• Tuberculosis and Respiratory Diseases
• /
• v.44 no.4
• /
• pp.871-888
• /
• 1997

Background : It is now thought that the earliest manifestation of idiopathic pulmonary fibrosis is alveolitis, that is, an accumulation of inflammatory and immune effector cells within alveolar walls and spaces. Inflammatory cells including alveolar macrophages and resident normal pulmonary tissue cells participate through the release of many variable mediators such as inflammatory growth factors and cytokines, which contribute to tissue damage and finally cause chronic pulmonary inflammation and fibrosis. This study was performed to investigate the source and distribution pattern of transforming growth factor-${\beta}_1$(TGF-${\beta}_1$), platelet derived growth factor(PDGF), basic fibroblast growth factor(bFGF), interleukin 1(IL-1), interleukin 6(IL-6), tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and the role of these mediators on bleomycin(BLM)-induced pulmonary injury and fibrosis in rats. Method : Wistar rats were divided into three groups(control group, BLM treated group, BLM and vitamine E treated group). Animals were sacrificed periodically at 1, 2, 3, 4, 5, 7, 14, 21, 28 days after saline or BLM administration. The effects were compared to the results of bronchoalveolar lavage fluid analysis, light microscopic findings, immunohistochemical stains for six different mediators(TGF-${\beta}_1$, PDGF, bFGF, IL-1, IL-6 and TNF-$\alpha$) and mRNA in situ hybridization for TGF-${\beta}_1$. Results : IL-1 and IL-6 are maximally expressed at postbleomycin 1~7th day which are mainly produced by neutrophils and bronchiolar epithelium. It is thought that they induce recruitment of inflammatory cells at the injury site. The expression of IL-1 and IL-6 at the bronchiolar epithelium within 7th day is an indirect evidence of contribution of bronchiolar epithelial cells to promote and maintain the inflammatory and immune responses adjacent to the airways. TNF-$\alpha$ is mainly produced by neutrophils and bronchiolar epithelial cells during 1~5th day, alveolar macrophages during 7~28th day. At the earlier period, TNF-$\alpha$ causes recruitment of inflammatory cells at the injury site and later stimulates pulmonary fibrosis. The main secreting cells of TGF-${\beta}_1$ are alveolar macrophages and bronchiolar epithelium and the target is pulmonary fibroblasts and extracellular matrix. TGF-${\beta}_1$ and PDGF stimulate proliferation of pulmonary fibroblasts and TGF-${\beta}_1$ and bFGF incite the fibroblasts to produce extracellular matrix. The vitamine E and BLM treated group shows few positive cells(p<0.05). Conclusion : After endothelial and epithelial injury, the neutrophils and bronchiolar epithelium secrete IL-1, IL-6, TNF-$\alpha$ which induce infiltration of many neutrophils. It is thought that variable enzymes and $O_2$ radicals released by these neutrophils cause destruction of normal lung architecture and progression of pulmonary fibrosis. At the 7~28th day, TGF-${\beta}_1$, PDGF, bFGF, TNF-$\alpha$ secreted by alveolar macrophages sting pulmonary fibroblasts into proliferating with increased production of extracellular matrix and finally, they make progression of pulmonary fibrosis. TNF-$\alpha$ compares quite important with TGF-${\beta}_1$ to cause pulmonary fibrosis. Vitamine E seems to decrease the extent of BLM induced pulmonary fibrosis.

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.11 no.3
• /
• pp.63-70
• /
• 1997

The objective of this study was to investigate the color preference and the recognition of color names among college students. The study revealed the following: 1) The most favorite colors included blue, purple, white and green in that order; and the least favorite colors included achromatic colors, ocher and red in that order. 2) Brown was the favorite color in furniture while red was the disliked color; In colthing, white was preferred while red was disliked; Red was appropriate for accent colors, and bright colors were for product packages. 3) In regards with seasonal image, yellow, blue, brown and white were associated with spring, summer, fall and winter, respectively; Blue represented self-image most. 4) Black, grey, red and green in that order showed the higest recognitions in color names while indigo, crimson, deep carmine and havy blue showed the lowesR ; Color name recognitions showed the order of achomatic, neutial, warm and cool colors.

• Korean Journal of Food Science and Technology
• /
• v.23 no.4
• /
• pp.400-404
• /
• 1991

Protease was purified from Aspergillus niger propagated on katsuobushi. The optimal pH and temperature of the enzyme were 7.2 and $45^{\circ}C$, respectively. The enzyme was stable at $pH\;5{\sim}8$ and at below $40^{\circ}C$. Enzyme activity was promoted by $K^{-}\;and\;Fe^{2+}$, whereas it was inhibited by $Hg^{2},\;Zn^{2},\;Mn^{2}\;and\;Cd^{2}$. The acidic, basic and neutral amino acid compositions were found to be 22.63, 13.57 and 63.80%, respectively. The content of nonpolar, poler and sulfur-containing amino acids were 39.72, 20.03 and 9.53% respectively, and aspartic and glutamic acids were abundant. The molecular weight was 42,000 and isoelectric point was estimated pH 5.6.

• Journal of Astronomy and Space Sciences
• /
• v.2 no.1
• /
• pp.19-33
• /
• 1985

The singularities of differential Newtonian equation of motion in three body problem cause the loss of accuracy and the considerable increase of the computer time. These singularities could be eliminated during the process of regularization to transform the independent variables and the coordinate of Newtonian equations of motion. In this study, we calculated the positions and velocities of three body along the time scale to find out the unique solution of regularized Newtonian equations of motion with the $5^{th}$ order Runge-Kutta method by assuming the suitable initial velocities and positions. As the results of these calculations it is shown that the tripe stellar system eventually distintegrated, two of them formed a binary, and the last one escaped from this system with a hyperbolic orbit. This may suggest one possible explanation for the binary formation.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.9 no.2
• /
• pp.422-427
• /
• 2005

In this paper, Doherty amplifier is designed by the need of improving the linearity and efficiency of wireless network and repeater for WCDMA. It is designed to maintain the high linearity and efficiency at the low efficiency period of the power amplifier after analyzing Doherty technique using the active load-pull in condition of the high efficiency power amplifier implementation according to the variation of input power. CW 1-tone experimental results at the WCDMA frequency 2.11$\~$2.17 CHz shows that Doherty amplifier, which achieves pore. add efficiency(PAE) 50$\%$ at 6dB back off the point from maximum output power 52.3dBm, obtains higher efficiency of 13.3$\%$ than class AB. finding optimum bias point after adjusted gate voltage, Doherty amplifier shows that IMD3 improves 4dB.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.5 no.1
• /
• pp.166-172
• /
• 2001

A RF wideband receiver for INMARSAT-B satellite communications system was composed of low noise amplifier and high gain amplifier, The low noise amplifier used to the resistive decoupling circuit for input impedance matching and self-bias circuits for low noise. The high gain amplifier consists of matched amplifier type to improve receiver gain. The active bias circuit can be used to provide temperature stability without requiring the large voltage drop or relatively high-dissipated power needed with a bias stabilization resistor. The bandpass filter was used to reduce a spurious level. As a result, the characteristics of the receiver implemented here show more than 60 dB in gain and less than 1.8:1 in input and output voltage standing wave ratio(VSWR), especially the carrier to noise ratio which is input signal level -126.7 dB m at 1537.5 MHz is a 45.23 dB /Hz at a 1.02 kHz.

• The Korean Journal of Food And Nutrition
• /
• v.23 no.1
• /
• pp.63-69
• /
• 2010

With the increase of the use of antibiotics and invasive procedures, infections caused by multidrug-resistant Acinetobacter baumannii(MRAB) are increasing. We screened the antibiotic producing strain B-51 for antibacterial activity against MRAB from the soils and studied the effects of culture medium on the antibiotic production of B-51. The medium conditions for maximum antibiotic productivity of B-51 was 2% glycerol, 0.5% soybean meal, 0.01% $CaCl_2$, 0.01% $MgSO_4{\cdot}7H_2O$ and 0.01% $KH_2PO_4$ at an initial pH of 6.0, at $30^{\circ}C$ for 76 h.

• The Journal of the Acoustical Society of Korea
• /
• v.11 no.3
• /
• pp.5-13
• /
• 1992

Taking devantage of the property that Korean digit is a mono-syllable word, we proposed a spoken Korean-digit recognition scheme using the multi-layer perceptron. The spoken Korean-digit is divided into three segments (initial sound, medial vowel, and final consonant) based on the voice starting / ending points and a peak point in the middle of vowel sound. The feature vectors such as cepstrum, reflection coefficients, ${\Delta}$cepstrum and ${\Delta}$energy are extracted from each segment. It has been shown that cepstrum, as an input vector to the neural network, gives higher recognition rate than reflection coefficients. Regression coefficients of cepstrum did not affect as much as we expected on the recognition rate. That is because, it is believed, we extracted features from the selected stationary segments of the input speech signal. With 150 ceptral coefficients obtained from each spoken digit, we achieved correct recognition rate of 97.8%.

• KIEAE Journal
• /
• v.16 no.5
• /
• pp.29-37
• /
• 2016

Purpose: Indoor thermal comfort can be identified by combination of temperature, humidity, and air flow, etc. However, most thermal indexes in regard to thermal comfort are temperature dominant since it has been considered as a significant factor affecting to indoor thermal comfort The purposes of this study are to investigate indoor neutral temperature range of young Koreans with humidity perception, and to introduce a neutral temperature for temperature preference as well as temperature sensation in order to define the neutral temperature range chosen by occupants. It could be used as basic data for heating and cooling. Method: 26 research participants volunteered in 7 thermal conditions ($18^{\circ}C$ RH 30%, $18^{\circ}C$ RH 60%, $24^{\circ}C$ RH 30%, $24^{\circ}C$ RH 40%, $24^{\circ}C$ RH 60%, $30^{\circ}C$ RH 30%, $30^{\circ}C$ RH 60%) and completed subjective assessment in regard to temperature/humidity sensation and preference twice per condition in an indoor environmental chamber. Result: In RH 30%, sensation neutral temperature was $25.1^{\circ}C$ for men and $27.0^{\circ}C$ for women, and preference neutral temperature was $25.5^{\circ}C$ for men and $27.8^{\circ}C$ for women. In RH 60%, sensation neutral temperature was $23.6^{\circ}C$ for men and $25.9^{\circ}C$ for women, and preference neutral temperature was $23.4^{\circ}C$ for men and $26.3^{\circ}C$ for women. Neutral temperature increased with increasing relative humidity. Women were sensitive to humidity changes. Men expressed humidity changes as temperature variations. In most conditions, preference neutral temperatures were higher than sensation neutral temperatures, however, the preference neutral temperature for men in humid condition was lower than the sensation neutral temperature.

• Applied Chemistry for Engineering
• /
• v.18 no.4
• /
• pp.391-395
• /
• 2007

This study investigated the feasibility of enhanced electrokinetic (EK) remediation of soil contaminated with approximately 20000 Pb-mg/kg. Enhanced EK remediation was evaluated by using mixed solution (0.3 M acetic acid and 0.03 M EDTA, EK-M) and by exchanging electrodes for preventing precipitation of metal hydrate. For the EK-M, the lead removal efficiency was only 2% lower than the case where 0.03 M EDTA was solely used (EK-Blank, EK-B). Considering the costly expense of EDTA, the application of EK-M would be economically viable. The efficiency of of EK-E was higher by 2% than the EK-B method. More impertantly, the pH values of entire soil packed column presented to be neutral (7~8) in the EK-E process. Unlike to EK-B and EK-M, the deposition of heavy metals to any specific area was avoided in the EK-E process.