• Radiation Oncology Journal
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• v.21 no.3
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• pp.245-249
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• 2003

A primary malignant melanoma of the vagina is a very rare gynecological malignant tumor. Its clinical behavior is more aggressive than that of cutaneous and vulvar melanomas. We present a case of a large sized primary melanoma of the lower third of the vagina, with a cervical lesion, in a 58-year-old postmenopausal woman. The patient was treated with conventional external radiation therapy and intracavitary radiotherapy (ICR), without surgical treatment. Although the primary lesion showed a partial response, the patient died of extensive metastases, which were found 4.5 months after the initial diagnosis. We suggest that shortening the treatment period, such as hypofractionated radiation therapy and surgical removal, and various systemic therapies for preventing early distant metastasis, are appropriate treatments for a primary malignant melanoma of the vagina, with a large tumor size.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.4
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• pp.205-215
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• 2006

Purpose : To identify factors related to the severity and frequency of hot flush of postmenopausal women who participated in a clinical trial. Methods : A cross-section study of 34 postmenopausal women between 40 and 60 years of age was done. VAS(visual analog scale) was used to evaluate the hot flush degree. Statistical analysis was performed with multiple linear regression analysis. Results : Hot flush VAS was proportional to the percent body fat with 1.467 regression coefficient (p-value= 0.010). It implies that the symptom of hot flush becomes worse as the percent body fat increases. Some hormones also have effects on hot flush. We found that LH might cause increment of hot flush VAS(i.e., the corresponding regression coefficient is 0.912). Sasang constitution was not relevant to the hot flush degree. Hot flush VAS seemed to increase as the vascular aging degree by SA-2000 getting worse, but it was not statistically significant (p-value= 0.594). Conclusion : This study is a part of a prospective clinical trial. For more accurate result, larger-scale cross-section study or clinical trial are necessary.

• Journal of the korean academy of Pediatric Dentistry
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• v.27 no.1
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• pp.77-84
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• 2000

Although ferric sulfate has been proposed as an alternative to formocresol in pulpotomy treatment in primary teeth, it has been given little concern regarding its cytotoxicity and mutagenicity. In the present study, we assessed the in vitro genotoxic effect of a ferric sulfate on human gingival fibroblast cell line (HGF-1). DNA damage was evaluated using comet assay (single cell alkaline gel electrophoresis) and obtained the results as follows: 1. A dose-response relationship was found between ferric sulfate concentrations (0 to 5mM) and DNA damages. 2. Above the concentration of 0.1mM, DNA damage was significantly increased than those of the control (p<0.05). 2. At the fixed concentration of 0.05mM, no significant difference was found between exposure time and DNA damage. These findings suggest that ferric sulfate as a pulpotomy agent can induce DNA damage in human gingival fibroblasts.

• The Journal of Korean Academy of Prosthodontics
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• v.56 no.1
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• pp.70-76
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• 2018

Excessive tooth wear can lead to decrease in occlusal vertical dimension and can cause pathological changes in the oral environment and masticatory system. When recovering occlusal vertical dimension and occlusion, accurate diagnosis and analysis are essential. This clinical case describes a 75-year-old woman with severely worn dentition due to loss of the posterior support. Full mouth rehabilitation with occlusal vertical dimension increment was planned. Clinical and radiographic examinations, occlusal vertical dimension evaluation, and diagnostic wax-up were performed and patient adaptability was evaluated using provisional restorations. As for definitive restoration, considering economic condition of the patient, removable partial denture was fabricated and solitary implants were placed in the mandibular left and right posterior region to increase support and retention of the removable partial denture. During one year of follow-up, functional and esthetic outcomes were observed satisfactory.

• The Journal of the Korean bone and joint tumor society
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• v.5 no.3
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• pp.178-182
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• 1999

We report a case of bizarre parosteal osteochondromatous proliferation of the right femur in an 18-year-old man. Roentgenograms showed a calcific mass attached to the underlying cortex with a broad base. Histologically, the lesion showed hypercellular cartilaginous tissue with maturation into trabecular bone, which contained spindle cells and lymphocytes in the intertrabecular spaces. Bizarre parosteal osteochondromatous proliferations are a form of heterotopic ossification and should not be mistaken for osteosarcoma or chondrosarcoma.

• Journal of the Korean Society of Food Science and Nutrition
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• v.12 no.1
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• pp.51-56
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• 1983

The recent work on symptomatology and therapy of essential fatty acid (EFA) deficience has been reviewed. EFA deficiency is due to an absence of dietary linoleic acid which cannot be synthesized endogenously in man. The diagnosis of EFA deficiency is based on clinical features such as the appearance of scaly skin rash, sparse hair growth or failure to thrive, which occur late in the course of EFA deficiency and biochemical features occurring within two weeks of fat-free diet. The amount of linoleic acid required to prevent EFA deficiency varies with age of the patient and route of fat administration.

• Annals of Clinical Neurophysiology
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• v.1 no.1
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• pp.64-69
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• 1999

Background : Syncope was defined as transient loss of consciousness and postural tone. The mechanisms of changes in cerebral hemodynamics during syncope have not been fully evaluated. Transcranial Doppler Ultrasonography can continuously monitor the changes in cerebral hemodynamics during head-up tilt (HUT). TCD could reveal the different patterns of changes in cerebral hemodynamics during syncope. Syncope without hypotension or bradycardia could be detected by TCD. We investigated the changes in cerebral blood flow velocity during HUT using TCD in 33 patients with a history of recurrent syncope or presyncope of unknown origin. Methods & Results : The positive responses were defined as presyncope or syncope with hypotension, bradycardia, or both. During HUT without isoproterenol infusion, there were a $86{\pm}23%$ drop in DV and a $41{\pm}34%$ drop in SV in 5 patients with positive reponses, and mean changes in those were less than 10% in patients with negative reponses (p=.00, p=.00). During HUT with isoproterenol infusion, TCD showed a $80{\pm}18%$ drop in diastolic velocity in 14 patients with positive reponses, and a $47{\pm}10%$ drop in that in patients with negative reponses (p=.00), however the change in systolic velocity did not differ. TCD showed three patterns during positive responses; loss of all flow, loss of end diastolic flow, and a decrease in diastolic velocity. Loss of consciousness occurred in the patients with loss of all flow or end-diastolic flow during positive reponses. Conclusions : TCD shows different patterns of changes in cerebral hemodynamics during HUT. TCD can be used to investigate the pathophysiology of neurocardiogenic syncope.

• Annals of Clinical Neurophysiology
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• v.6 no.1
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• pp.26-30
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• 2004

Background: Electrophysiologic study accurately predicts the degree of degenerated motor axons but cannot give precise information on the type of injury that occurred in Bell's palsy. Because of these limitation for prognostic prediction in Bell's palsy, we evaluated divergence of electrophysiological time course for the purpose of presuming the type of injury in Bell's palsy. Methods: We did bilateral facial nerve conduction studies in 103 Bell's palsy patients, who visited to Han-Gang sacred heart hospital from 1998 to 2001. We compared the CMAP amplitude of disease site with that of normal site and suggested that decremental CMAP amplitude ratio (percentage) as a degree of denervation of affected facial nerve. Then we demonstrated the time course of denervation percentage. After defining normal range of CMAP amplitude difference from normal control group, we also evaluated if distinct time course of early minimal denervation is present. Results: Our results show that time course of the denervation in early stage of Bell's palsy reflect various injury type such as axonotmesis, neurotmesis or other unidentified type. We cannot identify the distinct time course of early minimal denervation. Conclusions: The time course as well as the maximal value of denervation are the best prognostic guidelines in Bell' s palsy. So repeated serial electrophysiologic test are inevitable to assess prognosis. As an another topic, early minimal denervation for prognostic prediction deserve to be evaluated as a future work up for prognostic prediction.

• Journal of Korean society of Dental Hygiene
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• v.13 no.4
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• pp.543-552
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• 2013

Objectives : The aim of the study is to investigate job performance expectations according to duration of work and to specify the clinical practice of dental hygienists by career expectations. Methods : The subjects were 310 dental hygienists in Seoul and Incheon. They completed the self-reported questionnaires and 304 data were analyzed except incomplete 6 answers. Results : The tasks performed by dental hygienists were as follows ; SS crown restoration in pediatric dentistry accounted for 25.1%, orthodontics (42.1 %), plaque removal (71.4 %), temporary fillings (60.5%), and impression taking of abutments and bite registration (58.9%). In order to be a skillful dental hygienists, it took two to three years of clinical filed work. Conclusions : On the job training (OJT) is the most important in dental hygiene curricula. So it is necessary to develop the OJT performance skill.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.15 no.2
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• pp.118-121
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• 2004

배경 및 목적 : 한국 구개열환자에게는 된소리 자음(농음0의 구음산출의 난도가 높다는 것은 임상적으로 잘 알려져 있다. 그러므로 본 연구에서는 한국 구개열 환자에게 있어서 난도가 높은 농음의 산출 메커니즘의 기본적 요소를 규명하므로서 언어치료의 새로운 방법모색에 기여하고져 하였다. 연구방법; 비강자음에 후속된 3종의 어두 파열자음 산출시의 구개범거근의 근활동 양상의 차이를 비교검토하므로서 농음의 산출특성을 검색하고져 하였다. 관찰기록 방법은 근전도는 유구침금전극(hooked wire electrodes)을 구강내로부터 경점막적으로 유도하였다. 연구결과 : 격음과 농음의 파열자음에서 평음보다 높은 구개범거근의 근활동이 관찰되었으나 격음과 농음 사이에선 유의미적인 차이는 보이지 않았다. 결 론 : 금후의 과제로는 피험자를 늘려 재확인을 하는 일, 및 농음과 격음의 변별요소에 관해 더욱 검토할 필요가 있는 것이 시사되었다.