• Journal of Life Science
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• v.31 no.1
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• pp.100-108
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• 2021

In the oral cavity, there are hundreds of microbial species that exist as planktonic cells or are incorporated into biofilms. The accumulation and proliferation of pathogenic bacteria in the oral biofilm can lead to caries and periodontitis, which are typical oral diseases. The oral bacteria in the biofilm not only can resist environmental stress inside the oral cavity, but also have a 1,000 times higher resistance to antibiotics than planktonic cells by genes exchange through the interaction between cells in the oral biofilm. Therefore, if the formation of oral biofilm is suppressed or removed, oral diseases caused by bacterial infection can be more effectively prevented or treated. In particular, since oral biofilms have the characteristic of forming a biofilm by gathering several bacteria, quorum sensing, a signaling system between cells, can be a target for controlling the oral biofilm. In addition, a method of inhibiting biofilm formation by using arginine, an alkali-producing substrate of oral bacteria, is used to convert the distribution of oral microorganisms into an environment similar to that of healthy teeth or inhibit the secretion of glucosyltransferase by S. mutans to inhibit the formation of non-soluble glucans. It can be a target to control oral biofilm. This method of inhibiting or removing the oral biofilm formation rather than inducing the death of pathogenic bacteria in the oral cavity will be a new strategy that can selectively prevent or therapeutic avenues for oral diseases including dental caries.

• Journal of the Korea institute for structural maintenance and inspection
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• v.26 no.2
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• pp.84-91
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• 2022

This study investigated the behavior of out-of-plane skewed moment connections that were designed as IMFs, as per the Korean standards. A total of 14 finite element models were constructed with the consideration of two types (single- and double-sided connections) and four levels of skew angle (0°, 10°, 20°, and 30°). The results indicated that the skewed connections considered in this study met the acceptance criteria for IMFs given by the codes. However, the load-carrying capacities of skewed connections were decreased as the skew angle increased. For the connection with a skew angle of 30°, the peak load was noted to be 13% less and the energy dissipation capacity could be 26% less than that of non-skewed connection. In addition, because of the skewed nature, the stress distribution in the skewed beam flange near the connection was asymmetric and the stresses were concentrated on the beam inner flange. Column twisting induced by the skewed configuration was very small and negligible in the beam and column combination considered in this study.

• Journal of the Korean Geotechnical Society
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• v.25 no.11
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• pp.105-115
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• 2009

The Jeju sand was sampled from the beach in Jeju Island and its basic properties were analyzed. The cementation effect of Jeju coastal sediments was evaluated from in-situ tests such as SPT, CPT, and the Suspension-PS test. It was shown from test results that the Jeju sand has high extreme void ratios due to the angularity of grains and the intra-particle voids of hollow particles, similar to typical calcareous sands. From cone penetration test in the calibration chamber, it was found that the cone resistance($q_c$)-relative density($D_R$)-vertical effective stress(${\sigma}_v'$) relation of Jeju sand almost matches that of high compressible quartz sand. However, the $q_C-D_R-{\sigma}_v'$ correlation suggested for uncemented Jeju sand overestimates the relative density of coastal sediments of Jeju Island due to the cementation effect. From the analysis of the relation of cone resistance, N value, and small strain shear modulus measured in-situ, it seems reasonable to assume that the coastal sediment of Jeju Island is a naturally cemented one.

• The Journal of Engineering Geology
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• v.34 no.1
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• pp.1-12
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• 2024

South Korea's mining industry was actively developed until 1980, but subsequent declining profitability forced many mines to close. Most of the abandoned mines are susceptible to persistent subsidence because of the length of time since mining ceased. Accurate prediction of the locations and times of subsidence is difficult; therefore, this study aims to apply continuum analysis to past cases of subsidence to establish a method of predicting the location and magnitude of future subsidence. The study area is an area of ○○ mining located between the Yangsan fault zone and the Moryang fault zone, in which three subsidence events occurred between 2005 and 2009. Drilling surveys and electrical resistivity surveys were performed at subsidence sites determined the distribution of strata, and through laboratory tests obtained the physico-mechanical properties of the rock. Numerical analysis of the results found that the plastic status area includes the areas of actual subsidence and that continuum analysis can also be used to predict the location and magnitude of subsidence caused by mine goaf.

• Radiation Oncology Journal
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• v.20 no.2
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• pp.155-164
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• 2002

Purpose : A ginkgo biloba extract (GBE) has been known as a hypoxic cell radiosensitizer. Its mechanisms of action are increase of the red blood cell deformability, decrease the blood viscosity, and decrease the hypoxic cell fraction in the tumor. The aims of this study were to estimate the effect of GBE on fractionated radiotherapy and to clarify the mechanism of action of the GBE by estimating the blood flow in tumor and normal muscle. Materials and Methods : Fibrosarcoma (FSall) growing in a C3H mouse leg muscle was used as the tumor model. When the tumor size reached 7 mm in diameter, the GBE was given intraperitoneally at 1 and 25 hours prior to irradiation. The tumor growth delay was measured according to the various doses of radiation (3, 6, 9, 12 Gy and 15 Gy) and to the fractionation (single and fractionated irradiation) with and without the GBE injection. The radiation dose to the tumor the response relationships and the enhancement ratio of the GBE were measured. In addition, the blood flow of a normal muscle and a tumor was compared by laser Doppler flowmetry according to the GBE treatment. Results : When the GBE was used with single fraction irradiation with doses ranging from 3 to 12 Gy, GBE increased the tumor growth delay significantly (p<0.05) and the enhancement ratio of the GBE was 1.16. In fractionated irradiation with 3 Gy per day, the relationships between the radiation dose (D) and the tumor growth delay (TGD) were TGD $(days)=0.26{\times}D$ (Gy)+0.13 in the radiation alone group, and the TGD $(days)=0.30{\times}D$ (Gy)+0.13 in the radiation with GBE group. As a result, the enhancement ratio was 1.19 ($95\%$ confidence interval; $1.13\~1.27$). Laser Doppler flowmetry was used to measure the blood flow. The mean blood flow was higher in the muscle (7.78 mL/100 g/min in tumor and the 10.15 mL/100 g/min in muscle, p=0.005) and the low blood flow fraction (less than 2 mL/100 g/min) was higher in the tumor $(0.5\%\;vs.\;5.2\%,\;p=0.005)$. The blood flow was not changed with the GBE in normal muscle, but was increased by $23.5\%$ ( p=0.0004) in the tumor. Conclusion : Based on these results, it can be concluded that the GBE enhanced the radiation effect significantly when used with fractionated radiotherapy as well as with single fraction irradiation. Furthermore, the GBE increased the blood flow of the tumor selectively.

• The korean journal of orthodontics
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• v.37 no.2 s.121
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• pp.98-113
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• 2007

Objective: The purpose of this study was to evaluate the displacement pattern and the stress distribution shown on a finite element model 3-D visualization of a dry human skull using CT during the retraction of upper anterior teeth. Methods: Experimental groups were differentiated into 8 groups according to corticotomy, anchorage (buccal: mini implant between the maxillary second premolar and first molar and second premolar reinforced with a mini Implant, palatal: mini implant between the maxillary first molar and second molar and mini implant on the midpalatal suture) and force application point (use of a power arm or not). Results: In cases where anterior teeth were retracted by a conventional T-loop arch wire, the anterior teeth tipped more postero-inferiorly and the posterior teeth moved slightly in a mesial direction. In cases where anterior teeth were retracted with corticotomy, the stress at the anterior bone segment was distributed widely and showed a smaller degree of tipping movement of the anterior teeth, but with a greater amount of displacement. In cases where anterior teeth were retracted from the buccal side with force applied to the mini implant placed between the maxillary second premolar and the first molar to the canine power arm, it showed that a smaller degree of tipping movement was generated than when force was applied to the second premolar reinforced with a mini implant from the canine bracket. In cases where anterior teeth were retracted from the palatal side with force applied to the mini implant on the midpalatal suture, it resulted in a greater degree of tipping movement than when force was applied to the mini implant between the maxillary first and second molars. Conclusion: The results of this study verifies the effects of corticotomies and the effects of controlling orthodontic force vectors during tooth movement.

• Journal of Korea Water Resources Association
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• v.45 no.2
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• pp.137-149
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• 2012

Field measurements of resistance to flow are analyzed for 739 rivers vegetated with grass (281 channels), shrubs (150 channels) and trees (308 channels). The measured distribution of Manning roughness coefficients ranges from 0.015~0.250 for grass, 0.016~0.250 for shrubs, 0.018~0.310 for trees. Significant trends are obtained between Darcy-Weisbach (or Manning roughness coefficients) and flow discharge, friction slope, and relative submergence. The regression equations for Darcy-Weisbach and Manning roughness coefficients in vegetated rivers are: $f_{veg}=0.436Q^{-0.363}$, $f_{veg}=3.305S_f^{0.508}$, and $n_{veg}=0.061Q^{-0.124}$, $n_{veg}=0.144S_f^{0.199}$, $V=5.3(h/d_{50})^{1/8.3}{\sqrt{ghS_f}}$, $\sqrt{8/f}(=V/u*)=5.75log(5h/d_{50})$, respectively. These semi-empirical relationships should be useful for hydraulic engineering practice.

• KSBB Journal
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• v.16 no.1
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• pp.87-94
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• 2001

The biosynthesis of Lovastatin, a cholesterol lowering agent formed by the filamentous fungus, cerulenin-resistant Aspergillus terreus mutant was studied in shake flasks and bioreactors. The lovastatin production could be improved by fed-batch under the limited condition of carbon source. The relationship between the fungal morphology and the lovastatin production was also examined during the fed-batch cultures. The fed-batch studies in shake flasks were carried out to find the optimum glucose feeding method, and the pulsed feeding of glucose from 3 days onward at 24 hours intervals was found to be optimal to increase the lovastatin production and reduce the average pellet size. When the pH was controlled at around 5.8 during the whole fermentation period, the lovastatin concentration reached 384 mg/L, which is much higher than the values obtained pH-uncontrolled and pH 7.4. The optimal glucose feeding strategies was found that 30 g/L of glucose was added initially in batch mode, and then fed-batch was conducted by continuous addition of glucose solution(180 g/L) from 72 to 240 hr at a rate of 1.2 mL/hr at $28^{\circ}C$, pH 5.8, 400 rpm, and 1.0 vvm. The lovastatin concentration of 547 mg/L was obtained in 168 hr. It was about 1.5 times higher than the value of the batch fermentation.

• The Journal of Engineering Geology
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• v.23 no.4
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• pp.457-465
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• 2013

We integrated and correlated datasets from surface and subsurface geophysics, drilling cores, and engineering geology to identify geological interfaces and characterize the joints and fracture zones within the rock mass. The regional geometry of a geologically weak zone was investigated via a fence projection of electrical resistivity data and a borehole image-processing system. Subsurface discontinuities and intensive fracture zones within the rock mass are delineated by cross-hole seismic tomography and analyses of dip directions in rose diagrams. The dynamic elastic modulus is studied in terms of the P-wave velocity and Poisson's ratio. Subsurface discontinuities, which are conventionally identified using the N value and from core samples, can now be identified from anomalous reflection coefficients (i.e., acoustic impedance contrast) calculated using a pair of well logs, comprising seismic velocity from suspension-PS logging and density from logging. Intensive fracture zones identified in the synthetic seismogram are matched to core loss zones in the drilling core data and to a high concentration of joints in the borehole imaging system. The upper boundaries of fracture zones are correlated to strongly negative amplitude in the synthetic trace, which is constructed by convolution of the optimal Ricker wavelet with a reflection coefficient. The standard deviations of dynamic elastic moduli are higher for fracture zones than for acompact rock mass, due to the wide range of velocities resulting from the large numbers of joints and fractures within the zone.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.05b
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• pp.482-486
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• 2005

불투수지역의 증가에 따른 도시지역의 비점오염원 해석 및 예측은 수자원 관리측면에서 중요성이 증가하고 있다. 그러나, 실측자료의 부족, 오염물질 발생경로의 불명확, 간헐성, 강우 및 유역특성에 따라 오염부하량 및 첨두농도 등의 변화가 심하므로 인하여 연구에 어려움이 많은 실정이다. 이를 극복하기 위해서는 장기적인 자료수집과 국내실정에 맞는 모형개발이 이루어져야 할 것이다. 따라서, 본 연구에서는 초기강우에 의한 수질항목별 오염부하량 및 농도계산이 가능한 ILLUDAS-NPS 모형을 개발하였다. 본 모형은 국내의 도시지역 유출해석에 주로 사용되는 ILLUDAS 모형에 건기 및 우기시의 수질해석 과정들을 추가하여 해석되어 진다. 건기시의 경우 유량 및 수질 계산은 계수지정법을 사용하였으며, 우기시의 경우 유량계산은 기존 ILLUDAS 모형의 알고리즘을 이용하였고, 수질 계산은 일일 오염물 축적법과 쓸림방정식을 적용하여 계산시간별 오염물질 부하량 및 농도 등을 계산하였다. 모형의 검정을 위하여 홍제천 시험유역의 총 3가지 강우사상을 대상으로 검토한 결과 총부하량, 첨두농도, 첨두농도 발생시간 등에서 전반적으로 실측치와 유사한 결과를 얻을 수 있었다. 또한, ILLUDAS-NPS 모형과 SWMM, STORM 등의 기존 도시유출$\cdot$수질 모형들에 의한 결과들의 비교에서 SWMM 모형과 다소의 차이는 있으나 대부분 잘 일치함을 확인할 수 있었다. 추후, 합리적이고 보다 정확한 비점오염 해석을 위하여 도시지역의 건거시 오염물질의 축적율 및 초기강우에 의한 오염물질 쓸림량 등에 관한 실험 및 현장자료 축적이 필요하다.월이 긴 것으로 나타났다. 이러한 현상은 유입수가 저수지로 유입되면서 초기수위가 높은 경우에 운동량이 상대적으로 많이 소멸되기 때문으로 판단된다. 또한 탁수층의 두께도 8월 성층의 경우가 상대적으로 큰 것으로 나타났다. 이는 중층의 8월 수온분포 또는 밀도분포가 상대적으로 균일하기 때문에 연직방향 이송$\cdot$확산이 많이 이루어졌기 때문으로 판단된다.이는 토성간의 침투속도 및 투수속도의 경향이 반영된 것이다. 경사에 따라서는 경사도가 증가할수록 지수적으로 감소하였으며 $10\% 경사일 때를 기준으로 $I(mm)=I_{10}{\times}1.17{\times}e^{-0.0164s(\%)}$로 나타났다. 같은 조건에서 강우량과 유거수의 관계는 $Ro_{10}(mm)=5.32e^{0.11R(mm)}(r^2=0.69)$로 나타났다. 이는 토양의 투수특성에 따라 강우량 증가에 비례하여 점증하는 침투수와 구분되는 현상이었다. 경사와 토양이 같은 조건에서 나지의 경우 역시 $Ro_{B10}(mm)=20.3e^{0.08R(mm)(r^2=0.84)$로 지수적으로 증가하는 경향을 나타내었다. 유거수량은 토성별로 양토를 1.0으로 기준할 때 사양토가 0.86으로 가장 작았고, 식양토 1.09, 식토 1.15로 평가되어 침투수에 비해 토성별 차이가 크게 나타났다. 이는 토성이 세립질일 수록 유거수의 저항이 작기 때문으로 생각된다. 경사에 따라서는 경사도가 증가할수록 증가하였으며 $10\% 경사일 때를 기준으로 $Ro(mm)=Ro_{10