• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.1
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• pp.98-103
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• 2002

The serum lipid-lowering effect of garlic was examined in hypercholesterolemic rats. The food intake was not significantly different by garlic powder supplementation. The inclusion of 1% garlic powder in a diets containing 1% cholesterol brought a reduction in the serum cholesterol and triglyceride. Liver lipids were not affected by the addition of l% garlic Powder in hypercholesterolemic rats. Earlier studies have suggested that the effect of garlic on serum cholesterol may be related to the sulfur-containing amino acids of products released during protein digestion. However, our results in rats fed garlic powder diet showed no specific effect on plasma free amino acid concentrations. In conclusion. this study clears shows that garlic intake is able to reduce the levels of serum cholesterol in hypercholesteroolemic rats. However, further studies have to be done in order to elucidate the mechanism underlying this phenomenon.

• Proceedings of the KSCN Conference
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• 2004.05a
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• pp.414.1-414
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• 2004

2001년 사망원인 통계결과를 보면 암, 뇌혈관질환, 심장질환, 당뇨병 등의 사망자가 전체의 50.4%를 차지하여 우리나라가 식생활의 변화로 질병의 양상과 사망원인이 변하고 있으며 선진국형 질병양상을 보여주고 있다. 심장순환기계질환의 위험인자 중 고지혈증, 고혈압, 흡연, 신체활동 부족 등이 중요 인자로 포함된다. 따라서 본 연구는 대구지역 평균 연령 46 $\pm$ 3.4 세의 성인 남성 중 공복의 혈 중 콜레스테롤이 200 mg/dl 혹은 중성지방이 200 mg/dl를 기준으로 그 이상인 사람을 고지혈증으로 간주한 43명과 그 이하인 정상인 76명을 대상으로 영양소 섭취상태와 운동습관 및 식습관을 조사하여 영양교육의 기초자료를 제공하고자 하였다.(중략)

• Journal of the East Asian Society of Dietary Life
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• v.9 no.4
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• pp.421-426
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• 1999

This study was performed to evaluate the effect of persimmon vinegar on serum lipid components in the hypercholesterolemic Sprague-Dawley male rats. Forty rats were divided into four groups and fed diets containing l% cholesterol for 4 weeks. Experimental diets added to distilled water, 1.5%, 3%, and 7% persimmon vinegar(PV) as drinking water. Concentration of total cholesterol, LDL and HDL cholesterol, triglyceride in serum and activity of AST, ALT in serum were assayed. Average food intake, weight gain and FER of experimental rats were not significantly different by contents of persimmon vinegar. Concentration of total cholesterol and LDL cholesterol in serum were lowest in 7% persimmon vinegar group. However concentration of HDL cholesterol in serum was highest in 3% persimmon vinegar group. Concentration of triglyceride in serum was significantly lower in persimmon vinegar group than control group. Activities of AST and ALT in serum were lowest in 7% persimmon vinegar group. The results in this study suggest that persimmon vinegar is effective in lowering serum triglyceride level.

• Korean Journal of Food Science and Technology
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• v.46 no.2
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• pp.219-223
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• 2014

The purpose of this study was to investigate the protective effects of fucoidan on acute alcohol-induced liver injury in rats. Experimental animals were randomly divided into four groups: (1) a control group, (2) a group fed 25% ethanol, (3) a group fed 25% ethanol and 250 mg/kg BW of fucoidan (25% ethanol+FUCO250), and (4) a group fed 25% ethanol and 500 mg/kg BW of fucoidan (25% ethanol+FUCO500). Each group was fed orally two times per day for 15 days. Liver weights in the 25% ethanol group were increased compared to the control group, while liver weights in the 25% ethanol+FUCO500 group were significantly decreased compared to the 25% ethanol group (p<0.05). Plasma concentrations of triglyceride, cholesterol, and LDL-cholesterol were elevated in the 25% ethanol group; however, these levels in the 25% ethanol+FUCO250 group were significantly decreased compared to the 25% ethanol group (p<0.05). The glutamic-pyruvic transaminase activity of the 25% ethanol+FUCO500 group also was significantly lower than the 25% ethanol group (p<0.05). These results indicate that fucoidan might protect against acute alcohol-induced liver injury.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.1
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• pp.35-41
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• 2008

The purpose of this study was to investigate the effects of Chungkookjang viscous biopolymer supplementation on blood glucose and serum lipid-lowering in Streptozotocin (STZ)-induced diabetic rats. The rats were divided into three experimental groups; a normal group (N), diabetic control group (D), and a diabetic group with the supplementation of Chungkookjang viscous biopolymer (DCB). The groups were given experimental diets for four weeks. The normal group (C) was fed a casein-based diet, and the Chungkookjang viscous biopolymer group (DCB) received 3% biopolymer added to the casein-based diet. In the diabetic group (D), food intake increased significantly, but weight gain decreased significantly. The food efficiency ratio was significantly lower in the diabetic group. Liver weight increased significantly in the D group as compared to the N group. However, the DCB group showed a significant decrease in liver weight when compared to the D group. Blood glucose decreased significantly in the DCB group after receiving the experimental diet for four weeks, as compared to the diabetic control (p<0.05). Serum triglyceride levels were significantly lower in the DCB group than in the D group, whereas HDL-cholesterol levels were significantly higher (p<0.05). Total cholesterol was decreased in DCB group, but there were no significant differences. Also, LDL-cholesterol level was not significantly different among the experimental groups. Hepatic triglyceride and cholesterol were lower in the DCB group with no significant differences among groups. These results indicate that dietary supplementation of Chungkookjang viscous biopolymer improved glucose lowering and lipid metabolism in diabetic rats.

• Journal of the Korean Chemical Society
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• v.37 no.4
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• pp.378-389
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• 1993

The release of steroids such as progesterone, testosterone, estrone and estradiol were investigated in two types of block copolymer matrices, which were AB type block copolymer composed of poly(γ-benzyl-L-glutamate)[PBLG] as the A segment and polyoxypropylene[POP] as the B segment and ABA type triblock copolymer composed of the A segment and poly(propylene glycol)[PPG] as the B segment. The release rates of progesterone, estradiol and testosterone through PBLG-POP1 and PBLG-POP2 matrices and those of progesterone, estrone and testosterone through GPG1 of ABA type triblock copolymer were higher in an acidic solution than in a basic one. However, the release rate of estrone through PBLG-POP1 and PBLG-POP2 matrices and that of estradiol through GPG1 of ABA type triblock copolymer were higher in a basic and neutral solutions than in an acidic one. The order of release rate in three different matrices was GPG1 > PBLG-POP1 > PBLG-POP2. The results also showed that the molecular weight of steroids is inversely proportional to the rate of release.

• Journal of Nutrition and Health
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• v.48 no.2
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• pp.140-148
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• 2015

Purpose: The purpose of this study was to evaluate the role of coffee in diabetic rats in order to prevent hyperglycemia and hyperlipidemia, and to improve antioxidant enzyme activity in streptozotocin induced diabetic rats. Methods: Thirty two male Sprague-Dawley rats (body weight $200{\pm}5g$) were divided into two groups; diabetic and nondiabetic groups. The groups were each randomly divided into two subgroups; fed control and coffee (5 g coffee powder/kg diet) diets. Diabetes was induced by intramuscular injection of 50 mg streptozotocin/kg body weight. Rats with blood glucose concentrations ${\geq}300mg/dL$ were considered diabetic for these experiments. All rats were fed an experimental diet and deionized water ad libitum for 4 weeks. Results: The results of this study indicate that body weight gain was significantly lower in diabetic groups than in nondiabetic groups regardless of diet. Mean food intake was significantly higher in diabetic groups than in nondiabetic groups, and significantly higher in the coffee group than in the control group in diabetic rats. Food efficiency ratio (FER) was significantly lower in diabetic groups than in nondiabetic groups regardless of diet. The fasting blood glucose of coffee supplemented groups was significantly lower compared with the control group in diabetic and nondiabetic rats. The levels of serum LDL-cholesterol and atherogenic index were significantly lower in the coffee group than in the control group in diabetic and nondiabetic rats, and serum HDL-cholesterol was significantly higher in the coffee group than in control groups. The contents of hepatic triglyceride were significantly lower in the coffee group than in the control group in diabetic and nondiabetic rats. The lipid peroxidation of malondialdehyde (MDA) contents was significantly lower in the coffee group than in the control group in diabetic and nondiabetic rats. Activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase in liver was not significantly different by experimental diets among all groups. Conclusion: In conclusion, effects of 0.5% coffee powder supplemented diet were beneficial on blood glucose and lipids in diabetic rats.