• Speech Sciences
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• v.15 no.2
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• pp.101-110
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• 2008

The purpose of this study was to investigate the speech intelligibility of voice disordered patients when we consider the severity and utterance level as variables. Based on the severity level, 12 patients were divided into three groups, G1, G2, and G3 group, respectively. Words, phrases and sentences produced by the speakers were judged by four listeners with normal hearing, and we compared the intelligibility scores of the three groups. As a result, the speech intelligibility was decreased as the severity level was increased, and the difference was statistically significant. However, the mean difference among words, phrases and sentences was not significant, and the variation of intelligibility according to the utterance level was not under the regular rules.

• Phonetics and Speech Sciences
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• v.8 no.3
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• pp.79-90
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• 2016

The purpose of this study was to investigate the effects of stuttering severity on articulation rate measured from different types of utterances in preschool children who stutter. Participants were 40 boys who stutter (CWS) and age-matched 10 boys who do not stutter (CWNS). CWS were sub-grouped based on the severity of their stuttering: 15 mild, 13 moderate, and 12 severe. Utterances were categorized as "overall utterance" including all utterances that children spoke and "fluent utterance" which did not contain any disfluencies. Utterances containing abnormal disfluencies were categorized as "SLD utterance" for CWS. The results revealed no significant difference among groups in any type of utterance. There were significant positive correlations in articulation rates between utterance types. Stuttering severity was not a factor for characterizing the articulation rate of each type of utterance. Also, current findings suggest that articulation rate may not predict speech motor control ability in preschool CWS.

• Journal of Yeungnam Medical Science
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• v.30 no.1
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• pp.58-61
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• 2013

Enterovirus commonly causes neurologic diseases (aseptic meningitis, encephalitis, etc.), hand-foot-mouth disease, herpangina, and acute hemorrhagic conjunctivitis. However, it rarely causes pneumonia in immunocompetent adults. In Korea, no case has been reported about pneumonia caused by enterovirus in healthy adults. We can cite the case of a 20-year-old woman who presented severe community-acquired pneumonia caused by enterovirus. The diagnosis was based on reverse transcriptase polymerase chain reaction (RT-PCR) of a respiratory specimen.

• Annals of Clinical Neurophysiology
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• v.8 no.2
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• pp.203-205
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• 2006

There have been several reports about coexistence of myasthenia and other autoimmune disease. Psoriasis is a papulosquamous disease defined by erythematous plaques with a silvery scale and a T-cell-mediated autoimmune disease. We report a case of a 49-year-old man with generalized myasthenia gravis (MG) superimposed by psoriasis. MG was diagnosed by clinical symptoms, increased acetylcholine receptor antibody titer and repetitive nerve stimulation test. Psoriasis was diagnosed by clinical manifestations and specific skin biopsy findings. MG and psoriasis are both autoimmune diseases. The coexistence of MG and psoriasis suggest a close connection of pathogenesis.

• Annals of Clinical Neurophysiology
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• v.8 no.2
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• pp.182-185
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• 2006

Various immunotherapeutic modalities have been used based on the autoimmune pathogenic mechanisms of myasthenia gravis (MG). Cell-mediated immunity as well as auto-antibodies may play a role in the remission and relapse of MG. We recently experienced two patients with MG who showed spontaneous remission after inadvertent severe leukopenia. These findings suggest that the cell-mediated immune process is important in the treatment of MG, and selective suppression of leukocyte may induce remission in the patients with intractable MG.

• The Science & Technology
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• v.31 no.2 s.345
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• pp.67-71
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• 1998

1990년 9월 프렌치 엔더슨(현 남가주대학 유전자치료센터 소장)과 2명의 동료들이 미 연방정부의 승인을 받고 처음으로 유전자를 이용하여 중증 종합면역결핍증(SCID)을 앓고 있던 아샨티 데실비양을 치료한 이래 유전자치료에 대한 관심은 전세계적으로 번져 나가 현재 2천5백명 이상의 환자들이 이런 요법의 임상실험을 받고 있다. 우리나라에서도 1995년 서울대병원을 시작으로 1996년에는 중앙대병원과 삼성서울병원에서 말기 암환자를 대상으로 유전자치료 임상시험을 하고 있다. 그런데 열성적인 일부 연구자들과 업계대표들 그리고 매체들의 유전자치료의 '장미빛 미래'를 지나치게 강조한 나머지 일반인에게 유전자치료가 이미 광범위한 응용단계로 들어갈 정도로 발전한 것 같은 인상을 주고 있다. 그러나 전세계를 통틀어 유전자치료를 받거나 받고 있는 환자중에서 결정적으로 완쾌된 환자는 아직도 거의 없다는 것이 오늘의 현실이다. 유전자치료의 현황과 그 앞날을 알아본다.

• Herbal Formula Science
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• v.20 no.2
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• pp.199-211
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Gamisoyo-san on severe menopausal disorder patients. Methods : We recruited 2 severe menopausal disorder patients who have been suffering from hot flush and heat sensation. The patients had been administrated Gamisoyo-san. The patients of severe menopausal disorder had been estimated with Kupperman's index(KI), Menopause rating scale(MRS), Beck's depression Inventory(BDI), Visual analogue scale(VAS) and Heart rate variability (HRV). Kupperman's index, Menopause rating scale and Beck's depression inventory for every seven days. We measured VAS everyday. Heart rate variability was estimated twice, before and after treatment. Results : After the treatments, symptoms of menopausal disorder were decreased. Conclusions : This study suggests that Gamisoyo-san is significantly effective on severe menopausal disorder patients with hot flush and heat sensation.

• The Korean Journal of Pain
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• v.19 no.2
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• pp.285-287
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• 2006

Hundreds of drugs have been implicated as the causes of antibody-mediated thrombocytopenia. Naproxen is a commonly used nonsteroidal anti-inflammatory drug, and it is generally considered to be safe with few hematological side effects such as thrombocytopenia. In this case, severe thrombocytopenia associated with petechia and epistaxis appeared after initiation of naproxen therapy in the 59-year-old man. We report here on a case of severe thrombocytopenia that was recognized at 10 days after the use of naproxen, and the patient rapidly recovered to a normal platelet count without bleeding symptoms or any complications, although immunoglobulin or steroid was not used.

• Speech Sciences
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• v.10 no.3
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• pp.37-45
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• 2003

This study attempted to determine the effects of a context-based drawing task on the language expression of a severe Wernicke's and Broca's aphasic. The subjects in this study showed a poor auditory comprehension and naming performance. They also showed paraphasia and perseveration. This study focused on improving language expression by a drawing task based on conversation at hand. Ten target words were chosen which were easily drawnable and familiar to the subjects. The results showed that the context-based drawing task was effective on improving the subjects' confrontation naming ability and expressive language ability in terms of explanation of sentences. In addition, the Broca's aphasic showed improved naming ability when the contextual cues were given and he was supposed to spontaneously name words.

• Journal of Chest Surgery
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• v.25 no.12
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• pp.1516-1522
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• 1992

Thirty patients with myasthenis gravis[MG] underwent transternal extended thymectomy between 1983 and 1992 in Pusan National University Hospital. The age of patients was 11 to 62 years[mean; 35.2 years] with female dominant[M: F=l: 4]. According to modified Osserman classification, group I was in 6, II A in 7, II B in 13, III in 2, IV in 2 patients respectively. Their clinical response to thymectomy was evaluated. The follow-up period ranged from 2 months to 9.5 years[average; 51.3 months]. Fourteen patients[13.3%] had remission and eleven[43.3%] were improved after operation; half of patients were benefited from operation. Twenty patients had thymic hyperplasia and seven had non-infiltrating thymoma. In thymomatous MG one patient had remission and five were improved. Postoperative death was in a female patient. The cause of death was respiratory failure in the severe generalized MG preoperatively.