fed a diet containing 10% HNSP01 and another containing 10% HNSP02 for 6 weeks. Results: The supplementation of ob/ob mice with HNSP01 and HNSP02 resulted in decreased body weight gain, reduced adipose tissue weight, and a smaller size of lipid droplets in the adipose tissue and liver. Furthermore, the ob/ob-HNSP01 and ob/ob-HNSP02 supplemented groups exhibited lower levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, and insulin, as well as a reduced atherogenic index in comparison with the control group. Molecular analysis also demonstrated that the intake of HNSP01 and HNSP02 resulted in a diminished activation of factors associated with fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase, while concurrently enhancing factors associated with lipolysis, including adipose triglyceride lipase and hormone-sensitive lipase, in the adipose tissue. Conclusion: Taken together, these findings collectively demonstrate the potential of sweet pumpkin powder as a functional food ingredient with therapeutic properties against obesity and its associated metabolic disorders, such as insulin resistance and dyslipidemia.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2011.05a
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• pp.387-388
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• 2011

• Journal of Clinical Otolaryngology Head and Neck Surgery
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• v.29 no.2
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• pp.286-289
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• 2018

Liposarcoma is a malignant tumor that occurs in adipocytes, accounting for 5% of all sarcomas. Generally, it has no symptoms and it occurs in any parts of the body. There are various types of liposarcoma. Of these, 40-45% are known as highly differentiated liposarcoma, and highly differentiated liposarcoma is also referred to as atypical lipomatous tumor. We report a case of an atypical lipomatous tumor on the left neck.

• Proceedings of the Korean Society of Computer Information Conference
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• 2020.07a
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• pp.675-676
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• 2020

지방자치단체(이하 지자체)는 경제, 사회, 문화 등 다양한 분야의 지표 및 데이터를 관리하고 있다. 지자체의 데이터를 수집하여 분석하고자 하는 사회과학 분야 연구자들은 이렇게 지자체별로 흩어져 있는 관련 데이터를 수집하는데 많은 시간과 노력을 투여하고 있다. 만약 지자체의 경제, 사회, 문화 등 관련 지표를 통합적으로 제공하는 데이터베이스가 구축되고, 이를 다양한 기법으로 검색할 수 있는 시스템에 구축된다면, 사회과학분야 연구자들에게 많은 도움이 될 것이다. 본 연구는 지난 5년 동안 구축한 지자체 통합데이터베이스(이하 통합DB)에 대하여 소개하고, 통합DB를 활용하여 구축한 경제, 사회, 문화 지표 통합 검색 시스템에 대하여 소개하고자 한다.

• Korean Journal of Social Welfare Studies
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• v.42 no.3
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• pp.207-231
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• 2011

The purpose of this study is to investigate the effect of the intergovernment relationship on the local government's social welfare expenditure. The data of 230 local governments from 2003 to 2008 were analyzed with the PCSE(Panel Corrected Standard Errors) Model of Beck and Kats. The results were as follow. First, financial transfer from the higher governments increase the social welfare expenditure of the local governments. Second, the party structure, that is the political relationships among local, regional, and central governments, affect the social welfare expenditure of the local governments. Third, the local governments compete each other to expand the social welfare expenditure in Korea. These results suggest that the relationship of local governments with the higher ones as well as the community factors is important in Korea, where the centralization is still strong in the local autonomy system, to understand the development of social welfare.

• Journal of the Korean Society of Radiology
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• v.83 no.5
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• pp.1160-1167
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• 2022

Epipericardial fat necrosis (EPFN) is a relatively rare cause of acute chest pain, with only five pediatric cases having been reported in the English-language medical literature to date. EPFN can be diagnosed based on the clinical symptoms of acute pleuritic chest pain and classic CT features of typically ovoid fatty lesions surrounded by a rim or capsule in the mediastinal or pericardial areas. Previous studies have reported that contrast-enhanced MRI can detect typical fat signal changes in adults with EPFN. We report a pediatric EPFN case diagnosed using gadolinium-enhanced MRI. Thus, contrast-enhanced MRI may be used to confirm EPFN in the differential diagnoses of the causes of acute chest pain.

• Journal of the Korean Regional Science Association
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• v.35 no.1
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• pp.33-46
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• 2019

In the previous literature, there have been many attempts to probe the relationship between fiscal decentralization and regional balanced development. Much of the literature on this issue argued that the balanced development could be achieved by deviating power from central government to local government. However, several research has raised concerns about the relationship between the two, showing that decentralization could serve as a factor which could further exacerbate the regional imbalance. In particular, they insisted that most of the local taxes that due to the promotion of fiscal decentralization may be concentrated in the metropolitan area. The aim of this study is to verify the hypothesis that the net effect of decentralization promotion may be different depending on local governments' financial conditions. The empirical analysis of this study showed that local government could expand local taxes of about 18 trillion won if the fiscal decentralization was realized. However it was also be found that fiscal decentralization have shown the decrease in the local taxes.

• Journal of the Korean Society of Radiology
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• v.13 no.3
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• pp.465-472
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• 2019

To investigate the effects of iterative reconstruction algorithms on fat measurements using computed tomography (CT), we comparatively and quantitatively analyzed the ratios of visceral, subcutaneous, and visceral-subcutaneous fat areas as well as the variations of HU and noise of visceral and subcutaneous fat using ADMIRE strength and attempted to identify any difference between them. Experimental results showed that no statistically significant difference existed among the visceral, subcutaneous, and visceral-subcutaneous fat area ratios HU of visceral fat area and HU of subcutaneous fat area when applying ADMIRE as compared with existing conventional filtered back projection algorithms. However, as the ADMIRE strength increases, the noise of visceral and subcutaneous fat decreases by up to 12.1% and 19.2%, respectively. In conclusion, iterative reconstruction algorithms have no effect on the visceral, subcutaneous, and visceral-subcutaneous fat area ratios, which are indicators of fat measurement using CT.

• Food Science and Industry
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• v.51 no.2
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• pp.127-135
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• 2018

The action of antioxidants was different depending on the environments where antioxidants were located. Although basic mechanisms of lipid oxidation and antioxidants were related each other, their contribution on the degree of oxidation was different. In thisreview, terminology on antioxidant properties were defined such as antioxidant activity and antioxidant capacities. In addition, antioxidant mechanisms including primary and secondary antioxidants or hydrogen donating or electron transferring antioxidants were introduced. Also, the impact of physical points of view and antioxidant polar paradox were introduced. Depending on the types of food matrice including bulk oil, oil-in-water emulsion (O/W), or solid state, antioxidant actions showed different degree and this point was explained in detail.