• 치위협보
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• s.41
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• pp.1-8
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• 2000

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.4
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• pp.18-44
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• 2017

Purpose: The object of this study was to observe the anti-climacterium activity of Gagamguibiondam-tang (GGOT) on ovariectomized (OVX) rats, a well-documented rodent models resembles with women postmenopausal climacterium symptoms, as including cardiovascular diseases, obesity, hyperlipidemia, osteoporosis, organ steatosis and mental disorders. Methods: In this study, anti-climacteric effects were evaluated separated into three categories; 1) anti-obese, 2) anti-uterine atrophy and 3) anti-osteoporotic effects. Five groups were used (8 rats in each group); sham control, OVX control, GGOT 500, 250 and 125 mg/kg administered groups. Twenty-eight days after bilateral OVX surgery, GGOT were orally administered, once a day for 84 days, and then the changes on the body weight and gain during experimental periods, serum estradiol levels, abdominal fat pad and uterus weights with histopathology of abdominal fat pads (total thickness and mean adipocyte diameters) and uterus (total, epithelial and mucosal thickness, percentages of uterine gland regions) for anti-obese and estrogenic effects. In addition, femur, tibia and fourth or fifth lumbar vertebrae (L4 or L5) wet, dry and ash weights, mineral density (BMD), bone strength (failure load), serum osteocalcin and bone specific alkaline phosphatase (bALP) contents, histological and histomorphometrical analyses - bone mass and structure with bone resorption, were monitored for anti-osteoporosis activity. Results: As a result of OVX, noticeable increases of body weight and gains, food and water consumption, weights of abdominal fat pad deposited in dorsal abdominal cavity, serum osteocalcin levels were demonstrated in this experiment with decrease of uterus, femur, tibia and L5 weights, serum bALP and estradiol levels. In addition, marked hypertrophic changes of adipocytes located in deposited abdominal fat pads, uterine disused atrophic changes, decreases of bone mass and structures of femur, tibia and L4 were also observed in OVX control rats with dramatic increases of bone resorption markers, the Ocn and OS/BS at histopathological and histomorphometrical analysis in this study as compared with sham-operated control rats, suggesting the estrogen-deficient climacterium symptoms - obese and osteoporosis were induced by OVX, respectively. However, these estrogen-deficient climacterium symptoms induced by bilateral OVX in rats were significantly inhibited by 84 days of continuous oral treatment of GGOT 500, 250 and 125 mg/kg, respectively. Especially, GGOT 500, 250 and 125 mg/kg showed clear dose-dependent inhibitory activities on the OVX-induced climacterium signs. Conclusion: The results suggest that oral administration of GGOT 500, 250 and 125 mg/kg has clear dose-dependent favorable anti-climacterium effects - estrogenic, anti-obese and anti-osteoporotic activities in OVX rats in this experiment.

• Bulletin of Korea Environmental Preservation Association
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• v.17 no.3
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• pp.64-65
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• 1995

• Journal of Veterinary Clinics
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• v.24 no.1
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• pp.35-37
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• 2007

Eight dogs were presented with anal sacculitis with purulent exudates and/or open in the right or left anal sac. Patient dogs, ranging in size from 3-to-8 kg, were treated with closed anal sacculectomies, in which the balloon of a Foley catheter (No. 6, 1.5 ml) was used to facilitate surgical dissection of the sac. In all cases, the Foley catheter successfully distended the anal sac during its removal. Clinical signs associated with the diseased anal sac were abated In the all dogs for a follow-up period of one-to-three months. Anal sacculectomy is a good therapeutic option for cases of chronic anal sacculectomy or impaction. The use of a small Foley catheter to distend the anal sacs during surgery was easy, Inexpensive, and successful.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.4
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• pp.16-38
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• 2018

Objectives: The objective of this in vivo study is to observe the anti-osteoporotic activities of Gojineumja aqueous extracts (GJEJ) on the ovariectomized (OVX) mice as compared to those of risedronate sodium (RES). Methods: Thirty five days after bilateral OVX, GJEJ was orally administered, for 35 days once a day and then the changes on the body weight and gain during experimental periods, femur weights, bone mineral density (BMD), bone strength (failure load), mineral contents - calcium (Ca) and inorganic phosphorus (IP), histological profiles and histomorphometrical analyses at sacrifice were conducted with serum biochemistry - osteocalcin contents and bone specific alkaline phosphatase (BALP) activities. And the results of GJEJ were compared with RES orally administered OVX mice. Results: As a result of OVX, noticeable increase of body weight and gains and serum osteocalcin levels, decrease of serum BALP activities, femur weights, femur Ca and IP contents, BMD and strength were observed as compared to those of sham control mice, respectively. Also, the decrease of all histomorphometrical indices indicating the bone mass and structure, and the increase of indices about resorption were also detected in the femur of OVX control. However, these estrogen-deficient osteoporotic signs were significantly and dose-dependently inhibited by 35 days of continuous oral treatment of GJEJ, at dose levels of 500, 250 and 125 mg/kg, respectively. Especially, GJEJ 500 mg/kg showed favorable inhibitory activities against estrogen-deficient osteoporosis symptoms induced by OVX as comparable to those of RES 2.5 mg/kg. Conclusions: The results in this study suggest that oral administrations of GJEJ have clear dose-dependent favorable anti-osteoporotic activities in OVX mice.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.293-293
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• 1994

본 연구에서는 Scutellariae Radix (黃芩)으로부터 분리한 다섯종의 플라보노이드와 그외 구조면에서 관심이 있는 아홉가지 관련 플라보노이드 물질들에 대한 브라디키닌 길항활성물 적출장관 및 여러 in vivo 실험을 통하여 검색하였다. 적출회장 및 자궁실험에 서는 검체들이 거의 모두 BK 길항효과를 나타내었고 특히 적출 자궁실험에서 skullcalflavone 11 와 2'-methoxyflavone이 40 $\mu\textrm{g}$/ml 농도에서 각각 90 및 87%의 억제율을 나타내어 가장 억제적이었다. in vivo 검색에서는 플라보노이드들과 양성대조약물로 사용된 마스피린은 각 실험개시 24시간 및 1시간전에 200 mg/kg의 용량으로 생쥐에게 경구투여하여 BK 길항활성을 비교하였다. 혈장일출, 초산으로 인한 신전반응 및 LPS-유도 septic shock 유발억제 실험에서 특히 2'-methoxyflavone은 신전반응 및 내독소 실험에서 거의 완전하게 억제효과를 나타내었다. 이러한 플라보노이드들은 펩타이드구조를 가진 BK길항제와 비교하여 효력을 낮으나 non-peptide구조로 인해 생리적조건에서 보다 안정한 물질로 연구될 가치가 있다. 본 실험에서는 또한 체내에서 BK와 그 생리작용이 아주 유사한 히스타민에 대한 길항제들중 피페라진핵을 지니고 있는 약물들에 대한 BK 억제효과를 검토해본 결과 homochlorcyclizine이 가장 큰 억제효과를 나타냈으며 이 물질의 해리함수는 6.25 이었고 correlation coefficient는 0.984 로 경쟁적 길항제 이었다. 반면 수용체 결합실험에서는 이 약물은 25%의 수용체결합 억제활성을 나타내었다.

• Journal of the korean academy of Pediatric Dentistry
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• v.39 no.1
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• pp.97-102
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• 2012

Odontoma is a mixed tumor formed by the overgrowth of ectodermal epithelial cells and mesodermal cells. It arises during normal tooth development and only grows to a certain level. It is not a true neoplasm and therefore it is considered as hamartomas. Odontomas are classified into compound and complex types based on morphology. Compound odontoma is commonly found in the anterior region of the maxilla, and has a radiopaque lesion that resembles small teeth. Usually, odontoma is treated by conservative surgical removal and there is little probability of recurrence. This paper describes three cases of compound odontoma diagnosed in children with 1 year of follow-up. These case reports present patients having eruption disturbance of primary and permanent teeth due to the presence of compound odontoma. In order to induce spontaneous eruption, conservative surgical removal was performed showing favorable results.

• Journal of Veterinary Clinics
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• v.28 no.5
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• pp.542-545
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• 2011

A 12-year-old Yorkshire Terrier bitch evaluated with vaginal prolapsed and vaginal bleeding. Abdominal sonography and radiography demonstrated abnormal enlargement of uterus in abdominal cavity. The dog had been submitted to the vaginal mass resection and the ovariohysterectomy. In gross examination, the vaginal mass was firm and multiple cysts were detected in both ovaries and uterine horns. In microscopic examination, vaginal fibroma, uteroovarian cystadenocarcinoma were revealed. To our knowledge, this report is a very rare case of multiple complex neoplasms in the genital organs of dog. These findings may contribute to study and enhance the knowledge on genital tumors.

• The Korean Journal of Zoology
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• v.30 no.3
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• pp.231-238
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• 1987

생쥐의 체장, 신장 및 혈청내 LDH 활성에 있어서 간장과 신장에서는 염화메틸수은 투여군과 염화 메틸수진-홍삼추출물 투여군의 총 LDH 활성치가 대조군에 비하여 감소되었으나 염화 메틸수은-홍삼추출물 투여군의 활성치는 염화메틸수기 투여군 보다 약간 감소되었다. 혈청에서는 염화 메틸수은 투여군의 LDH 활성치가 대조군에 비하여 2배로 크게 증가되었으며 염화 메틸수은홍삼추출물 투여군의 활성치는 대조군과 유사하였다. LDH isosyme의 전기영동상에 있어서 간장의 대조군과 염화 메틸수은-홍삼적출물 투여군에서는 5가지 LDH isoBym삐 모두 나타났으나 염화 메틸수진투여군에서는 LDH1 제외한 4가지 LDH isosyme 나타났다. 신장과 혈청에서는 3군 모두에서 5가지 LDH isozyme 나타났다.

• Food Science and Preservation
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• v.18 no.3
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• pp.383-389
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• 2011

This study was carried out to investigate the effects of Plantago asiatica L. extract on anti oxidative potential, free radical generation and the lipid levels in rats. Sprague-Dawley(SD) rats were divided into two groups based on their diet, as follows: the AIN-76 diet (control group), and the modified AIN-76 diet(cholesterol 0.5%) with 0.5% P. asiatica extract, for 7 weeks. The body weight and teed efficiency ratios of the two groups did not significantly differ. The antioxidative potentials more significantly increased in the group that was fed P. asiatica extract than in the control group(p<0.05). There was no difference in the rate of free radical generation, though. The weights of the organs, such as heart, kidney, liver, and spleen, of the rats in the two groups did not differ, though. The ratio of the HDL cholesterol to the total cholesterol in the P. asiatica group was significantly higher than that in the control group, and the other serum lipid parameters (total cholesterol, HDL cholesterol, triglyceride, and phospholipids) did not differ between the two groups. These results imply that supplementation with P. asiatica extract may improve the antioxidant potential and decrease the lipid levels in the blood.