• Sleep Medicine and Psychophysiology
• /
• v.12 no.2
• /
• pp.139-143
• /
• 2005

Periodic limb movements in sleep (PLMS) have been diagnosed easily by nocturnal polysomnography (NPSG) and treated effectively with dopamine receptor agonist, benzodiazepine and opioid. However, few reports have objectively assessed the treatment responses. We treated a PLMS patient with clonazepam and pramipexole, and evaluated their efficacy with actigraphy. Clonazepam improved sleep quality without reducing frequency of limb movements, and pramipexole reduced frequency of limb movements without improving sleep quality, results which are consistent with previous study findings. Actigraphy proved useful in evaluation of treatment response of PLMS.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.21 no.3
• /
• pp.91-100
• /
• 2017

The solution was developed for the maintenance decision support of combined cycle power plant gas turbine. The developed solution was applied to MHI501G gas turbine and is, in present, on the process of field test at GUNSAN combined cycle power plant, South Korea. The developed solution provides the calculated result of optimal overhaul maintenance period through following modules: Real Time Performance Monitoring, Model-Based Diagnostics, Performance Trend Analysis, Optimal Overhaul Maintenance Interval, Compressor Washing Period Management, and Blade Path Temperature Analysis. Model-Based Diagnostics module analyzed the differences between the data of gas turbine performance model and the online measurement. Compressor washing management module suggests the optimal point of balancing between the compressor performance and the maintenance cost.

• Korean Journal of Microbiology
• /
• v.44 no.4
• /
• pp.299-304
• /
• 2008

Monocytic cells in myeloid lineage are known for latent site of HCMV Previous studies have suggested that HCMV regulates cell cycle progression in a variety of cells, but studies in monocytic cells are limited. In this study, we attempted to understand cell cycle changes after HCMV infection in the monocytic cell lines. Flow cytometric analyses using propidium iodide revealed that the proportion of G0-G1 phase was increased and the proportion of S phase decreased in HCMV-infected THP-1 cells, but not in HL-60 cells. BrdU-incorporation assay supported that cell proliferation was inhibited in HCMV-infected THP-1 cells by inhibition of de novo DNA synthesis. Western blot analysis revealed that p21, inhibitor of cell cycle progression from G1 phase to S phase, was induced in HCMV-infected THP-1 cells but not in HL-60 cells. Thus, HCMV inhibited cell pro-liferation by arresting the cell cycle at G0-G1 phase through induction of p21 protein in promocytic THP-1 cells.

• Proceedings of the Korean Nuclear Society Conference
• /
• 1996.05b
• /
• pp.455-460
• /
• 1996

원자력발전소의 기기들에 대한 허용정지시간과 점검주기는 운영기술지침서(Technical Specification)에 명시되어 있는데 점검주기가 짧은 기기의 잦은 점검은 손상부품의 교체를 통하여 발전소의 불이용도를 감소시키는 효과가 있는 반면 점검원의 부담을 늘려 보수시 인적오류의 증가로 인한 불이용도 증가의 가능성이 있다. 본연구에서는 기기의 허용정지 시간과 점검주기를 변화시켜 계통의 불이강도를 IRRAS 5.0을 이용하여 허용정지시간과 점검주기의 변화가 계통의 불이용도에 미치는 영향을 분석하는 평가체계를 개발하고 영광 3,4호기 보조급수계통에 적용하였다.

• Journal of radiological science and technology
• /
• v.38 no.1
• /
• pp.31-38
• /
• 2015

$^{18}F-FDG$ PET/CT has been known a useful modality to diagnose high-glucose-using cells such as cancer cells by glucose metabolism of FDG. Mainly, FDG takes on cancer and inflammatory cells; however, there have been FDG uptakes on normal tissues by individual physiological characteristics, occasionally. Especially, in fertile females, unusual FDG uptake of breast changes as the menstrual cycle, and disturb diagnosis. Therefore, the study aimed to evaluate the change of breast FDG uptake in menstrual cycle on $^{18}F-FDG$ PET/CT. 160 females ($34{\pm}3.5$ years old) who do not undergo a gynecologic anamnesis and have regular menstrual cycle over the previous 6 months were examined. They were divided 4 groups (each 40 patients) as flow phase, proliferative phase, ovulatory phase and secretory phase using Pregnancy Calculator 0.14. and history taking. Discovery Ste (GE Healthcare, Milwaukee, Mi, USA) was used a s PET/CT. We analyzed SUVs on accumulated region on breast, and 3 nuclear medicine specialists did the Blind test. SUVs on the Breast were flow phase ($1.64{\pm}0.25$), proliferative phase ($0.93{\pm}0.28$), ovulatory phase ($1.66{\pm}0.26$) and secretory phase ($1.77{\pm}0.28$). It showed high uptake value in secretory, flow phase and ovulatory phase (p<0.05). In gross analysis, the accumulation of breast was divided into 3 grades as comparing with lung and liver. The breast's uptake was equal to lung (Grade I); between lung and liver (Grade II); equal to or greater than liver (Grade III). The results showed high uptake value in secretory, flow phase and ovulatory phase (p<0.05). In fertile females, FDG uptake of breast changed as menstrual cycle, and it available to diagnose breast disease. Therefore, we consider reducing false-negative finding of breast disease, by doing examination on appropriate period through history taking about individual menstrual cycle.

• ETRI Journal
• /
• v.14 no.4
• /
• pp.148-164
• /
• 1992

본 논문에서는 TDX-10 데이터베이스 데이터의 고장을 주기적으로 진단하고 복구할 수 있는 고장진단 전문가 시스팀을 제안하고 구현하였다. 실시간 환경 및 분산구조를 갖는 데이터베이스 관리 시스팀에서 데이터베이스의 효과적인 접근을 위해서 필요한 데이터베이스의 데이터 즉, 디렉토리와 딕셔너리는 매우 중요하며 고장이 발생할 경우 데이터베이스 관리시스팀에 미치는 영향은 치명적이다. 따라서, 실시간 환경을 갖는 데이터베이스 관리 시스팀에서 데이터베이스 데이터에 대한 고장 진단 및 복구는 필수적이라고 할 수 있다. 본 논문에서 제안한 고장진단 전문가 시스팀은 데이터베이스 데이터를 운용중 변하는 부분과 변하지 않는 부분으로 분류하고 미리 주어진 고장진단 규칙에 따라 진단하는 방법이다. 데이터베이스 데이터의 고장진단 데이터, 고장진단 규칙, 고장진단 데이터 생성기, 고장진단 데이터 검증기, 그리고 고장진단기로 구성되어 있다. 고장진단 데이터는 고장진단기가 데이터베이스 데이터를 주기적으로 진단하기 위하여 사용하는 마스터 데이터로서 두개가 존재한다. 고장진단 데이터 생성기는 데이터베이스 데이터의 고장진단을 위한 데이터 구조를 생성하고 데이터베이스로부터 데이터베이스를 데이터를 중복하여 읽어들이는 역할을 한다. 이와 같은 과정은 시스팀이 초기에 동작을 시작하거나 운용중 운용자에 의해서 릴레이션의 추가 및 삭제, 그리고 튜플의 추가등과 같은 사건이 발생할 경우에 이루어진다. 데이터베이스 검증기는 고장진단 데이터 생성기가 중복하여 생성한 데이터에 대해서 데이터베이스 데이터의 제작시의 초기 오류를 검증해냄으로써 데이터베이스 관리 시스팀의 안전한 운용을 가능하게 하며 고장진단기가 데이터베이스 데이터를 주기적으로 진단할 데이터를 탄생시킨다. 마지막으로 고장진단기는 주기적으로 데이터베이스 데이터의 고장을 진단하여 고장이 발생한 데이터를 미리 분류한 규칙에 따라 원래의 데이터로 복구하거나 운용자에게 보고함으로써 고장에 대비하도록 한다. 그리고 데이터베이스 상의 운용자에 의한 변경을 감지하여 고장진단 데이터의 재생성을 지시한다. 본 논문에서 제시하고 구현한 데이터베이스 데이터의 고장진단 및 복구를 위한 전문가 시스팀은 실시간 환경과 고장허용 환경, 분산 구조 그리고 빈번한 접근을 갖는 데이터베이스 관리 시스팀에서 아주 중요한 역할을 할 수 있다.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.9 no.2 s.42
• /
• pp.17-27
• /
• 2005

This paper presents an integrated optimum design and a cost effectiveness evaluation method of a viscoelastically damped structural system. The criterion selected for the optimization is the minimization of the life?cycle cost which is a function of structural sizing variables and the amount of the viscoelastic damper. A genetic algorithm is used as a numerical searching technique in order to simultaneously find the optimum parameters of the integrated system. Optimal distributions of design variables according to various seismic characteristics are investigated by applying the proposed design method to a numerical example of a 10?story building structure. The cost effectiveness of viscoelastically damped structural system is also evaluated by comparing the life-cycle cost of the structure without viscoelastic dampers. The results show that the viscoelastic damper is effective in a region of low to moderate seismicity.

• Land and Housing Review
• /
• v.6 no.4
• /
• pp.165-175
• /
• 2015

This study is focusing on the needs to introduce policy decision making based on identification of the definition for 'business life cycle' and 'public enterprises' for proper public enterprises management. For this purpose, the study is planning to define categorical variables for enterprise life cycle and provide basic data for public enterprises management policy. This study explored 'Korea Expressway Corporation', 'K-water', 'Korea Railroad', 'Korea Land and Housing Corporations', because of they are the public institutions recently underwent 'management normalization policy' due to rapidly increasing debt. First, there follows the analysis on priority and standard of categorical variables for quasi-market oriented SOC public enterprise life cycle by using AHP and frequency study on expert survey. Next, this study investigated and analyzed the enterprises management plan for expected 'declining period' through forecasting 'declining period' by conducting 2nd expert survey.

• Journal of Energy Engineering
• /
• v.25 no.2
• /
• pp.52-64
• /
• 2016

The production of nuclear energy from thorium which is non-fissile material was a main issue until the middle of 1970's, because of the thorium's abundance as energy resources, its capability of breeding fissile material U233, and the reduction of long-lived actinides. However, to use thorium as nuclear fuel, some obstacles such as the necessities of external neutron source and long-term neutron irradiation for effective breeding, and the production of high radioactive isotopes in the course of thorium breeding cycle should be overcome. The difficulties to resolve these cons of thorium cycle became the reason of interruption of the related researches in the middle of 1970's. But in the 21st century, the change of societal perspective regarding nuclear energy and the appearance of accelerator-driven nuclear reactor shift those cons into pros and rehabilitate the study of thorium. The high activity of thorium cycle turned out to be a good option as higher resistance and easier detectibility of nuclear proliferation and the employment of subcritical accelerator-driven reactor as external neutron sources is considered to enhance the nuclear safety. In this study we compare the thorium cycle with the currently-used uranium cycle and analyze the technical status and perspective of thorium researches which use accelerator-driven reactors.

• Journal of Haehwa Medicine
• /
• v.16 no.2
• /
• pp.53-60
• /
• 2007

韓醫學的時間醫學是在天人合一思想的基礎上, 利用陰陽五行學說與五運六氣學說來研究人體周期性問題的學問, 經過長期的臨床實踐已經形成了其理論和體系, 至今其有效性亦得到驗證, 屬於比較實用的學問. 關於韓醫學的時間醫學, 在"黃帝內經"中已經提出日週期和月週期以及年週期等, 形成了時間醫學的基礎, 後在"傷寒論"中得到臨床上的實際應用. 自唐代王氷補入運氣篇後, 關於年週期和超年週期的硏究得到了比較大的發展. 後來, 曆經宋金元明淸, 出現了子午流注針法, 並於藥物服用時間的硏究, 時令病的認識, 對疾病的時間診斷學的硏究等方面, 均得到了持續而多樣的發展. 在以晝夜之變化爲特征的日週期中, 晝夜陰陽消長週期與晝夜升降浮沈週期, 對發熱疾患的治療及痊愈時間的預測有所幫助, 衛氣運行週期於睡眠機制的說明有所深化, 而五臟主時週期對五臟疾病的預防和病勢的預測以及投藥時期的確定有所幫助. 而日死亡週期可以活用於死亡時間的把握, 經脈氣血流注週期則對以後的按時取穴之子午流注針法和靈龜八法以及飛騰八法等的發展, 起到了主要作用.