• Review of KIISC
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• v.34 no.2
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• pp.29-38
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• 2024

양자컴퓨터의 급속한 발전으로 인해 현재 사용되는 암호화 알고리즘들은 위협에 직면해 있다. 이를 대비하여 양자컴퓨터로부터 안전한 양자내성암호 알고리즘을 개발하기 위해 미국 NIST에서는 양자내성암호 표준화 공모전을 개최하여 최근 4개의 표준화 알고리즘이 선정되었다. NIST는 다양성을 위해 다른 기반 문제를 갖는 알고리즘 선정을 위해서 현재 4라운드를 진행하고 있다. 하지만 4라운드 후보군 알고리즘은 모두 공개키 알고리즘이 선정되어 전자서명 알고리즘에 대한 후보군 알고리즘은 존재하지 않아 NIST는 2023년 PQC 전자서명 추가 공모전을 개최하였다. 따라서 본 논문에서는 NIST PQC 전자서명 추가 공모전에 대해 소개하고, 1라운드에 진출한 알고리즘의 특징과 최신 동향을 살펴본다.

• Journal of Wetlands Research
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• v.16 no.2
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• pp.269-274
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• 2014

The purpose of this study is to compare CT (disinfectant concentration * time) values in removing the antibiotic resistance bacteria, antibiotic resistance gene and transfer of antibiotic resistance genes. Different concentration of chlorine(C) and contact time(T) according to the removal of antibiotic resistance was calculated for each. As a result, for the 90% removal of antibiotic resistant bacteria, around 176~353 mg min/L CT values are needed. For the removal of the antibiotic resistance gene, 195~372 mg min/L CT values are required. For the 90% reduction of antibiotic resistance gene transfer by chlorine disinfection, 187~489 mg min/L CT values are needed. Based on our results, higher CT value was required for removing antibiotic resistant genes rather than antibiotic resistance bacteria.

• Tuberculosis and Respiratory Diseases
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• v.64 no.6
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• pp.414-421
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• 2008

Background: Recently, in addition to multi-drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) has become rapidly growing public health threat. This study examined the clinical differences between pulmonary TB patients with extensively drug resistance (XDR) and multi-drug resistance (MDR) at the National Medical Center in Korea in order to determine the clinical characteristics associated more with XDR-TB than MDR-TB. Methods: Patients who received a diagnosis of culture-confirmed pulmonary TB and a drug sensitivity test (DST) for anti-TB drugs at the National Medical Center between January 2000 and August 2007 were enrolled in this study. The patients were identified into the XDR-TB or MDR-TB group according to the DST results. The clinical characteristics were reviewed retrospectively from the medical records. Statistical analysis for the comparisons was performed using a ${\chi}^2$-test, independent samples t-test or binary logistic regression where appropriate. Results: A total 314 patients with culture-confirmed pulmonary TB were included. Among them, 18 patients (5.7%) had XDR-TB and 69 patients (22%) had MDR-TB excluding XDR-TB. A comparison of the clinical characteristics, revealed the XDR-TB group to have a higher frequency of a prior pulmonary resection for the treatment of TB (odds ratio [OR], 3.974; 95% confidence interval [CI], 1.052~15.011; P value 0.032) and longer average previous treatment duration with anti-TB drugs, including a treatment interruption period prior to the diagnosis of XDR, than the MDR-TB group (XDR-TB group, 72.67 months; MDR-TB group, 13.09 months; average treatment duration difference between two groups, 59.582 months; 95% CI, 31.743~87.420; P value, 0.000). In addition, a longer previous treatment duration with anti-TB drugs was significantly associated with XDR-TB (OR, 1.076; 95% CI, 1.038~1.117; P value, 0.000). A comparison of the other clinical characteristics revealed the XDR-TB group to have a higher frequency of male gender, diabetes mellitus (DM), age under 45, treatment interruption history, cavitations on simple chest radiograph and positive result of sputum AFB staining at the time of diagnosis of XDR. However, the association was not statistically significant. Conclusion: Pulmonary TB patients with XDR have a higher frequency of a prior pulmonary resection and longer previous treatment duration with anti-TB drugs than those with MDR. In addition, a longer previous treatment duration with anti-TB drugs is significantly associated with XDR-TB.

• Review of KIISC
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• v.33 no.1
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• pp.41-49
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• 2023

다변수 이차식 기반 전자서명은 양자내성암호 중 짧은 서명 길이와 빠른 서명 생성 및 검증으로 인해 자원이 제한된 기기에 적합할 것으로 예상된다. SFLASH는 NESSIE 표준으로 선정되었으며, NIST 양자내성암호 표준 공모에 다수의 다변수 이차식 기반 서명이 제출되었다. 또한 HiMQ는 국내 TTA 표준으로 선정되었다. 이러한 다변수 이차식 기반 전자서명의 장점으로 인해 NSIT 양자내성암호 표준의 추가 전자서명 공모에도 다변수 이차식 기반 전자서명이 제출될 것으로 예상되며, 국내 양자내성암호 국가공모전에는 MQ-Sign이 1라운드 후보로 공개되었다. 본 논문에서는 대표적인 다변수 이차식 기반 전자서명에 대해서 살펴보고, 다변수 이차식 기반 전자서명의 표준화 동향에 대해 살펴본다.

• Ecology and Resilient Infrastructure
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• v.4 no.1
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• pp.34-43
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• 2017

The Naeseong Stream as a tributary of Nakdong River has conserved the unique structure and function of a typical sand-bed stream ecosystem. However, it is expected to change the stream bed environments and then the fish fauna in the downstream of the dam after the operation of the Yeongju Dam from 2016. We collected fishes and investigated their habitat environments from 2014 to 2016 in the downstream of the Yeongju Dam under construction in order to monitor changes in habitat environment, fauna and community structure of fishes in the Naeseong Stream. The size of the bed materials increased immediately downstream of the Yeongju Dam under construction. Before the operation of the Yeongju Dam, Zacco platypus was dominated and Opsarichthys uncirostris amurensis, Coreoleuciscus splendidus, Hemibarbus longirostris and Pseudogobio esocinus were sub-dominated according to the different sampling sites. Hemibarbus labeo, H. longirostris, Pseudogobio esocinus, Gobiobotia nakdongensis, Cobitis hankugensis and Leiocassis ussuriensis were found as a psammophilous fish specific to sand stream in the Naeseong Stream. At the downstream of the dam, the fish community was classified into a group of gravel-bed fishes such as Microphysogobio yaluensis, Coreoleuciscus splendidus and Coreoperca herzi and a group of sand-bed fishes such as Hemibarbus labeo, Cobitis hankugensis and Gobiobotia nakdongensis. These fish communities gradually tended to change from sand-bed fish community to gravel-bed fish community during the construction of the Yeongju Dam. Therefore, it is necessary to collect the baseline data for the stream ecosystem conservation in the sandy stream by continuously monitoring changes in the environment and fish in the downstream of the Youngju Dam.

• 보건세계
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• v.60 no.3
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• pp.34-37
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• 2013

결핵, 지금도 우리 주위에서 건강을 위협하는 중요 전염병이다. 매년 새로운 환자가 3만~4만여 명이나 발생하고 사망자도 2,300여 명에 이른다. 우리 나라는 정부와 민간이 함께하는 그간의 성공적인 결핵퇴치사업으로 분명히 결핵관리 모범국이 되었지만, 아이러니하게도 결핵의 발생률과 사망률은 전염병 질환 중 모두 1위다. 아직 갈 길이 먼 것이다. 이에 결핵연구원 측은, 무엇보다 가장 큰 문제점은 "전 세계 곳곳에서 여러 항생제에 동시에 내성을 보여 치료가 어려운 다제내성결핵, 광범위 내성결핵이 우리나라에도 적지 않다"는 사실을 지적한다.

• Clinical and Experimental Pediatrics
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• v.48 no.1
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• pp.40-47
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• 2005

Purpose : S. pneumoniae is one of major pathogens of community-acquired respiratory infections. The rate of antibiotic resistance to this organism has increased, and resistance to multiple antimicrobial agents in a single strain of S. pneumoniae may compromise the efficacy of empiric antimicrobial treatment commonly used for respiratory infections. We did this study to find out the penicillin resistant distributions and oral antibiotics susceptibility patterns against S. pneumoniae, isolated from pediatric patients with community-acquired respiratory infections in Korea. Methods : One hundred fifty six pneumococcal isolates obtained from pediatric patients with community-acquired respiratory infections such as acute otitis media(AOM), sinusitis and pneumonia between May 2000 to June 2003. And MICs of penicillin and oral antibiotics(amoxicillin, amoxicillin-clavulanate, cefaclor) were performed by broth microdilution methods according to the NCCLS(2003a). Results : Seventy eight percent of the isolates were resistant to penicillin. The isolates, collected from AOM patients showed the highest penicillin resistance(92.7%). The resistant rates of amoxicillin (16.7%) and amoxicillin-clavulanate(9.6%), based on susceptibility breakpoints established by the NCCLS, were markedly lower than these of penicillin. But, the resistant rate of cefaclor was very high, above 95%. Conclusion : We concluded that pneumococci isolated from study cases may be one of the world's highest penicillin resistant rates. But, amoxicillin and amoxicillin-clavulanate can be used as a first-line antibiotics. Finally, we hope that a continuous surveillance study to monitor resistant patterns of pneumococcal respiratory infections will be needed for the standard guidelines of empiric antibiotic treatment.

• The Journal of the Korean Society for Microbiology
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• v.21 no.4
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• pp.461-471
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• 1986

Shigella strains isloated in the Teagu area during the period from 1973 to 1985 were studied for species distribution, drug resistance, and R plasmids. Approximately 1,200 strains were isolated during this period, and most of them were classified into Shigella flexneri, S. sonnei occupied less than 20%, and S. dysenteriae and S. boydii were very rarely isolated. More than 95% of them were resistant to one or more of these drugs; chloramphenicol (Cm), tetracycline (Tc), streptomycin (Sm), sulfisomidine (Su), ampicillin (Ap), and trimethoprim (Tp). Strains resistant to kanamycin, nalidixic acid (Na), and rifampin (Rf) were rare, and no strain was resistant to cephaloridine, gentamicin, and amikacin. Approximately half of the isolates were resistant to drugs in 1973, but the rate of resistant strains increased to more than 95% from 1977. Strains resistant to the four drugs (Cm, Tc, Sm, and Su) occupied the majority of resistant strains until 1977, but the most prevalent multiplicity of drug resistance increased to six drugs (Cm, Tc, Sm, Su, Ap, and Tp) from 1978 with the marked increase of Ap- and Tp-resistant strains. Approximately 75% of them transferred resistance to Escherichia coli by conjugation, and the resistance was considered to be mediated by R plasmids. Almost all of them transferred the complete patterns of resistance to drugs except Na and Rf. However, among some strains of recent isolates, small numbers of segregants of transferred resistance were observed. The R plasmids in Shigella were mostly classified into Inc FII, and only small numbers into Inc B. Segregants were in most cases unclassified.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.11a
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• pp.290-292
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• 2021

양자 컴퓨터 기술의 발전에 따라 현재 사용되고 있는 암호 알고리즘과 시스템들이 위협받고 있다. 이러한 시대적 흐름에 따라 양자 컴퓨터로도 쉽게 해결할 수 없는 양자내성암호의 개발이 요구되고 있으며, 미국 NIST 에서는 양자내성암호의 표준화를 위한 공모전을 진행하고 있다. 본 논문에서는 공모전 최종 후보 중 하나인 NTRU 알고리즘을 가속화하기 위한 성능 분석을 진행하였다.

• Review of KIISC
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• v.33 no.1
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• pp.51-58
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• 2023

차세대 컴퓨터인 양자 컴퓨터는 현재 정보화시스템에서 널리 사용되고 있는 공개키 암호 시스템인 RSA와 Elliptic Curve Cryptography (ECC)의 안전성을 위협하고 있다. 특히 양자 알고리즘인 Shor 알고리즘은 RSA와 ECC가 기반하고 있는 수학적 난제들을 다항 시간 내에 해결할 수 있기 때문에 NIST에서는 양자컴퓨터 상에서 내성을 가진 공개키 암호 표준화 공모전을 개최하였다. 2022년도에 NIST에서는 4개의 3라운드 최종 표준화 알고리즘을 발표하였다. 이와 동시에, 4라운드 표준화 알고리즘을 진행함으로써, 공개키 분야에서 코드 기반 또는 아이소제니 기반의 새로운 암호 알고리즘을 추가로 표준화할 예정이다. 이에 본 논문에서는 NIST 양자 내성 암호 표준화 공모전 4라운드의 후보 알고리즘인 코드 기반 암호 Classic McEliece, BIKE, HQC와 아이소제니 기반 암호 SIKE의 최신 동향에 대해 확인해본다. 추가적으로, 해당 암호 알고리즘에 대한 분석 기법과 공격 사례에 대해 살펴보고록 한다.