• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.5
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• pp.2125-2132
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• 2012

Fluoxetine and tianeptine are commonly used as antidepressants (AD), and haloperidol and risperidone are widely used as antipsychotic drugs (APD), and it modulates various ion channels. TREK2 channel subfamily is very similar to physiological properties of TREK1 channel which can play important roles in the pathophysiology of mental disorders such as depression and schizophrenia, therefore, the pharmacological effect of psychiatric and depression drug on TREK2 channel may be similar to those of TREK1. Using the excised inside-out patch-clamp technique, we have examined the effects of APD and AD on cloned TREK2 channel expressed CHO cells. Fluoxetine (selective serotonin release inhibitor, SSRI) inhibited the TREK2 channel in a concentration-dependent manner ($IC_{50}$ $13{\mu}M$), whereas selective serotonin reuptake enhancer (SSRE) tianeptine increased without reducing the TREK2 channel activity. Haloperidol also inhibited the TREK2 channel in a concentration-dependent manner ($IC_{50}$ $44{\mu}M$), whereas even higher concentration ($100{\mu}M$) of risperidone did not completely inhibit on the activity. This study showed that TREK2 channel was preferentially blocked by fluoxetine rather than tianeptine, and inhibited by haloperidol rather than risperidone, suggesting differential effect of TREK2 channels by APD and AD may contribute to some mechanism of adverse side effects.

• 건강소식
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• v.24 no.4 s.257
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• pp.11-11
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• 2000

수면은 우리 삶의 많은 부분을 차지하는 중요한 삶의 영역이다. 그러나 여러 가지 원인으로 인하여 많은 현대인들이 수면의 즐거움을 제대로 누리지 못하고 있다. 미국의 경우 수면 장애에 의한 졸리움증으로 생기는 사회적ㆍ개인적 손실의 규모를 연간 약 150억 달러로 추정하고 있을 정도다. 우리나라 성인 중에 수면 장애의 하나인 불면증을 경험한 사람의 비율은 73.4%나 될 정도로 광범위하게 나타나고 있지만 정작 그 해결책을 찾지 못하고 있는 실정이다. 수면장애에는 크게 불면증을 보이는 수면 장애, 낮에 과도한 졸리움을 일으키는 수면 장애, 자다가 이상한 행동을 보이는 수면 장애로 구분되어지는데 우리가 일상에서 인식하는 수면 장애는 불면증 정도로 그치는 것이 일반적이다. 더욱이 이러한 수면 장애를 해결하는 방법의 이해 부족으로 수면제나 담배, 술 등에 의존하기 쉽고 단순히 잠을 자야 한다는 강박관념에 시달려 오히려 증상을 악화시키는 경우가 많다. 그러나 수면 장애를 올바르게 이해하고 있다면 그 해결 방안은 의외로 간단하다. 우리의 몸속에 있는 생체 시계의 주기를 규칙적으로 맞추어 가는 것이 중요하다. 또한 수면은 신체적인 요소보다는 정신적인 요소가 많이 작용하기 때문에 무엇보다도 편안한 마음가짐과 무의식적인 수면 유도가 필요하다. ('이달의 건강길라잡이'에 관한 자세한 내용은 건강길라잡이 홈페이지(http://healthguide.hihasa.re.kr)에 있습니다.)

• Proceedings of the Korea Contents Association Conference
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• 2014.11a
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• pp.437-438
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• 2014

오늘날 자살은 현대사회의 심각한 사회현상으로 인식되고 있다. 자살에 대한 역사적 이해와 성경의 자살 이야기들을 간략하게 다룬 다음 자살의 원인을 살펴보게 될 것이다. 자살문제에 대한 해법을 제대로 찾기 위해 반드시 필요한 것은 그 원인이 무엇인지에 대한 올바른 이해가 선재되어야 하기 때문이다. 학자들의 견해는 대략적으로 생물학적 원인, 정신과적 원인, 그리고 사회학적 원인 세 부류로 나눠진다. 논자의 주요 논지는 자살을 이런 요인들이 복합적으로 작용한 결과로 발생한다는 것이다. 이에 대한 해결책으로 성경의 생명존중을 기초로 한 세 가지 사실을 제시한다. 첫째, 하나님의 형상으로 창조된 인간의 생명은 고귀하다. 둘째, 인간은 궁극적 의미에서 영원한 생명이라는 희망의 미래를 조망해야 할 존재이다. 셋째, 자살은 범죄행위라기보다는 치료가 필요한 질병이라는 인식의 확산이 필요하다.

• Korean Journal of Environmental Biology
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• v.35 no.1
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• pp.21-36
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• 2017

Phthalates, known as typical endocrine disruptors, are plasticizers used to soften plastics such as polyvinyl chloride (PVC). Because of their material properties, phthalates are used extensively in the production of toys, flooring, wood processing, detergents, and even cosmetics as lubricants and perfume solvents. Due to their endocrine disrupting effect and other adverse health effects published, recently, phthalates have been regulated in many countries. Besides, in an effort to replace phthalates, several chemical plasticizers such as trioctyltrimellitate (TOTM) and dioctylterephthalate (DIOP) have been used instead of the existing harmful phthalates, and novel alternatives are continuously being developed. Nonetheless, phthalates are still being detected in several plastic products, and the safety of alternatives that are considered safe is being questioned. In this review, we describe the adverse health effects of phthalates, their regulation and the current status of their alternatives.

• Korean Journal of Cognitive Science
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• v.27 no.4
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• pp.501-539
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• 2016

The human mind is a self-evolving system that develops along a multidimensional hierarchical pathway in response to traumatic stimulus. In absence of trauma, a mind integrated in conflict-free state is called monistic. When the monistic mind responses to a traumatic stimulus, a response polarity forms toward stimulus polarity within the mind, turning it into a bipartite structure. Dialectical interaction between the two opposites, originating from their incompatibility, creates a new third polarity in the upper dimension. Thereby, the mind turns into a trinity structure. When the interaction among the three polarities becomes optimized, the plasticity of the mind gets maximized into the "far-from-equilibrium state," and the function of three polarities is synchronized. Through this recalibration, the mind returns back to its monistic structure. If the mind with the recurred monistic structure responds to another traumatic stimulus, this cycle of hierarchical transformation repeats itself in this cyclical and fractal growth process through synchronization of basic trinity system. Applying this concept to the process of post-traumatic growth (PTG), this paper explores how the mind transforms traumatic experiences into PTG and proposes a 'PTG Clock' that shows a fundamental sequence in the development of the human mind. The PTG Clock consists of seven hierarchical phases, and each of the first six phases has two opposite sub-phases: shocked/numbed, feared/intrusive, paranoid/avoidant, obsessional/explosive, dependent/depressive, and meaningless/searching for meaning. The seventh, the synchronization phase, completes one cycle of the mind's transformation, realizing a grand trinity system, where the mind synchronizes its biological, social, and existential dimensions. At that point, the mind becomes more susceptible to not only the stimulus of its own traumatic experience but also the pain of others. Thereby, the PTG Clock sets out on a journey to another cycle of transformation in higher dimensions. The validity of this transformational process for the PTG Clock will be examined by comparing it to Horowitz's theory of stress response syndrome.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.2
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• pp.35-48
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• 2016

Individual characteristics and entrepreneurship are important factors to determine entrepreneurial intentions. Despite this, little attention has been given to external factors, which effects to venture start-up decision. This study examines the relationship between individual characteristics and entrepreneurship by moderating effect of Hofstede's cultures dimensions theory. For this, 244 copies of the questionnaire were empirically analyzed. According to the results of analysis, internal locus of control, self-efficacy were found to have positive effects on autonomy, innovativeness, pro-activeness. In addition, uncertainty avoidance of Hofstede's cultures dimensions theory were found the moderating effects on entrepreneurship and entrepreneurial intentions. Therefore, this study suggests theoretical and practical implications, as below, according to the results. Firstly, pro-activeness take a important part on venture start-up. Thus, venture start-up institution and venture managers need to develop "venture education curriculum" that fostering the pro-activeness mind of entrepreneur. Secondly, In order to anticipate entrepreneurial intentions more precisely, analyzing the interaction between environmental variables and individual variables is desirable. Lastly, in the future study of entrepreneurship, the comprehensive analysis of correlation between the factors that including three factors of entrepreneurship is need to be conducted and more effective way of readdressing the entrepreneurship is necessary.

• Korean Journal of Psychosomatic Medicine
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• v.7 no.2
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• pp.263-273
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• 1999

Headache is a symptom with varied etiologies and extraordinarily frequent. Headaches can be a symptom of another diseases, such as meningitis, subarachnoid hemorrhage or brain tumor, may represent the disease entity itself as the case in migraine. The international Headache Society criteria were the first to distinguish between primary and secondary headache disorders. When evaluating a patient who presents with headache, the physician abviously needs to identify or exclude the myriad conditions that can cause secondary headache and initial diagnostic workup should be considered. If patient meets the criteria for a primary headache disorder, treatment commonly initiated without additional neurodiagnostic tests. The headache type, its associated feature, and the duration and the intensity of the pain attack all can influence the choice of acute therapy in migraine. Pharmacologically, such as NSAIDs, combination analgesics, vasoactive antimigraineous drugs, neuroleptics, antidepressants, or corticosteroids. Other approches to managing headache include a headache diary to identify triggers, biofeedback, relaxation technique and behavioral modification. Daily preventive medication should be considered by his attack frequency and intensity, and maintained for 4 to 6 months. Tension-type headaches are distinguished between episodic and chronic tension-type headache, but physician must make sure that patient is not drug-overuse or independent during symptomatic abortive therapy or preventive medication. The most difficult headache patients to treat are those with chronic daily headache. They often have physical dependency, low frustration tolerance, sleep problems, and depression. So discontinuation of overused medication is crucial. New developments in migraine therapy are broadening the scope of abortive and prophylactic treatment choices available to the physician. The enhanced ease of the use of sumatriptan and DHE will likely increase patient compliance and satisfaction.

• Journal of Ethics
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• no.80
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• pp.1-30
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• 2011

Confucianism and Buddhism were compatible in the period of Goryeo Dynasty. And then, the rulers worshiped Confucianism and repressed the religious activity of the Buddhist monk in the early years of the Joseon Dynasty. But King Sejong planed to bring reconciliation between Confucianism and Buddhism. Especially on the ceremonies of mourning and sacrificial rituals, he always performed the two religious style. The reason of sticking to his amicable consciousness is as follows. Firstly, he thinks that both the theory of Confucianism and the religious spirit of Buddhism are very important for the building up the foundation of his Dynasty. Secondly, his mind has been of a same faith cure on the incurable disease. Therefor, when the Royal family is taken ill he must pray to Buddha for recovery from the first stage. Thirdly, he regards social conditions to be the most important and respect for man's life and dignity for the purpose of beneficent administration. But Joseon's government line was the anti-Buddhist policy. So, the policy came in the wake of a debate among King Sejong and Confucian government officials. However his harmonious mind was unchanged between Confucianism and Buddhism. After all, in the last phase of his life he was deeply religious on Buddhism. I think that King Sejong's amicable consciousness could make a contribution to overcome religious conflicts and to create a new political cultural form in the modern society

• Journal of Nutrition and Health
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• v.48 no.6
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• pp.519-529
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• 2015

Purpose: The purpose of this study was to examine the prevalence of food insecurity in Korean elderly and to analyze the health status as well as food and nutrient intakes according to food insecurity status. Methods: A total of 939 elderly subjects (over 65 years old) were used in our analysis from the fifth 2010 Korean National Health and Nutrition Examination Survey (KNHANES V-1). The variables consisted of general characteristics, physical and mental health, nutrient intake, rate of deficient intake of energy and nutrients compared with Dietary Reference Intakes for Koreans (KDRIs) and food quality and diversity according to the status of food insecurity. Food insecurity status was measured using a self-reported food security questionnaire on the dietary situation in the previous year, and participants were classified according to three groups: food secure group, mildly food insecure group, and moderately/severely food insecure group. Results: The proportion of the food insecure group was approximately 67% and the food insecure group had lower income and educational status than the food secure group. Food insecurity was associated with worse physical and mental health status after adjusting potentially confounding variables. The results showed that food insecurity in Korean elderly significantly affected mental health (including stress cognition, depression experience, and suicide thoughts) which exceeded stages of physical health. In addition, food insecurity showed significant association with low nutrient intake and high rate of deficient intakes of energy and nutrients compared with KDRIs, and a reduction of dietary quality and diversity was indicated in the food insecure group. Conclusion: This study concludes that the prevalence of food insecurity may affect the physical and mental health as well as dietary intake of the elderly Korean population. Therefore, food insecurity should be considered as an important public health issue in Korea.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.14 no.1
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• pp.12-25
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• 2003

Objectives：As increasing number of new antidepressants have been being introduced in clinical practice, pharmacological understanding has been broadened. These changes mandate new information and theories to be incorporated into the treatment process of children with depressive disorders. In light of newly coming knowledge, this review intended to recapitulate the characteristics of new antidepressants and to consider the pivotal issues to develope guidelines for the treatment of depression in childhood and adolescence. Methods：Searching the Pub-Med online database for the articles with the key words of 'new', 'antidepressants' and 'children' ninety-seven headings of review articles were obtained. The author selected the articles of pertinent subjects in terms of either treatment guideline or psychopharmacology of new antidepressants. When required, articles about the clinical effectiveness of individual antidepressants were separatedly searched. In addition, the safety information of new antidepressants was acquired by browsing the official sites of the United States Food and Drugs Administration and Department of Health and Human Services. Results：1) For the clinical course, treatment phase, and treatment outcome, the reviews or treatment guidelines adopted the information from adult treatment guidelines. 2) Systematic and critical reviews unambiguously concluded that selective serotonin reuptake inhibitors(SSRIs) excelled tricyclic antidepressants( TCAs) for both efficacy and side effect profiles, and were recommend for the first-line choice for the treatment of children with depressive disorders. 3) New antidepressants generally lacked treatment experiences and randomized controlled clinical trials. 4) SSRIs and other new antidepressants, when used together, might result in pharmacokinetic and/or pharmacodynamic drug-to-drug interaction. 5) The difference of the clinical effectiveness of antidepressants between children and adults should be addressed from developmental aspects, which required further evidence. Conclusion：Treatment guidelines for the pharmacological treatment of childhood and adolescence depression could be constructed on the basis of clinical trial findings and practical experiences. Treatment guidelines are to best serve as the frame of reference for a clinician to make reasonable decisions for a particular therapeutic situation. In order to fulfill this role, guidelines should be updated as soon as new research data become available.