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http://dx.doi.org/10.3345/kjp.2009.52.1.56

Rotavirus-associated neonatal necrotizing enterocolitis  

Seo, Hyun Joo (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Jung, Yu Jin (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Park, Soo Kyung (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Choi, Seo Hui (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Lee, Ji Hyuk (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Myo Jing (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Chang, Yun Sil (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Park, Won Soon (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.1, 2009 , pp. 56-60 More about this Journal
Abstract
Purpose : This study aimed to test whether rotavirus-associated necrotizing enterocolitis (RV+NEC) produced different clinical findings or outcomes from those of non-rotavirus necrotizing enterocolitis (RV-NEC). Methods : Eight patients from the RV+NEC group and 22 patients from the RV-NEC group diagnosed with modified Bell stage II or higher NEC were selected for this study. Fecal specimens from all infants were tested for rotavirus infection using a monoclonal antibody-based enzyme immunoassay (EIA). Clinical, radiographic, and clinical outcome data were analyzed retrospectively. Results : RV+NEC infants had a significantly higher birth weight and were born at a significantly higher gestational age ($33.5{\pm}3.3$ weeks vs. $29.3{\pm}4.4$ weeks; P=0.01). There were no differences in the occurrence of thrombocytopenia, mural gas, and pneumoperitoneum between the 2 groups. However, portal vein gas was more common in the RV+NEC group (88% vs. 9%; P<0.01). Neither the incidence of Bell stage III (or higher) NEC nor surgical intervention differed between the two groups. The number of complications and mortality rates were also similar. Conclusion : Rotavirus-associated NEC occurs in infants with a higher birth weight and those born at a greater gestational age. However, the severity of the condition and the resulting outcomes did not differ from those for infants affected by non-rotavirus NEC.
Keywords
Rotavirus infections; Enterocolitis; Necrotizing; Newborn;
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