• Journal of Digital Convergence
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• v.14 no.1
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• pp.305-310
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• 2016

Recently as the ultrasonography became generalized, the annual change rate of the incidence of thyroid cancer extraordinarily grew to 24.5% in Korea. Therefore, the aim of this study was performed to identify the risk factors of thyroid cancer apart from conventional risk factors of dietary iodine and ionizing radiation. In this retrospective study, 411 patients underwent fine-needle aspiration biopsy were examined from January 2011 to March 2013. The subjects are divided into two groups which are 260 patients with benign nodule and 151 patients with malignancy nodule. We compared age, hematologic values, body mass index, waist circumference, menopausal status, breast nodules status, uterine myoma status, fatty liver status of targeted group of patients. According to the result, in thyroid cancer group with obesity, the number of case of breast nodules and myoma was higher, and their thyroid stimulating hormone values was higher than the benign nodule group. In order to establish factors influencing thyroid and thyroid cancer, there is a definite need for continuous study.

• The Journal of Korean Obstetrics and Gynecology
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• v.15 no.4
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• pp.136-148
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• 2002

This study was performed to investigate the relation between Iridological constitution and Gynecological disease. Iris is one of the most complicated part of our bodies. It reflects perfectly organ's status, toxic accumulation, person's characteristics and healing effects. Many signs of Iridology were closely researched to examine the relation between Iridology and disease. After studying these matters, we could find that lacuna and auto-nerve wreath are intimately related. Especially the portions of auto-nerve wreath loss are accorded with the organ's present illness. Most of patients have scurf ring and vessel congestion sign. Large Intestine's structure also shows us the meaningful result that ballooned is the most common, spasticity and stricture are next. Connective tissue weakness constitution is 39.22%, complex 35.29% and blood-originated 25.49%. According to the three-step constitution by the Genetic facter, average type is 52.94%, weak type 35.29% and strong type 11.76%. Above these results, we can reach a conclusion that Iridological constitution are intimately related with Gynecological disease. And further study are requested to get a objectivity in a Gynecological diagnose. Iridology is a bright prospective study and interesting diagnostic method. If we deeply investigate this science, before long we can have a great outcome and more objective diagnostic skill.

• YAKHAK HOEJI
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• v.51 no.6
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• pp.402-408
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• 2007

The aim of this study was to evaluate the effect of menstration among the influencing factors for the GnRH agonist (as G: depot goserelin 3.6 mg) therapy prior to the planned myomectomy for women who wanted to preserve their fertility. We reviewed total 48 patients. with the G therapy prior to the planned myomectomy from August 1st, 2005 to August 31st, 2006. The patients were classified by the G group (n=28) and the immediate surgery (as S) group (n=20). The G group (n=19) underwent the G therapy for 3 month courses, and then the efficacy was evaluated by menstruation and the myoma volumes. In the G group (n=19), therapy was effective, and the mean age was $32.4{\pm}6.5$ years. After the completion of G therapy, the mean volume of the myoma by ultrasonography was reduced to $85.2{\pm}71.2cm^3$ comparing of $430.6{\pm}248.8cm^3$ at first visit. The 11 patients had menstruation and the rest 8 patients with amenorrhea had less reduced volume of the myoma ($124.05{\pm}79.85cm^3\;v.s.\;329.41{\pm}234.0cm^3$ p<0.05). In the immediate S group, the myoma volumes by sonography was also checked for accuracy (${\alpha}=1.0$). As the result, the initial myoma volume had the positive correlations to the effectiveness with G therapy. However, the occurrence and frequency of the menstruation during the G therapy had a negative correlation. In conclusion, the use of G prior to the planned myomectomy was effective in reducing myoma volume and the menstruation.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.1
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• pp.109-131
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• 2011

Objectives: This study aims to search the clinical cases that treated leiomyoma through the traditional Chinese medicine, to understand the study trend on leiomyoma in China, and to clairfy the cause of leiomyoma and its treatment by the oriental medicine herbs. Methods: We searched the key word "leiomyoma" in the China National Knowledge Infrastructure (CNKI)[http://www.cnki.net], and narrowed its searching area to the papers published in the year 2010. Of 720 study papers, we chose 21 clinical papers on the leiomyoma, and studied the patient case, treating method, result of treatment, and checked the category, cause, treatment method of leiomyoma. Results: The results are shown in the Table 1-3. Conclusions: Leiomyoma is categorized in the traditional Chinese medicine as both lump occuring inside the body and stony abdominal lump. The main cause of leiomyoma is qi-stagnation and blood stasis, essence deficiency and pathogen affluence. The treatment method is used by activating blood and resolving stasis but harmonizing the spleen and stomach to prevent damaging healthy qi. The development herbal medicine of treating leiomyoma is Gyehongbyeolgaphwan, Gyejibongnyeonggyonang, Gungryusogyonang, Angonpyoen etc. In treating leiomyoma, the herbs were much used to regulate qi as Baekbokryung, Danggwi, Baekchul, Doin, Moryeo, Achul, Mokdanpi etc. Traditional Chinese Medicine(TCM) treatment of leiomyoma has efficiency of improve symptom but low ratio of complete recovery.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.4
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• pp.1073-1077
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• 2006

The purpose of this study is to find out oriental medical management and treatment of uterus myoma patients by investigating and analyzing them. We analyzed the results of medical records for 132 patients who were diagnosed as uterus myoma and visited Dong-Eui University Oriental Medical Center from March 2001 to December 2004. We investigated the frequency of symptom, the company frequency of symptom, the variety of treatment method. The frequency of symptom was dysmenorrhea 79 persons 59.85%, menorrhagia 61 persons 46.21%, subjective symptom of mass 12 persons 9.09%, infertility 4 persons 3.03%, lumbago 24 persons 18.18%, dysuria 10 persons 7.58%, dyschezia 22 persons 16.67'/), and the average number was 2.33. We investigated the company frequency of symptom, silent patients were 16 persons 12.12%, 116 persons 87.88(/) had myoma symptom. The treatment method; The frequency of taking herb medicine was 115 persons 87.12% and the average period was $50.65{\pm}5757$. The frequency of taking pill medicine was 56 persons 42.42% and the average period was $54.34{\pm}74.02$. The frequency of taking acupuncture treatment was 83 persons 62.88% and auricular acupuncture treatment was 30 persons 22.73%. We could find out the possibility of oriental medical management and treatment of uterus myoma.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.1-12
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• 2007

Purpose: Uterine leiomyomas (fibroids) are common estrogen-dependent uterine tumors. Houttuynia cordata thunberg has cancer-preventing properties and often used in Chinese medicine. In the present study we used Houttuynia cordata thunberg to determine its effect on cell proliferation and apoptosis in human uterine leiomyoma cells. Methods: Primary cultured human uterine leiomyoma cells were treated with Houttuynia cordata thunberg. Cell viability analysis was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTS) assay and Flow cytometry was performed to ascertain the effects Houttuynia cordata thunberg. Expression of cell cycle related proteins and apoptosis related proteins were evaluated by Western blot analysis. Results: Cell viability was significantly influenced by Houttuynia cordata thunberg treatment in a dose-dependent manner in leiomyoma cells compare to normal myometrial cells. Flow cytometric analysis showed that Houttuynia cordata thunberg induced Sub G1 arrest. DNA fragmentation assay was carried out and apoptosis was detected. Activation of caspase-3, down-regulation of Bcl-2, with concomitant increase in p21 was observed. Houttuynia cordata thunberg treatment of uterine leiomyoma cellsresulted in a concentration-dependent cell death induced via the caspase dependent mechanism. Conclusion: These results suggest that Houttuynia cordata thunberg treatment in uterine leiomyoma cells leads to growth inhibition and induced apoptosis. These results suggest that Houttuynia cordata thunberg will be a promising agent for use in therapeutics agents against human uterine endometrial cancer.

• The Journal of Korean Obstetrics and Gynecology
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• v.36 no.3
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• pp.196-210
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• 2023

Objectives: The purpose of this study is to review the research trends of infertile women with uterine myoma in Korean medicine and to recognize the efficacy of Korean medicine intervention. Methods: A search was conducted on November 18, 2022, using six databases, including Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS), Cochrane Library Central, Pubmed, China National Knowledge Infrastructure (CNKI) and WangFang Med Online. We analyzed the studies using Korean medicine on women with uterine myoma preparing for pregnancy or complaining infertility. Results: Total 4 studies were selected and all of which were case reports. Among 6 cases, Korean medicine treatment including herbal medicine, acupuncture, electroacupuncture, moxibustion was used alone. Ikgibohyeol-tang-gami-bang, Gyejibokryeong-hwan, Saenghwa-tang-gami-bang were prescribed in 2 cases each. Angelicae Gigantis Radix and CV4 were most frequently used herb and acupoint. All subjects were successful in becoming pregnant. Conclusion: This review shows that Korean medicine treatment can be effective in infertile women with uterine myoma. However, the number of included studies is small, so the level of evidence needs to be raised through more clinical studies in the future.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.1
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• pp.161-171
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• 2009

Purpose: We intended to observe relation between general symptom and the number of uterine myoma. Methods: We surveyed 948 women from 35 to 45 years old who had received Korean oriental medical questionnaires about general symptom pattern and pelvic ultrasonography at Kyung-Hee university medical center from May, 2007 to October, 2008. After we divided women into three groups (Mono-uterine myoma, Bi-uterine myoma & uterine myoma above 3) by ultrasonography result, we compared general symptom pattern according to the number of uterine myoma. For statistics, we used Kruskal-Wallis Test, SPSS 13.0 for windows. Results: In relation to sleep pattern, severity of dreaming & awaking showed statistical significance according to the number of uterine myoma. In relation to digestion pattern, appetite & heartburn showed statistical significance according to the number of uterine myoma. In relation to evacuation pattern, hardening of stool showed statistical significance according to the number of uterine myoma. In relation to sweating pattern, severity of refreshing after sweating showed statistical significance according to the number of uterine myoma. In relation to the other patterns, hypertonicity of nape neck showed statistical significance according to the number of uterine myoma(p<0.05). Conclusion: The result showed that prevalence of uterine myoma had to be considered in respect of sleep, digestion, evacuation and sweating pattern. we need further study based on this preliminary result.

• Journal of the Korean Society of Radiology
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• v.81 no.5
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• pp.1083-1095
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• 2020

Since 2019, ultrasound and magnetic resonance imaging for evaluation of urogenital disorders have been covered by the National Health Insurance (NHI) in Korea. Patients with urogenital malignancies were already insured by NHI for ultrasound and MRI. With the expansion of NHI coverage, patients with suspected prostate or gynecologic cancer, uterine fibroids before myomectomy and some other benign disease such as congenital anomaly can receive benefits of NHI. In consideration of these changes, radiologists and other clinicians should be aware of the indications and standard images of each examination and the required reporting forms. Clinical application based upon thorough understanding of the NHI guidelines will aid in improving the standard care of patients.

• Clinical and Experimental Reproductive Medicine
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• v.28 no.3
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• pp.215-223
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• 2001

Objective: The purpose of this study was to make a guideline of uterine artery embolization for the treatment of uterine leiomyomas accompanying with adenomyosis in Korea. Materials and Methods : We performed the retrospective study for 37 women who had uterine leiomyomas accompanying with adenomyosis. Bilateral uterine artery embolization was performed in 37 patients (age range 25-65) during 17 months with pain, hypermenorrhea, urinary frequency etc due to leiomyomas. Ultrasound imaging was performed before the procedure and at mean 6.9 months after the procedure. Results: All procedures were technically successful. Mean clinical follow-up was 12.8 months. Minor complication occurred in 82% patients after the procedure. After imaging follow-up (mean, 6.9 months postprocedure), median uterine volume decreased 34.4%, and dominant myoma volume decreased 86%. There was no statistical difference in uterine volume reduction and dominant myoma size reduction whether occluding agents was polyvinyl alcohol, polyvinyl alcohol plus gelfoam, and gelfoam, and whether ultrasound measured Resistance Index value before the procedure was low or high. Conclusion: Primary candidates for uterine artery embolization include those with symptomatic uterine leiomyomas who no longer des ire fertility but wish to avoid surgery or are poor surgical risks. To our study, uterine volume reduction and dominant myoma size reduction in patients who had adenomyosis were similar to previous other studies in patients who had not adenomyosis. Therefore adenomyosis should not be considered as a contraindication for uterine artery embolization. Because there is little data about subsequent reproductive potential after this procedure, it should not be routinely advocated for infertile women. Further investigation is warranted for occluding agents and Resistance Index.