• Journal of Korean Clinical Nursing Research
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• v.14 no.2
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• pp.103-114
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• 2008

Purpose: The purpose of this study was to investigate the level of QoL of the terminal cancer patients at home and to identify any influencing factors on QoL. Method: Subjects of this study consisted of 72 terminal cancer patients who were receiving home care nursing for more than 2 weeks in 6 general hospitals. Data were collected by a self-reporting questionnaire on QoL, pain, physical functioning, and symptom experience from Feb, 2006 to Dec, 2006. Data were analyzed by t-test, one way ANOVA, Pearson correlation coefficients, and multiple regression using SPSS Win 14.0. Results: Mean score of QoL was 98.6(230 in total). Except the level of family coping, general characteristics and disease related variables did not show significant difference in QoL. QoL was higher in the family with better coping, and QoL showed negative correlation with three types of pain, physical functioning, and symptom experiences. Least pain, physical functioning, and level of family coping explained QoL up to 26.7%. Conclusion: The QoL was closely related with pain, physical functioning, symptom experience, and family coping. And the least pain, physical functioning and level of family coping were important factors influencing on QoL of terminal cancer patients. However, some other variables influencing the QoL need to be investigated in the future.

• Research in Community and Public Health Nursing
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• v.25 no.2
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• pp.109-118
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• 2014

Purpose: This study examined the effectiveness of a forest-experience-integration intervention in community dwelling cancer patients. Methods: The study was done with a nonequivalent control group pretest-posttest design. The subjects of the present study were 53 community dwelling cancer patients who were registered in a community health center in Gyeongsangbuk-do. The subjects were divided into an experimental group (n=26) who participated in the forest-experience-integration intervention and a control group (n=27) who did not participate. Data were collected from May to June in 2011. Collected data were analyzed using SPSS PC+ 19.0 through $x^2$ test, and independent t-test. Results: There were significant differences between the groups in depression (t=-4.51, p<.001), self-regulation resilience (t=6.95, p<.001), interpersonal resilience (t=10.10, p<.001), positivity resilience (t=9.67, p<.001), and total resilience (t=13.93, p<.001) measurements. Conclusion: The forest- experience-integration intervention delivered to community dwelling cancer patients was an effective method for relieving depression and enhancing self-regulation resilience, interpersonal resilience, positivity resilience, and total resilience, and can be utilized as an effective nursing intervention for community dwelling cancer patients.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.19 no.2
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• pp.139-149
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• 2012

Purpose: The purpose of this study is to provide the basic data required for quality improvement of home health care nursing and development of nursing services for cancer patients by examining the frequency of practices, level of service needs and satisfaction for nursing services. Methods: The subjects were 231 patients who agreed in participating on this study and were receiving home health care nursing services by the home health care advanced practice nurse from two national hospitals and four subsidiary general hospitals, located in Seoul from September 30, 2008 to February 28, 2009. Data were analyzed by frequency, percentage, t-test and ANOVA, using SPSS WIN 12.0 program. Results: The most frequent practices were 'checking vital sign' and 'explaining what patient want to know.' Total service need had an average of 3.03 point and emotional domain showed the highest average of 3.44 point. Total satisfaction had an average of 4.23 point and satisfaction along diseases had the highest average of 3.65 point in case of non-metastasis cancer. Conclusion: The subjects were highly satisfied with home health care nursing services which gave positive effect to them. It will be helpful to give cancer patients physical and spiritual care complementally when home health care nurses provide nursing services.

• Journal of Korean Public Health Nursing
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• v.30 no.3
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• pp.420-433
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• 2016

Purpose: This study was performed to identify the nursing needs of home-dwelling breast cancer patients based on counseling contents. Methods: Descriptive research was conducted with content analysis. This study included 185 patients who underwent treatment for breast cancer in a tertiary hospital. The data were collected using personal counseling via telephone or face-to-face between March 2011 and July 2013. A total of 536 counseling contents were used in the analysis. Inductive content analysis was used to analyze the contents related to nursing counselling. Results: According to the results. the most frequently reported nursing needs was symptom management, followed by information needs and supportive intervention needs; symptom management needs included symptoms related to chemotherapy, daily living, surgery, and medication side effects; information needs included treatments, medication, clinical tests, and alternative therapies; and supportive intervention needs were related to emotional and social aspects. Conclusion: Our findings suggest that nursing interventions for home-dwelling breast cancer patients should be designed and provided with a consideration to these relevant nursing needs.

• Asian Oncology Nursing
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• v.3 no.1
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• pp.56-65
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• 2003

Purpose: The study was to develop psychoeducational intervention and identify its effect for symptom management of home cancer patient. Method: Study subjects were 24 patients in control group and 18 patients in experimental group. In experimental group, individualized psychoeducation was done after pretest and then continued to educate and consult through calling by telephone once a week for 4 weeks. The data were collected using several tools such as symptom distress by McCorkle(2000). Physical functioning, a part of Medical Outcome Study by Ware and Sherbouine(1992) and QOL- cancer patient version by Ferrell and Grant(1995) from 18th of Feb. to 30th of July. Data were analysed to ${\chi}^2$ test and t test using SAS VER8.12. Results: The mean score of symptom distress was 21.6 in experimental group and 24.2 in control group. Experimental group was shown lower score than control group. Physical functioning of experimental group was better as mean score 23.3 than 20.6 in control. Psychological wellbeing was 69.7 in experimental group and 66.1 in control group. Social wellbeing was 32.2 in experiment and 25.8 in control. Psychosocial wellbeing of experimental group was higher than control group. However there was no significant differernce between two groups among these variables. Conclusion: The psycho educational intervention was not made symptom mangement, physical functioning, and psycho social wellbeing improved but shown positive tendency. It is expected having a statistically significant finding if enlarged sample size and prolonged the intervention term in future. Therefore it is suggested psycho educational intervention study do repeatedly.

• Journal of Korean Public Health Nursing
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• v.27 no.1
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• pp.50-63
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• 2013

Purpose: The purpose of this research was to develop and evaluate the effects of an empowerment program. Method: We developed an 8-week empowerment program to decrease cancer symptoms and increase self-efficacy, self-esteem, and empowerment. This program includes aspects concerning self-knowledge and management, self-help groups, self-advocacy, resource network, and laughter therapy. We evaluated the effects of this program on 32 home-based cancer patients (one group pretest-posttest design). The data collection was performed from August 22, 2011 to October 13, 2011. Data were analyzed using the SPSS/WIN 18.0 program. Result: There were significant differences in self-esteem derived from the empowerment program. However, there were no significant differences in cancer symptoms, self-efficacy, and empowerment after the program. Conclusion: More research, using a control group pretest-posttest design that considers an appropriate intervention duration, is needed to more accurately examine the effects of the program. We expect this intervention to improve the empowerment of home-based cancer patients.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.188-188
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• 1994

GM-CSF는 생체내에서 백혈구의 형성을 조절하는 인자이기 때문에 골수이식을 한 환자 및 화학요법이나 방사선 치료를 받은 암환자에게서 발생하는 백혈구의 감소현상을 완화시키는 역활을 한다. 항암 보조 치료제로서 의학적 효능을 나타낼 것으로 간주되는 인체의 GM-CSF를 유전자 재조합 기술로 효모에서 발현, 정제하여 물리화학적 특성을 밝히고 역가를 측정하고자 하였다. 효모로부터 rhGM-CSF의 발현율을 상승시키기 위해 초 분비 돌연변이 균주를 선별하였고 발효 배지 조성의 차이에 따른 발현율도 비교 측정하였다. 정제된 rhGM-CSF(LBD-005)는 여러 물리화학적 특성조사를 통해 구조나 역가면에서 상대치와 거의 일치함을 보여주었다. LBD-005는 당화된 GM-CSF와 당화되지 않은 형태의 혼합물이므로 Con-A column등을 사용하여 분리하고자 하였다. 당화된 GM-CSF와 혼합물의 물리화학적 특성을 각각 조사하였으나 유사하였고 당화에 따른 역가의 차이도 없었음을 알 수 있었다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.66-66
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• 1993

혈액 세포 형성 과정인 조혈 작용은 콜로니 자극인자 (Colony Stimulating Factor, CSF)라 불리는 몇 종류의 당 단백질에 의해 조절된다. 이들 자극인자 중, GM-CSF는 다계통에 작용하는 조절인자로서 과립구와 거식세포의 생성을 조절한다고 알려져 있다 한편 GM-CSF는 생체내에서 백혈구의 형성을 조절하는 인자이기 때문에 골수이식을 한 환자 및 화학요법이나 방사선 치료를 받는 암환자에게서 발생하는 백혈구의 감소현상을 완화시키는 역할을 한다. 혈액의 보조화와 관련하여 의학적 효능을 나타낼 것으로 간주되는 GM-CSF를 유전자 재조합 기술로 효모에서 발현, 정제하여 물리화학적 특성 및 역가를 측정하는 것이 이 연구의 기본목적이다.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.65-69
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• 2011

Purpose: Normal pancreas has low uptake rate in $^{18}F$-FDG PET scan. However, it is possible to diagnose malignancy of pancreatic cancer which has high uptake rate. Many studies approve a high prevalence of diabetes in pancreatic cancer and if the blood glucose level (BGL) is over the normal range, FDG uptake will be decreased and there will be inconvenience for patients from the delay time to reduce the high BGL or could cause difficulty to arrange the schedule. Therefore, we studied the relation of BGL and image quality in pancreatic cancer on PET. Materials and Methods: A hundred patients had PET scan. The prevalence of pancreatic cancer and diabetes were evaluated using SPSS ver. 17. The fasting BGL of patients were examined and sorted as diabetes mellitus (DM) group and Non-DM group. For the evaluation, patients were divided into 3 groups (Non-DM, DM; BGL${\geq}7.0mmol/L$, and DM; BGL<7.0 mmol/L). The ROI was drown on Liver and Lung for the PET imaging analysis. Results: Fifty three male and forty seven female were in the patients. The average age was $60.1{\pm}13.5$. There were 36 patients (male: 22, female: 14, 36%) who had pancreatic cancer with DM. There were 15 patients who showed over 7.0 mmol/L in their fasting BGL and 85 patients who showed under 7.0 mmol/L in their fasting BGL. Among the Non-DM, DM; BGL${\geq}7.0mmol/L$, and DM; BGL<7.0 mmol/L, there was not a statistical significance (p>0.05). Conclusion: The prevalence of pancreatic cancer was comparatively high in this study. If the fasting BGL was slightly over the normal BGL, we believe it will not give a severe disturbance when the patients have PET scan. Furthermore, the examination schedule doesn't need to change and the inconvenience from the delay of patients preparation will be reduced.

• Journal of the Korean Society of Radiology
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• v.84 no.3
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• pp.606-614
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• 2023

Purpose This study aimed to evaluate the efficacy and safety of transcatheter arterial embolization (TAE) for bleeding due to uterine body cancer. Materials and Methods In this retrospective study, six patients with varying types of uterine body cancer who underwent TAE for bleeding control were investigated. Angiographic findings, cross-sectional images, TAE details, and clinical outcomes were studied. Technical and clinical success rates were calculated. Results The identified patients had endometrioid adenocarcinoma, sarcoma, and gestational trophoblastic neoplasia, and most were patients with advanced-stage cancer. In four patients, tumor bleeding presented as vaginal bleeding. Technical success was achieved in all seven TAE procedures in six patients. Two patients with recurrent masses who had undergone hysterectomy presented with hematochezia, and TAE was able to provide technical success in these patients as well. The clinical success rate was 50%, indicating bleeding control for > 1 week. Rebleeding was directly associated with death in one patient. On the following day, mild fever was observed in one patient. Conclusion TAE can be considered an effective and safe method of bleeding control for uterine body cancer, especially during critical periods throughout the disease course of patients with inoperable, advanced-stage cancer.