• Title/Summary/Keyword: 중증

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Neutrophil Apoptosis and $H_2O_2$ Release by LPS in Diabetics (내독소로 자극된 당뇨환자의 중성구에서 기획성 세포사멸과 과산화수소 분비능)

  • Seo, Ki Hyun;Na, Joo Ock;Moon, Seung Hyug;Uh, Soo Taek;Kim, Yong Hoon;Park, Choon Sik
    • Tuberculosis and Respiratory Diseases
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    • v.57 no.3
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    • pp.250-256
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    • 2004
  • Background : Bacterial infections in diabetic patients are an important cause of increased morbidity and mortality. It has been reported that bacterial infections in diabetics showed more impaired PMN functions such as reduced PMN respiratory burst and decreased microbicidal activity in inflammed tissues. Also, apoptosis(programmed cell death) is postulated to be a key mechanism for neutrophil elimination. It is very important that PMN apoptosis keeps the balance from an area of inflammation. Actuallly, as little was known about PMN apoptosis and respiratory burst in diabetes, we investigated PMN apoptosis and hydrogen peroxide production after endotoxin exposure. Methods : Peripheral venous blood samples were collected by routine venipuncture from healthy volunteers and diabetics to harvest neutrophils. We respectively measured the PMN apoptosis, the production of hydrogen peroxide, and the cell viability. Results : Normal neutrophils showed a tendency to decreased apoptosis after endotoxin treatment. In patients with diabetes, PMN apoptosis was significantly decreased compared with healthy controls. In addition, the LPS-induced neutrophils in diabetics demonstrated more decreased apoptosis. However, the production of hydrogen peroxide was not different between groups. Conclusion : These observations suggest that the decreased PMN apoptosis in diabetics with endotoxin exposure may also affect the increased susceptibility and severity of infections.

Correlation of Nitric Oxide and Corticosteroids Along the Course of Sepsis (패혈증의 경과에 따른 혈중 스테로이드와 Nitric Oxide의 연관성)

  • Lee, Keu Sung;Kim, Young Sun;Lee, Hyoung No;Park, Joo Hun;Oh, Yoon Jung;Sheen, Seung Soo;Choi, Young Hwa;Park, Kwang Joo;Hwang, Sung Chul
    • Tuberculosis and Respiratory Diseases
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    • v.62 no.4
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    • pp.308-313
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    • 2007
  • Background: The nitric oxide (NO) released by inducible NO synthase (iNOS) plays an important role in the pathophysiology of sepsis. Corticosteroids also play a role in the hemodynamic and inflammatory reactions in sepsis. Both have been shown to have a relationship theoretically, but their correlation and clinical impacts have rarely been evaluated. Methods: 26 patients with sepsis and 14 healthy controls were enrolled in this study. The initial random plasma total NO and the serum cortisol levels were measured. The same measurements were serially carried out on the $3^{rd}$, $5^{th}$, and $7^{th}$ days. Results: The initial total plasma levels of NO and cortisol were higher in the patients with sepsis than in the healthy controls. The total NO levels were higher in patients with severe sepsis than in the those with mild sepsis. There was a correlation between the total NO and cortisol level throughout the study. Conclusion: In patients with sepsis, the levels of plasma NO and cortisol were well correlated during the first week of sepsis, which suggests an interrelationship. However, the clinical and pathogenetic implications await further evaluation.

Assessment of Indoor Air Quality and the Eye Symptom of Occupants in Newly-built Office Building after Planting Indoor Plants (신축사무실 내 식물 적용 후 재실자 안구 증상 및 실내공기질 평가)

  • Kim, Hyojin;Kim, Ho-Hyun
    • Journal of Korean Ophthalmic Optics Society
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    • v.21 no.3
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    • pp.265-274
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    • 2016
  • Purpose: The aim of this study was to evaluate relationship between worker's ophthalmoxerosis symptom and IAQ (Indoor Air Quality) variation after planting indoor plants at newly-built office building. Methods: We selected a new office building located in Sejong-si and occupants who work in the Office for study. The indoor air pollutant was investigated according to applying indoor plants. The indoor air quality of the new building was evaluated by measuring volatile organic compounds (VOCs), aldehydes, temperature and humidity. The level of dry eye symptoms was classified into normal, mild, moderate and severe by using the Ocular Surface Disease Index (OSDI). Results: There was VOCs' reduction effect according to placing indoor plants because the concentration of VOCs in newly-built government office (Sejong-si) was highly decreased when the indoor plants was placed at the office. The occupants' SBS (Sick Building Syndrome) symptoms score was gradually decreased in accordance with applying indoor plants. However, SBS symptoms score was increased when the office was not applied indoor plants. There was not statistical significance in workers' dry eye questionnaire results. Conclusions: There was reduction effect of indoor air pollutant in applied indoor plants office. Also, in case of questionnaire results of ophthalmoxerosis and SBS (Sick Building Syndrome) symptoms score were showed positive effect. This study is needed longer-term study because of complements of difference of individual sensitivity and there are some limitations due to field survey research.

Rotavirus-associated neonatal necrotizing enterocolitis (로타바이러스 감염이 관련된 신생아 괴사성 장염)

  • Seo, Hyun Joo;Jung, Yu Jin;Park, Soo Kyung;Choi, Seo Hui;Lee, Ji Hyuk;Kim, Myo Jing;Chang, Yun Sil;Park, Won Soon
    • Clinical and Experimental Pediatrics
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    • v.52 no.1
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    • pp.56-60
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    • 2009
  • Purpose : This study aimed to test whether rotavirus-associated necrotizing enterocolitis (RV+NEC) produced different clinical findings or outcomes from those of non-rotavirus necrotizing enterocolitis (RV-NEC). Methods : Eight patients from the RV+NEC group and 22 patients from the RV-NEC group diagnosed with modified Bell stage II or higher NEC were selected for this study. Fecal specimens from all infants were tested for rotavirus infection using a monoclonal antibody-based enzyme immunoassay (EIA). Clinical, radiographic, and clinical outcome data were analyzed retrospectively. Results : RV+NEC infants had a significantly higher birth weight and were born at a significantly higher gestational age ($33.5{\pm}3.3$ weeks vs. $29.3{\pm}4.4$ weeks; P=0.01). There were no differences in the occurrence of thrombocytopenia, mural gas, and pneumoperitoneum between the 2 groups. However, portal vein gas was more common in the RV+NEC group (88% vs. 9%; P<0.01). Neither the incidence of Bell stage III (or higher) NEC nor surgical intervention differed between the two groups. The number of complications and mortality rates were also similar. Conclusion : Rotavirus-associated NEC occurs in infants with a higher birth weight and those born at a greater gestational age. However, the severity of the condition and the resulting outcomes did not differ from those for infants affected by non-rotavirus NEC.

Development of IoT-based real-time Toxic Chemical management System (IoT 기반의 실시간 유해 화학물 관리 시스템 개발)

  • Kang, Min-Soo;Ihm, Chunhwa;Jung, Yong-Gyu;Lee, Minho
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.16 no.5
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    • pp.143-149
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    • 2016
  • Recent accidents caused by toxic chemicals and the social problems caused by frequent. As of 2010, there are more than 100,000 types of deadly toxic chemicals being distributed throughout Korea, and severely intoxicated patients along with an enormous number of patients can be induced at the time of an accident involving deadly toxic chemicals. Internationally, the seriousness of large-scale disasters due to a NBC disaster (nuclear, biologic and chemical disaster) is being highlighted as well. So, we obtain the information of the RFID tag attached to a glass bottle with containing the toxic chemical to transfer the data to the smart device has been studied a system that can monitor the status of the toxic chemical in real time. The proposed system is the information was sent to the main system using a zigbee communication by recognizing the tag vial containing the toxic chemical with the 13.56MHz bandwidths good permeability. User may check the information in real time by utilizing the smart device. However, the error of the system for managing the toxic chemical generates a result that can not be predicted. Failure of the system was detecting the error by using a comparator as this can cause an error. And the detected error proposed a duplex system so that they do not affect the overall system.

Varietal Difference in Changing Aspect of Daily Sink Filling During the Grain Filling Period in the Rice Plants (수도증열기간중 Sink충전의 경시적 변화와 그 품종간 차이)

  • 최해춘
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.31 no.1
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    • pp.43-48
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    • 1986
  • The experiment was conducted to know the varietal difference in changing aspect of daily filling sink during of rice using three cultivars; ‘Suweon 295’ (japonica), ‘Suwoen 264’ and ‘IR 1317-70-1’ (semi-dwarf indica) cultivated in the field and green house of the Crop Experiment Station in 1983. There was not significant varietal difference in flowering habit and duration of flowering period each panicle. Semi-dwarf indica cultivars showed shorter days to physiological maturity of rice kernel than the japonica one. The former also displayed earlier decrease in water content of rice grain during ripening than the latter. Japonica variety revealed larger difference in ripening advancement between vigorous florets and inferior one than semi-dwarf indica varieties. The semi-dwarf indica rice cultivars expressed significantly shrewder parabola of daily filling of sink per panicle during ripening than the japonica one. The time showing maximum capacity of daily filling of sink per panicle during ripening was 10-12 days after anthesis. The filling capacity of daily sink filling per panicle for 'IR 1317-70-1', 'Suweon 264' and 'Suweon 265' at this time were about 240 mg, 165 mg and 145 mg, respectively. Pattern of sink filling per panicle during ripening was slightly changed by the cultural environment. ‘Suweon 295’ showed slightly sharper parabola and 2-3 days earlier time showing maximum capcity of daily sink demand per panicle during ripening in the field than those in the green house.

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Heart Rate Variability in Patients with Coronary Artery Disease (관상동맥질환 환자의 심박동변이도)

  • Kim Wuon-Shik;Bae Jang-Ho;Choi Hyoung-Min;Lee Sang-Tae
    • Science of Emotion and Sensibility
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    • v.8 no.2
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    • pp.95-101
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    • 2005
  • This study is based on previous information regarding reduced cardiac vagal activity in patients with coronary artery disease(CAD), on reduced variance(SDNN : standard deviation of all normal RR intervals), low-frequency power(LF), and the complexity of heart rate variability(HRV) in patients with chronic heart failure(CHF), and on the normalized high-frequency power of HRV is the highest in the right lateral decubitus position among 3 recumbent postures in patients with CAD, However, nothing is known about the nonlinear dynamics of HRV for the 3 recumbent postures in patients with CAD. To investigate the linear and non-linear characteristics of HRV in patients with CAD, 29 patients as CAD group and 23 patients as control group were studied. Electrocardiogram(ECG) with lead II channel was measured on these patients for 3 recumbent postures in random order. The HRV from ECG was analyzed with linear method(for time and frequency domains) and nonlinear method. The lower the high-frequency power in normalized unit(nHF) in the supine or left lateral decubitous position, the higher the increase in nHF when the position was changed from supine or left lateral decubitous to right lateral decubitous. Among the 3 recumbent postures in patients with severe CAD, the right lateral decubitus position was observed to induce the highest vagal modulation, the lowest sympathetic modulation, and the highest complexity of human physiology system.

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Mental Status Change of Patients Receiving Radiation Therapy (방사선치료 시 환자의 심리적 상태의 변화 양상)

  • Yang, Eun-Ju;Lee, Seung-chul;Kim, Young-Jae
    • Journal of the Korean Society of Radiology
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    • v.11 no.2
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    • pp.123-130
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    • 2017
  • Patients diagnosed with the serious disease of cancer may have anxiety and fear of closed spaces while receiving radiation therapy. This study investigated patients receiving treatment based on Linac and Tomotherapy to look into this anxiety and fear. Study method was survey. The survey was performed according to treatment duration (treatment within 5 minutes, 10 minutes, over 20 minutes, and over 30 minutes). The patients were also surveyed about any experience of changing treatment rooms or machines due to machine failure. A total of 200 survey questionnaires with full answers were researched in this study. As a result, it was found that the less the patients' experience on radiation therapy, the higher their anxiety was. The dominating reason for this result was because the patients expected possible pain during the treatment process. In terms of treatment machine, Linac showed the highest anxiety of all for the openness of its patient stand. The most stable status was found in the case of treatment between 20 minutes and 30 minutes using Tomotherapy. The reason was the coziness of Tomotherapy machine. In the case of receiving the treatment for over 30 minutes, patients felt anxious for the isolation from the outside. The study findings are expected to serve as the necessary data for quality medical service with enhanced patient satisfaction in the clinical field.

A Case of Epidural Abscess Complicated from Acute Mastoiditis Caused by Streptococcus pneumoniae (폐렴구균에 의한 급성 유양돌기염에서 합병된 경막외농양 1례)

  • Choi, Jee-Hyun;Kim, Min-Sung;Kim, Jong-Hyun;Son, Byung-Chul;Kim, Seong Joon;Park, So Hyun;Lee, Jung Hyun;Oh, Jin Hee;Koh, Dae Kyun
    • Pediatric Infection and Vaccine
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    • v.21 no.2
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    • pp.144-149
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    • 2014
  • Acute otitis media (AOM) is one of the most common childhood infectious diseases. Despite antibiotic treatment for AOM, AOM and its complication still continue to develop. Acute mastoiditis is a serious complication of AOM and epidural abscess constitutes the commonest of all intracranial complication of AOM. Neurological complication of acute mastoiditis are rare but can be life threatening. Their presentation may be masked by the use of antibiotics. We report the rare case of acute otitis media progressing to acute mastoiditis, epidural abscess formation and lateral sinus thrombophlebitis caused by Streptococcus pneumoniae in a child. She was admitted with acute otitis media with fever. Despite proper antibiotics, acute mastodititis and epidural abscess were developed, and after surgical drainage and antibiotics therapy she was recovered without sequalae.

Hindlimb Lameness Secondary to Bilateral Femoral Artery Occlusion in a Dog with Systemic Arterial Dirofilariasis (전신성 동맥 사상충증에 이환된 개의 양측성 대퇴동맥의 폐쇄)

  • Choi, Woo-Shin;Song, Jin-Young;Lee, Young-Jae;Lee, Dong-Hoon;Kim, Ju-Hyung;Chang, Jin-Hwa;Kang, Ji-Houn;Chang, Dong-Woo
    • Journal of Veterinary Clinics
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    • v.29 no.4
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    • pp.334-338
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    • 2012
  • A 3-year-old, intact male Pungsan dog was presented for a 2-week history of a non-weight-bearing lameness of left hindlimb with anorexia. The dog had no history of trauma, and never been routinely vaccinated or treated with heartworm preventatives. The complete blood count showed severe leukocytosis and neutrophilia with left shift. Serum biochemistry showed hypoalbuminemia, azotemia, and increased hepatobilliary enzyme activity. A canine heartworm antigen test was positive. Thoracic radiographs were consistent with heartworm disease as evidences by main pulmonary artery enlargement, right-sided cardiomegaly, and interstitial lung pattern. Echocardiography revealed pulmonary valvular regurgitation and pulmonary hypertension. Selective femoral arterial angiogram was performed, and bilateral femoral arterial occlusion was identified. The dog died after angiogram, and necropsy was performed. At necropsy, adult heartworm and a large blood clot were found within the lumen of left and right femoral artery. This case report describes an unusual migration of heartworm to femoral artery that caused hindlimb lameness.