• 대한조선학회논문집
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• 제59권4호
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• pp.214-224
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• 2022

It is necessary to estimate manoeuvring characteristics of submerged bodies at the design stage in order to ensure the safe operations. In this study, added mass coefficients in the mathematical model of submerged bodies are estimated by captive model tests and numerical calculations. Two kinds of models, MARIN 'BB2'submarine model and AUV (Autonomous unmanned vehicle) model are utilized in the forced oscillation tests. Compared to BB2 submarine, AUV with cylindrical type hull form shows relatively small added masses in roll, pitch, and yaw directions. Next, numerical calculations based on potential theory are performed under the assumption that viscous effects on inertia forces are negligible. Added masses obtained by numerical calculations are in good agreements with forced oscillation test results. And if slow manoeuvres of submerged bodies are presumed, some of velocity coupled terms can be approximated by combinations of added mass coefficients.

• 대한본초학회지
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• 제28권5호
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• pp.69-77
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• 2013

Objectives : The purpose of this study was to characterize the effect of the Ethanolic extract of Stachys sieboldii and Lycopus lucidus on the learning and memory impairments induced by scopolamine. Methods : The genetic difference of Stachys sieboldii and Lycopus lucidus were observed with RAPD analysis. The cognition-enhancing effect of Stachys sieboldii and Lycopus lucidus was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : As a result of RAPD analysis, Stachys sieboldii and Lycopus lucidus Radix was found to be genetically different and The results of learning memory analysis showed that Stachys sieboldii extract-treated group (500 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Water maze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. These results suggest that Stachys sieboldii extract maybe a useful cognitive impairment treatment, and its beneficial effects are depending on the origin plants. Conclusions : Commercially available Stachys sieboldii Radix consists of two original plant, one of them people misuse. To clarify the origin of the plant Memory tests were performed. These results suggest that 80% Ethanol extract of Stachys sieboldii showed significant anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent of the learning models.

• 대한토목학회논문집
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• 제28권2B호
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• pp.249-259
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• 2008

본 연구에서는 투과성잠제의 비탈면경사가 주변 파동장에 미치는 영향을 검토하기 위해 투과성구조물에 의한 유체저항(관성저항, 층류저항 및 난류저항)을 고려할 수 있는, 즉 파-구조물-지반의 상호작용을 해석할 수 있는 수치모델에 LES 난류모델을 도입한 새로운 수치해석기법(LES-WASS-2D)을 제안하여 기존에 수행되었던 수리모형실험과의 비교를 통하여 검증하였다. 이러한 수치해석기법을 이용하여 투과성잠제의 비탈면경사의 변화에 대한 수치모의를 수행한 결과, 비탈면경사가 완만해질수록 반사율 및 투과율이 감소함과 동시에 에너지손실(Energy loss)이 커지는 것을 알 수 있었다. 또한, 잠제의 비탈면경사의 변화에 따른 마루에서 쇄파점의 위치 및 잠제 배후에서의 순환류와 평균와도의 규모에 대해서도 논의하였다.

• 대한토목학회논문집
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• 제29권5B호
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• pp.463-472
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• 2009

본 연구에서는 잠제가 설치된 연안역에서 해안의 곡률반경이 잠제 주변 파동장에 미치는 영향을 파악하기 위하여 파 구조물 해빈/해저지반의 상호작용을 해석할 수 있는 3차원 수치모델 LES-WASS-3D를 이용하여 시뮬레이션을 실시하였다. 먼저 기존의 수리모형실험결과와 비교 검토를 통하여 타당성과 유효성을 확인하였으며, 수치실험을 통해 얻어진 수치해석결과로부터 잠제 주변의 파고분포, 평균수위분포, 상층흐름분포, 평균류분포 그리고 연안에서의 처오름 높이분포를 비롯한 잠제 주변의 3차원적 수리특성에 미치는 해안곡률의 영향에 관하여 고찰하였다.

• 영어영문학
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• 제58권5호
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• pp.839-858
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• 2012

This study is to analyze dreams and madness in Don Quixote and Hamlet which makes these two heroes quite identical rather than antithetical. Don Quixote is usually considered to be an idealistic, enthusiastic, and unselfish doer, whereas Hamlet is a skeptical, melancholic, and self-conscious thinker. However, Don Quixote and Hamlet both reveal a heroic desire to embody an ideal world into a reality through their dreams and madness. Based on Freud's interpretation of the similarities between dream and neurosis, this article focuses on the aspects of Don Quixote's waking dream and Hamlet's affected madness to find out their characteristics as new types of heroes. Don Quixote, the waking dreamer, acts like a maniac and tries to remain in a state of madness to sustain the dream world where he wanders to save the weak, the poor, and the deprived. He accepts psychic breakdown as well as physical trauma if only he can do the role of a knight errant. Sleepless Hamlet witnesses the dream world and experiences it tangibly while he hears an order from the murdered King's ghost. Yet, instead of becoming a neurotic, Hamlet waits for the chance to perform his task to regain the harmony of his family and kingdom. Even on the border of madness, Hamlet does not forsake his own life and duty but dreams in reality and acts without losing his reason. Although there are some apparent outstanding differences between Don Quixote and Hamlet, they have fundamental similarities with each other; Both of them exemplify a new type of hero who desperately tries to fulfill a mad dream to face the suffocating, suspicious, and strange world.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2023년도 춘계학술대회
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• pp.151-151
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• 2023

무인잠수정의 정밀한 제어 시스템 개발에는 높은 정도의 조종 유체력 미계수 추정이 필수적이다. 전통적으로 조종 미계수는 모형을 이용한 실험(사항, Planar Motion Mechanism, Rotating Arm)과 단순한 이론과 경험을 기반으로 개발된 경험식으로 추정하였다. 그러나 최근 크게 향상된 계산기 성능의 발전은 전산유체역학의 적용성을 크게 확대하였다. 따라서 본 논문에서는 만타형 무인잠수정의 조종 유체력 미계수 추정을 위한 전산유체역학 해석기법을 개발하고자 한다. 특히, 수직 동적 PMM 시험법에 관한 해석기법을 중점적으로 개발한다. 개발된 기법을 이용하여 만타형 무인 잠수정의 6자유도 유체력을 추정하고 그 결과를 실험과 비교하여 개발된 기법을 검증한다. 본 연구에서는 1/6 모형을 이용한다. 수치해석기법 개발은 RASN 기반 상용 해석소프트웨어인 STAR-CCM+를 사용하였다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 춘계학술대회
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• pp.76-76
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• 2020

Stachys sieboldii Miq. (chinese artichoke), which has been extensively used in oriental traditional medicine to treat of ischemic stroke; however, the role of Stachys sieboldii Miq. (SSM) in cerebral ischemia/reperfusion (I/R) injury is not yet fully understood. In the current study, the neuroblastoma cell line (SH-SY5Y) were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) to simulate I/R injury in vitro model. The results showed that SSM improved OGD/R-induced inhibitory effect on cell viability of SH-SY5Y Cells. SSM displayed anti-oxidative activity as proved by the decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in OGD/R-induced SH-SY5Y Cells. In addition, cell apoptosis was markedly decreased after SSM treatment in OGD/R-induced SH-SY5Y Cells. The up-regulation of Bcl-2 and down-regulation of Bax, thus reducing the Bax/Bcl-2 ratio that in turn protected the activation of caspase-9 and -3, and inhibition of poly (ADP-ribose) polymerase cleavage, which was associated with the blocking of cytochrome c release to the cytoplasm. Collectively, SSM protected human neuroblastoma SH-SY5Y cells from OGD/R-induced injury via preventing mitochondrial-dependent pathway through scavenging excessive ROS, suggesting that SSM might be a potential agent for the ischemic stroke therapy.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2021년도 춘계학술대회
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• pp.59-59
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• 2021

Stachys sieboldii Miq. (SSM) and Acorus gramineus Soland. (AGS) have been used as traditional medicines for thousands of years in parts of Asia, including Korea, China, and Japan. Recent researches on SSM and AGS have documented a wide spectrum of therapeutic properties, including anti-inflammatory, anti-oxidative, neurodegenerative disease effects. However, the toxicity and safety of SSM and AGS, and their mixture (medicinal herber mixture, MHMIX) were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of SSM, AGS and MHMIX. SSM, AGS and MHMIX were orally administered at a dose of 5,000 mg/kg in ICR mice. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. We also measured parameters of organ weight, clinical chemistry, and hematology. No dead and no clinical signs were found during the experiment period after administration of a single oral dose of SSM, AGS and MHMIX. There were no adverse effects on clinical signs, body weight, or organ weight and no gross pathological findings in any treatment group. Therefore, LD50 value of SSM, AGS and MHMIX may be over 5,000 mg/kg and it may have no side toxic effect to ICR mice. The results on the single-dose toxicity of SSM, AGS and MHMIX indicate that it is not possible to reach oral dose levels related to death or dose levels with any harmful side effects.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2021년도 춘계학술대회
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• pp.57-57
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• 2021

Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. Stachys sieboldii Miq. (Chinese artichoke), which has been extensively used in oriental traditional medicine to treat of ischemic stroke; however, the role of S. sieboldii Miq. (SSM) in OGD/R induced neuronal injury is not yet fully understood. The present research is aimed to investigate the protective effect and possible mechanisms of SSM extract treatment in an in vitro model of OGD/R to simulate ischemia/reperfusion Injury. Pretreatment of these cells with SSM significantly attenuated OGD/R-induced production of reactive oxygen species (ROS) by increasing GPx, SOD, and decreasing MDA. SSM decreased mitochondrial damage caused by OGD/R injury and inhibited the release of cyt-c from mitochondrion to cytoplasm in SH-SY5Y cells. Furthermore, neuronal cell apoptosis caused by OGD/R injury was inhibited by SSM, and SSM could decrease apoptosis by increasing ratio of Bcl-2/Bax and inhibiting caspase signaling pathway in SH-SY5Y cells. SSM demonstrated a neuroprotective effect on the simulated cerebral ischemia in vitro model, and this effect was the inhibition of mitochondria-mediated apoptosis pathway by scavenging of ROS generation. Therefore, SSM may be a promising neuroprotective strategy against ischemic stroke.

• 한국항행학회논문지
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• 제26권6호
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• pp.464-473
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• 2022

본 논문에서는 자율무인잠수정에 사용되는 UHF-GPS 안테나의 성능을 만족하는 경량화 설계에 대해 제안하였다. 설계 프로세스에 사용된 구조해석, 수밀외압시험 그리고 비파괴 검사는 수중운용 환경에서 발생하는 외력에 대한 구조 안전성을 고려하여 결정하였다. 먼저 수상에서 모함과 통신을 위한 UHF-GPS 안테나 성능과 수중 운용 시 발생하는 20 bar 압력을 고려한 레이돔 재질을 선정하였으며, 전자기장해석 및 구조해석을 수행하여 무게 대비 강도 및 강성이 높고 유전율이 우수한 PA-GF 소재를 선정하였다. 그리고 UHF-GPS 안테나의 요구 중량을 만족하기 위한 레이돔 두께별 전자기장해석 및 구조해석을 추가 수행하였으며, 최종 모델 선정 후 수밀외압시험 및 비파괴 검사를 통해 구조 안전성을 검증하였다.