• Korean Journal of Food Science and Technology
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• v.46 no.4
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• pp.516-521
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• 2014

The mechanisms underlying the refractory effects of flutamide, a first-line oral anti-androgen drug, have not been entirely elucidated. In the present study, we investigated the mechanism of flutamide-induced hormone-refractory prostate cancer cell growth and its modulation by resveratrol, a phytoalexin present in grapes. Resveratrol significantly attenuated interleukin 6 (IL-6)-induced signal transducer and activator of transcription 3 (STAT3) transcriptional activity and dihydrotestosterone (DHT) or IL-6-induced prostate-specific antigen (PSA) transcriptional activity. Furthermore, compared to treatment with DHT or IL-6 alone, combination treatment of cells significantly increased PSA transcriptional activity, and resveratrol markedly diminished DHT plus IL-6-induced STAT3 and PSA transcriptional activities. Thus, the inhibitory effects of resveratrol on IL-6-, DHT-, and flutamide-induced hormone-refractory prostate cancer cell growth are partly mediated by the suppression of STAT3 reporter gene activity, suggesting that resveratrol represents a promising therapy for prostate cancer.

• Korean Journal of Remote Sensing
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• v.28 no.1
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• pp.121-128
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• 2012

High resolution intertidal DEM is a basic material for science research like sedimentation/erosion by ocean current, and is invaluable in a monitoring of environmental changes and practical management of coastal wetland. Since the intertidal zone changes rapidly by the inflow of fluvial debris and tide condition, remote sensing is an effective tool for observing large areas in short time. Although radar interferometry is one of the well-known techniques for generating high resolution DEM, conventional repeat-pass interferometry has difficulty on acquiring enough coherence over tidal flat due to the limited exposure time and the rapid changes in surface condition. In order to overcome these constraints, we tested the feasibility of radar interferometry using Cosmo-SkyMed tandem-like one-day data and ERS-ENVISAT cross tandem data with very short revisit period compared to the conventional repeat pass data. Small temporal baseline combined with long perpendicular baseline allowed high coherence over most of the exposed tidal flat surface in both observations. However the interferometric phases acquired from Cosmo-SkyMed data suffer from atmospheric delay and changes in soil moisture contents. The ERS-ENVISAT pair, on the other hand, provides nice phase which agree well with the real topography, because the atmospheric effect in 30-minute gap is almost same to both images so that they are cancelled out in the interferometric process. Thus, the cross interferometry with very small temporal baseline and large perpendicular baseline is one of the most reliable solutions for the intertidal DEM construction which requires very accurate mapping of the elevation.

• Journal of the Korean earth science society
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• v.22 no.1
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• pp.30-39
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• 2001

To consider the distribution of the surface sediments and sedimentary processes in tidal flat after the construction of sea-walls in the semiclosed Muan Bay, the southwest coast of Korea, studies on the sediments and sedimentation rates along two transect lines from February 1999 to March 2000 were carried out. The surface sediments in the bay are classified into 5 facies on the basis of textural parameters. The gravelly sediments including the cobbles and pebbles deposited in the bay-mouth are relic sediments which are formed in nearshore and fluvial environments at the low stand of sea level. In addition, it is considered that the muddy sediments widely distributed on the tidal flat might be originated from suspended matter transported from several rivers and/or offshore. Although the sedimentation rates on the tidal flat vary with season, their estimation rates are -8.9 mm/yr on Line-GR and -48.9 mm/yr on Line-YH, respectively. The erosion-dominated processes in the tidal flat would be caused by strengthened ebb tides due to the decrease of tidal choking at Mokpogu and the migration of tidal currents at the bay-mouth. The hydrodynamical changes mentioned above are interpreted to be occurred after/before the construction of sea-dike/sea-walls in coastal zone of Mokpo.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.30 no.6
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• pp.286-297
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• 2018

In the present study, wave measurements at KOGA-W01 were analyzed and then the numerical wind waves simulations have been conducted to investigate the characteristics of wind waves in the Yellow sea. According to the present analysis, even though the location of the wave stations are close to the coastal region, the deep water waves are prevailed due to the short fetch length. Chun and Ahn's (2017a, b) numerical model has been extended to the Yellow Sea in this study. The effects of tide and tidal currents should be included in the model to accommodate the distinctive effect of large tidal range and tidal current in the Yellow Sea. The wave hindcasting results were compared with the wave measurements collected KOGA-W01 and Kyeockpo. The comparison shows the reasonable agreements between wave hindcastings and measured data, however the model significantly underestimate the wave period of swell waves from the south due to the narrow computational domain. Despite the poorly prediction in the significant wave period of swell waves which usually have small wave heights, the estimation of the extreme wave height and corresponding wave period shows good agreement with the measurement data.

• Journal of the Korean Society for Marine Environment & Energy
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• v.12 no.4
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• pp.264-272
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• 2009

Due to an oil spill accident occurred in Taean coastal zone wide range of coastal waters were polluted. Inaccurate prediction of spilled oil trajectory is known as a cause that has increased the pollution damage in the beginning stage. In this study, a numerical modeling of spilled oil dispersion has been conducted to know which physical factors caused the severe and wide pollution. Especially the simulation is focused on how to model hydrodynamic circulation accurately. The simulation results showed that the hydrodynamic flow is very important in predicting oil fate, specially, in the short-term dispersion of spilled oil.

• Journal of Digital Convergence
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• v.10 no.9
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• pp.449-456
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• 2012

The college students who have relatively weak academic background feel more difficult in learning programming language grammars and programming skills in introductory course. At the end of semester, most of students had the negative attitude to programming and only a few students could write the programs for the given problems because they spent most of time to learn grammars instead of learning problem solving skills and logics. In this study, we propose to use Scratch in introductory programming course to help students to understand grammars and problem solving skills. It's necessary to educate first-time programmers how to solve the problems before they learn grammars of the programming language in their first programming language course. This paper shows that Scratch allows students not only to learn problem solving skills in programming but also to motivate students themselves in the class.

• Journal of Advanced Marine Engineering and Technology
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• v.35 no.1
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• pp.126-132
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• 2011

With the worldwide trend of controlling the utilization fossil fuels inducing global climate change, many efforts will have to be made on securing stable supply of the energy due to UNFCCC. Tidal currents are a concentrated form of gravitational energy. Tidal current resource is significant, but limited locations. Technical and economic feasibility demonstration is the next needed step in the technology development process. So, we investigated overview of tidal in-stream energy in the sea near Wando, and then analytically estimated tidal energy resources and annual energy output of TECS arrays.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.6
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• pp.669-676
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• 2014

A three-way catalyst substrate for domestic passenger car satisfies the design criteria for exhaust gas exchange and pressure drop but does not have satisfactory thermal fatigue performance. Prefracture faults in this three-way catalyst substrate has often been discovered in vehicle repair or vehicle inspection facilities. This paper presents a thermal fatigue performance estimation method for a three-way catalyst substrate using a probabilistic strength reduction factor model. This method is superior to the thermal fatigue performance estimation method for a three-way catalyst substrate that uses a deterministic strength model.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.18 no.1
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• pp.63-68
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• 2006

Time series of waterline changes during a flood/ebb cycle can be utilized for supplementary data for measuring bottom topography. The waterlines extracted from consecutive images are substituted for depth contours using water level data. The distances between contours are quantified through a rectification image process. This technique is applied to the Keunpoolan beach in the Daeijak Island near Incheon. A camera monitoring technique supported by natural water level changes produces bottom topography with high precision. It is also less time consuming and more economical. The technique also can be utilized effectively to the physical modeling f3r measuring bottom changes in the three dimensional basin.

• Journal of Ocean Engineering and Technology
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• v.12 no.3 s.29
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• pp.1-8
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• 1998

The purpose of this study is to determine the distribution of the suspended matter caused by dredging at the northeastern part of Kwangyang Bay and to determine the effect of the single silt protector for it. According to the direction of the tidal current, six sampling stations were chosen from the dredging site to the southeast. At the high tide, the high concentration of the suspended matter was observed below the mid-depth near the dredging site. As the tidal currents were stronger. its concentrations below the mid-depth at the inner stations of the single silt protector were rapidly increased, but those of the outer stations did not show any significant change. The concentrations at the inner stations of the silt protector at that time were from 20~140mg/l and those of the outer stations, which was only about 30 m apart from the inner station, were from 20~30mg/l. It suggests that the large amount of suspended matter caused by dredging were moved to the inner stations near the silt protector at the ebb tide and that the silt protector is very effective for the suspended matter.