• Journal of Veterinary Clinics
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• v.30 no.3
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• pp.196-200
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• 2013

A 7 years-old intact female dog (4.8 kg) was referred with primary complaints of enlarged surface lymph nodes, cardiac murmur, coughing and exercise intolerance. Diagnostic imaging studies found cardiomegaly with distended caudal vena cava, marked left ventricular and interventrciular septal thickening and flattening, severe aortic and pulmonic stenosis (~5 m/s), and mitral and tricuspid regurgitation (~4 m/s). Cytology for the samples obtained from submandibular lymph node and left ventricle revealed high grade malignant lymphoma. The case was diagnosed as cardiac lymphoma. The dog was treated with prednisolone (2 mg/kg, PO, q24h), lomustine (80 $mg/m^2$ PO, q3wk), diltiazem (1 mg/kg, PO, q12h) and enalalpril (0.5 mg/kg, PO, q12h). The clinical signs were improved after therapy. The dog is still on the chemotherapy and regularly checked up.

• Korean Journal of Clinical Laboratory Science
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• v.39 no.3
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• pp.196-200
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• 2007

In clinical practice, homocysteine has gained popularity because its elevated values are strongly associated with an increased risk of cardiovascular disease. More recently, a new enzymatic colorimetric assay for homocysteine in biological sample, suitable for automated clinical analyzers, has been proposed. To evaluate one of these enzymatic methods and compare the results obtained with this method with those of an immunoenzymatic method, thirty-two samples were analyzed for total homocysteine by HiSens$^{(R)}$ homocysteine reagent on the automated chemistry analyzers TBA 200FR and compared to the widely used immunoenzymatic method ADVIA Centaur. In TBA 200FR, the within-run CVs of two control materials were 3.23% and 0.92%, respectively; the between run CVs were 4.58% and 2.55%, respectively. And in ADVIA 1650, the within-run CVs were 6.81% and 0.99%, respectively; the between run CVs were 9.0% and 3.9%, respectively. The recovery for homocysteine was 100% ($60.8{\mu}mol/L$), 99.1% ($48.64{\mu}mol/L$), 96.3% ($36.48{\mu}mol/L$), 96.1% ($24.32{\mu}mol/L$), and 92.1% ($12.16{\mu}mol/L$). The regression equation of TBA 200FR vs. ADVIA Centaur was y=0.9095x-2.5086 (r=0.9632). And the regression equation for the ADVIA 1650 chemistry vs. Immulite 2000 was y=0.8418x + 0.3207 (r=0.9625). In conclusion, this enzymatic method using automated chemistry analyzer for homocysteine assay shows acceptable analytical performance. I suggest that this assay will be suitable for routine analysis.

• Korean Journal of Clinical Pharmacy
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• v.22 no.4
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• pp.316-323
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• 2012

미숙아는 단백질 대사 속도가 빠르기 때문에 성장이 충분히 이루어질 수 있도록 ASPEN 가이드라인에서는 아미노산 초기용량을 1-2 g/kg/day로 투여하도록 권장하고 있다. 또한 최근 여러 연구에서 출생초기 고용량 (1.5-4 g/kg/day) 아미노산 투여에 대해 보고하고 있다. 이를 근거로 하여 삼성서울병원 신생아 중환자실에서도 2009년 6월부터 아미노산 초기용량을 0.5 g/kg/day에서 1.5~2 g/kg/day으로 증량하여 투여하고 있다. 본 연구에서는 신생아 중환자실에서 정맥영양요법을 받은 미숙아를 대상으로 고용량 아미노산 공급 효과를 평가하고자 하였다. 2009년 6월 기준으로 출생 후 48시간 이내에 0.5 g/kg/day로 아미노산을 투여 받은 저용량 환아군(38명: 대조군)과 1.5~2 g/kg/day로 투여 받은 고용량 환아군(38명: 시험군)의 전자의무기록을 후향적으로 검토하였다. 고용량 아미노산 공급 효과를 체중증가량 및 총 정맥영양기간, 경구 및 경장 영양 시작 시기, 재원기간으로 평가하였고, 안전성 평가를 위해 혈액화학검사 및 합병증을 조사하였다. 또한 두 군의 인구학적 및 주산기 인자, 영양 공급량 등에 대해 조사하였다. 두 군의 인구학적 및 주산기 인자는 재태기간에서만 차이를 보였으며, 시험군에서 재태기간이 길었다(p < 0.05). 초기 아미노산 용량만이 생후 28일간 일평균 체중증가량에 영향을 미치는 인자였으며 시험군의 일평균 체중증가량이 대조군보다 유의하게 큰 것으로 나타났다($12.6{\pm}4.5$ g/day vs $9.8{\pm}4.5$ g/day, p < 0.05). 목표 체중증가량에 도달한 비율도 시험군이 높았다(65.8% vs 47.4%). 총 공급열량, 총 정맥영양 공급 기간과 경구 및 경장 영양 시작 시기는 두 군간 차이가 없었으나 시험군에서 목표열량 도달시간, 신생아 중환자실 재원기간이 단축되었다(p < 0.05). 혈액화학검사 결과 및 대사성 산증, 호흡곤란증후군, 괴사성장염 발생은 두 군간 차이가 없었으며 고혈당 및 감염, 기관지폐이형증, 뇌실내출혈 발생률은 대조군에서 유의하게 높았다(p < 0.05). 연구 결과, 미숙아에서 출생 초기 고용량 아미노산 공급은 혈액화학검사 이상이나 합병증 없이 체중증가와 재원기간 감소에 효과가 있음을 확인하였다. 따라서 미숙아에 대한 출생초기 영양지원으로 1.5~2 g/kg/day 아미노산 공급은 안전하고 효과적이라고 사료된다.

• Journal of Veterinary Clinics
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• v.30 no.4
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• pp.292-295
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• 2013

A 9-year-old, male, Doberman pinscher dog with 5-month history of intermittent hematuria, vomiting and glucosuria was referred to local animal hospital. Abdominal ultrasonography showed an irregular and hyperechoic mass in the renal medulla of the enlarged left kidney. Grossly atrophied renal cortex and medulla and marked hydronephrosis were observed on the cut surface of kidney. A single, numerous papillary projected, pedunculated mass 4~5.5 cm in diameter was occupied in renal pelvis, and extended from pelvis to the inlet of ureter. Histopathologically, the mass had numerous papillary structures with arboriform pattern. These papillae were consisted of fibro-vascular stalks that were lined by multiple layers of neoplastic urothelium (transitional epithelium) with marked cellular atypia. Immnohistochemical (IHC) staining demonstrated that the neoplastic cells showed strong positive reactions for cytokeratin (CK) 7, CK 19, CK clone MNF116 and CK high molecular weight, but negative signals for CK 8 low molecular weight. Based on the gross findings, histopathology and CKs profile using IHC staining, this mass was diagnosed as renal pelvis transitional cell carcinoma in a dog.

• Journal of the korean veterinary medical association
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• v.47 no.2
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• pp.165-176
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• 2011

구제역은 우제류 동물이 걸리는 급성열성전염병으로, 본 병에 걸린 동물은 발열이나 식욕부진을 지나 병명대로 구강과 혀 점막, 발굽 주위나 유방의 피부에 수포를 형성한다. 이후 이환된 가축은 섭취 장애나 보행장애가 일어나고, 산육능력이나 비유량이 저하됨에 따른 경제동물로서의 가치를 현저하게 떨어지게 한다. 또한 본 병의 전파는 극히 빠르고 동물이나 축산물에 대하여 엄격한 이동제한이나 방역조치가 본 병의 전파나 확대를 막기 위해 실시하기 때문에 본 병에 의해 생기는 경제적 피해는 농가의 지역단위 뿐만 아니라 국가단위에도 미쳐 심각하다. 그 때문에 자유무역을 표방하는 WTO체재하에 있어서도 구제역의 만연방지를 목적으로 한 무역제한은 국제적으로 용인되어져 오고 있고, 세계동물보건기구에 의해 국가나 지역단위의 청정도 구분이 장해져 각국의 법에 반영되어져 있다. 구제역의 병원체로 있는 바이러스는 숙주역이 넓고, 적지 않은 바이러스양에도 감염이 성립, 감염동물체내에서 바이러스가 신속하게 복제, 감염동물로부터 다량의 바이러스가 배설, 접촉전파만이 아닌 공기전파를 일으킨다는 등이 본 병의 전파나 확대에 유리한 복잡한 성성을 가질 경우에 구제역의 방역 및 박멸을 어렵게 하기 때문에 수의학영역에서 가장 경계해야할 전염병의 하나이다. 따라서 본 필자는 최근의 국내 구제역 발생상황속에서 관련자료정리를 하다가 대동물 임상수의사가 알아야 부분과 일본 동물위생연구소 등에서 구제역바이러스 인공감염 및 화학물질(T-1105)투여시험 결과 내역를 정리하여 소개해두고 저 한다.

• Journal of Korean Clinical Nursing Research
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• v.21 no.2
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• pp.180-187
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• 2015

Purpose: This study was done to identify the effects of semen sinapsis albae acupressure on fatigue and sleep among patients undergoing chemotherapy for breast neoplasms. Methods: The design was a nonequivalent control group nonsynchronized design. Participants were 46 hospitalized patients (23 in the experimental group and 23 in the control group) who were undergoing chemotherapy during November and December 2014. The experimental group underwent routine chemotherapy nursing care and at the same time received acupressure on the spots of Zoksamli, Samumgyo and Shinmun. The control group underwent routine chemotherapy nursing care. The data were analyzed using test and t-test with the SPSS 21.0 program. Results: The level of fatigue in the experimental group was lower than in the control group (t=5.82, p<.001). The level of sleep in the experimental group was higher than in the control group (t=-5.16, p<.001). Conclusion: The findings of the study indicate that acupressure is an effective nursing intervention to decrease fatigue and increase sleep in patients with breast neoplasm undergoing chemotherapy.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.1
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• pp.54-60
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• 2001

The treatment of maxillary cancer has been commonly performed by the surgery and radiation therapy, alone or in combination. Multimodal treatment has been introduced with improvement of chemotherapy and immunotherapy. Multimodal treatment for the maxillary cancer is composed of surgery, radiation therapy, and regional intra-arterial chemotherapy. The present study was performed to evaluate the effectiveness of the multimodal treatment with Morita's method, with a slight modification, for the maxillary cancer. Twenty-four cases of the maxillary cancer were analyzed. The multimodal treatment increased the 5-year-survival rate up to 66% and reduced the need for maxillectomy. This method made the morphological and funtional preservation possible. This method may be recommended for the treatment of maxillary cancer.

• Journal of the Korean Chemical Society
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• v.36 no.4
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• pp.496-503
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• 1992

An ISFET urea sensor was fabricated by immobilizing the urease using photosensitive polymer, poly(vinyl alcohol)-SbQ on the H$^+$ sensing $Si_3$$N_4$ thin film of pH-ISFET. The sensor could determine the urea concentration in the range of 1∼50 mg/dl with fast response and good repeatability. For its application to clinical analysis, the interferences of the various materials which cause inhibition in urease catalytic reactions in blood was investigated. The results of the urea measurements in blood plasma using the ISFET urea sensor were compared with these of conventional spectrophotometric method.

• Journal of the Korean Chemical Society
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• v.53 no.6
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• pp.731-741
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• 2009

‘One-pot’ reaction procedure for the synthesis of novel morpholino pyrimidines (10-18) under microwave irradiation in ‘dry media’ in the presence of heterogeneous $NaHSO_4.SiO_2$ catalyst was developed. All the synthesized compounds were screened for their in vitro antibacterial activities against clinically isolated bacterial strains namely Bacillus subtilis, Bacillus cerues, Micrococcus luteus and Salmonella typhii and antifungal activities against fungal strains namely Aspergillus niger, Candida 6 and Candida 51. Structure activity relationship of the synthesized compounds against microbiological results was discussed.

• Journal of Korean Clinical Nursing Research
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• v.25 no.2
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• pp.189-197
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• 2019

Purpose: The purpose of this study was to identify the effects of symptom experience and depression on the falls efficacy of elderly patients who were undergoing chemotherapy. Methods: The questionnaires were administered to 105 elderly patients over 65 years hospitalizing for chemotherapy from October 25 to December 30, 2018. The data were analyzed by descriptive statistics, t-test, ANOVA, $Scheff{\acute{e}}$ test, Pearson's correlations and Multiple Linear Regression, ursing an SPSS/WIN 22.0 program. Results: Falls efficacy was negatively correlated with the symptom experience (r=-.58, p<.001), and depression (r=-.57, p<.001). Symptom experience and depression were positively correlated (r=.72, p<.001). The significantly influential factors of falls efficacy were age (${\beta}=-.34$, p<.001), symptom experience (${\beta}=-.24$, p=.022), and the history of falls (${\beta}=-.15$, p=.040), explaining 57.0% of the variance in falls efficacy. Conclusion: The main findings of this study can be used as the foundation for developing programs to increase the falls efficacy of elderly patients undergoing chemotherapy.