• Journal of Life Science
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• v.25 no.10
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• pp.1184-1195
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• 2015

The zebrafish is an emerging vertebrate model organism in reproductive biology. The oocyte maturation of zebrafish is triggered by maturation inducing hormone (MIH, 17α,20β-Dihydroxy-4-pregnen-3-one). In almost all animals, the oocyte maturation is governed by activation of pre-MPF which consists of cyclinB and inactive Cdk1. In the oocyte of Xenopus and mice, the activity of Cdk1 is regulated in two ways, one is the interaction with cyclinB and the other is phosphorylation/dephosphorylation of T14/Y15 residues on the Cdk1 by Wee1 and Cdc25. Unlike Xenopus and mice that have a sufficient amount of pre-MPF, pre-MPF is absent in GV oocyte of most teleost including zebrafish. Therefore, the activation of MPF during zebrafish oocyte maturation might totally depend on de novo synthesis of cyclinB proteins. It is reported that the translation of maternal mRNA is regulated by combination of several RNA binding proteins such as CPEB, Dazl, Pum1/Pum2, and insulin-like growth factor2 mRNA-binding protein 3 in the zebrafish oocytes. However, the definitive mechanism of these proteins to regulate the translation of stored maternal mRNAs remains to be elucidated. Therefore, the investigation of the maturation process of the zebrafish oocyte will provide new information that can help identify the role of translational control in early vertebrate oocyte maturation.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.5
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• pp.343-349
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• 2007

Radioiodide transport has been extensively and successfully used in the evaluation and management of thyroid disease. The molecular characterization of the sodium/iodide symporter (NIS) and cloning of the NIS gene has led to the recent expansion of the use of radioiodide to cancers of the breast and other nonthyroidal tissues exogenously transduced with the NIS gene. More recently, discoveries regarding the functional analysis and regulatory processes of the NIS molecule are opening up exciting opportunities for new research and applications for NIS and radio iodide. The success of NIS based cancer therapy is dependent on achievement of maximal radioiodide transport sufficient to allow delivery of effective radiation doses. This in turn relies on high transcription rates of the NIS gene. However, newer discoveries indicate that nontranscriptional processes that regulate NIS trafficking to cell membrane are also critical determinants of radioiodide uptake. In this review, molecular mechanisms that underlie regulation of NIS transcription and stimuli that augment membrane trafficking and functional activation of NIS molecules will be discussed. A better understanding of how the expression and cell surface targeting of NIS proteins is controlled will hopefully aid in optimizing NIS gene based cancer treatment as well as NIS based reporter-gene imaging strategies.

• The Journal of Korean Academy of Sensory Integration
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• v.1 no.1
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• pp.17-23
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• 2003

Objective : The purpose of this study is to identify the developmental characteristics of sensory integration according to age and sex distinction using COMPS for school-aged children and to provide the preparatory data for standardization appropriate for our social and cultural environment. Methods : The COMPS was administered to 40 normal children in the first grade of elementary school by 4 occupational therapists. Results : By comparison between age groups, 6 and 7 year olds performed similarly and statistically in all items. Between males and females, there was no significant difference in performance of all items Conclusion : Findings from the study suggested that the performance of the COMPS by children followed developmental trends. The COMPS is easy to administer to groups and beneficial to discriminate children with motor problems, and it should be standardized.

• Korean Journal of Applied Biomechanics
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• v.17 no.2
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• pp.83-91
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• 2007

This experiment studied the change in a human's control of his or her static posture by analyzing the stabilogram diffusion and, by using the said study, evaluated the control ability of different groups with different experiences. The postures had a rising requirement of heel-rise according to three conditions: heel-toe, ball, toe; the groups were divided into dance major student and non-dance majors. The results of the critical points according to posture did not show a direct relation with the change in postures that had a rising requirement of heel-rise. The diffusion coefficient(D) had greater stochastic activity for short-term regions that utilize open-loop controls without feedback than for long-term regions that used closed-loop controls with feedback to maintain balance. The directional results of the body undergoing disturbance showed that A/P direction's diffusion coefficient (D) was larger than that of M/L direction. Both feet's planar diffusion coefficients were a linear combination of the diffusion coefficients calculated for the x and y axis. In studying the different abilities to control posture between a dance major student and a non-dance majors, a comparison of open-loop control's diffusion coefficient(D) was effective, and dance major student had superior control ability to that of non-dance majors.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.4
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• pp.327-330
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• 2015

The safety and success of dental sedation for children depend mainly on respiratory status of patients. A special condition, that is, nasal breathing in supine position with their oral airway blocked by rubber dam, should be considered. Therefore, irrespective of medical consultation, pediatric dentists themselves should do respiratory assessment especially adenotonsillar hypertrophy, nasal obstruction, posterior nasal drainage and airway hypersensitivity. Patients with sinusitis, allergic rhinitis, asthma, snoring and OSAS(obstructive sleep apnea syndrome) can induce the sedation failure and complete management of these can improve the safety of dental sedation.

• The Journal of Korean Physical Therapy
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• v.24 no.5
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• pp.348-354
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• 2012

Purpose: This study examined the effects of computerized feedback postural training on the balance and electromyography activity of subjects with stroke. Methods: A total of 30 chronic stroke patients were enrolled in this study. Subjects were divided into an experimental group (n=15) and a control group (n=15). Computerized feedback postural training was used in the experimental group. Both groups received intervention for six weeks, 5 times per 30 minutes period. Data analysis was performed using analysis of covariance for determination of statistical significance. Results: Significant difference in static and dynamic balance was observed in the experimental group, compared with the control group (p=0.05), and a significant difference in muscle activity was observed in the gastrocnemius muscle, quadriceps muscle, and elector spinae muscle. However, the hamstring muscle showed no significant difference. Conclusion: Computerized feedback postural training is more effective in improving the ability of balance and muscle activity than neurological physical therapy.

• Journal of Korean Physical Therapy Science
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• v.8 no.2
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• pp.1059-1064
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• 2001

This study is aimed at diagnosing transmutation aspect with the respective of hemiplegia patient's static adaptation of posture which is influenced by anti-gravity excercise, center of gravity shifting movement and segmental movement adaption of the legs and arms by key-point control in the process of Bobatli's treatment approach. The patients for the investigation of this study were selected as a total 17 patients who were doing the physical-therapy in Tae-gu Rehabilitation Center, and diagnosed as hemiplegia patients by Rehabilitation Medicine department in Kyung-buk University hospital. And also, there investigated into temporal transition that keep the attitude with one-leg standing on the ground concerning static attitude adaption on the basis of the before of anti-gravity movement and the after of 4-weeks movement. The findings of this study were as follows: With the respective the time to keep standing pose by one-leg at static attitude transmutation, affected side showed meaningful differences as a l.86/sec, 2.62/sec at 4 weeks later considering the before and after of this experiment.(p<0.01), non-affected side at the aspect of attitude keeping time, but there didn't showed meaningful differences statistically.

• Journal of Applied Biological Chemistry
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• v.59 no.1
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• pp.25-29
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• 2016

Hepatitis B virus infection can cause hepatic fibrosis leading to cirrhosis and hepatocellular carcinoma. However the mechanism remains poorly understood. In this study, we found that Hepatitis B virus X-protein (HBx) increases vimentin, fibronectin, slug, snail and NOX4 expression. Because NOX4-mediated reactive oxygen species can increase slug and snail, which can induce fibrosis, HBx may be a key regulator of hepatic fibrosis development via NOX4 induction.

• Journal of Korean Physical Therapy Science
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• v.7 no.2
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• pp.427-437
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• 2000

편마비 환자의 물리치료는 장애 결과를 완화시키는 것에 초점을 두고 있다. 본 연구는 신경생리학적 개념을 기초로 한 중재 접근 방법 중 편마비 환자에게 신경 발달 치료와 신경근 균형 접근 기법의 중재 효과를 비교 하였다. 연구 대상은 서울특별시와 전라북도에 소재한 종합병원 및 정형외과 의원에 입원 및 통원하고 있는 47-71세의 연령 범위에 있는 편마비 환자 30명 이다. 중재 집단의 기능적 능력 향상을 평가하기 위해 편마비 환자를 위한 운동 평가 척도와 수정된 바델 척도를 평가도구로 사용하였다. 편마비 환자의 기능적 능력 향성을 평가도구에 의해 측정된 결과를 분석한 바 운동평가 척도 항목중 바로누운 자세에서 옆으로 눕기와 앉아서 균형 취하기 영역에서, 수정된 바델 척도 항목 중 식사하기 영역에서 통계적으로 유의한 차이를 보였다(P<.05). 편마비 환자의 손상 부위, 손상 형태, 마비 부위 등의 손상의 본질에 따른 대상의 선정과 운동 조절 형태에 관한 지식 그리고 신경학적 결함 정도를 심도있게 다루어 기능적 능력 향상의 임상적 효과를 검증하는 것이 중요하다.

• The Korean Journal of Physiology
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• v.4 no.2
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• pp.19-24
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• 1970

Since the discovery of the muscle spindle by Hassall (1831), an intensive studies of its anatomical and physiological characteristics had been undertaken. Recent morphological studies of Boyd (1962) demonstrated that the muscle spindles have two different intrafusal muscle fibers, nuclear bag and nuclear chain fiber, and these intrafusal fibers are under independent motor innervation by ${\gamma}_1$ and ${\gamma}_2$ motor neurone. Neurophysiological studies of Hunt and Kuffler (1951) showed regulatory effect of ${\gamma}$ motor neurone upon the excitability of the spindle afferents. Harvey and Mathews (1961) observed the dynamic and static characteristics of the two different spindle afferents, the primary and secondary ending. Furthermore, Mathews (1962) postulated the functional existance of two kind of ${\gamma}$ motor neurones, namely, the dynamic and static fusimotor fiber. Recent report of Kim and Partridge(1969) pointed out that the descending vestibular signals had increased the slope of the length-tension relationship in stretch reflex; Kim (1967) demonstrated that the descending vestibular impulses act upon the stretch reflex loop through the ${\gamma}$ motor pathway. These experimental evidences from the morphological and neurophysiological studies on the muscle spindles support the concept that the stretch reflex action of the skeletal muscle operates as a negative feedback control system. The author had discussed the way by which the f system participates in the control of stretch relfex feed back system. that was taken for a prototype of posture and movement.