• Journal of Life Science
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• v.19 no.5
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• pp.680-683
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• 2009

Glycosidase inhibitors are major targets in the treatment of type II diabetes, cancer and viral infections. This study was carried out to investigate the glycosidase inhibitory substances from bamboo (Phyllostachys bambusoides). Bamboo was extracted with methanol and then further fractionated with n-hexane, chloroform, n-BuOH and aqueous to get an active fraction. All extracts were evaluated for ${\alpha}$-glucosidase inhibitory activities to identify the n-hexane fraction with 33.5 ${\mu}$g/ml of IC50 value. Active compound 1 in the n-hexane fraction was identified as linoleic acid, which exhibited inhibitory activity with 12.4 ${\mu}$M of IC50 value. Mechanistic analysis showed that linoleic acid exhibited noncompective inhibition. This is the first study in which bamboo is reported to show ${\alpha}$-glucosidase inhibitory activity.

• Proceedings of the Korean Information Science Society Conference
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• 2002.04a
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• pp.265-267
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• 2002

인터넷에서 멀티미디어 응용들이 증가함에 따라 서비스 품질(QoS: Quality of Service)을 보장해 줄 수 있는 여러 가지 방안이 제안되어 왔는데, 일반적으로 이들 방안은 확장성과 종단간 QoS 보장 간에 상호 모순이 발생하는 경향을 가지고 있다. 본 논문에서는 이와 같은 상호 모순을 피할 수 있는 QoS 지원 방안으로서 DQSP(Dynamic QoS Support Protocol)를 제안한다. DQSP는 도메인 내에서의 자원 예약과 연결 수락 제어 메커니즘을 정의한다. DQSP는 링크 자원을 각 에지 라우터로부터의 트래픽 클래스별로 동적으로 할당하고 에지 라이투가 자신에게 할당된 링크 자원에 관한 정보를 유지하도록 한다. DQSP는 목적지로의 연결 수락 제어를 위한 QoS 신호 프로토콜이 필요 없이 에지 라우터에서 매 사용자 플로우별로 직접적으로 연결 수락 결정을 내리므로 확장성 문제 및 코어 라우터의 복잡한 기능 요구 사항 문제를 해결한다. 또한 UQSP는 에지 라우터가 트래픽 부하에 따라 자신에게 할당되어 있는 자원을 반납하거나 추가적인 자원을 제공받을 수 있도록 해 자원 오버 프로비져닝으로 인해 발생할 수 있는 비효율적인 자원 활용 문제를 해결한다. 또한 DQSP는 경로 재계산을 수행하여 라우팅을 조정해 나감으로써 효율적일 네트워크 자원 활용이 가능하다. 시뮬레이션을 통하여 DQSP와 기존의 자원 할당 및 공유 방식들을 비교한 결과 DQSP가 시그널링과 상태 정보 유지를 위한 오버헤드 면에서 기존의 종단간 QoS 보장을 제공하는 구조인 IntServ에서와 같은 확장성 문제를 발생시키지 않으면서도 효율적으로 네트워크 자원을 활용할 수 있음을 확인할 수 있었다.재 상용화 되어있는 Bellcore 의 S/KEY 시스템과의 비교를 수행하였다. 분석에서는 제품의 효율성뿐만 아니라 보안성을 중요하게 생각하였으며, 앞으로 보안 관련 소프트웨어 개발에 사용될 수 있는 도구들이 가이드 라인에 대한 정보를 제공한다.용할 수 있는지 세부 설계를 제시한다.다.으로서 hemicellulose구조가 polyuronic acid의 형태인 것으로 사료된다. 추출획분의 구성단당은 여러 곡물연구의 보고와 유사하게 glucose, arabinose, xylose 함량이 대체로 높게 나타났다. 점미가 수가용성분에서 goucose대비 용출함량이 고르게 나타나는 경향을 보였고 흑미는 알칼리가용분에서 glucose가 상당량(0.68%) 포함되고 있음을 보여주었고 arabinose(0.68%), xylose(0.05%)도 다른 종류에 비해서 다량 함유한 것으로 나타났다. 흑미는 총식이섬유 함량이 높고 pectic substances, hemicellulose, uronic acid 함량이 높아서 콜레스테롤 저하 등의 효과가 기대되며 고섬유식품으로서 조리 특성 연구가 필요한 것으로 사료된다.리하였다. 얻어진 소견(所見)은 다음과 같았다. 1. 모년령(母年齡), 임신회수(姙娠回數), 임신기간(姙娠其間), 출산시체중등(出産時體重等)의 제요인(諸要因)은 주산기사망(周産基死亡)에 대(對)하여 통계적(統計的)으로 유의(有意)한 영향을 미치고 있어 $25{\sim}29$세(歲)의 연령군에서, 2번째 임신과 2번째의 출산에서 그리고 만삭의 임신 기간에, 출산시체중(出産時體重) $3.50{\sim}3.99kg$사이의 아이에서 그 주산기사망률(周産基死亡率)이 각각

• Journal of the Korea Computer Industry Society
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• v.5 no.1
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• pp.131-146
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• 2004

As Electronic Commerce(EC) has been emerged and has developed, many researchers have tried to establish EC framework for automated contract and negotiation using agent technologies. Traditional researches, however, often had limitations. They often enforced the user's participations during the automated contract process of agents. They also could only consider a few of the user's requirements for a specific goods and did not have supported the procedures and methodologies for making the best contract. In this paper, we propose business model on EC based on multiagents to overcome the defects of the previous researches. We apply CSP techniques to brokerage process to satisfy various preferential requirements from the user. We also propose efficient negotiation mechanism using negotiation model of game theory. The contract candidates automatically negotiate and mediate in terms of their benefits through the proposed negotiation mechanism. For the optimal brokerage and automated negotiation, the agents process activities for contract on three layers, which are called competition layer, constraint satisfaction layer and negotiation layer in the proposed model. We also design the message driven communication protocol to support the automated contract among the agents. Finally, we have implemented prototype systems applying the proposed model and have shown the various experimental results for efficiency of the proposed model.

• Journal of the Korea Concrete Institute
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• v.18 no.5 s.95
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• pp.595-602
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• 2006

An experimental study was conducted to investigate seismic behaviour of post-tensioned(PT) exterior slab-column connections used for the purpose to resist gravity loads only. For these, 2/3-scale, two PT post-tensioned exterior connections with two different tendon arrangement patterns and one conventional reinforced concrete(RC) exterior connection was tested under quasi-static, uni-directional reversed cyclic loading. During the lateral testing, gravity forces transferred to the column were kept constant to closely simulate a moment to shear ratio of a real building. One of the objectives of this study was to assess the necessity and/or the quantity of bottom bonded reinforcement needed to resist moment reversal which would occur under significant inelastic deformations of the adjacent lateral force resisting systems. The ACI 318 and 352 provisions for structural integrity were applied to provide the bottom reinforcement passing through the column for the specimens. Prior test results were also collected to conduct comparative studies for some design parameters such as the tendon arrangement pattern, the effect of post-tensioning forces and the use of bottom bonded reinforcement. Consequently, the impact of tendon arrangement on the seismic performance of the PT connection, that is lateral drift capacity and ductility, dissipated energy and failure mechanism, was considerable. Moreover, test results showed that the amount of bottom reinforcement specified by ACI 352. 1R-89 was sufficient for resisting positive moments arising from moment reversal under reversed cyclic loads. Shear strength of the tested specimens was more accurately predicted by the shear strength equation(ACI 318) considering the average compressive stress over the concrete($f_{pc}$) due to post-tensioning forces than that without considering $f_{pc}$.

• Journal of Life Science
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• v.30 no.6
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• pp.501-512
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• 2020

Sasa quelpaertensis Nakai leaf has been used as a folk medicine for the treatment of gastric ulcer, dipsosis, and hematemesis based on its anti-inflammatory, antipyretic, and diuretic characteristics. We have previously reported the procedure for deriving a phytochemical-rich extract (PRE) from S. quelpaertensis and how PRE and its ethyl acetate fraction (EPRE) exhibits an anticancer effect by inducing apoptosis in various gastric cancer cells. To explore the molecular targets involved in this apoptosis, we investigated the mRNA and microRNA profiles of EPRE-treated SNU-16 human gastric cancer cells. In total, 2,875 differentially expressed genes were identified by RNA sequencing, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicated that the EPRE-modulated genes are associated with apoptosis, mitogen-activated protein kinase, inflammatory response, tumor necrosis factor signaling, and cancer pathways. Subsequently, protein-protein interaction network analysis confirmed interactions among genes associated with cell death and apoptosis, and 27 differentially expressed microRNAs were identified by further sequencing. Here, GO and KEGG pathway analysis revealed that EPRE modified the expression of microRNAs associated with the cell cycle and cell death, as well as signaling of tropomyosin-receptor-kinase receptor, transforming growth factor-b, nuclear factor kB, and cancer pathways. Taken together, these results provide insight into the mechanisms underlying the anticancer effect of EPRE.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.760-767
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• 2020

Sustainable growth of hydroelectric power plants is expected in consideration of climate change and energy security. However, hydroelectric power plants always have a risk of water hammer damage, and safety assurance is very important. The water hammer phenomenon commonly occurs during operations such as rapid opening and closing of the valves and pump/turbine shutdown in pipe systems, which is more common in cases of emergency shutdown. In this study, a computational numerical model was developed using the MOC-FDM scheme to reflect the mechanism of water hammer occurrence. The proposed model was implemented in boundary conditions such as reservoir, pipeline, valve, and pump/turbine conditions and then applied to simulate hypothetical case studies. The analysis results of the model were verified using the analysis results at the main points of the pipe systems. The model produced reasonably good performance and was validated by comparison with the results of the SIMSEN package model. The model could be used as an efficient tool for the safety assessment of hydroelectric power plants based on accurate prediction of transient behavior in the operation of hydropower facilities.

• Journal of KIISE:Information Networking
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• v.30 no.4
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• pp.461-473
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• 2003

Multimedia applications are much more sensitive to QoS(Quality of Service) than text based ones due to their data continuity. In order to provide a fast moving MH(Mobil Host) using multimedia application with a consistent QoS,an efficient call admission mechanism is in need. This paper proposes the 2SCA(2-Step Call Admission) scheme based on cal admission scheme using pripority to guarantee the consistent QoS for mobile multimedia applications. A calls of MH are classified new calls, hand-off calls, and QoS upgrading calls. The 2SCA is composed of the basic call admission and advanced call admission; the former determines the call admission based on bandwidth available in each cell and the latter determines the call admission by applying DTT(Delay Tolerance Time), PQeueu(Priority Queue), and UpQueue(Upgrade Queue) algorithm according to the type of each call blocked at the basic call admission stage. In order to evaluate the performance of our mechanism, we measure the metrics such as the dropping probability of new calls, dropping probability of hand-off calls, and bandwidth utilization. The result shows that the performance of our mechanism is superior to that of existing mechanisms such as CSP(Complete Sharing Policy), GCP(Guard Channel Policy) and AGCP(Adaptive Guard Channel Policy).

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.11
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• pp.846-850
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• 2009

Recently, wireless sensor networks have found their way into a wide variety of applications and systems with vastly varying requirements and characteristics such as environmental monitoring, smart spaces, medical applications, and precision agriculture. The sensor nodes are battery powered. Therefore, the energy is the most precious resource of a wireless sensor network since periodically replacing the battery of the nodes in large scale deployments is infeasible. Energy efficient mechanisms for gathering sensor readings are indispensable to prolong the lifetime of a sensor network as long as possible. There are two energy-efficient approaches to prolong the network lifetime in sensor networks. One is the compression scheme to reduce the size of sensor readings. When the communication conflict is occurred between two sensor nodes, the sender must try to retransmit its reading. The other is the MAC protocol to prevent the communication conflict. In this paper, we propose a novel approaches to reduce the size of the sensor readings in the MAC layer. The proposed scheme compresses sensor readings by allocating the time slots of the TDMA schedule to them dynamically. We also present a mathematical model to predict latency from collecting the sensor readings as the compression ratio is changed. In the simulation result, our proposed scheme reduces the communication cost by about 52% over the existing scheme.

• Journal of Dairy Science and Biotechnology
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• v.32 no.1
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• pp.17-29
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• 2014

GRAS probiotics can be used to modulate intestinal microbiota and to alleviate various gastrointestinal disorders. In several recent studies, researchers have explored the potential expansion and usability of probiotics to reduce the risk factors associated with diseases, including obesity, hypercholesterolemia, arterial hypertension, hyperhomocysteinemia, and oxidative stress. In this review, our aim was to clarify the mechanism underlying interactions between hosts (animal or human) and probiotics and the beneficial effects of probiotics on human health.

• KEPCO Journal on Electric Power and Energy
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• v.5 no.3
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• pp.209-213
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• 2019

Recently, demand for high energy density and long cycling stability of energy storage system has increased for application using with frequency regulation (F/R) in power grid. Supercapacitor have long lifetime and high charge and discharge rate, it is very adaptable to apply a frequency regulation in power grid. Supercapacitor can complement batteries to reduce the size and installation of batteries. Because their utilization in a system can potentially eliminate the need for short-term frequent replacement as required by batteries, hence, saving the resources invested in the upkeep of the whole system or extension of lifecycle of batteries in the long run of power grid. However, low energy density in supercapacitor is critical weakness to utilization for huge energy storage system of power grid. So, it is still far from being able to replace batteries and struggle in meeting the demand for a high energy density. But, today, LIC (Lithium Ion Capacitor) considered as an attractive structure to improve energy density much more than EDLC (Electric double layer capacitor) because LIC has high voltage range up to 3.8 V. But, many aspects of the electrochemical performance of LIC still need to be examined closely in order to apply for commercial use. In this study, in order to improve the capacitance of LIC related with energy density, we designed new method of pre-doping in anode electrode. The electrode in cathode were fabricated in dry room which has a relative humidity under 0.1% and constant electrode thickness over $100{\mu}m$ was manufactured for stable mechanical strength and anode doping. To minimize of contact resistance, fabricated electrode was conducted hot compression process from room temperature to $65^{\circ}C$. We designed various pre-doping method for LIC structure and analyzing the doping mechanism issues. Finally, we suggest new pre-doping method to improve the capacitance and electrochemical stability for LIC.