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The Effect of 2-Week Dual Therapy with Proton Pump Inhibitor and Amoxicillin in the Eradication of Helicobacter pylori Infection for Treatment of Children with Recurrent Abdominal Pain (만성 반복성 복통 환아에서 Helicobacter pylori 감염에 대한 Proton Pump Inhibitor 및 Amoxicillin 2주 치료 효과)

  • Lee, Young-Mock;Lee, Chang-Han;Chung, Ki-Sup
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.3 no.1
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    • pp.23-29
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    • 2000
  • Purpose: It has recently been recognized that Helicobacter pylori (H. pylori) is an important factor in the pathogenesis of recurrent abdominal pain (RAP) in children. But, the best treatment for H. pylori infection is still unsettled. This study was performed to evaluate the efficacy of 2 weeks dual therapy with proton pump inhibitor (PPI) and amoxicillin for children with H. pylori infection associated with RAP. Method: Our study included 24 children with RAP who were H. pylori positive assessed by CLO test and histologic examination (silver stain). We used the regimen consisted of PPI (omeprazole, 0.7 mg/kg/day) and amoxicillin (50 mg/kg/day) for 2 weeks to eradicate H. pylori. Eradication of H. pylori was determined 4 weeks after the termination of treatment using the CLO test and histologic examination. Results: The endoscopic diagnoses of patients were nodular gastritis in 11 cases, superficial gastritis in 7 cases, peptic ulcer in 4 cases and normal finding in 2 cases. H. pylori was eradicated in 12 cases by omeprazole and amoxicillin dual therapy for 2 weeks and the eradication rate was 50%. In 4 of 12 children in whom H. pylori had not been eradicated with that regimen, we successfully eradicated H. pylori with other regimens of which 2 or 3 drugs among omeprazole, amoxicillin, clarithromycin, colloidal bismuth subcitrate ($Denol^{(R)}$) and metronidazole were used. Conclusion: The dual therapy with PPI and amoxicillin for 2 weeks had no clear advantage over other regimens for the eradication of H. pylori infection in children. We concluded that the combi-nation of PPI and amoxicillin for 2 weeks is not so good for H. pylori eradication as other commonly used regimens.

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Film Dosimetry for Intensity Modulated Radiation Therapy : Dosimetric Evaluation (필름을 사용한 세기변조치료법에 대한 선량측정)

  • Ju Sang Gyu;Yeo Inhwan Jason;Huh Seung Jae;Choi Byung Ki;Park Young Hwan;Ahn Yong Chan;Kim Dae Yong;Kong Young Kun
    • Radiation Oncology Journal
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    • v.20 no.2
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    • pp.172-178
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    • 2002
  • Purpose : X-ray film over responds to low-energy photons in relative photon beam dosimetry because its sensor is based on silver bromide crystals, which are high-Z molecules. This over-response becomes a significant problem in clinical photon beam dosimetry particularly in regions outside the penumbra. In intensity modulated radiation therapy (IMRT), the radiation field is characterized by multiple small fields and their outside-penumbra regions. Therefore, in order to use film dosimetry for IMRT, the nature the source of the over-response in its radiation field need to be known. This study is aimed to verify and possibly improve film dosimetry for IMRT. Materials and Method : Modulated beams were constructed by a combination of five or seven different static radiation fields using 6 MeV X-rays. In order to verify film dosimetry, we used X-ray film and an ion chamber were used to measure the dose profiles at various depths in a phantom. In addition, in order to reduce the over-response, 0.01 inch thick lead filters were placed on both sides of the film. Results : The measured dose profiles showed a film over-response at the outside-penumbra and low dose regions. The error increased with depths and approached 15% at a maximum for the field size of $15{\times}15cm^2$ at 10 cm depth. The use of filters reduced the error to 3%, but caused an under-response of the dose in a perpendicular set-up. Conclusion : This study demonstrated that film dosimetry for IMRT involves sources of error due to its over-response to low-energy Photons. The use of filers can enhance the accuracy in film dosimetry for IMRT. In this regard, the use of optimal filter conditions is recommended.

Study on the Elimination of Heavy Metal Pollutants in the Soil by Vascular Plant in the River Area (하천유역의 관속식물을 이용한 토양내의 중금속 오염원 제거에 관한 연구)

  • 강경홍;김인성
    • Journal of Korea Soil Environment Society
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    • v.1 no.2
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    • pp.23-34
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    • 1996
  • The biological magnification of Pb, Cu, Zn and Fe in vascular plant, Persicaria thunbergii, Trapa japonica and Nymphoides peltata natually grown at the river and riverside and relationship between the concentration of heavy metals in these vascular plants and in the soil were investigated in the Chonju river, Chonju city. The biological magnification values of these metals in P thunbergii were founded as follows ; Pb, Cu, Zn and Fe were 80.4~254.6$mu\textrm{g}$/g, 284.6~688.4$mu\textrm{g}$/g, 635.5~1979.4$mu\textrm{g}$/g and 1160.0~3590.9$mu\textrm{g}$/g respectively. In the case of T. japonica, Pb, Cu, Zn and Fe were 107.8~306.0$mu\textrm{g}$/g, 282.7~963.0p$mu\textrm{g}$/g, 1328.3~3546.$mu\textrm{g}$/g and 656.8~9944.0$mu\textrm{g}$/g and in N. peltata, 140.1~ 193.9$mu\textrm{g}$/g, 187.7~327.3$mu\textrm{g}$/g, 1126.6~1723.6$mu\textrm{g}$/g and 611.7~1914.6$mu\textrm{g}$/g respectively. The amount of the biological magnification of heavy metals in the leaf, stem and root of these plants was generally increased in the sequence of leaf

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Studies on the Effect of Cation on the Activity at the 5th Instar Larvae of Bombyx mori (5령유충의 배맥관운동에 대한 양이온의 영향에 관한 연구)

  • 윤종관;사기언
    • Journal of Sericultural and Entomological Science
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    • v.18 no.2
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    • pp.89-93
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    • 1976
  • The physiological saline solution for animals is known as Ringer's solution which is used for keeping the function of cold blooded vertebrate animals. Primaily the saline solution is used for the purpose of perfusion experiment in frogs. Later the saline solution is applied in several kinds of animals including human being with satisfactory results. However, this saline solution was introduced to silkworm and it was found that the result was not as successful as in the case of other animals and human being. Normally, in the case of silkworm, the physiological saline solution is prepared in order to maintain the normal function of separated organs and tissues. To this end, the saline solution is adjusted to contain the certain amount and strength of ions, osmosis pressure and hydrogen concentration. The most of cases, the physiological saline solution should be prepared so that the constituent of the solution be the same with the blood selium and body fluid. The hydrogen concentration in the ion element of the saline solution is adjustable by adding Na$\^$+/, K$\^$+/, Ca$\^$++/, Mg$\^$++/ which are followed by adding of buffer solution such as NaHCO$_3$and NaH$_2$PO$_4$. Determination of optimum concentration of cation in the physiological saline solution, and the optimum mixing rate of more than two kinds of cations are based on the movement of dorsal vessel in the silkworm larvae. The optimum concentration of cations in the solution is prepared by adding NaCl solution which is under zero point. However, this solution was further added with the different concentration of KCl and CaCl$_2$. By dropping the prepared solution on the 5th larvae, the effects of solution was measured. The measurement was done by observation of movement' of dorsal vessel and its time length, and the number of pulses. According to the experiment, it was found that when only NaCl solution was applied, the number of pulses is increased for a moment, and the pulse stopped after one hour or so. When KCl solution was added the time of pulse was prolonged and in the contrast, the number of pulses was slow down. If KCl and CaCl$_2$solutions are added the time of pulse was further prolonged. Even though the adding of KCl and CaCl$_2$are found to be effectible, the correlation between the concentration of solution and the movement of dorsal vessel was not observed. However, it was same in the case of adding Ca$\^$++/ or K$\^$+/. It was found that when Mg$\^$++/ was added to dorsal vessel the number of the pulses was not decreased although the prolonged time pulse was observed.

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Study on the Anchovy Boat Seine - II - On The Hydrodynamic Resistance and Performance of Patti-net (기선권현망의 연구 II - 파치망의 유체저항과 그물꼴에 관하여 -)

  • Lee, Byoung-Gee;Su, Young-Tae;Han, Hi-Soo
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.14 no.2
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    • pp.63-68
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    • 1978
  • A boat seine has been used as a major fishing gear for catching anchovy (Engraulis japonica) in the southern coastal waters of Korea since the 1920s. Since the 1950s some improvement from the original seine has been made; powered boats equipped with net hauler has been used instead of rowing boats with hand-driven capstan, and the seining method has been changed into the trawling method. But even now, there are many problems to be solved in the view point of decreasing man power without decreasing catching efficiency. For the purpose, patti-net has been introduced from Japan and experimented on the commercial base since 1972, and it was known that the patti-net could be operated with man power as half as needed in the coventional net, but catching efficiency was not so desirable. Therefore, the study on the characteristics of it were required. The authors carried out a model experiment with a Qne-twentieth scale model net towed by a powered boat on the sea. The obtained results run as follows: 1. Hydrodynamic resistance of the model net can be explained as $R_p=69.6 V_{I.66}$ $R_h=37 v^2$ where $R_p$ and $R_b$ denote the resistance of the whole gear and the cod end in kg respectively, and v the towing speed in mlsec. 2. Performance of wing and cod end showed no deformation such as observed at the conventional net. 3. The ratio of opening at the entrance of bag net to that of cod end showed about 2: 1. Therefore, when we intend to enlarge the net to be able to operate in the deep fishing ground, the cod end should be enlarged in the same proportion and increased towing power is needed .. Then, it will be better to increase the ratio for increasing fishing efficiency without increasing towing power.

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Assessment of Right Ventricular Function in Patients with Chronic Obstructive Pulmonary Disease Using Echocardiographic Tei Index (만성 폐쇄성 폐질환 환자에서 Tei 지수를 이용한 우심실기능 평가)

  • Oh, Yoon-Jung;Shin, Joon-Han;Kim, Deog-Ki;Choi, Young-Hwa;Park, Kwang-Joo;Hwang, Sung-Chul;Lee, Yi-Hyeong
    • Tuberculosis and Respiratory Diseases
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    • v.50 no.3
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    • pp.343-352
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    • 2001
  • Background : Advanced chronic obstructive pulmonary disease is characterized by progressive pulmonary hypertension leading to right heart dysfunction, which plays a Important role in clinical evaluation but remains difficult and challenging to quantify. The noninvasive doppler echocardiographic value referred to as the Tei index has been suggested as a simple, reproducible and reliable parameter of the right ventricular function. The purpose of this was to assess the right ventricular function in patients with chronic obstructive pulmonary disease using the Tei index and to evaluate its relationship with the pulmonary functional status. Methods : The study population comprised of 26 patients with chronic obstructive pulmonary disease and 10 normal control subjects. The Tei index was obtained by dividing the sum of the isovolumetric contraction and the relaxation times by the ejection time using a pulsed-wave doppler. It was compared with the other available Doppler echocardiographic parameters of systolic or diastolic function and with the pulmonary function of the patients. Results : The Tei indices of the patients with COPD were significantly higher than those of normal subjects($0.45{\pm}0.17$ vs. $0.27{\pm}0.03$, p<0.01). The isovolumetric contraction time/ejection time($0.32{\pm}0.08$ vs. $0.25{\pm}0.05$, p<0.05), the isovolumetric relaxation time/ejection time($0.29{\pm}0.16$ vs. $0.15{\pm}0.08$, p<0.05)and the preejection period/ejection time ($0.46{\pm}0.10$ vs. $0.38{\pm}0.06$, p<0.05) were prolonged and the ejection time ($255.2{\pm}32.6$ vs. $314.2{\pm}16.5$ msec, p<0.05) was significantly shortened in patients with COPD compared to normal subjects. The tei indices were inversely correlated with the $FEV_1$ (r=-0.46, p<0.05) and were prolonged significantly in patients with a severe obstructive ventilatory dysfunction(less than 35% of predicted $FEV_1$) compared to those with a mild and moderate ventilatory dysfunction. The tei indices showed an inverse correlation to with the ejection time (r=-0.469), the isovolumetric contraction time/ejection time(r=0.453), the isovolumetric relaxation time/ejection time(r=0.896) and the preejection period/ejection time(r=0.480). Conclusion : The tei index appeared to be a useful noninvasive means of evaluating the right ventricular function. It revealed a significant correlation with the pulmonary function in patients with COPD.

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Studies on the Seedling Production of the Freshwater Crab, Eriocheir japonicus (De Haan) 4. Combined Effects of Temperature-Salinity on the Moulting Intervals of Larvae (동남참게, Eriocheir japonicus (De Haan)의 종묘생산에 관한 생물학적 기초연구 4. 성장단계별 유생에 대한 脫皮 간격일수에 미치는 수온-염도의 복합적인 영향에 관하여)

  • KWON Chin-Soo;LEE Bok-Kyu
    • Journal of Aquaculture
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    • v.7 no.1
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    • pp.21-39
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    • 1994
  • In order to study the optimum environmental condition for larvae culture of the freshwater crab, Eriocheir japonicus, larvae from different growth stages and young crab were cultured under the 16 different conditions of $4\times4$ temperature-salinity combinations (4 different temperatures at 22, 24, 26, $28^{\circ}C$ with 10.5, 17.5, 24.5 and $31.5\%$ of salinity). The duration of metamorphosis, metamorphosis rate, the interval of moulting period, and survival rate were measured from each experimental group of larvae and young crab under the different conditions. The results indicated that the optimum conditions may be a $24.5\%o$ of salinity at water temperature at 22, 24, and $26^{\circ}C$. At $28^{\circ}C$ with $24.5\%o$), the duration of metamorphosis reduced somewhat, nevertheless metamorphosis and survival rate decreased a lot. And the lower the salinity showed the lower the metamorphosis and survival rates at $28^{\circ}C$.

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Analysis on the Spatial Characteristics Caused by the Cropland Increase Using Multitemporal Landsat Images in Lower Reach of Duman River, Northeast Korea (다시기 위성영상을 이용한 두만강 하류지역의 농경지 개간의 공간적 특성분석)

  • Lee, Min-Boo;Han, Uk;Kim, Nam-Shin;Han, Ju-Youn;Shin, Keun-Ha;Kang, Chul-Sung
    • Journal of the Korean Geographical Society
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    • v.38 no.4
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    • pp.630-639
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    • 2003
  • This study aims to analysis the distribution and change of cropland and forest, the Onseong, Saebyeol, and Eundeok counties on the lower reach of Duman(Tumen) river, northeast Korea, using 1992 year Landsat TM data, 2000 year Landsat ETM data, and digital terrain elevation data(DTED). Land cover and land use of the study areas are classified into cropland, forest, village, and water body, using the supervised classification method including 1:50,000 DTED analysis, image band composition, and principal component analysis(PCA). Results of quantitative analysis present that each growth rate of cropland of Onseong and Eundeok are 22.8% and 14.7% corresponding to decreasing rates of forest, 8% and 13.6% during 8 years from 1992 to 2000. In Onseong, Saebyeol, and Eundeok, each values of mean elevations and slope gradients increased to 192m, 95m, and 91m from 157m, 85m, and 78m, and to 6.6$^{\circ}$, 3.0$^{\circ}$, and 4.4$^{\circ}$ from 5.2$^{\circ}$, 2.5$^{\circ}$, and 3.0$^{\circ}$. Especially, in case of newly developed cropland, the values of mean elevation and mean gradient have 225m, 122m, and 127m, and 9.4$^{\circ}$, 5.1$^{\circ}$, and 8.0$^{\circ}$, in above three regions. These new croplands were developing along to deeper valleys and toward lower hill and mountain slope up to knickpoint zone of gradient change. Deforested lands for cropland have formed irregular pattern of patch-type, and become sources for the sheet erosion, rilling and gulleying in mountain slope and sedimentation in local river channel. Though there were no field checking, analysis using landsat images and GIS mapping can help understand actual environmental problems relating to cropland development of mountain slope in North Korea.

Effect of Globe Growth and Chromogenic on Day and Night Temperature and the LED Light Treatment of Expert Grafted Cactus (Chamecereus silvestrii f. variegata) Cultivar 'Hee-Mang' (수출 접목선인장 산취 '희망'의 주.야 온도 및 LED광 처리가 모구 생육과 발색에 미치는 영향)

  • Nam, Sang-Yong;Park, Sun-Mi;Ahn, Dong-Hyun
    • Journal of Bio-Environment Control
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    • v.19 no.3
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    • pp.140-146
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    • 2010
  • This experiment was conducted to find the day and night temperature combination and the light-emitting diodes (LEDs) on the most effective globe coloration and growth of Chamecereus silvestrii f. variegata 'Hee-Mang'. The $L^*$value, $a^*$value and $b^*$value were all significant difference in the yellow globe color expression in the day and night temperature combination. Especially, the bright yellow color and visual value were the highest in the temperature combination, the day temperature of $20^{\circ}C$ and night temperature of $20^{\circ}C$. Globe color quality was lowered from the day temperature of $25^{\circ}C$ and night temperatures of $5^{\circ}C$ and $10^{\circ}C$ combination. In light-emitting diodes (LEDs) treatments, $a^*$value and $b^*$value are significant difference. A unique beautiful yellow coloration and globe quality were maintained the $a^*$value of +5.23, $b^*$value of +39.9 in a red LED. The optimum temperature range and light-emitting diodes (LEDs) on the globe color expression were the most effective the day temperature of 200e and night temperature of $20^{\circ}C$ and a red LED. In addition, the outer globe color quality of Chamecereus silvestrii f. variegata cultivation, rather than the light environment improvement is better in a proper temperature environment to keep. Especially, a unique globe color expression of yellow lines was most effective in a red LED.

Fruiting body development and genetic analysis of somatic hybrids by protoplast fusion in edible fungi (식용버섯의 원형질체 융합체의 자실체 발생 및 유전분석)

  • Yoo, Young Bok;Kong, Won Sik;Oh, Se Jong;Jhune, Chang Sung;Shin, Pyung Gyun;Kim, Beom Gi;Kim, Gyu Hyun;Park, Minsun;Min, Byung Re
    • Journal of Mushroom
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    • v.2 no.3
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    • pp.115-126
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    • 2004
  • Somatic hybrids of inter-compatible and inter-incompatible strains were obtained by protoplast fusion. The fusion products between compatible strains, Pleurotus ostreatus and P. florida, formed heterokaryons, while fusants between incompatible strains such as P. cornucopiae + P. florida, P. ostreatus + Ganoderma applanatum, P. florida + Ganoderma lucidum, and P. ostreatus + Flammulina velutipes formed synkaryons that retained genes from both parents. The heterokaryons showed the same level of basidioma development. In contrast, the synkaryons showed unique characteristics including clamp connection formation at mitosis, either partner basidioma development, and abnormal segregation and recombination compared with inter-compatible strains. Synkaryons can be classified into homokaryoyic and heterokaryotic type. A comparison of somatic hybrids with compatible and incompatible strains was made using random amplified polymorphic DNA (RAPD) analysis. The heterokaryons between compatible species showed the same level of variability and contained both parental RAPD bands. In contrast, most of the synkaryons between incompatible species showed similarity to those of either parental bands and non-parental RAPD bands. Synkaryons can be classified into microgenome insertion type and macrogenome insertion type. A tetrapolar mating system was found among monospore isolates in somatic hybrids and wild type P. ostreatus. Homokaryons from each somatic hybrid combination were paired with tester homokaryons of the initial wild type of P. ostreatus. The changed mating types were identified in progenies. The pattern of mating type switching in somatic hybrids depends on compatibility of fusion partner. There are several factors related to the mechanism of clamp connection formation and fruiting body development of synkaryons. Of these,the major factor may be associated with self-fertility and mating type switching such as homokaryotic fruiting of wild type P. ostreatus. This review will discuss these aspects.

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