• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.311-311
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• 1994

어류를 이용한 화학물질의 독성평가 방법 및 기작에 관한 연구의 일환으로 암수동체 점박이 송사리에서 N-methyl-N'-nitrosourea (NMU)에 의해 유발되고 여성 호르몬의 일종인 17$\beta$-estradiol (E$_2$)에 의해 촉진유도된 갑상선 종양의 조직학적 특징을 광학 현미경과 전자현미경 수준에서 조사하였다. 본 연구에서 유도된 갑상선 종양은 광학현미경 수준에서 포유류와 유사하게 hyperplasia형, medullary형, papillae형, follicle형, 그리고 papillae형과 follicle형의 혼합형으로 구분할 수 있었다. 전자현미경 관찰 결과 미토콘드리아의 변형, 핵의 크기 증가 및 핵내 세포질 봉입체 함입등의 특징이 인간을 포함한 포유류의 양상과 매우 유사하였다. 이상의 결과는 본 종이 신약의 갑상선 종양유발성을 검증하는데 매우 유용한 실험동물 모델임을 시사한다.

• Journal of Life Science
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• v.30 no.6
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• pp.563-569
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• 2020

Oncoplastic surgery (OPS) combines oncologically safe tumor resection with aesthetically satisfying reconstruction of defects using established plastic surgery techniques. OPS is characterized by initial excision as extensive as is beneficial for oncological safety, and, once sufficient resection is complete, displacement or replacement techniques are selected based on remnant volume. The size of the lesion and the individual patient are important factors when considering the appropriate approach, and when pre-operative imaging, including MRI, is used to determine the technique, the complete removal of cancer cells by permanent pathology is essential. A frozen section is used during the operation to reduce the reoperation rate, but it is difficult to cover the entire margin surface theoretically and even harder in practice. A recent report about adequate margins has empowered OPS in its oncological safety. Considering the patients to whom each modality could be applied, basic breast volume is an important factor, and this is influenced by ethnic differences. In Europe or the US, for example, the average breast size is 36D (600 ㎤) and reduction mammoplasty is predominantly used. However, the average size of patients in our institution is 33A (300 ㎤), and so quite different approaches are selected in most cases. New techniques involving radiofrequency and fluorescence have been proposed as safe and easily accessible ways of reducing complications.

• The Journal of the Korean bone and joint tumor society
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• v.8 no.3
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• pp.96-105
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• 2002

Purpose: The purpose of this study was to assess the oncologic results and functional outcomes of limb salvage surgery performed in patients of primary bone tumors of the shoulder girdle. Materials and Methods: Twenty-nine patients who underwent limb sparing resection for shoulder girdle neoplasm between 1982 and 2001 were analyzed. Follow up periods averaged 7 years and 1 month. Mean age of the patients was 35 (11~71) years. There were 14 males and 15 females. Primary malignant bone tumors of shoulder girdle (proximal humerus 21, scapula 3, both 1) were 23 cases; osteosarcomas 7, chondrosarcoma 14, parosteal osteosarcoma 1, hemangioendothelioma 1, and giant cell tumor of proximal humerus were 6 cases. Limb salvage surgery was performed by curettage and cementing in 7 patients, by cement molding arthroplasty in 10 patients, and by tumor prosthesis in 7 patients, by other method such as resection only, bone graft, arthrodesis in 5 patients. The Musculoskeletal Tumor Society functional rating system was used to assess functional outcomes. Results: One osteosarcoma and 2 chondrosarcoma patients died, and the survival of the salvaged limb was 88.6% at the final follow-up. There were 6 local recurrences, 2 lung metastases, 2 local recurrences and lung metastases. The functional outcome was 80%. There was statistically significant difference of functional results among the patients treated by cement filling (86%), cement molding arthroplasty and IM nailing (71%), and tumor prosthesis (83%). (p=0.034) There were three complications including 1 radial nerve palsy and 1 axillary nerve palsy, and 1 wound infection. Dislodgement of vascularized fibular graft in one patient was treated by internal fixation. Conclusion: Limb salvage surgery seems to be useful method to treat bone tumors of the shoulder girdle.

• Proceedings of the Korea Multimedia Society Conference
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• 2003.11a
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• pp.277-280
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• 2003

본 연구에서는 자궁종양 세포를 정상, 비정상으로 진단하기 위한 세포핵의 특성값 추출 방법으로 3차원 형태학적 분석 방법을 제안한다. 컨포컬 현미경을 이용하여 3차원 볼륭데이터를 획득하고 3차원 연결 성분 레이블링을 적용하였다 레이블링 후, 각각의 세포핵으로부터 3차원 형태학적 특성값을 추출하였으며 정상세포핵과 비정상세포핵의 3차원 형태계측에 대한 차이를 비교하였다. 이는 잘린 단면의 각도나 두께에 따라 서로 다른 분석 결과를 나타내는 2차원 영상분석방법의 한계를 극복할 수 있으며 실체에 가까운 계측으로 보다 객관적이고 정확한 병리진단을 위한 보조도구로써 활용될 수 있다.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2007.11a
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• pp.520-529
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• 2007

간암은 세계적으로 흔한 악성 종양에 속하지만 우리나라에서 간암은 위암, 폐암 다음으로 높은 사망률을 보이며 이러한 간암은 조기진단이 요구된다. 전문의는 간암의 진단을 위해 조영증강 CT영상을 이용하여 육안으로 간암을 판별하는데, 조영증강 CT영상을 이용한 진단은 주 종양의 진단에는 도움이 되지만 주 종양에서 주위 간 조직으로 전이된 간암들을 판별하는 것은 어려우며 실제로 시술 중에야 전이된 간암의 존재를 알 수 있다. 본 논문에서는 조영증강 CT영상을 이용하여 간과 주 종양을 자동으로 추출한 후, 미세하게 주 종양 주위로 전위된 간암들을 추출하는 방법을 제안하여 전문의를 보조할 수 있는 보조 전문가 시스템으로서의 유용성을 확인하고자한다. 조영증강 CT영상은 흉부에서 5mm간격으로 40 ${\sim}$ 50장정도로 촬영된다. 조영증강 CT영상을 이용하여 간 영역을 추출하기 위해서 간의 형태학적 정보 그리고 명암도와 명암의 분포도를 이용한 양자화 기법 등을 적용하여 추출하며 추출된 간 영역에서 간암의 후보 영역 추출은 간암의 명암도와 형태학적 특징 정보를 이용하여 추출한다. 본 논문에서는 간암의 추출을 위해 맵 상에 흩어져 분포되어 있는 유사 패턴들의 무게 중심을 찾아 하나의 패턴으로 그룹화 하는 개선된 SOM 알고리즘을 제안하여 간암 판별에 적용한 후, 기존의 SOM 알고리즘과 비교 분석한 결과. 본 논문에서 제안된 SOM 알고리즘을 적용한 간암 추출이 더 효율적임을 확인 할 수 있었으며, 전문의가 판별한 것과 비교 분석한 결과, 전문의를 보조할 수 있는 보조 전문가 시스템으로서의 가능성을 확인할 수 있었다.

• Journal of Gastric Cancer
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• v.5 no.1
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• pp.40-46
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• 2005

Purpose: Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gastrointestinal tract. GISTs are positive for the expression of c-Kit protein at immunohistochemistry, and their clinical presentations vary. This retrospective study was performed to evaluate the clincopathologic characteristics of GISTs and to define the prognostic factors. Materials and Methods: 40 patients who underwent a complete resection of a GIST during the period $1996\~2003$ at the Department of Surgery, Korea University College of Medicine, were studied. We divided them into low- and high-risk. groups by using tumor size and mitotic count: 23 cases were low risk, and 17 were high risk. Clinicopathologic features, immunohistochemical findings, and prognoses were compared between the low- and the high-risk groups. Results: The mean age of the 40 patients was $61.3\pm11.1$years, and the male-to-female ratio was 1：1.1. There was no significant difference in age and sex between the groups. A comparative analysis revealed tumor size, mitotic count, clinical symptoms, preoperative pathologic diagnosis, ulceration, and necrosis to be variables that had statistically significant differences between the high- and the low-risk groups. In the univariate analysis, tumor size, mitotic count, ulceration, necrosis, and abnormal endoscopic ultrasound findings were associated with disease-free survival, but in the multivariate analysis, mitotic activity was the only independent factor associated with disease-free survival. 8 patients had recurrences during the follow-up period, and four of them were treated with STI-571 (imatinib mesylate, $Gleevec^{(R)}$). The treated patients have survived until now; however, two of non-treated patients died from disease progression. Conclusion: Based on this study, tumor size, ulceration, and necrosis are significant factors affecting survival, and mitotic activity may be a useful prognostic marker. STI-571 may be used in an adjuvant setting because the drug has shown anticancer activity in patients with recurrence or metastasis.

• The Korean Journal of Cytopathology
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• v.1 no.1
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• pp.43-50
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• 1990

The authors report 16 cases of mediastinal fine-needle aspiration cytology from Jan. 1985 to Mar. 1988 at the Seoul National University Hospital. Among them, diagnostic material were obtained in fifteen cases, establishing the diagnosis of 7 thymomas, 2 germinomas, 2 neurogenic tumosr, 1 lymphoma, and 3 meastatic carcinomas. The 9 cytologic diagnoses could be confirmed by histologic examination in 8 patients and by another cytologic method in one patient, allowing concordance rate of 77%.

• Radiation Oncology Journal
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• v.20 no.2
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• pp.100-107
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• 2002

Purpose : The aim of this retrospective study was to assess the treatment results of 30 patients with pineal region tumors who were underwent radiation therapy under the diagnosis by either CT or MRI. There was no histological verification. We analyzed the prognostic factors that have a significant effect on the overall survival (OS) and disease free survival (DFS) rates. Materials and Methods : A total 30 patients with pineal region tumors were treated between March 1983 and August 1995. After a trial radiation therapy of $20\~30\;Gy/2\~3$ weeks, the patients were evaluated for their clinical response and radiological response by either CT or MRI and the final treatment direction was then decided. According to their response to the trial radiation therapy and the involved site, radiation treatment was given in various fields i.e., local, ventricle, whole brain and craniospinal field. The radiation dose ranged from 40.8 to 59.4 Gy (Median 50.4 Gy). The median follow up was 36.5 months $(4\~172\;months)$. Results : An improvement or stability in the clinical symptoms was observed in 28 patients $(93.3\%)$ after the trial RT. Nineteen patients $(63.3\%)$ showed a partial or complete response by CT or MRI. The two-year and five-year survival rates of the patients were $66.7\%$ and $55.1\%$, respectively. No significant difference in the survival rates according to the degree of the radiological response was abserved after the trial RT. The results of univariate analysis showed that age, the primary site, the performance status $(KPS\geq70)$, the degree of response after completing RT and the RT field were significant prognostic factors affecting the survival and disease free survival rates (p<0.05). Conclusion : The clinical and histological characteristics of pineal region tumors are quite complex and diverse. Therefore, it is difficult to predict the histological diagnosis and the possibility of radiocurability only with the initial response to RT. We think that the development of less invasive histological diagnostic techniques and tailored treatment to the histological type of each tumor are needed.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1993.05a
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• pp.96-96
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• 1993

Because of the diversity of tumor types and the relative rarity of salivary gland neoplasm, exact diagnosis and treatment decision have been difficult. Seventy cases of salivary gland tumors which were diagnosed at our hospital from January 1981 to December 1992 were reviewed according to age, sex, site, presenting symptoms, staging, histology, and outcome, retrospectively. The following results were obtained ; 1) Of all salivary gland tumors, 35 cases(50%) arose in the parotid gland, 16 cases(23%) in the submandibular gland, and 19 cases(27%) in the minor salivary glands. 2) There were 55(79%) benign tumors, and 15(21 %) malignant tumors. The most frequent benign tumor was pleomorphic adenoma(89%), and malignant tumor was adenoid cystic carcinoma(40%). 3) The symptoms varied in duration from several weeks to 26 years. 29 cases(41 %) had symptoms for one to five years. 4) Among the parotid and submandibular glands, postoperative facial nerve paralysis was occurred 9 cases(18%). Recurrence was seen in 4 cases(6%).

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2007.04a
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• pp.63-74
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• 2007

간은 인체의 생명을 유지하고 성장할 수 있도록 하는 영양섭취와 매우 밀접한 관계를 가진 중요한 장기이다. 이러한 간의 중요성에도 불구하고 현재 우리나라의 간암 발병률이 세계에서 가장 높은 수치를 기록하고 있으며 이에 따라 간암을 조기 진단하고 예방할 수 있는 방법의 중요성이 확대되고 있다. 따라서 본 논문에서는 영상 의학적 검사 방법 중 하나인 CT 촬영으로 획득된 조영 증강 CT 영상에서 간 영역과 간 종양 영역을 정확히 검출하고 간 종양의 악성도를 판별할 수 있는 방법을 제안한다. 흉부로부터 5mm 간격으로 약 $40\;{\sim}\;50$장 정도로 촬영한 조영 증강 CT 영상에서 명암도와 명암의 분포도를 이용한 양자화 기법과 장기들의 위치 및 형태학적 특징정보, 그리고 흉부와 복부 양방향으로 인접한 CT 영상들의 정보를 분석하여 간 영역을 검출한다. 간 종양 영역은 과혈관성 종양의 특징을 분석하고 간 영역의 검출 방법에 적용하여 추출한다. 추출된 간 종양 영역은 퍼지 기반 SOM 알고리즘을 제안하여 간 종양의 악성도를 분석하는데 적용한다. 제안된 퍼지 기반 SOM 알고리즘은 SOM의 이웃 반경을 동적으로 조정하는데 퍼지 제어 기법을 적용하여 기존의 SOM 알고리즘보다 종양의 악성 정도를 분류하는 정확성을 개선하였다. 제시된 간 영역과 간 종양 검출 및 분석 방법의 결과와 전문의가 진단한 결과를 비교 분석한 결과, 기존의 간 영역 및 간 종양 영역 검출 방법보다 정확성이 향상된 것을 확인할 수 있었다.