• Journal of the Society of Naval Architects of Korea
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• v.59 no.4
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• pp.214-224
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• 2022

It is necessary to estimate manoeuvring characteristics of submerged bodies at the design stage in order to ensure the safe operations. In this study, added mass coefficients in the mathematical model of submerged bodies are estimated by captive model tests and numerical calculations. Two kinds of models, MARIN 'BB2'submarine model and AUV (Autonomous unmanned vehicle) model are utilized in the forced oscillation tests. Compared to BB2 submarine, AUV with cylindrical type hull form shows relatively small added masses in roll, pitch, and yaw directions. Next, numerical calculations based on potential theory are performed under the assumption that viscous effects on inertia forces are negligible. Added masses obtained by numerical calculations are in good agreements with forced oscillation test results. And if slow manoeuvres of submerged bodies are presumed, some of velocity coupled terms can be approximated by combinations of added mass coefficients.

• The Korea Journal of Herbology
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• v.28 no.5
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• pp.69-77
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• 2013

Objectives : The purpose of this study was to characterize the effect of the Ethanolic extract of Stachys sieboldii and Lycopus lucidus on the learning and memory impairments induced by scopolamine. Methods : The genetic difference of Stachys sieboldii and Lycopus lucidus were observed with RAPD analysis. The cognition-enhancing effect of Stachys sieboldii and Lycopus lucidus was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : As a result of RAPD analysis, Stachys sieboldii and Lycopus lucidus Radix was found to be genetically different and The results of learning memory analysis showed that Stachys sieboldii extract-treated group (500 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Water maze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. These results suggest that Stachys sieboldii extract maybe a useful cognitive impairment treatment, and its beneficial effects are depending on the origin plants. Conclusions : Commercially available Stachys sieboldii Radix consists of two original plant, one of them people misuse. To clarify the origin of the plant Memory tests were performed. These results suggest that 80% Ethanol extract of Stachys sieboldii showed significant anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent of the learning models.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2B
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• pp.249-259
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• 2008

The present paper studies the effect of the slope gradient of a fully permeable submerged breakwater using a newly developed numerical model that is able to consider the flow through a porous midium with inertial, laminar and turbulent resistance terms, i.e. simulate directly WAve-Structure (submerged breakwater)-Sand seabed interaction and can determine the eddy viscosity with LES turbulence model in 2-Dimensional wave field (LES-WASS-2D). The developed model was validated through the comparison with an existing experimental data, and further used for various numerical experiments in oder to investigate the complicated hydrodynamics on the varying slope gradient of permeable submerged breakwater. We found an acceptable phenomenon, as we expect intuitively, that reflection and transmission coefficients decrease simultaneously as slope gradient decrease. In addition, the breaking point, the circulation flow and mean vorticity around a submerged breakwater are throughly discussed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.5B
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• pp.463-472
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• 2009

The aim of this study is to examine the effect of beach curvature on wave fields in coastal area with Submerged Breakwaters using the 3D numerical model that is able to simulate directly interaction of WAve Structure Sandy beach (LES-WASS-3D). At first, the adopted model was validated through the comparison with an existing experimental data and showed fairly nice agreement. And then, the numerical simulations have been performed to investigate the effect of according to the variation of beach curvature. Based on the numerical results, the wave height, mean surface elevation, mean flow around submerged breakwaters and longshore distributions of run-up height have been discussed in relation to the variation of beach curvature.

• Journal of English Language & Literature
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• v.58 no.5
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• pp.839-858
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• 2012

This study is to analyze dreams and madness in Don Quixote and Hamlet which makes these two heroes quite identical rather than antithetical. Don Quixote is usually considered to be an idealistic, enthusiastic, and unselfish doer, whereas Hamlet is a skeptical, melancholic, and self-conscious thinker. However, Don Quixote and Hamlet both reveal a heroic desire to embody an ideal world into a reality through their dreams and madness. Based on Freud's interpretation of the similarities between dream and neurosis, this article focuses on the aspects of Don Quixote's waking dream and Hamlet's affected madness to find out their characteristics as new types of heroes. Don Quixote, the waking dreamer, acts like a maniac and tries to remain in a state of madness to sustain the dream world where he wanders to save the weak, the poor, and the deprived. He accepts psychic breakdown as well as physical trauma if only he can do the role of a knight errant. Sleepless Hamlet witnesses the dream world and experiences it tangibly while he hears an order from the murdered King's ghost. Yet, instead of becoming a neurotic, Hamlet waits for the chance to perform his task to regain the harmony of his family and kingdom. Even on the border of madness, Hamlet does not forsake his own life and duty but dreams in reality and acts without losing his reason. Although there are some apparent outstanding differences between Don Quixote and Hamlet, they have fundamental similarities with each other; Both of them exemplify a new type of hero who desperately tries to fulfill a mad dream to face the suffocating, suspicious, and strange world.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2023.05a
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• pp.151-151
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• 2023

An accurate prediction of the hydrodynamic maneuvering darivatives is essential to desing a robust control system of a UUV(unmanned underwater vehicle). Typically, these derivatives were estimated by either the towing tank experiment or semi-empirical methods. With the enhancement of high performance computing capacity, a numerical analysis using computational fluid dynamics has reach the level of experiment. Therefore, the aims of the present research are to numerically develop a computational model for the vertical planar motion mechanism of a UUV and to estimate the hydrodynamics loads in 6-DOF. The target structure of the present study was manta type UUV (12meter length). The numerical model was developed in 1/ 6 model scale. Numerical results were compared with the results of the towing tank experiment for validation. In the present study, a commercial RANS-based viscous solver STARCCM+ (ver 17.06) was used.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.08a
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• pp.76-76
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• 2020

Stachys sieboldii Miq. (chinese artichoke), which has been extensively used in oriental traditional medicine to treat of ischemic stroke; however, the role of Stachys sieboldii Miq. (SSM) in cerebral ischemia/reperfusion (I/R) injury is not yet fully understood. In the current study, the neuroblastoma cell line (SH-SY5Y) were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) to simulate I/R injury in vitro model. The results showed that SSM improved OGD/R-induced inhibitory effect on cell viability of SH-SY5Y Cells. SSM displayed anti-oxidative activity as proved by the decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in OGD/R-induced SH-SY5Y Cells. In addition, cell apoptosis was markedly decreased after SSM treatment in OGD/R-induced SH-SY5Y Cells. The up-regulation of Bcl-2 and down-regulation of Bax, thus reducing the Bax/Bcl-2 ratio that in turn protected the activation of caspase-9 and -3, and inhibition of poly (ADP-ribose) polymerase cleavage, which was associated with the blocking of cytochrome c release to the cytoplasm. Collectively, SSM protected human neuroblastoma SH-SY5Y cells from OGD/R-induced injury via preventing mitochondrial-dependent pathway through scavenging excessive ROS, suggesting that SSM might be a potential agent for the ischemic stroke therapy.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.59-59
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• 2021

Stachys sieboldii Miq. (SSM) and Acorus gramineus Soland. (AGS) have been used as traditional medicines for thousands of years in parts of Asia, including Korea, China, and Japan. Recent researches on SSM and AGS have documented a wide spectrum of therapeutic properties, including anti-inflammatory, anti-oxidative, neurodegenerative disease effects. However, the toxicity and safety of SSM and AGS, and their mixture (medicinal herber mixture, MHMIX) were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of SSM, AGS and MHMIX. SSM, AGS and MHMIX were orally administered at a dose of 5,000 mg/kg in ICR mice. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. We also measured parameters of organ weight, clinical chemistry, and hematology. No dead and no clinical signs were found during the experiment period after administration of a single oral dose of SSM, AGS and MHMIX. There were no adverse effects on clinical signs, body weight, or organ weight and no gross pathological findings in any treatment group. Therefore, LD50 value of SSM, AGS and MHMIX may be over 5,000 mg/kg and it may have no side toxic effect to ICR mice. The results on the single-dose toxicity of SSM, AGS and MHMIX indicate that it is not possible to reach oral dose levels related to death or dose levels with any harmful side effects.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.57-57
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• 2021

Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. Stachys sieboldii Miq. (Chinese artichoke), which has been extensively used in oriental traditional medicine to treat of ischemic stroke; however, the role of S. sieboldii Miq. (SSM) in OGD/R induced neuronal injury is not yet fully understood. The present research is aimed to investigate the protective effect and possible mechanisms of SSM extract treatment in an in vitro model of OGD/R to simulate ischemia/reperfusion Injury. Pretreatment of these cells with SSM significantly attenuated OGD/R-induced production of reactive oxygen species (ROS) by increasing GPx, SOD, and decreasing MDA. SSM decreased mitochondrial damage caused by OGD/R injury and inhibited the release of cyt-c from mitochondrion to cytoplasm in SH-SY5Y cells. Furthermore, neuronal cell apoptosis caused by OGD/R injury was inhibited by SSM, and SSM could decrease apoptosis by increasing ratio of Bcl-2/Bax and inhibiting caspase signaling pathway in SH-SY5Y cells. SSM demonstrated a neuroprotective effect on the simulated cerebral ischemia in vitro model, and this effect was the inhibition of mitochondria-mediated apoptosis pathway by scavenging of ROS generation. Therefore, SSM may be a promising neuroprotective strategy against ischemic stroke.

• Journal of Advanced Navigation Technology
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• v.26 no.6
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• pp.464-473
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• 2022

In this paper, about a lightweight design that satisfies the performance of UHF-GPS Antenna used in autonomous underwater vehicle is proposed. Structural analysis, watertight external pressure test and non-destructive testing used in the design process are decided in consideration of structural safety for operating external forces in the underwater environment. First, the material of radome is selected for the performance of the UHF-GPS Antenna for communication with the carrier on the underwater operation in consideration of the 20 bar pressure generated. And the material of radome as PA-GF is selected by conducting electromagnetic field analysis and structural analysis and by considering high strength, rigidity and high dielectric constant. Electromagnetic field analysis and structural analysis by the thickness of radome are additionally performed in order to satisfy the required weight of UHF-GPS antenna. After selecting the final model, its structural safety is verified through watertight external pressure test and non-destructive testing.