• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.245-245
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• 2000

후각기는 후각신경과 삼차신경의 기능을 객관적이고 정량적으로 검사할 수 있는 기기로, 객관적으로 인정받을 수 있는 후각기의 제작에는 많은 어려움이 있기 때문에, 현재까지 후각신경과 삼차신경의 기능을 정확하게 측정할 수 있는 방법이 없었다. 그러나, 산업이 발달하고 공해가 더욱 심해질수록 후각의 변화가 생기고, 비강 내 질환이나, 공해물질 등에 의해 삼차신경이 민감한 반응을 일으키므로, 앞으로는 이 신경들의 측정이 중요할 것으로 여겨진다. 또한 각종 산업분야에서 이제까지 사람의 미각이나 후각에 의존하여 제품을 생산해오던 방법을 변화시켜 객관적인 수치를 이용하여 제품을 생산할 수 있다. 따라서 이번 연구에서는 사람이나 동물에게 다양한 후각물질을 원하는 정확한 농도로 투여하는 기기로, 온도와 습도를 사람의 신체 조건과 동일한 공기와 혼할하여 원하는 정확한 농도(ppm)의 후각 자극을 만들어 mass flow controller와 solenoid valve를 이용하여 square-shape의 자극모양이 되도록 한 후, 피검자에게 자극하여 전기생리학적 반응을 얻는 기기를 개발하였다.

• The Korean Journal of Physiology
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• v.23 no.1
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• pp.129-138
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• 1989

In an attempt to characterize the ventral root afferent fibers, arterial blood pressure responses to stimulation of the ventral root (VR) were observed in anesthetized cats. Effects of the morphine administered either intravenously or direct spinally and of the spinal lesions on the pressor responses were compared. Followings are the results obtained. 1) Stimulation of the VR with C-strength, high frequency stimuli evoked a marked pressor response. No depressor response, which had been reported during peripheral nerve stimulation, was observed during VR stimulation with low frequency. 2) Acute cervical spinalization abolished the pressor response, indicating the involvement of supraspinal mechanism. 3) The ascending spinal pathways of the pressor response were located in the dorsolateral funiculus bilaterally. 4) Intravenously administered morphine exaggerated the pressor response to VR stimulation, while direct spinally administered morphine suppressed it. From the above results it was concluded that the ventral root afferent fibers have more similar properties to muscular C-afferent fibers than to cutaneous C-fibers.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.40 no.2
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• pp.132-137
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• 2004

In order to assess electrophysiological responses of fish, a recording of Electroretinogram (ERG) was made on the dark-adapted eyes of anesthetized jack mackerel Trachurus japonicus in the strobe-flash frequency range of 1.7~25 Hz and in the intensity range of 56~415 lx.s. The amplitude change of the ERG is highest at the moment when the strobe light is irradiated and becomes weakest soon after, then gradually increases and becomes stable. The amplitude of the ERG by strobe flash frequencies looked stable tendency after about 12~17 minutes elapsed. During the test duration of 30 minutes, the maximum of amplitude change and stimulation amount over all the tested frequencies was found at 10 Hz. The reduction of the flash intensity caused the decrease in the amplitude and stimulation amount.

• Journal of the korean academy of Pediatric Dentistry
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• v.27 no.3
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• pp.400-409
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• 2000

This study used in vivo intracellular and extracellular field potential recording to evaluate the intrinsic membrane properties and connection pattern within facial nucleus. 1. There were four subdivisions of medial, intermediate, lateral, and dorsolateral in facial nucleus. 2. Principal cells in the facial nucleus was recorded from and filled with neurobiotin in anesthetized rats. The extent of their dendrites and the characteristics of cell body were examined. 3. Principal cells had a large amplitude action potential and afterhyperpolarization was followed a single action potential. 4. The response from facial motonucleus to electrical stimulation of the facial nerve was mainly a monophasic wave, with a latency of 1 msec, which was assumed to reflect antidromic activation of facial motoneurons. In some of rats the response in addition showed late components at a latency of about 7-8 msec, but its amplitude was small. 5 Most of cells exhibited accommodation of spike discharge upon depolarization of membrane by 0.8 nA for 400 ms. Our results support the hypothesis that there normally are weak connections between different parts of the facial motonucleus to explain pathophysiology of hemifacial spasm and facial naive paralysis.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.2
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• pp.420-429
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• 2004

It has been needed diagnosis technology of the EFG(Electro Functio Gram) measurement concept which is incorporated characteristic of modern science and biomedical engineering, because function abnormality diagnosis can't diagnose with visualization instruments or clinical pathology. The general diagnosis system(EFG system) has been developed to use basic diagnosis instrument that has reappearance, reliance and convenience using the functio diagnosis technology, in the field of western/oriental medicine. Also, we improved sticking electrode and simultaneous measurement method of the limbs 8CH, head 2CH to diagnose body circulation of Qi and acupoints for Oriental Medicine diagnosis/therapy. The result of clinical for adult man 20 persons, the EFG system can diagnose state of 12 meridians and autonomic nervous system. Therefore, in this paper, we designed of oriental medicine diagnosis system by bio-electric response with materialized H/W and S/W for 12 meridians state diagnosis of human body and system construction of the EFG.

• Proceedings of the KIEE Conference
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• 2008.04a
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• pp.139-140
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• 2008

휴대폰 전자파로 인해 두통, 불면증, 단기간의 기억력 소실 등의 신경 생리학적 증상을 호소하는 휴대론 전자파 과민증 (EHS, Electromagnetic Hypersensitivity) 환자들이 늘어나고 있다. 그러나 휴대폰 전자파 과민반응의 원인이 막연한 불안감 때문인지 혹은 전자파 노출로 인한 증상 인지에 대하여 확실하게 규명이 되지 않고 있다. GSM 방식의 휴대폰의 경우 전자파 노출 시 EHS 군을 대상으로 혈압, 맥박수 변화 등의 과민 반응에 대한 연구들이 수행되었으나 일반인과 EHS 군의 실험-대조군 연구로 생체신호, 자각증상 및 전자파 인지 여부에 대한 복합석인 연구와 CDMA 휴대폰 EHS 연구는 거의 없는 실정이다. 본 연구예서는 일반인 6명과 EHS 6명을 대상으로 30분간 300mW의 CDMA 휴대폰 전자파에 노출시 교감신경의 흥분을 나타내는 맥박, 호흡수, HRV(heart rate variability의 변화를 측정하였다. 그 결과, 일반인과 EHS 군 모두 전자파 노출여부에 따라 맥박, 호흡수, HRV의 변화가 없었다.

• Journal of Life Science
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• v.18 no.6
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• pp.814-825
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• 2008

Ascochlorin (ASC) is prenyl-phenol compound that was isolated from the fungus Ascochyta viciae. ASC reduces serum cholesterol and triglyceride levels, and suppresses hypertension, tumor development, ameliorates type I and II diabetes. Here, to better understand the mechanisms by which ASC regulates physiological or pathological events and induces responses in the pharmacological treatment of inflammation, we performed differential analysis of the proteome of the mouse macrophage RAW264.7 cells in response to ASC. In this study, we used a proteomic analysis of LPS-induced RAW264.7 cells treated by ASC, to identify proteins potentially involved in inflammatory processes. The RAW264.7 cell proteomes with and without treatment with ASC were compared using two-dimensional electrophoresis (2-D SDS-PAGE), matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS) and bioinformatics. The largest differences in expression were observed for the calreticulin (4-fold decrease), ${\beta}-actin$ (4-fold decrease) and vimentin (1.5-fold decrease). In addition, rabaptin was increased 3-fold in RAW264.7 cells treated with ASC. The expression of some selected proteins was confirmed by RT-PCR analysis.

• Science of Emotion and Sensibility
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• v.13 no.4
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• pp.721-732
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• 2010

As increasing of electrical device usage, social concerns about the possible effects of 60Hz electromagnetic fields (EMF) on human health have increased. The number of people with self-attributed electromagnetic hypersensitivity (EHS) who complain of subjective symptoms such as headache, insomnia etc. also increased. However, we don't know whether the EHS results from psychological factor or real perception to the electromagnetic field. In this study, we simultaneously investigated physiological changes(heart rate, respiration rate, heart rate variability, alpha and beta waves in EEG), subjective symptoms and perception accuracy to assess origins of subjective symptoms according to the EMF exposure. Experiment consists of real and sham sessions and 60Hz 12.5uT magnetic field was on(real) or off(sham) to 15 EHS and 16 nonEHS. As the results, EMF exposure did not have any effects on physiological parameters or subjective symptoms for both groups. There was also no evidence that EHS group perceived the EMFs correctly than the control group. Therefore, the origins of subjective symptoms is not the 60Hz magnetic field but psychological factors.

• Journal of the korean academy of Pediatric Dentistry
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• v.27 no.1
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• pp.7-14
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• 2000

Inhibitory cells are critically involved in shaping normal hippocampal function and are thought to be important elements in the development of hippocampal pathologies. The present study was carried out in hippocampal CA1 area in vivo to compare with hippocampal slice studies. Intracellular and extracellular recordings with or without bicuculline electrodes were obtained in the intact brain of anesthetized rats, and cells were intracellularty labelled with neurobiotin. Electrical stimulation of fimbria-fornix resulted in an initial short-latency population spike. In the presence of $10{\mu}M$ bicuculline, orthodromic stimulation resulted in bursts of population spikes. The amplitude of population spikes in the CA1 region increased with stimulus intensity, as did the number of population spikes when the field recording electrode contained $10{\mu}M$ bicuculline. We measured the level of excitability in the CA1 area, using a paired-pulse stimulus paradigm to evoke population spikes. Population spikes showed strong paired-pulse inhibition at short interstimulus intervals. Burst afterdischarges up to 400 ms were observed after paired-pulse stimulus. These result suggest that hippocampal CA1 inhibitory interneurons can affect the excitability of pyramidal neurons that can not be appreciated in conventional in vitro preparation.

• The Journal of Korean Physical Therapy
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• v.12 no.1
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• pp.49-56
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• 2000

The purpose of this study was to investigate the influnce of afferent stimuli, transcutaneous electrical nerve stimulation and ultra sound, on the electrdiagnostic study of normal subjects. Electrodiagnostic study was performed before and after the application of afferent stimulation of the right popliteal fossa on 18 healthy female volunteers. After the transcutaneous electrical nerve stimulation, there is no significantly change of latencies and amplitudes of SEP, H-reflex, peroneal nerve F-wave, and sensory nerve conduction. After the ultra sound, there is no significantly change of latencies and amplitudes of SEP, H-reflex, peroneal nerve F-wave, and sensory nerve conduction. Tibial nope F-wave and motor nerve shows prolonged latency after TENS and US (p<0.01). Ultrasound may have a similar mechanism of action compared to transcutaneous electrical nerve stimulation by having localized inhibitory effects of the peripheral nerve. However, further investigation is needed to assess their mechanism of action and the precise relevance of stimulation modality.