• Title/Summary/Keyword: 임상연구법

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Clinical considerations for complete denture relining (의치상 첨상재의 종류와 임상적 고려사항)

  • Young-Eun Cho
    • Journal of Dental Rehabilitation and Applied Science
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    • v.40 no.2
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    • pp.39-45
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    • 2024
  • The residual alveolar ridge below the denture base undergoes physiologic changes over time, which results in the existing dentures becoming less accurate with the residual alveolar ridge. In addition, changes of the occlusal plane, decreasing in vertical dimension and loss of denture retention and facial support can occur. Consequently, denture relining may be required to accommodate these changes and ensure an ongoing close fit. Relining a denture can be performed directly on the chairside using autopolymerizing relining materials or indirectly in the laboratory using heat-cured relining materials. A direct relining method is not only simple but also time and cost effective. However, irritation or burning sensation of the mucosa can occur, and poor bonding of the relining material to the denture base can be cited as disadvantages. The indirect relining method exhibits relatively high bonding strength between the relining material and the denture base, but the patient might experience discomfort during relining process period. This report will examine the characteristics of relining materials, including those used in the relining of CAD-CAM dentures, and explore the clinical considerations for relining procedures.

Optimization of Automated Solid Phase Extraction-based Synthesis of [18F]Fluorocholine (고체상 추출법을 기반으로 한 [18F]Fluorocholine 합성법의 최적화 연구)

  • Jun Young PARK;Jeongmin SON;Won Jun KANG
    • Korean Journal of Clinical Laboratory Science
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    • v.55 no.4
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    • pp.261-268
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    • 2023
  • [18F]Fluorocholine is a radiopharmaceutical used non-invasively in positron emission tomography to diagnose parathyroid adenoma, prostate cancer, and hepatocellular carcinoma by evaluating the choline metabolism. In this study, a radiolabeling method for [18F]fluorocholine was optimized using a solid phase extraction (SPE) cartridge. [18F]Fluorocholine was labeled in two steps using an automated synthesizer. In the first step, dibromomethane was reacted with [18F]KF/K2.2.2/K2CO3 to obtain the intermediate [18F]fluorobromomethane. In the second step, [18F]fluorobromomethane was passed through a Sep-Pak Silica SPE cartridge to remove the impurities and then reacted with N,N-dimethylaminoethanol (DMAE) in a Sep-Pak C18 SPE cartridge to label [18F]fluorocholine. The reaction conditions of [18F]fluorocholine were optimized. The synthesis yield was confirmed according to the number of silica cartridges and DMAE concentration. No statistically significant difference in the synthesis yield of [18F]fluorocholine was observed when using four or three silica cartridges (P>0.05). The labeling yield was 11.5±0.5% (N=4) when DMAE was used as its original solution. On the other hand, when diluted to 10% with dimethyl sulfoxide, the radiochemical yield increased significantly to 30.1±5.2% (N=20). In conclusion, [18F]Fluorocholine for clinical use can be synthesized stably in high yield by applying an optimized synthesis method.

Detection of Viral Antigens in Stool Using EIA in Hospitalized Children and Clinical Implication (간접 효소 면역측정법을 이용한 입원 환아의 대변에서 바이러스 항원의 검출과 임상적 의의)

  • Min, Jung Hye;Seo, Jeong Wan;Park, Hye Kyung
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.7 no.2
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    • pp.143-152
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    • 2004
  • Purpose: The purpose of this study is to detect viral coproantigens in children who were hospitalized with acute diarrhea and to compare its association with clinical symptoms. Methods: Seventy-four stool samples were collected from children admitted to Ewha Mokdong Hospital from March 1996 to December 1999. The samples were frozen and analyzed for rotavirus, adenovirus, enterovirus, astrovirus, and calicivirus by enzyme immunoassay (EIA) with monoclonal antibody. 53 stool samples were collected from patients with diarrhea (diarrheal group) and 21 stool samples from patients hospitalized for reasons other than diarrhea (control group). Clinical features and laboratory findings were reviewed in both groups. Results: Among 74 stool samples, virus antigens were detected in 60 samples. Of the 60 virus-positive stool samples, 47 enterovirus, 26 rotavirus, 16 adenovirus, 11 astrovirus, and 11 calicivirus antigens were detected by EIA. Of the 60 virus-positive stool samples, 28 samples have one viral antigen, 30 samples have 2 or more viral antigens, and 2 samples showed a simultaneous infection of Salmonella group B and enterovirus. There was no relationship between the detected virus and clinical features. Conclusion: In this study, viral coproantigen and clinical symptoms were not associated. In the future, further larger scale studies are necessary.

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Ethical perception from practice of ethics education (윤리 교육경험에 따른 윤리 지식수준에 관한 연구)

  • Kim, Yun-Jeong;Kwag, Jung-Suk
    • Journal of Korean society of Dental Hygiene
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    • v.7 no.2
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    • pp.115-122
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    • 2007
  • 이 연구는 보건계열 학과에 재학 중인 학생들의 윤리교육 경험과 윤리교육 필요성인지에 따른 윤리지식수준의 차이를 살펴보고자, 보건계열 학과에 재학 중인 596명을 대상으로 자기기입법에 의한 설문조사법으로 2005년 4월 한달 동안 실시하였다. 연구에 사용된 연구도구로 독립변수는 의료 윤리 교육경험, 전문윤리 교육경험, 직업윤리 교육경험, 임상실습 경험, 전문윤리 교육 필요성 인지, 의료윤리 교육 필요성 인지이었고, 종속변수는 면허관련법규 지식수준, 전문윤리 지식수준, 의사결정판단 지식수준, 팀웍 지식수준이었다. 수집된 자료를 SPSS 12.0을 사용하여 기술통계와 t-test를 실시한 결과, 임상실습경험 직업윤리 교육경험 의료윤리 교육경험, 전문윤리 교육경험, 전문윤리 교육 필요성 인지에 따라 유의한 차이가 있었으며, 이 중 직업윤리 교육경험에 따라서는 4가지 윤리지식수준에서 유의한 차이가 있는 것으로 나타났다. 따라서 정상적으로 학교에서의 윤리교육이 이루어져야 하고, 일반 윤리교육에 비해서 직업 윤리교육이 강화되어야 한다고 사료되었다.

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의학연구에서 반복측정 실험 계획법

  • 박선일
    • Journal of the korean veterinary medical association
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    • v.38 no.10
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    • pp.892-914
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    • 2002
  • 의학연구에서는 여러 가지 이유로 반복측정 실험이 자주 수행된다. 저자가 대한수의학회지와 임상수의학회지에 발표된 최근 몇 년의 실험연구를 분석한 결과 상당수의 논문이 반복측정 실험계획을 활용하였지만 자료분석에서는 매우 잘못된 분석을 수행함으로써 결과의 신빙성과 객관성에 많은 문제점을 안고 있는 것으로 조사되었다. 아무리 훌륭한 실험을 수행하였다고 하더라도 실험계획에 적합하지 않는 자료분석은 논문으로서의 가치가 없음을 너무나 분명한 사실이다. 많은 국내외 저자들이 의학연구에서 자료분석의 오류가 끊임없이 지적하였음에도 불구하고 이에 대한 교육 부재와 필요성에 대한 인식부족은 여전하다. 본 원고에서는 의학연구에서 흔하게 접하는 두가지 예제를 들어 반복측정 실험계획의 기본원리와 분석법 및 결과의 해석에 초점을 맞추어 설명하고자 한다. 본 실험계획법에 대하여 관심이 있는 독자는 저자에게 연락하면 자세한 논의를 할 수 있다.

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Maximum tolerated dose estimation using continual reassessment method in Phase I Clinical Trial (연속재평가방법에 가속화 단계를 적용한 MTD 추정법)

  • Kwon, Dohee;Kim, Dongjae
    • The Korean Journal of Applied Statistics
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    • v.32 no.5
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    • pp.741-752
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    • 2019
  • The purpose of a Phase I Clinical Trial is to determine the maximum tolerated dose (MTD). MTD is important because it affects subsequent clinical trials; however, the existing method has a problem due to an inadequate dose allocated to patients. In this paper, an MTD estimation method is proposed to complement the problems of the existing MTD estimation method. The suggested method applies the initial acceleration step to the modified continual reassessment method. Monte Carlo Simulation Study is adapted to compare a suggested MTD estimation method with the standard design and the modified continual reassessment method.

Detection of Macro-Aspartate Aminotransferase (AST) in an Asymptomatic Patient with Persistent Elevation of AST (지속적으로 AST가 증가된 무증상 환자에서 Macro-AST의 검출)

  • Yang, Eun Ju;Lim, Sung Soo;Shin, Kyeong Seob
    • Korean Journal of Clinical Laboratory Science
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    • v.53 no.2
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    • pp.188-192
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    • 2021
  • The persistent increase of aspartate aminotransferase (AST) due to the presence of a macro-AST can confuse diagnostic or therapeutic decisions in many clinical situations. In this study, we report a case of isolated and persistent AST-elevation without any clinical sign of dysfunction in organs such as the liver, skeletal muscle, cardiac muscle, etc. Despite various investigations, no definite cause for the elevation of AST could be found. With the help of polyethylene glycol (PEG) precipitation, we showed that macro-AST formation was responsible for the elevation of the AST titer in this case. Early recognition of macro-AST by PEG precipitation can prevent diagnostic confusion and unnecessary and even invasive tests.

The Effect of Splinting with Concomitant Root Planing;Clinical and Digital Subtraction Radiographic Study (치근활택술과 스프린트 병행처치의 효과에 관한 연구;디지털 공제 촬영술을 이용한 임상적 연구)

  • Lee, Ji-Young;Kye, Seung-Bum;Kim, Won-Kyoung;Lee, Yong-Moo;Ku, Young;Ryu, In-Chul;Chung, Chong-Pyoung;Choi, Sang-Mook;Han, Soo-Boo
    • Journal of Periodontal and Implant Science
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    • v.31 no.1
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    • pp.207-227
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    • 2001
  • 스프린트는 치주처지료에서 부가적 처치법으로 널리 사용되고 있으며, 한편, 디지털 공제 활영술은 기존방사선촬영술의 한계점을 극복하기 위해 기발된 새로운 방법이다. 이번 연구에서는 치근활택술 단독시행시와 스피린트 병행 처치시의 효과를 임상적, 방사선학적으로 비교하였다. 중정도의 성인성 치주염을 가진 20명의 환자를 대상으로 하되 10명은 치근활택술 단독으로, 나머지 10명은 스프린트 병행처치로 처치하였다. 임상적, 방사선학적인 평가는 처치전, 처치후 6개월에 행하고, 임상적 평가의 경우 3개월에 추가로 실시하였다. 이번 연구에서 사용된 임상 지수로는 치태지수, 치은지수, 치은퇴축, 치주낭깊이, 임상부착수준, 임상부착증가, 탐침시출혈, 치아동요도 등이며, 방사선학적 평가는 기존 방사선촬영술에 의한 방법과 디지털 공제촬영수렝 의한 방법으로 행하였다. 디지털 공제 촬영술에 의한 평가시, 영상은 Digora 프로그램에 의해 획득하고 Emago 프로그램으로 처리 하여 다음과 같은 결론을 얻었다. 1. 처치후 3개월에 치태지수, 치은지수, 치은퇴축, 치주낭깊이, 임상적부착수준, 탐침시 출혈 등의 임상지수들이 변했으며, 특히 이러한 변화는 치주낭깊이, 치은퇴축, 탐침시출혈에서 유의성이 있었다. ( p<0.05 ) 그러나 두군간 차이는 인정되지 않았다. ( p>0.05 ) 2. 처치후 6개월에도 치태지수, 치은지수, 치은퇴축, 치주낭깊이, 임상적부착수준, 탐침시출혈, 치아동요도 등의 임상지수들이 변했으며, 특히 이러한 변화는 치주낭깊이, 치은퇴축, 탐침시출혈, 치태지수, 치아동요도에서 유의성이 있었다. ( p<0.05 ) 그러나 두 군간 차이는 인정되지 않았다. ( p>0.05 ) 3. 켄달 상관분석시, 임상적 평가와 기존 방사선 촬영술에 의한 평가사이의 관련성을 낮았으며 거의 0에 가까운 수치를 보였으며 (r=0.110, p=0.639 ) 임상적 평가와 디지털 공제 방사선 촬영술에 의한 평가사이에서 약간 높은 관련성을 보였다. ( r=0.257, p=0.315 ) 즉 치주치료후의 골변화는 디지털 공제 방사선 촬영술에 의한 평가시 기존 방사선 사진보다 임상적 부착증가와 더욱 긴밀한 관련성을 보여준다. 이상의 결과로 볼 때, 스프린팅 처치는 치주 치료에 있어 치근활택술에 부가적 표과를 제공하지 못한다.

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The Study about Nursing Students' Experience on Emergency Room Environment Observation (간호 대학생의 응급실 관찰 경험)

  • Kim, Hae-Ok;Seo, Bong-Hwa;Nam, Mun-Hee;Park, Euna
    • Journal of Digital Convergence
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    • v.11 no.12
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    • pp.589-598
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    • 2013
  • The research about nursing students' experience on the clinical environment observation is essential to developed effective strategy for clinical education and to improve quality for clinical practice of nursing education. This study is aimed to above goal by the report about nursing students' experience on emergency room environmental observation. The number of participants is 30 nursing students who are senior in the practicing at emergence room. Data analysis was centered on scrutinizing the contents of the participants' replies in order to deduce any relevant meaning. Also, data were analyzed by the meaning of learning based on self-examination through the practical learning. The positive and negative topics stated. Nursing students' experience on emergency room observation will supply the thinking about their own self-portrait in near future, and will give self reflection about correct nursing interventions to nursing students.

A Nonparametric Stratified Test Based on the Jonckheere-Terpstra Trend Statistic (Jonckheere-Terpstra 추세 검정통계량에 근거한 비모수적 층화분석법)

  • Cho, Do-Yeon;Yang, Soo;Song, Hae-Hiang
    • The Korean Journal of Applied Statistics
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    • v.23 no.6
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    • pp.1081-1091
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    • 2010
  • Clinical trials are often carried out as multi-center studies because the patients enrolled for a trial study are very limited in one particular hospital. In these circumstances, the use of an ordinary Jonckheere (1954) and Terpstra (1952) test for testing trend among several independent treatment groups is invalid. We propose a the stratified Jonckheere-Terpstra test based on van Elteren (1960)'s stratified test of Wilcoxon (1945) statistics and an application of our method is demonstrated through example data. A simulation study compares the efficiency of stratified and unstratified Jonckheere-Terpstra trend tests.