Journal of the korean academy of Pediatric Dentistry (대한소아치과학회지)
- Volume 27 Issue 1
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- Pages.7-14
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- 2000
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- 1226-8496(pISSN)
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- 2288-3819(eISSN)
ELECTROPHYSIOLOGICAL CHARACTERISTICS OF GABAERGIC INHIBITION IN THE HIPPOCAMPAL CA1 OF THE RAT IN VIVO
생체내 흰쥐 해마 CA1 세포에서 가바성 억제에 대한 전기생리학 특성
- Choi, Byung-Ju (Department of Dental Pharmacology, College of Dentistry, Kyungpook National University) ;
- Cho, Jin-Hwa (Department of Dental Pharmacology, College of Dentistry, Kyungpook National University) ;
- Kim, Young-Jin (Department of Pedodontics, College of Dentistry, Kyungpook National University)
- Published : 2000.02.29
Abstract
Inhibitory cells are critically involved in shaping normal hippocampal function and are thought to be important elements in the development of hippocampal pathologies. The present study was carried out in hippocampal CA1 area in vivo to compare with hippocampal slice studies. Intracellular and extracellular recordings with or without bicuculline electrodes were obtained in the intact brain of anesthetized rats, and cells were intracellularty labelled with neurobiotin. Electrical stimulation of fimbria-fornix resulted in an initial short-latency population spike. In the presence of
가바성 억제 신경세포는 해마의 정상적인 기능을 조절하는데 중요한 역할을 하며 해마 병변을 유발하는 중요한 요소이다. 본 연구는 in vivo 실험법을 사용하여 해마 CA1 영역에서의 전기 생리학적 반응을 측정함으로써 가바성 신경세포의 기능을 분석하고 이를 슬라이스 실험법과 비교하고자 하였다. Fimbria-fonix 전기자극시 전형적인 population spike가 나타났고
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