• Journal of Life Science
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• v.21 no.2
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• pp.286-291
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• 2011

Hypoxia is a common condition found in a wide range of solid tumors and is often associated with metastasis and poor clinical outcomes. In the present study, we found that HIF-$1{\alpha}$ was induced by cobalt chloride (500 ${\mu}M$) treatment on human lung cancer cells, A549 and H460, for 24 hr. However, cobalt chloride (500 ${\mu}M$) did not affect cell proliferation of A549 and H460 in 48 hr. Cobalt chloride (500 ${\mu}M$) additionally induced epithelial-to-mesenchymal-like transition (EMT) such as reduced E-cadherin expression and increased ${\alpha}$-SMA expression. These results were confirmed by immunofluorecence experiment in H460 cells. E-cadherin was localized on the outer cell membrane. However, when the cells were treated with 500 ${\mu}M$ cobalt chloride for 24 hr, diffuse E-cadherin staining was observed, characteristic of a migratory mesenchymal phenotype. We also found that cobalt chloride induced integrin ${\beta}3$ expression and FAK phosphorylation in human lung cancer cells using western blotting and FACS anlaysis. Our data suggest that integrin ${\beta}3$-induced FAK phosphorylation may be developed into target molecules for blocking tumor metastasis.

• Journal of the Korean Geosynthetics Society
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• v.18 no.1
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• pp.39-53
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• 2019

Bi-directional pile load test (briefly called 'BDH PLT') cannot be performed at loading levels where ultimate bearing capacity could be assessed in field, it is not possible to precisely determine both ultimate load and yield load and under loading. Since the load is transmitted separately to the skin and the end unlike the static pile load test (briefly called 'SPLT') and the direction of loading on the skin is opposite, such methods could have a result different from actual movements of shafts. In this study, three-dimensional finite element method (briefly called '3D FEM') analysis was conducted from results of the BDH PLT, made with barret piles, which were large-diameter cast-in-place concrete piles, and the calculated design constants were applied to the 3D FEM analysis of the SPLT to interpret them numerically and then, actual behaviors of cast-in-place concrete piles were estimated. First, using the results of the BDH PLT with cast-in-place concrete piles, behaviors of the piles made by loading upwards and downwards were analyzed to calculate load-displacement. Second, the design constants, calculated by the 3D FEM analysis and the back analysis, were applied on the 3D FEM analysis for the SPLT, and from these results, behaviors of the SPLT through the BDH PLT was analyzed. Last, the results of the 3D FEM analysis of the SPLT through the BDH PLT was expressed in relationships as {A ratio of bearing capacity of the SPLT and of the BDH PLT (y)} ~ {A ratio of reference displacement and pile circumference (x)}, and they were all classified by reference displacement at 10.0 mm, 15.0 mm, and 25.4 mm.

• (The) Research of the performance art and culture
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• no.35
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• pp.203-227
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• 2017

In this thesis, I examined the characteristics of modernism in this work, focusing on the melodrama "Sarang ye soggo donye wulgo(means 'Crying in Love and Crying for Money')", which was popular in the 30s when the consciousness of modernity was overflowing. There has never been an example of a connection between modernism and drama in the 1930s. The characteristic of modernism is clearly embedded in the representative drama of "Sarang ye soggo donye wulgo(means 'Crying in Love and Crying for Money')" at that time. In the title "Sarang ye soggo donye wulgo(means 'Crying in Love and Crying for Money')". 'Don' reveals modern elements. 'Love' can be seen as revealing melodramatic elements. The flair of modern art, which is a background to reveal modern elements, is spread throughout the works. Hongdo fails to complete the relationship with his family, as well as with the couple. It became a person who accepted the modernistic phenomenon by showing the domination of matter. While the typical method of constructing conflicts in the pre-modern narrative works is horizontal and sequential, it can be said that it was in the form of a train station, while the post-modern era of narrative conflict formation from the 30s forms a plurality of conflicts simultaneously, can do. The fear of the ordinary people who see the reality that urban and western values are already rampant by attempting new contents that lead the change of values in "Sarang ye soggo donye wulgo(means 'Crying in Love and Crying for Money')" became a factor to transfer into internal conflict again.

• Journal of Life Science
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• v.34 no.4
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• pp.279-285
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• 2024

The zonula occludens (ZO) protein serves as a scaffolding protein, providing structural support at the junctions between cells and the cytoplasmic surface. It acts as a bridge between integral membrane proteins and the cytoskeleton. Besides its structural role, it also participates in regulating cell growth and proliferation. Recent studies have highlighted the involvement of ZO protein in various diseases, including cancer. Specifically, research has indicated that ZO protein influences the cancer microenvironment surrounding cancer cells, thereby facilitating their growth and development. ZO proteins exert diverse functions in the cancer microenvironment, impacting processes such as angiogenesis, inflammatory responses, the epithelial-mesenchymal transition, and interactions with mesenchymal stem cells. The specific mechanisms vary depending on the type of cancer and environmental conditions. Recent research unveiled several signaling pathways involving ZO protein, which could potentially impede cancer progression in the tumor microenvironment. Consequently, these insights open avenues for novel treatment strategies. While the numerous physiological, structural, and morphological roles of ZO protein have been observed at the cellular and in vivo levels, understanding the signaling mechanisms it operates in vivo and how these mechanisms influence the cancer microenvironment remains a challenge. In this review, we delineate the characteristics and regulatory mechanisms of ZO protein in the context of the cancer microenvironment. Additionally, we propose leveraging the properties of ZO protein to devise defense mechanisms within the cancer cell environment and provide an overview of its in vivo role.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.19 no.5
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• pp.492-501
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• 2007

Coastal disasters have become one of the most important issues in every coastal country. In Korea, coastal disasters such as storm surge, sea level rise and extreme weather have placed many coastal regions in danger of being exposed or damaged during subsequent storms and gradual shoreline retreat. A storm surge is an onshore gush of water associated with a tow pressure weather system, typically in typhoon season. However, it is very difficult to predict storm surge height and inundation due to the irregularity of the course and intensity of a typhoon. To provide a new scheme of typhoon damage prediction model, the scenario which changes the central pressure, the maximum wind radius, the track and the proceeding speed by corresponding previous typhoon database, was composed. The virtual typhoon scenario database was constructed with individual scenario simulation and evaluation, in which it extracted the result from the scenario database of information of the hereafter typhoon and information due to climate change. This virtual typhoon scenario database will apply damage prediction information about a typhoon. This study performed construction and analysis of the simulation system with the storm surge/coastal inundation model at Masan coastal areas, and applied method for predicting using the scenario of the storm surge.

• Journal of the Korean Society of Hazard Mitigation
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• v.1 no.1 s.1
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• pp.139-155
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• 2001

We investigate the vertical velocity models beneath the newly installed broadband seismic network of KMA (Korea Meteorological Administration) by using receiver function inversion technique. The seismic phases are primarily P-to-S conversions and reverberations generated at the two highest impedance interfaces like the Moho (crust-mantle boundary) and the sediment-basement contact. We obtained the teleseismic P-wave receiver functions, which were derived from teleseismic records of Seoul (SEO), Inchon (INCN), Tejeon (TEJ) , Sosan (SOS/SES), Kangnung (KAN), Ulchin (ULC/ULJ), Taegu (TAG), Pusan (PUS), and Ullung-do (ULL) stations. For Kwangju (KWA/KWJ) and Chunchon (CHU) stations, the Moho conversion Ps arrivals and waveforms of radial receiver functions are azimuthally inconsistent and unclear. From the receiver function inversion result, we found that crustal thickness is 29 km at INCN, SEO, and SOS (SES) stations, 28 km at KAN station in the Kyonggi Massif, 32 km at TEJ station in Okchon Folded Belt, 34 km at TAG, 33 km at PUS station in the Kyongsang Basin, 32 km at KWJ station (readjusted station by prior KWA station) included in the Youngdong-Kwangju Depression Zone, 28 km at ULC station in the eastern margin of the Ryongnam Massif, and 17 km at ULL station in the Ullung Island of the East Sea, respectively. The Moho configuration of INCN, SOS, KWJ, and KAN stations show a laminated smooth transition zone with a 3-5 km thick. The upper crusts(${\sim}5km$) of KAN, ULC, and PUS stations show complex structures with a high velocity. The unusually thick crusts are found at the TAG and PUS stations in the Kyongsang Basin compared to the thin (29-32 km) crust of the western part (INCN, SEO, SOS, TEJ, and KWA stations) The crustal thickness beneath Ullung Island (ULL station) shows the suboceanic crust with about 17 km thickness and complex with a high velocity layer of the upper crust, and the amplitudes of Incoming Ps waves from the western direction are relatively large compared to those from othor directions.

• Economic and Environmental Geology
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• v.44 no.5
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• pp.399-412
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• 2011

A DEM (digital elevation model) is produced using a digital topographic map and is now a commonly used tool in geologic surveys. This study aimed to clarify the relationship between knickpoints and faults in the Namdae stream by analyzing a DEM of the area. The Namdae drainage basin was divided into three subbasins (S1, S2 and S3) and their knickpoints developed for the middle to mid-upper regions were extracted from the DEM. The relative steepness Ks and concavity depending on the incision rate was higher in S1 than in S2 and S3 regions. We assumed that the incision rate caused by active erosion resulted from several faults crossing the basins rather than differences in rock types. There are 77 knickpoints in the Namdae drainage area, including the low-ranking branch, and 24 of thses are on the main river system (S1, S2, S3). Of these 77 knickpoints, 27 (38%) are matched by faults, and from the three basins, 13 (54%) correspond with faults, indicating that the knickpoints are connected closely with the faults. For example the average Ks (relative steepness), was 38.8, but in the overlapping area of the Samdang and Doocheon faults the Ks value was 42.99~43.39. We suggest that the faults resulted in geomorphic deformation such as the high-Ksn knickpoints. There was little evdence of relationship between the knickpoints and rock boundaries, with 54% of the knickpoints distributed on the S1, S2, and S3 subbasins. We concluded that the drainage basin knickpoints are the result of fault movement and are a type of geomorphologic deformation that could be useful for surveying Quaternary faults or fault extension.

• Journal of Music and Human Behavior
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• v.3 no.2
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• pp.29-44
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• 2006

Trust and understanding relationship promoted between a therapist and a client is the basic building block to successful recovery. Its importance is not only pertaining to the music therapy but also to counseling and psychological therapy. Because of its gnificance, broad spectrum of research has been conducted for quite a long time. Historically, researches have been focused on therapists or client's chological variables rather than emotional effects on each other that occur during the therapy session. Recently researchers turned their attention to emotional relationship between a therapist and a client. With recent advances in the field of music and psychological therapy, subsequent study has been conducted to investigate the role that music plays in the therapeutic relationship. For this research, eleven music therapy sessions were conducted for the adult females who are alcoholics. The first three sessions were of group therapy. Fourth to eleventh therapy session was done individually. Throughout the research case-by-case study has been conducted on the basis of the analysis of video and audio taped materials. Analysis depends heavily on its reference from the Amir's music research of 1990, which used Ferrara's seven phases of phenomenological study. Especially, verbal and nonverbal communications were closely analyzed in musical perspective. Research revealed that music and musical instruments act as a mediator between a therapist and a client. By doing so, it protects a therapist from unnecessary negative emotional displacements of a client and creates mutual reliability between a therapist and a client. Here, research suggests that music and musical instrument play a central role in building relationship between a therapist and a client, and it indicates that it has positive effect on treatment.

• Journal of Gastric Cancer
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• v.9 no.2
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• pp.51-56
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• 2009

Purpose: Peritoneal recurrence has been reported to be the most common form of recurrence of gastric cancer. Peritoneal recurrence can generally be suggested by several types of image studies and also if there is evidence of ascites or Bloomer's rectal shelf. It can be confirmed by explorative laparotomy, but diagnostic laparoscopy is a good alternative method and laparoscopic surgery has also been widely used. We reviewed and analyzed the ability of diagnostic laparoscopy to detect peritoneal recurrence or carcinomatosis, and especially for gastric cancer. Materials and Methods: We performed a retrospective review the 45 gastric cancer patients who were operated via diagnostic laparoscopy between 2004. 2. and 2009. 3. We analyzed the perioperative clinical characteristics and the accuracy of the diagnostic methods. Results: The study groups included 14 patients who had confirmed gastric cancer, but they suspected to have carcinomatosis, and 31 patients who had previously underwent gastric resection, but they suspected to have recurrence. The mean operation time was $44.1\pm26.9$ minutes and the mean postoperative hospital stay was $2.7\pm2.8$ days. There was one case of operation-related complication and no postoperative mortality occurred. The sensitivities for detecting peritoneal recurrence or carcinomatosis were 92.1% for diagnostic laparoscopy, 29.7% for detecting ascites and rectal shelf on the physical examination, 86.5% for abdominal computed tomography, 69.2% for PET CT and 18.8% for CEA. Conclusion: Diagnostic laparoscopy does not require a long operation time or a long hospital stay, and it showed a low complication rate in our study. It has high sensitivity for detecting peritoneal recurrence of gastric cancer. It can be an alternative diagnostic confirmative method and it is useful for deciding on further treatment.

• Radiation Oncology Journal
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• v.10 no.1
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• pp.7-14
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• 1992

Between August 1988 and December 1991, 24 patients with intracranial tumors were treated with stereotactic radiosurgery(RS) using a 10 MV linear accelerator at Severance Hospital, Yonsei University College of Medicine. There were 5 meningiomas, 3 craniopharyngiomas, 9 glial tumors, 2 solitary metastases, 2 acoustic neurinomas, 2 pineal tumors, and 1 non-Hodgkin's lymphoma. Ten patients were treated as primary treatment after diagnosis with stereotactic biopsy or neuroimaging study. Nine patients underwent RS for post-op. residual tumors and three patients as a salvage treatment for recurrence after external irradiation. Two patients received RS as a boost followed by fractionated conventional radiotherapy. Among sixteen patients who were followed more than 6 months with neuroimage, seven patients (2 meningiomas, 4 benign glial tumors, one non-Hodgkin's lymphoma) showed complete response on neuroimage after RS and nine patients showed decreased tumor size. There was no acute treatment related side reaction. Late complications include three patients with symptomatic peritumoral brain edema and one craniopharyngioma with optic chiasmal injury. Through this early experience, we conclude that stereotactically directed single high doses of irradiation to the small intracranial tumors is effective for tumor control. However, in order to define the role of radiosurgery in the management of intracraniai tumors, we should get the long-term results available to demonstrate the benefits versus potential complications of this therapeutic modality.