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Red Yeast Rice (Monascus purpureus) Extract Prevents Binge Alcohol Consumption-induced Leaky Gut and Liver Injury in Mice (알코올성 간 및 장 손상 마우스모델에서 홍국쌀 추출물의 항산화효과)

  • Gi-Seok Kwon;Dong-ha Kim;Hyun-Ju Seo;Young-Eun Cho;Jung-Bok Lee
    • Journal of Life Science
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    • v.33 no.2
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    • pp.183-190
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    • 2023
  • Red yeast rice, also known as Hong Qu and red Koji, has been used for a long time in Asian functional food and traditional medicine. It consists of multiple bioactive substances, which can potentially be used as nutraceuticals. Alcoholic liver disease (ALD) can range from simple steatosis or inflammation to fibrosis and cirrhosis, possibly through leaky gut and systemic endotoxemia. This study examined the liver and gut effects of red yeast rice (RYR) (Monascus purpureus) ethanol extract against binge ethanol-induced liver injury in mice. RYR extract was orally administered to C57BL/6N mice at a concentration of 200 mg/kg body weight per day for 10 days. Then, mice were administered binge alcohol (5 g/kg/dose) three times at 12 hr intervals. Binge alcohol exposure significantly elevated the endotoxin, aspartate aminotransferase (AST), and alanine transaminase (ALT) activity of plasma, as well as hepatic triglyceride levels; however, RYR treatments reduced these levels. In addition, RYR pretreatment significantly reduced the alcohol-induced oxidative maker protein and apoptosis maker in binge alcohol-induced gut and liver injuries. These results suggest that RYR may prevent alcohol-induced acute leaky gut and liver damage.

Real Estate Asset NFT Tokenization and FT Asset Portfolio Management (부동산 유동화 NFT와 FT 분할 거래 시스템 설계 및 구현)

  • Young-Gun Kim;Seong-Whan Kim
    • KIPS Transactions on Software and Data Engineering
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    • v.12 no.9
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    • pp.419-430
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    • 2023
  • Currently, NFTs have no dominant application except for the proof of ownership for digital content, and it also have small liquidity problem, which makes their price difficult to predict. Real estate usually has very high barriers to investment due to its high pricing. Real estate can be converted into NFTs and also divided into small value fungible tokens (FTs), and it can increase the the volume of the investor community due to more liquidity and better accessibility. In this document, we implement and design a system that allows ordinary users can invest on high priced real estate utilizing Black Litterman (BL) model-based Portfolio investment interface. To this end, we target a set of real estates pegged as collateral and issue NFT for the collateral using blockchain. We use oracle to get the current real estate information and to monitor varying real estate prices. After tokenizing real estate into NFTs, we divide the NFTs into easily accessible price FTs, thereby, we can lower prices and provide large liquidity with price volatility limited. In addition, we also implemented BL based asset portfolio interface for effective portfolio composition for investing in multiple of real estates with small investments. Using BL model, investors can fix the asset portfolio. We implemented the whole system using Solidity smart contracts on Flask web framework with public data portals as oracle interfaces.

Strategy and Technology for Digital Transformation of Design and Construction of RC Structures (철근콘크리트골조 설계와 현장관리 디지털전환 전략과 기술개발)

  • Chee Kyeong Kim
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.36 no.4
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    • pp.265-272
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    • 2023
  • This paper presents a conceptual strategy and technologies for the digital transformation of design and construction of reinforced concrete (RC) structures. The development of an automated detail design strategy for RC structures is described. Integrated digital platform based on 5D BIM concept is proposed for the replacement of the current technology environment-based 2D CAD. Generally, the detail design development is labor-intensive and iterative. Effective automation of relevant aspects can dramatically improve productivity and accuracy. The proposed solutions for the automated BIM modeling based on the rebar and formwork detail design automation achieves the productivity and accuracy sufficient for site application. The platform integrates and manages the information flow between each solution or application and provides it to all participants of the project. Finally, it is expected that the proposed strategy and technologies can be further enhanced to achieve the productivity and accuracy needed for widespread site application and digital transformation.

Relationship between Spatial Inclusivity and Social Participation According to Degree of Disability (장애 정도에 따른 공간적 포용성과 사회참여의 관계)

  • Kim, Si Hwa;Park, In Kwon
    • Journal of the Korean Regional Science Association
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    • v.39 no.3
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    • pp.65-83
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    • 2023
  • The purpose of this study is to conceptually define "spatial inclusivity" and empirically examine the impact of disability severity and spatial inclusivity on social participation among individuals experiencing physical discomfort. The social and spatial environment of the residential area is crucial for individuals with disabilities who face limited activity range and complex barriers due to physical constraints. In this study, spatial inclusivity from the perspective of people with disabilities is defined as establishment of equal relationships with non-disabled individuals within the local community, as well as the availability of basic facilities and services in a safe urban space that allows for access and utilization. This concept consists of three dimensions: individual networks, social environment, and physical environment. The physical environment encompasses safety levels, natural environment, living environment, public transportation conditions, medical services in residential areas. We used the 2019 Community Health Survey to examine the relationship between disability severity, spatial inclusivity, and social participation using a two level regression model. The findings are as follows: Firstly, personal relationships at the individual level and the physical environment at the local level have a positive impact on social participation. Secondly, when identifying dividing the physical environment into five sub-factors, no significant influence of individual factors is found. Thirdly, trustworthy and friendly social environment at the local level has a negative impact on social participation. These results provide empirical evidence that spatial inclusivity has an effect on the social participation of individuals with disabilities and suggest implications for urban planning to create and enhance conditions for the social participation of individuals with disabilities.

Development of an Automatic Tempo-Regulating Smartphone Application Using MIDI Playback Functions For Musical Instrument Practice (스마트폰 MIDI 재생 기능을 활용한 속도 증가 악기 연습 애플리케이션 개발)

  • Shim, In-Sup
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.8
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    • pp.143-150
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    • 2019
  • Playing musical instruments has long been a hobby enjoyed by many, whether amateur or professional. However, a lot of long and arduous practice is required if one wants to acquire the skills of musical artist and truly enjoy the pleasure of playing. This repetitive and tedious practice is often a hindrance to the process of learning a musical instrument, and numerous educators have put a lot of research and effort into making the process easier and more fun for students. In addition, various media practice tools are being developed to keep the students engaged and having fun. The core elements of this content primarily include controlling the speed of backing tracks in accordance with the skill level of students and providing a backing ensemble that enables them to enjoy the fun of playing. This paper studies and compares various MIDI playback techniques capable of controlling speed and pitch in smartphone applications. Modern applications of these techniques are seen in music educational contents, as well as entertainment contents. It also discusses the development and launching of Upbeat, a drum-loop metronome that automatically increases speed by applying different techniques to its respective smartphone operating systems, Android OS and iOS.

Comparisons of Awareness of Health Care Services and Characteristics in Persons with Speech-Language Disorder Related to Speech Therapy Use for Life Care : From National Survey of the Disabled Person of 2017 (라이프 케어를 위한 언어장애인의 언어치료 이용여부에 따른 특성 및 보건의료서비스 인식 비교 : 2017년 장애인 실태조사를 이용하여)

  • Kang, So-La;Moon, Jong-Hoon
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.3
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    • pp.249-258
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    • 2019
  • The health care services are the most basic social institutions that are provided to citizen including disabled persons for improvement of health. However, the study of the difference of health care services according to the speech therapy use in the people with speech-language disorders was insufficient. The aim of this investigation was to compare the awareness of health care services and characteristics of people with speech-language disorders according to speech therapy use. The researchers selected 229 people with language disorder using raw data of National Survey of the Disabled Person (2017). We compared the characteristics and health care services of people with speech-language disorders by distinguishing between speech therapy non-users and speech therapy users. Among the 229 people with language disorder, speech therapy users were 37 persons (16.2%). In comparison with non-users, users were younger, more preschoolers, more family incomes, and intellectual disabilities and autistic disorder were the most common types of disability enrollment. Users had a lower proportion of unmet medical needs than non-users. For the reasons of unmet medical need, there were 6.8% and 6.3% of the "economic reasons" and "communication difficulties" Both users and non-users responded that "disability management services" need to be strengthened by the government. In conclusion, we suggest that access to health care services needs to be increased to lower the barriers of speech therapy use.

Study of Hydrotreating and Hydrocracking Catalysts for Conversion of Waste Plastic Pyrolysis Oil to Naphtha (폐플라스틱 열분해유의 납사 전환을 위한 수첨처리 및 수첨분해 촉매연구)

  • Ki-Duk Kim;Eun Hee Kwon;Kwang Ho Kim;Suk Hyun Lim;Hai Hung Pham;Kang Seok Go;Sang Goo Jeon;Nam Sun Nho
    • Applied Chemistry for Engineering
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    • v.34 no.2
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    • pp.126-130
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    • 2023
  • In response to environmental demands, pyrolysis is one of the practical methods for obtaining reusable oils from waste plastics. However, the waste plastic pyrolysis oils (WPPO) are consumed as low-grade fuel oil due to their impurities. Thus, this study focused on the upgrading method to obtain naphtha catalytic cracking feedstocks from WPPO by the hydroprocessing, including hydrotreating and hydrocracking reaction. Especially, various transition metal sulfides supported catalysts were investigated as hydrotreating and hydrocracking catalysts. The catalytic performance was evaluated with a 250 ml-batch reactor at 370~400 ℃ and 6.0 MPa H2. Sulfur-, nitrogen-, and chlorine-compounds in WPPO were well eliminated with nickel-molybdenum/alumina catalysts. The NiMo/ZSM-5 catalyst has the highest naphtha yield.

The Translation of Korean Literature in Romania (루마니아에서의 한국문학번역: 실태와 개선점 및 번역교육에 대한 고찰)

  • Kwak, Dong Hun
    • East European & Balkan Studies
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    • v.43 no.1
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    • pp.3-30
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    • 2019
  • In order to understand the various cultural interactions caused by the wave of globalization, we need a proper lens that can observe and transmit correctly these phenomena. The result of understanding very differs depending on which lens is used. Translation can be regarded as a lens to communicate with each other in the world where language barriers exist. Literature is a kind of universal cultural heritage combined with the intellectual, artistic and social lifestyle of each society. Introducing this cultural complex, namely literature and impregnating people from other languages with the value of our Korean literature, begin with the correct translation. Translator should act as a literary missionary, not merely a simple communicator. The process of literary translation cannot be achieved by simple linguistic ability because it is a highly human scientific work that requires diverse talents from translators. The right translator for Korean literature in Romania is a person with diverse abilities and social experiences within the cultural framework of Korea and Romania. As the requirements of the translation environment from each country are different, the paradigm of foreign translation literature that Romania wants to accept may be very clear distinctively. With recognizing this characteristic environment of Romania, the value of Korean literature can be effectively spread in Romania. Translators are the creators of another original work. With this in mind, the education of Korean studies in Romania should pay more attention to the nurture of right and capable translators.

A study on game novel (게임소설 연구)

  • Ko, Hoon
    • Journal of Popular Narrative
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    • v.25 no.4
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    • pp.111-134
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    • 2019
  • Since This study is about game novel. I'm going to discuss the flow and features of game novels. Game novels developed in Korea, the game industry developed and made it possible. Fantasy novels, Muhyeop novels, and the generation of games met, so game novels could develop. By looking at the trends of game novels, I want to lay the foundation for the study of popular literature genre. The reason behind the emergence of game novels is the meeting of the game generation and the novel. The types of game novels can be distinguished according to the 'location of the main characters' and 'the narrative style'. It is not the best, but it is the minimum work to identify the genre. The biggest characteristic of game novels is their connection to games. It also uses the system of the real game. Another characteristic is that a variety of variations are possible with other genres. Game novels were influenced by fantasy novels and Muhyeop novels. Game novels now hold a solid place in the realm of popular literature. But the limits are also clear. It is the repeated use of game novel progression. Here are the limitations that game have to overcome. In addition, active research should be carried out. This study is intended to promote research on these game novel genres.

A Study on Audio-Visual Expression of Biometric Data Based on the Polysomnography Test (수면다원검사에 기반한 생체데이터 시청각화 연구)

  • Kim, Hee Soo;Oh, Na Yea;Park, Jin Wan
    • Korea Science and Art Forum
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    • v.35
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    • pp.145-155
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    • 2018
  • The goal of the study is to provide a new type of audio-visualization method through case analysis and work production based on Polysomnography(PSG) data that is difficult to interpret or not familiar to the public. Most art works are produced with conscious actions during waking hours. On the other hand, during sleep, we get into the world of unconsciousness. Therefore, through the experiment, want to discover if could get something new when we were in the subconscious state, and if so, wondered what kind of art could be made through it. The study method is to consider definition of sleep and sleep data first. The sleep data were classified into normal group and Narcolepsy, Insomnia, and sleep apnea by focusing on sleep disorder graphs that is measured by sleep polygraph. After that, I refined and converted the acquired biometric data into a text-based script. The degree of sleep in the text form of the script was rendered as a 3D animated image using Maya. In addition, the heart rate data script was transformed into a midi format, and the audition was implemented in the garage band. After Effects combines the image and sound to create four single channel images of 3 minutes and 20 seconds each. As a result of the research, I made an opportunity for anyone easy to understand the results, having difference with the normal data, through art instead of using difficult medical term. It also showed the possibility of artistic expression even when conscious actions did not occur. Through the results of this research, I expect the expansion and diversity of artistic audiovisual expression of biometric data.