• Feed Journal
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• v.2 no.9
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• pp.100-103
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• 2004

젖소의 우유내 지방은 95~98% 정도가 중성지방으로 구성되어 있고, 나머지는 인지질, 콜레스테롤, 유리 지방산 등으로 구성되어 있다. 중성지방을 구성하고 있는 지방산들은 결합된 탄소의 수에 따라서 단쇄 지방산, 중쇄 지방산, 그리고 장쇄 지방산으로 구분된다. (중략)

• Journal of Animal Science and Technology
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• v.50 no.3
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• pp.293-300
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• 2008

Muscle fat content including intramuscular fat content(IMF) is the most important parameter in meat quality of cattle. Triacylglycerol is the major component of fat and is found in adipocyte and skeletal muscle. In present study, we carried out the determined of triacylglycerol contents and mRNA expression patterns of genes related with triacylglycerol biosynthesis such as ACSS2, GPAT, MGAT and DGAT in Hanwoo longissimus muscle using the real-time PCR. The triacylglycerol contents were continuously increased during the fattening stages. Interestingly, the contents of triacylglycerol were 7.4 fold higher(0.34 vs. 2.51, P<0.01) in 27 months old group than 12 months old group. The mRNA levels of ACSS2, GPAT and DGAT genes were also increased during fattening stages, whereas that of MGAT gene did not show difference among the stages. Thus, these results suggested that increasing of the triacylglycerol contents in longissimus muscle during fattening stages may be related with increased expressions of triacylglycerol biosynthesis genes(ACSS2, GPAT and DGAT). These results will be helpful to understand the mechanism of muscle fat deposition in skeletal muscle.

• Journal of the Korean Data and Information Science Society
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• v.22 no.3
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• pp.413-421
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• 2011

The present study was carried out to summarize the effect of garlic in the hyperlipidemia rats by meta-analysis related studies. The association measure to test effect of garlic was the mean difference (MD). In this particular fixed-effect model of mean difference, body weight, liver weight, kidney weight and heart weight were significantly decreased (p < 0.05). Also, blood glucose, plasma total cholesterol, plasma triglycerides, LDL-cholesterol, liver cholesterol, liver triglycerides were significantly decreased. HDL-cholesterol was significantly increased. In this case of heterogeneous variable, random effect model was applied. In this model, liver weight, blood glucose, plasma total cholesterol, plasma triglycerides, LDL-cholesterol, liver cholesterol, liver triglycerides were significantly decreased. HDL-cholesterol was significantly increased. According to the meta-regression analysis, duration of injection was significantly for kidney weight, testis weight, plasma total cholesterol, plasma triglycerides, HDL-cholesterol, LDLcholesterol, liver cholesterol, liver triglycerides.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.2
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• pp.158-164
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• 2021

Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis. We previously reported that TG-induced cell death of macrophages is mediated via pannexin-1 activation, which increases the extracellular ATP and subsequent increase in potassium efflux, thereby activating the caspase-2/caspase-1/apoptotic caspases, including the caspase-8 pathway. Contrarily, some studies have reported that caspase-8 is an upstream molecule of caspase-1 and caspase-2 in several cellular processes. Therefore, this study was undertaken to investigate whether caspase-8 influences its upstream molecules in TG-stimulated macrophage cell death. We first confirmed that caspase-8 induces caspase-3 activation and poly ADP-ribose polymerase (PARP) cleavage in TG-treated macrophages. Next, we determined that the inhibition of caspase-8 results in reduced caspase-1 and -2 activity, which are upstream molecules of caspase-8 in TG-induced cell death of macrophages. We also found that ATP treatment restores the caspase-8 inhibitor-induced caspase-2 activity, thereby implying that caspase-8 affects the upstream molecules responsible for increasing the extracellular ATP levels in TG-induced macrophage cell death. Taken together, these findings indicate that caspase-8 potentiates the TG-induced macrophage cell death by activating its upstream molecules.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.3
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• pp.245-252
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• 2020

Macrophage cell death contributes to the formation of plaque, leading to the development of atherosclerosis. The accumulation of triglyceride (TG) is also associated with the pathogenesis of atherosclerosis. A previous study reported that TG induces the cell death of macrophages. This study examined whether the cytoplasmic release of cathepsin B from lysosome is associated with the TG-induced cell death of macrophage. The release of cathepsin B was increased in the TG-treated THP-1 macrophages, but the TG treatment did not affect cathepsin B expression. Furthermore, the inhibition of cathepsin B by its inhibitor, CA-074 Me, partially inhibited the TG-induced cell death of macrophage. TG-triggered macrophage cell death is mediated by the activation of caspase-1, -2, and apoptotic caspases. Therefore, this study investigated whether cathepsin B is implicated in the activation of these caspases. The inhibition of cathepsin B blocked the activation of caspase-7, -8, and -1 but did not affect the activity of caspase-3, -9, and -2. Overall, these results suggest that TG-induced cytoplasmic cathepsin B causes THP-1 macrophage cell death by activating caspase-1, leading to subsequent activation of the extrinsic apoptotic pathway.

• Korean Journal of Clinical Pharmacy
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• v.22 no.3
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• pp.195-201
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• 2012

목적: 이상지방혈증 환자의 치료는 우선적으로 저밀도지단백을 감소시키고, 저밀도지단백이 목표수치에 도달한 이후에도 혈중 중성지방이 높을 경우 nicotinic acid 또는 fibrate를 사용하도록 권장되고 있다. 본 연구는 이상지방혈증이 있는 환자에서 acipimox의 효과를 fenofibrate와 비교하여 분석하고자 시행되었다. 방법: 본 연구는 서울에 있는 한 3차 대학병원의 환자를 대상으로 후향적으로 의무기록을 분석하여 시행되었다. 혈중 중성지방 농도가 200 mg/dL 이상으로써 acipimox 또는 fenofibrate를 신규처방 받은 환자를 대상으로 각각의 약물이 지단백에 미치는 영향을 36주간 추적하여 비교분석 하였다. 결과: Acipimox를 투여 받은 환자 41명, fenofibrate를 투여 받은 환자 62명이 모집되었으며, 각각의 약물을 복용한 환자군의 기본적인 인구학적인 특성은 유의하게 상이하지 않았다. 3개월 간의 약물투여 후 두 약물군 환자 모두에서 총콜레스테롤(p < 0.05) 및 저밀도지단백(p < 0.001)이 약물투여 전과 비교하였을 때 유의하게 감소하였고, 고밀도지단백은 모든 환자에서 유의하게 증가하였다(p < 0.05). 한편 중성지방 감소율은 acipimox군이 fenofibrate군에서보다 더 크게 나타났다(p < 0.05). 약물유해반응의 빈도는 두 약물군 간에 유의한 차이가 없었다. 결론: 총콜레스테롤, 저밀도지단백 콜레스테롤 등을 감소시키거나 고밀도지단백 콜레스테롤을 증가시키는 효과는 acipimox와 fenofibrate가 유의하게 다르지 않았으며, 중성지방을 감소시키는 효과는 acipimox가 fenofibrate보다 우월하였다.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 2003.10a
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• pp.225.2-226
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• 2003

본 연구에서는 현미로부터 tocoles 획분을 분리하여 고콜레스테롤 식이를 섭취한 흰쥐의 체내 지질대사에 미치는 영향을 조사하였다. 실험동물은 SD계 숫컷 5주령을 구입하여 정상군, 대조군 (1% cholesterol), rice oil 첨가군, tocoles 첨가군의 4군으로 나누어 AIN-76 diet 조성에 의거하여 식이를 조제하여 4주 동안 섭취시켰다. 실험기간이 끝난 후 복부 대동맥으로부터 채혈하고 각 조직을 적출하여 간, 신장, 비장 및 부고환지방 조직의 무게를 측정하였다. 또한 혈청 lipid profile과 TBARS 함량 및 ALT, AST 및 ALP 활성을 분석하였고 간장중 중성지방, 콜레스테롤 및 TBARS 함량과 G6PDH 및 malic enzyme을 분석하였다. 그 결과 간장 및 부고환지방의 무게가 대조군에서 유의적으로 증가하였으나, tocoles 첨가군은 정상군의 수준으로 감소하였다. 혈청 내의 중성지방과 총 콜레스테롤은 실험군 간에 유의적인 차이는 나타내지 않았으나 감소하는 경향을 보였다. 간장 조직 내 지질함량은 대조군에서 높게 나타났으며, tocoles 군에서 중성지방과 콜레스테롤 및 총 지방의 함량이 유의하게 감소하였다. 지질 과산화물 함량은 혈청과 간장 조직 모두 유의적으로 감소하였다.

• The Monthly Diabetes
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• s.257
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• pp.38-39
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• 2011

호주 연구진이 산맥을 따라 걷기 운동을 연구한 결과, 아래 경사를 따라 결으면 혈당 수치가 감소하고, 위 경사를 따라 결으면 콜레스테롤의 주요 성분인 중성 지방의 수치가 감소한다는 사실을 밝혔다. 또, 아래 경사를 따라 운동을 하면 당뇨의 발현 가능성도 감소할 수 있다고 한다. 당뇨병환자에게는 혈당관리가 당뇨병관리의 기본이다. 또한, 고혈압에 걸릴 확률이 일반인의 2~3배 더 높으며 심장질환이나 혈관계통질환은 당뇨병환자 증세를 나쁘게 만들므로 중성지방의 수치도 중요하다. 올봄 위, 이래 경사를 걷는 등산으로 혈당과 중성 지방 수치, 두 마리 토끼를 잡기 위한 당뇨인의 등산법을 알아보자.

• The Journal of the Korea Contents Association
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• v.14 no.5
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• pp.235-243
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• 2014

The purposes of this study were to observe the effects of the exercise programs which have different order of walking and resistance exercises on the composition of the abdominal fat and the blood lipid profiles of the obese college women and to provide basic materials for the development of more effective and more efficient exercise program in order to reduce and prevent obesity. Classification of group, "A" group(resistance exercise after aerobic exercise) is a group of 12 people, "B" group(resistance exercise after aerobic exercise) is a group of 12 people. To determine the abdominal fat, intestine fat area, subcutaneous fat area, ratio of intestine fat area/subcutaneous fat area were analyzed, while for the blood lipid profiles, total cholesterol, triglyceride, high density lipid protein, and low density lipid protein were analyzed. First, there was statistically significant difference in the interaction in the abdomen subcutaneous fat. In the post analysis, the Resistance first group showed significantly more reduction to confirm that there was difference according to the order of the exercises. Second, there was statistically significant difference in the interaction effects in the factor of triglyceride. In the post analysis, the Resistance first group only showed significant reduction in the triglyceride to confirm that resistance exercise followed by aerobics would be better for the reduction of the triglyceride.

• Journal of the Korean Society of Food Science and Nutrition
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• v.15 no.1
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• pp.82-89
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• 1986

This study was designed to observe the effects of dietary P/S ratio on lipid component in plasma and tissues. Changes in plasma total cholesterol and triglyceride concentration and also cholesterol and triglyceride concentrations in liver, small intestine and aorta were determined in adult rats fed experimental diets providing different dietary P/S ratios as 0.05, 0.5, 1.0, 2.0, 3.0, and 4.0, respectively. The results obtained were summarized as follows; 1. Feed efficiency ratio was not significantly different among six groups at 2nd week. But at 4th week, the higher the dietary P/S ratio the higher the feed efficiency ratio. 2. Plasma cholesterol level was getting higher as increased dietary P/S ratio at 2nd week, But that was significantly decreased as P/S ratio increased at 4th week. 3. Plasma triglyceride level was significantly decreased as increased dietary P/S ratio at 4th week. 4. Cholesterol concentrations in liver and small intestines were getting higher as increased dietary P/S ratio at 4th week, But aortas cholesterol concentration was not influenced by P/S ratio. 5. Triglyceride concentrations in liver and small intestines were significantly increased as increased dietary P/S ratio. On the contrary, triglyceride concentration in aortas was not influenced by P/S ratio.