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http://dx.doi.org/10.6116/kjh.2013.28.5.69.

A Comparative Study of Memory Improving Effects of Stachys Rhizome and Lycopi Rhizome on Scopolamine-induced Amensia in mice  

Lee, Shin Woo (Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology)
Jung, Tae-Hong (Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology)
Shin, Yong-Wook (Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology)
Publication Information
The Korea Journal of Herbology / v.28, no.5, 2013 , pp. 69-77 More about this Journal
Abstract
Objectives : The purpose of this study was to characterize the effect of the Ethanolic extract of Stachys sieboldii and Lycopus lucidus on the learning and memory impairments induced by scopolamine. Methods : The genetic difference of Stachys sieboldii and Lycopus lucidus were observed with RAPD analysis. The cognition-enhancing effect of Stachys sieboldii and Lycopus lucidus was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : As a result of RAPD analysis, Stachys sieboldii and Lycopus lucidus Radix was found to be genetically different and The results of learning memory analysis showed that Stachys sieboldii extract-treated group (500 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Water maze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. These results suggest that Stachys sieboldii extract maybe a useful cognitive impairment treatment, and its beneficial effects are depending on the origin plants. Conclusions : Commercially available Stachys sieboldii Radix consists of two original plant, one of them people misuse. To clarify the origin of the plant Memory tests were performed. These results suggest that 80% Ethanol extract of Stachys sieboldii showed significant anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent of the learning models.
Keywords
Stachys sieboldii; Memory enhancing; scopolamine;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Sarter M, Bodewitz G, Stephens DN. Attenuation of scopolamine–induced impairment of spontaneous alternation behavior by antagonist but not inverse agonist and beta–carboline. Psycopharmacology. 1998 ; 94(4) : 491-5.
2 Morris RG. Development of a water maze procedure for studying spatial learning in the rat. J Neurosci Meth. 1984 ; 11 : 47-60.   DOI   ScienceOn
3 Choi HY, Kim DW, Kim DE, Suh YB, Ham IH. The Relative Identification of C. officinale and L. chuanxiong by PCR- Mediated Fingerprinting. Kor J Herbology. 2005 ; 20(4) : 151-61.   과학기술학회마을
4 Coyle, JT. Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science. 1993 ; 262 : 689-95.   DOI   ScienceOn
5 Hsieh HM, Wu WM, Hu ML. Genistein attenuates D-galactose-induced oxidative damage through decreased reactive oxygen species and NF-$\kappa{B}$ binding activity in neuronal PC12 cells. Life Sci. 2011 ; 88 : 82-8.   DOI   ScienceOn
6 Satoh T, Lipton SA. Redox regulation of neuronal survival mediated by electrophilic compounds. Trends Neurosci. 2007 ; 30 : 37-45.   DOI   ScienceOn
7 Jung SH. The development and application of enzyme inhibitors. seoul : Shinil Pub. 1997 : 7-11.
8 Choi CH. The effect of Gardenia Jasminoides Extract and geniposide ameliorate learning and memory impairment. Daegu Haany University. 2008.
9 McEwen BS. Streess and hippocampal plasticity. Annu Rev Neurosci 1999 ; 22 : 105-22.   DOI   ScienceOn
10 Tanabe F, Miyasaka N, Kubota T, Aso T. Estrogen and progesterone improve scopolamine-in duced impairment of spatial memory. J Med Dent Sci. 2004 ; 51 : 89-98.
11 Woo ER, Piao MS. Antioxidative Constituents from Lycopus lucidus Arch. Pharm Res. 2004 ; 27 : 173-6.
12 Shin SH, Sim Y, Kim YS, Chi HJ, Lee EB. Studies on Essential Oils of Lycopus lucidus Turcz. Kor J Pharmacogn. 1992 ; 23 : 29-33.   과학기술학회마을
13 Bak JP, Kim JB, Park JH, Yang YJ, Kim IS, Choung ES, Kang SC. Screening and Compound Isolation from Natural Plants for Anti-allergic Activity. J Korean Soc Appl Biol Chem. 2011 ; 54 : 367-75.   과학기술학회마을   DOI
14 Kim MH. The antidiabetic properties of fractions of Lycopus lucidic Turcz in streptozotocin diabetic rats. Korean J Soc Food Sci. 2000 ; 16 : 644-51.   과학기술학회마을
15 Brinker ND. Inhibition of endocrine function by botanical agents. J Naturopathic Med. 1990 ; 1 : 10-5.
16 Ingkaninan K, de Best CM, van der Heijden R, Hofte AJ, Karabatak B, Irth H, Tjaden UR, van der Greef J, Verpoorte R. High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products. J Chromatogr A. 2000 ; 872 : 61-73.   DOI   ScienceOn
17 Ryu BH, Kim SO. Effect of Methanol Extract of Stacys sieboldii MIQ on Acetylchloline Esterase and Monoamine Oxidase in Rat Brain. Korean J Food Nutr. 2004 ; 17(4) : 347-55.
18 Blois MS. Antioxidant determinations by the use of a stable free radical. Nature. 1958 ; 181 : 1199-200.   DOI   ScienceOn
19 Ellman GL, Courtney KD, Andres Jr V, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961 ; 7 : 88-95.   DOI   ScienceOn
20 LeDoux JE. Emotional memory: in search of systems and synapses. Ann N Y Acad Sci. 1993 ; 702 : 149-57.   DOI
21 Kasa P, Rakonczay Z, Gulya K. The cholinergic system in Alzheimer's disease. Prog Neurobiol. 1997 ; 52 : 511-35.   DOI   ScienceOn
22 Hong WS. Sophisticated translation version, su wen in Yellow Emperor's internal classic. Seoul : The Institute of Oriental Medicine. 1981 : 218.
23 Park SK, Lee HJ, Kim HT. An experimental study of driental medicine on cure for dementia : the effect of Jowiseungcheongtang and Hyungbangjihwangtang on cure for aged rats. J Oriental Neropsychiatry 1998 ; 9(2) : 19-35.   과학기술학회마을
24 Lee DW, Shin GJ, Lee WC. A Comparative Consideration of Treatment on Dementia in Oriental and Occidental Medicine. J Dong Guk Oriental Medicine. 1995 ; 3 : 67-80.
25 Lee CB. Illustrated flora of Korea. Seoul : Hyang Moon Sa. 1999 : 652.
26 Ryu BH. Park BG. Song SK. Antitumor effects of the hexane extract of Stachys sieboldii Miq. Kor J Biotechnol Bioeng. 2002 ; 17 : 520-4.   과학기술학회마을
27 Yin J, Yang G, Wang S, Chen Y. Purification and determination of stachyose in Chinese artichoke (Stachys Sieboldii Miq.) by high-performance liquid chromatography with evaporative light scattering detection. Talanta. 2006 ; 70 : 208-12.   DOI   ScienceOn
28 Yamahara G. Studies on the Stachys sieboldii Miq. II. Anti-anoxia action and the active constituents. Med Mega. 1990 ; 110 : 932-5.
29 Takeda Y, Fujita T, Satoh T, Kakegawa H. On the glycoside constituents of Stachys sieboldii Miq. and their effects on hyarulonidase activity. Yakugaku Zasshi. 1985 ; 105 : 955-9.   DOI
30 Hayashi K, Nagamatsu T, Ito M, Yagita H, Suzuki Y. Acteoside, a component of Stachys sieboldii Miq, may be a promising antinephritic agent. Jpn J Pharmacol. 1996 ; 70 : 157-68.   DOI
31 Shin JH, Shin YW. Illustrated book of Medicinal herbs from Hyang Yak Jip Seong Bang. Daegu : KMU Press. 2006 : 123, 147.
32 Talesa VN. Acetylcholine esterase in Alzheimer's disease. Mech Ageing Dev. 2001 ; 122 : 1961-9.   DOI   ScienceOn
33 Min SG. The Latest Psychiatry. Seoul : IlJoGak. 2006 : 203.
34 Frank B, Gupta S. A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry. 2005 ; 17 : 269-86.   DOI   ScienceOn
35 Hermona S, Shlomo S. Acetylcholinesterase-new roles for an old actor. Nat Rev Neurosci. 2001 ; 2 : 294-302.   DOI   ScienceOn