• Title/Summary/Keyword: 일체안전성

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Molecular Docking Affinity Comparison of Curcumin and Nano-micelled Curcumin with Natural Sea Salt on Transthyretin (울금의 주요 성분인 커큐민과 나노 마이셀링 기법 적용 염화 커큐민의 트랜스타이레틴 활성 부위에 대한 결합 친화도 비교분석)

  • Kim, Dong-Chan;Song, Pyo
    • Journal of Life Science
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    • v.26 no.2
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    • pp.253-258
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    • 2016
  • In this study, nano-micelled curcumin was produced with natural sea salt with a view to comparing the in silico molecular binding affinity of pure curcumin compound to the active site of transthyretin. Using an optical light microscope and an electron microscope, it was found that the structure of the surface and the cross-section of nano-micelled curcumin was significantly different from natural sea salt. In particular, the crystal structure and nano-components in the nano-micelled curcumin were united, and the layer was more strongly stabilized than untreated salts. In the virtual 3D structure, in silico molecular docking study, the ligand binding affinity of nano-micelled curcumin to the transthyretin active site was found to be higher than that of pure curcumin. In addition, a nano-micelled curcumin formula interacted with more amino acid residues of transthyretin domains. The pharmacophore feature of the nano-micelled curcumin also showed more condensed and constrained features than normal curcumin. These results suggest that nano-micelled curcumin may effectively bind to and stabilize transthyretin, thereby regulating transthyretin-related physiological diseases. Collectively, the nano-micelled curcumin process suggests that normal curcumin can be modified more efficiently into the novel bio-functional chemical formula to stabilize the transthyretin structure. Therefore, the nano-micelled curcumin process can be applied to the field of the regulation of Alzheimer's disease.

Analysis of Impact on the Circulating Water System due to an Installation of Helical Current Turbine at the Discharge Channel of the Power Plant (헬리컬 조류수차 설치로 인한 발전소 배수로 계통 영향 분석)

  • Kim, Ji-Young;Kang, Keum-Seok;Ryu, Moo-Sung
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.22 no.2
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    • pp.67-72
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    • 2010
  • In this study, the impact on the circulating water system has been analyzed due to an installation of helical turbine to develop hydro-kinetic energy at the discharge channel of the power plant. Numerical simulations of velocity and pressure variations have been performed when one set of $3.6\;m\;{\times}\;1.5\;m$ sized helical turbine is installed at the outlet of discharge culvert. In case of mean sea level, change of downstream water surface elevation does not affect upstream elevation of the weir because its propagation is blocked by the seal well weir. However in case of highest high water level, change of downstream elevation affects upstream elevation because flow pattern in discharge culvert becomes the full pipe flow with submerged weir. Although an unstable pressure change occurs in upstream of the weir during the intial 10 minutes after beginning of the discharge, it becomes stable after that time. In addition, a rise of water surface elevation by 0.2 m is observed but it is concluded that it hardly affects the safety of circulating water pump (CWP) although its required power is increased more or less. Therefore, the increase of required power of CWP needs to be considered for evaluation of the helical turbine applicability.

A Study on Design of Vacuum Silo for Batch Treatment System for Dredged Soil (준설토 일괄처리시스템을 위한 진공사이로 설계에 관한 연구)

  • Kim, Yong-Seok;Yang, Hae-Rim;Kim, Hac-Sun;Jeoung, Chan-Se;Yang, Soon-Yong
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.36 no.5
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    • pp.571-577
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    • 2012
  • In this study, a small movable batch treatment system for dredging soil deposited in a rain water tube is proposed; further, a vacuum silo sorting separation device with a vacuum silo, first-stage sorting separator, and conveyor is designed. The vacuum silo sorting separation device also consists of a storage tank, transferring screw, vacuum gate, screen bar, screen bar cleaner, and vacuum discharging device. In view of the fact that the flow of drawn air in the storage tank is a major factor influencing the sorting separation performance, the optimum shape of the tank is determined by CFD flow analysis. In addition, by using CAE structure analysis, the safety of a storage tank made of boards is examined. The specifications of the vacuum silo sorting separation device are determined by conducting mechanical and dynamic simulations of the driving mechanism of the vacuum silo sorting separation device through 3D-CAD modeling. Following this study, we will design a drum-screen-type second sorter, a decanter-type dehydration device, and waste water tank and pump as a secondary device. Further, on the basis of this design, we will construct a prototype model and carry out a field test.

An Effect of Steel Corrosion on Bond Stress-slip Relationship under Repeated Loading (반복하중하의 부착응력-슬립 관계에 미치는 철근 부식의 영향)

  • Kim, Chul-Min;Park, Jong-Bum;Chang, Sung-Pil;Kim, Jee-Sang
    • Journal of the Korea Concrete Institute
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    • v.22 no.2
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    • pp.179-186
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    • 2010
  • The bond between steel and concrete in reinforced concrete members is essential to resist external load, but the bond mechanism in reinforced concrete beams deteriorated by steel corrosion has not been clearly known yet. Most existing researches have dealt with the bond behavior of corroded steel under monotonic loading, but scarce are researches dealing with bond behavior of corroded steel under repeated loading. This study includes the experimental investigation on the bond behavior with respect to the various degrees of steel corrosion under repeated loading. According to the test results, the bond strength of corroded steel under monotonic loading increases as the rate of steel corrosion increases unless the splitting crack occurs. The slip versus number of load cycles relation was found to be approximately linear in double logarithmic scale, not only in specimens without steel corrosion but also in specimens with steel corrosion. The test results also show that the steel corrosion does not negatively affect the bond strength of corroded steel after repeated loading unless the splitting crack occurs. But the fatigue life decreases sharply after splitting crack occurs. This research will be helpful for the realistic durability design and condition assessment of reinforced concrete structures.

Seismic Response Analysis of a Two-Mass Rack System Considering Frictional Behavior (마찰거동을 고려한 이중질량시스템의 지진응답해석)

  • Park, Kwan-Soon;Ok, Seung-Yong;Lee, Jeeho
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.31 no.6
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    • pp.347-352
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    • 2018
  • This study proposes seismic response analysis technique of a two-mass rack system which sustains heavy loads with frictional behavioral characteristics. In order to deal with the nonlinear frictional characteristics of the mass on the rack system, the equations of motion of the system has been derived and the appropriate numerical simulation technique has been developed. In order to examine the seismic performance of the proposed system, we consider two parameters that are expected to have great influence on the seismic performance of the system. One is the ratio of the two masses of the load and the rack structure, and the other is the friction coefficient between rack and loaded mass. A number of numerical simulations of the seismic response of structures with various natural frequencies for both parameters have been performed in order to investigate the seismic safety of the rack structures. From the simulated results. it is observed that the maximum displacement of the rack system tends to decrease drastically as the natural frequency of the structure increases regardless of the two parameters of mass ratio and friction coefficient. The proposed study provides important reference data to guarantee the seismic safety of the rack system by considering nonlinear frictional behavior of the loaded mass.

Behavior of Lateral Resistance according to Embed Depth of Pile for the Wind Power Foundation Reinforced with Piles in the Rocky Layer (암반지반에서 말뚝으로 보강된 풍력발전 기초의 말뚝 근입깊이에 따른 수평저항력 거동)

  • Kang, Gichun;Kim, Dongju;Park, Jinuk;Euo, Hyunjun;Park, Hyejeong;Kim, Jiseong
    • Journal of the Korean Geosynthetics Society
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    • v.21 no.2
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    • pp.49-56
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    • 2022
  • This study conducted to obtain the lateral resistance of a wind power foundation reinforced with piles through an model experiment. In particular, the lateral resistance of the foundation was compared with the existing gravity-type wind power foundation by integrating the pile, the wind power generator foundation, and the rocky ground. In addition, changes in the lateral resistance and bending moment of the pile were analyzed by embeded depths of the pile. As a result, it was found that the lateral resistance increased with the depth of embedment of the piles. In particular, the pile's resistance increase ratio was 2.11 times greater in the case where the pile embedded up to the rock layer than the case where the pile was embedded into the riprap. It was found that the location of the maximum bending moment occurred at the interface between the wind turbine foundation and the riprap layer when the pile embeded to the rock layer. Through this, as the lateral resistance of the wind power foundation reinforced with piles is greater than that of the existing gravity-type wind power foundation, it is understood that it can be a more advantageous construction method in terms of safety.

Calculation of Crack Width of the Top Flange of PSC Box Girder Bridge Considering Restraint Drying Shrinkage (구속 건조수축을 고려한 PSC BOX 거더교 상부플랜지 균열폭 산정)

  • Young-Ho Ku;Sang-Mook Han
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.3
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    • pp.30-37
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    • 2023
  • The PSCB girder bridge is a closed cross-section in which the top and bottom flanges and the web are integrated, and the structural characteristics are generally different from the bridges in which the girder and the floor plate are separated, so a maintenance plan that reflects the characteristics of the PSCB girder bridge is required. As a result of analyzing damage types by collecting detailed safety diagnosis reports of highway PSCB girder bridges, most of the deterioration and damage occurring during use is concentrated on the top flange. In particular, cracks in the bridge direction on the underside of the top flange occurred in about 70 % of the PSCB girder bridges to be analyzed, and these cracks were judged to be caused by indirect loads such as heat of hydration and drying shrinkage rather than structural cracks caused by external loads. In order to improve durability and reduce maintenance costs of PSCB girder bridges in use, it is necessary to control restraint drying shrinkage cracks from the design stage. Therefore, in this paper, the cracks caused by drying shrinkage under restraint, which is the main cause of cracks under the flanges of the top part of the PSCB girder bridge, were directly calculated using the Gilbert Model, and the influencing factors such as the amount of reinforcing bars, diameter and spacing of reinforcing bars were analyzed. As a result of the analysis, it was found that the crack width caused by restraint drying shrinkage exceeded the allowable crack width of 0.2 mm for reinforcing bars with a reinforcing bar ratio of 0.01 or less based on the H16 reinforcing bar and a reinforcing bar with a diameter greater than H19 based on the reinforcing bar ratio of 0.01. Finally, based on the results of the crack width review, a method for controlling the crack width of the top flange of the PSCB girder bridge was proposed.

Analysis and Implication on the International Regulations related to Unmanned Aircraft -with emphasis on ICAO, U.S.A., Germany, Australia- (세계 무인항공기 운용 관련 규제 분석과 시사점 - ICAO, 미국, 독일, 호주를 중심으로 -)

  • Kim, Dong-Uk;Kim, Ji-Hoon;Kim, Sung-Mi;Kwon, Ky-Beom
    • The Korean Journal of Air & Space Law and Policy
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    • v.32 no.1
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    • pp.225-285
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    • 2017
  • In regard to the regulations related to the RPA(Remotely Piloted Aircraft), which is sometimes called in other countries as UA(Unmanned Aircraft), ICAO stipulates the regulations in the 'RPAS manual (2015)' in detail based on the 'Chicago Convention' in 1944, and enacts provisions for the Rules of UAS or RPAS. Other contries stipulates them such as the Federal Airline Rules (14 CFR), Public Law (112-95) in the United States, the Air Transport Act, Air Transport Order, Air Transport Authorization Order (through revision in "Regulations to operating Rules on unmanned aerial System") based on EASA Regulation (EC) No.216/2008 in the case of unmanned aircaft under 150kg in Germany, and Civil Aviation Act (CAA 1998), Civil Aviation Act 101 (CASR Part 101) in Australia. Commonly, these laws exclude the model aircraft for leisure purpose and require pilots on the ground, not onboard aricraft, capable of controlling RPA. The laws also require that all managements necessary to operate RPA and pilots safely and efficiently under the structure of the unmanned aircraft system within the scope of the regulations. Each country classifies the RPA as an aircraft less than 25kg. Australia and Germany further break down the RPA at a lower weight. ICAO stipulates all general aviation operations, including commercial operation, in accordance with Annex 6 of the Chicago Convention, and it also applies to RPAs operations. However, passenger transportation using RPAs is excluded. If the operational scope of the RPAs includes the airspace of another country, the special permission of the relevant country shall be required 7 days before the flight date with detail flight plan submitted. In accordance with Federal Aviation Regulation 107 in the United States, a small non-leisure RPA may be operated within line-of-sight of a responsible navigator or observer during the day in the speed range up to 161 km/hr (87 knots) and to the height up to 122 m (400 ft) from surface or water. RPA must yield flight path to other aircraft, and is prohibited to load dangerous materials or to operate more than two RPAs at the same time. In Germany, the regulations on UAS except for leisure and sports provide duty to avoidance of airborne collisions and other provisions related to ground safety and individual privacy. Although commercial UAS of 5 kg or less can be freely operated without approval by relaxing the existing regulatory requirements, all the UAS regardless of the weight must be operated below an altitude of 100 meters with continuous monitoring and pilot control. Australia was the first country to regulate unmanned aircraft in 2001, and its regulations have impacts on the unmanned aircraft laws of ICAO, FAA, and EASA. In order to improve the utiliity of unmanned aircraft which is considered to be low risk, the regulation conditions were relaxed through the revision in 2016 by adding the concept "Excluded RPA". In the case of excluded RPA, it can be operated without special permission even for commercial purpose. Furthermore, disscussions on a new standard manual is being conducted for further flexibility of the current regulations.

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Interpretation and Preservation Plan for Landscapes of Okyeonsipyeong at Buyongdae, Hahoe Village - Based on the Writings of "Okyeonseodanggi" and "Okyeonsipyeong" - (하회마을 부용대의 경관 해석 및 보전방안 - "옥연서당기(玉淵書堂記)"와 "옥연십영(玉淵十詠)"을 중심으로-)

  • Rho, Jae-Hyun;Oh, Hyun-Kyung;Shin, Sang-Sup
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.31 no.1
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    • pp.59-70
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    • 2013
  • This study was to suggest cultural landscape preservation, value creation, as well as utilization plan to help landscape development of Hahoe village by identify the existence of Okyeonsipyeong(玉淵十詠) natural features, which were set around Buyongdae(芙蓉臺) in Hahoe Village by Seoae(西崖) Ryu, Seongryong(柳成龍), and understanding their characteristics and meanings of natural features and meanings. Based on the writings of "Okyeonseodanggi" and "Okyeonsipyeong", the major results of this study are as belows. 'Okyeon(玉淵)' letters carved on the rocks, also known as the name of pavilion in Okyeonjeongsa(玉淵精舍), is the center of Okyeonsipyeong that symbolizes the enlightenment of clean noble man, as well as the symbolic locational expression of studying room. One of Okyeonsipyeong, 'Wansimjae', is assumed to be the name from the combination of two Buddhist names, 'Wanjeok(玩寂)' and 'Seshim(洗心)', 'Dangho(堂號)', lined on both sides with Wonlakjae, the residence of Seoae, as the center. Wansimjae is after all the natural feature indicating the overall Okyeonjeongsa as the core of Okyeonsipyeong with west edge Gyeomamjeongsa(謙巖精舍). Among ten Okyeonsipyeong natural features, Wansimjae(玩心齋), Ganjukmun(看竹門), Gyeomamsa(謙菴舍), Dalgwandae(達觀臺), Ssangsongae(雙松厓), and Dohwacheon (桃花遷) are on the right side of the stairway from Okyeonjeongsa to Gyeomamjeongsa, while Chuwoldam(秋月潭), Neungpadae(凌波臺), Gyeseonam(繫船巖), and Jijuam(砥柱巖) are on the road to the cliff under river cliff in Buyongdae as well as to the dock, and all are located within 500m radius close and diameter area. As the results of lexeme and context analyses of Okyeonsipyeong poet, they are mainly about Confucian teachings symbolizing the constancy of the classical scholar including ego becoming one with the nature and back to the nature, unworldliness and farsighted view, transcendence and seclusion, as well as integrity spirit. In Dohwacheon and Gyeomamsa poets, there is Tao characteristics and brotherhood that pursue fairylands such as Mooreungdowon(武陵桃源). To create tourism brand and landscape of Okyeonsipyeong, it is necessary to prepare storytelling plans including the letters carved on the rocks introduction in Buyongdae area, and also synopsis of the Silgyeongsusang musical, 'Buyongjiae(芙蓉之愛)' that is related to 10 natural features. In addition, the related plans of the experience road from Gyeseonam, which is the boat stop in Buyongdae, to Ganjukmun of Okyeonjeongsa, and again to viewing routes on the stairways to Gyeomamjeongsa using boats are necessary. For preliminary preservation and maintenance plans, the safety of the stairway from Okyeonjeongsa to Gyeomamjeongsa should be secured, the rock inscription should be preserved, landscape interpretation plates should be installed, trees and shrubs around Dohwacheon rock inscription should be removed, Dalgwandae letters carved on the rocks should be restored, and the bamboo forest outside Ganjukmun as well as Prunus persica plantation around Dohwacheon should be pointed out.

Validity and Pertinence of Administrative Capital City Proposal (행정수도 건설안의 타당성과 시의성)

  • 김형국
    • Journal of the Korean Geographical Society
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    • v.38 no.2
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    • pp.312-323
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    • 2003
  • This writer absolutely agrees with the government that regional disequilibrium is severe enough to consider moving the administrative capital. Pursuing this course solely to establish a balanced development, however, is not a convincing enough reason. The capital city is directly related to not only the social and economic situation but, much more importantly, to the domestic political situation as well. In the mid-1970s, the proposal by the Third Republic to move the capital city temporarily was based completely on security reasons. At e time, the then opposition leader Kim, Dae-jung said that establishing a safe distance from the demilitarized zone(DMZ) reflected a typically military decision. His view was that retaining the capital city close to the DMZ would show more consideration for the will of the people to defend their own country. In fact, independent Pakistan moved its capital city from Karachi to Islamabad, situated dose to Kashmir the subject of hot territorial dispute with India. It is regrettable that no consideration has been given to the urgent political situation in the Korean peninsula, which is presently enveloped in a dense nuclear fog. As a person requires health to pursue his/her dream, a country must have security to implement a balanced territorial development. According to current urban theories, the fate of a country depends on its major cities. A negligently guarded capital city runs the risk of becoming hostage and bringing ruin to the whole country. In this vein, North Koreas undoubted main target of attack in the armed communist reunification of Korea is Seoul. For the preservation of our state, therefore, it is only right that Seoul must be shielded to prevent becoming hostage to North Korea. The location of the US Armed Forces to the north of the capital city is based on the judgment that defense of Seoul is of absolute importance. At the same time, regardless of their different standpoints, South and North Korea agree that division of the Korean people into two separate countries is abnormal. Reunification, which so far has defied all predictions, may be realized earlier than anyone expects. The day of reunification seems to be the best day for the relocation of the capital city. Building a proper capital city would take at least twenty years, and a capital city cannot be dragged from one place to another. On the day of a free and democratic reunification, a national agreement will be reached naturally to find a nationally symbolic city as in Brazil or Australia. Even if security does not pose a problem, the governments way of thinking would not greatly contribute to the balanced development of the country. The Chungcheon region, which is earmarked as the new location of the capital city, has been the greatest beneficiary of its proximity to the capital region. Not being a disadvantaged region, locating the capital city there would not help alleviate regional disparity. If it is absolutely necessary to find a candidate region at present, considering security, balanced regional development and post-reunification scenario of the future, Cheolwon area located in the middle of the Korean peninsula may be a plausible choice. Even if the transfer of capital is delayed in consideration of the present political conflict between the South and the North Koreas, there is a definite shortcut to realizing a balanced regional development. It can be found not in the geographical dispersal of the central government, but in the decentralization of power to the provinces. If the government has surplus money to build a new symbolic capital city, it is only right that it should improve, for instance, the quality of drinking water which now everyone eschews, and to help the regional subway authority whose chronic deficit state resoled in a recent disastrous accident. And it is proper to time the transfer of capital city to coincide with that of the reunification of Korea whenever Providence intends.